Q9JLQ0
SS
Gene name |
Cd2ap (Mets1) |
Protein name |
CD2-associated protein |
Names |
Mesenchyme-to-epithelium transition protein with SH3 domains 1 , METS-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12488 |
EC number |
|
Protein Class |
|
Descriptions
The human CIN85 (Cbl-interacting protein of 85 kDa) is a multifunction adapter or scaffolding protein consisting of three SH3 domains in the N-terminal half of the protein connected by unstructured linkers followed by a proline rich region, a serine rich region, and a coiled coil domain at the C-terminus and plays important roles in both receptor tyrosine kinase downregulation and phosphatidylinositol 3 kinase inhibition. Prevention of the intramolecular interaction of SH3 domain C with the proline-rich motif P1 results in the complex formation of CIN85 with specific targets such as Cbl or p85 proteins via the SH3 domain C. <br>There are several examples in the literature of SH3 domains adjacent to proline rich motifs, e.g., in tec and in the p85 subunit of PI3-kinase where an interaction is observed between the SH3 domain and the proline rich motifs, either in an intramolecular fashion as in tec kinase or in an intermolecular fashion as in the case of the p85 subunit of PI-3 kinase.
Autoinhibitory domains (AIDs)
Target domain |
273-328 (SH3 domain-containing kinase-binding protein 1, third SH3 domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Philippe D et al. (2011) "Making ends meet: the importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85", Biochemistry, 50, 3649-59
29 variants for Q9JLQ0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389464677 | 17 | E>G | No | EVA | |
| rs3389413140 | 53 | F>L | No | EVA | |
| rs243995967 | 70 | I>V | No | EVA | |
| rs3389470606 | 117 | F>Y | No | EVA | |
| rs3407348313 | 124 | E>K | No | EVA | |
| rs3389475650 | 141 | V>A | No | EVA | |
| rs3389470649 | 146 | W>* | No | EVA | |
| rs3389455087 | 169 | E>D | No | EVA | |
| rs45681038 | 260 | T>A | No | EVA | |
| rs3389458026 | 278 | F>L | No | EVA | |
| rs3389470657 | 330 | E>* | No | EVA | |
| rs242704376 | 355 | S>L | No | EVA | |
| rs244545180 | 394 | A>P | No | EVA | |
| rs223343099 | 399 | S>N | No | EVA | |
| rs254089050 | 407 | A>T | No | EVA | |
| rs3407702622 | 409 | Y>D | No | EVA | |
| rs235186830 | 411 | K>M | No | EVA | |
| rs235186830 | 411 | K>R | No | EVA | |
| rs249160857 | 423 | A>T | No | EVA | |
| rs3389464679 | 479 | D>E | No | EVA | |
| rs3389422733 | 488 | H>N | No | EVA | |
| rs3389458315 | 535 | F>I | No | EVA | |
| rs50071400 | 545 | S>P | No | EVA | |
| rs48838911 | 578 | R>K | No | EVA | |
| rs240523678 | 581 | V>M | No | EVA | |
| rs3389458016 | 605 | E>G | No | EVA | |
| rs3389479665 | 615 | E>G | No | EVA | |
| rs3389463815 | 616 | E>D | No | EVA | |
| rs3389470660 | 638 | S>R | No | EVA |
No associated diseases with Q9JLQ0
6 regional properties for Q9JLQ0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 1 - 59 | IPR001452-1 |
| domain | SH3 domain | 108 - 167 | IPR001452-2 |
| domain | SH3 domain | 269 - 330 | IPR001452-3 |
| domain | CD2-associated protein, first SH3 domain | 3 - 58 | IPR035775 |
| domain | CD2-associated protein, second SH3 domain | 111 - 165 | IPR035776 |
| domain | CD2-associated protein, third SH3 domain | 271 - 327 | IPR035777 |
Functions
26 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin filament | A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| cell periphery | The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. |
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| centriolar satellite | A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| endocytic vesicle | A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| filamentous actin | A two-stranded helical polymer of the protein actin. |
| growth cone | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| nuclear envelope lumen | The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| podosome | An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
| slit diaphragm | A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. |
| trans-Golgi network membrane | The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| beta-catenin binding | Binding to a catenin beta subunit. |
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| clathrin binding | Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. |
| identical protein binding | Binding to an identical protein or proteins. |
| phosphatidylinositol 3-kinase regulatory subunit binding | Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
| vascular endothelial growth factor receptor binding | Binding to a vascular endothelial growth factor receptor. |
61 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| actin filament polymerization | Assembly of actin filaments by the addition of actin monomers to a filament. |
| adipose tissue development | The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| cell-cell adhesion mediated by cadherin | The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains. |
| cell-cell junction organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. |
| collateral sprouting | The process in which outgrowths develop from the shafts of existing axons. |
| endothelium development | The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. |
| ERK1 and ERK2 cascade | An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier |
| filopodium assembly | The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
| gene expression | The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. |
| glomerulus development | The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. |
| glucose import | The directed movement of the hexose monosaccharide glucose into a cell or organelle. |
| immunological synapse formation | The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| kidney development | The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. |
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| liver development | The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. |
| localization of cell | Any process in which a cell is transported to, and/or maintained in, a specific location. |
| lymph node development | The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. |
| maintenance of blood-brain barrier | Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation. |
| male gonad development | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. |
| membrane organization | A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. |
| negative regulation of neuron apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
| negative regulation of small GTPase mediated signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. |
| negative regulation of transforming growth factor beta1 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1. |
| nerve growth factor signaling pathway | The series of molecular signals initiated by nerve growth factor (NGF) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| neurotrophin signaling pathway | The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. |
| neurotrophin TRK receptor signaling pathway | The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| phosphatidylinositol 3-kinase/protein kinase B signal transduction | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. |
| podocyte differentiation | The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. |
| positive regulation of protein localization to nucleus | Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. |
| positive regulation of protein secretion | Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| protein heterooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| protein secretion | The controlled release of proteins from a cell. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| regulation of receptor-mediated endocytosis | Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. |
| regulation of synaptic plasticity | A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. |
| renal albumin absorption | A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. |
| response to glial cell derived neurotrophic factor | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus. |
| response to insulin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| response to transforming growth factor beta | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. |
| response to virus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
| stress-activated MAPK cascade | The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. |
| synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
| T cell receptor signaling pathway | The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. |
| transforming growth factor beta1 production | The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. |
| vesicle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96B97 | SH3KBP1 | SH3 domain-containing kinase-binding protein 1 | Homo sapiens (Human) | EV |
| Q9Y5K6 | CD2AP | CD2-associated protein | Homo sapiens (Human) | SS |
| Q8BZT2 | Sh3rf2 | E3 ubiquitin-protein ligase SH3RF2 | Mus musculus (Mouse) | PR |
| Q9JK48 | Sh3glb1 | Endophilin-B1 | Mus musculus (Mouse) | PR |
| Q62420 | Sh3gl2 | Endophilin-A1 | Mus musculus (Mouse) | PR |
| Q62419 | Sh3gl1 | Endophilin-A2 | Mus musculus (Mouse) | PR |
| Q62421 | Sh3gl3 | Endophilin-A3 | Mus musculus (Mouse) | PR |
| Q8R550 | Sh3kbp1 | SH3 domain-containing kinase-binding protein 1 | Mus musculus (Mouse) | SS |
| F1LRS8 | Cd2ap | CD2-associated protein | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVDYIVEYDY | DAVHDDELTI | RVGEIIRNVK | KLQEEGWLEG | ELNGRRGMFP | DNFVKEIKRE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TEPKDDNLPI | KRERQGNVAS | LVQRISTYGL | PAGGIQPHPQ | TKAIKKKTKK | RQCKVLFDYS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PQNEDELELI | VGDVIDVIEE | VEEGWWSGTL | NNKLGLFPSN | FVKELESTED | GETHNAQEES |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVPLTGPTSP | LPSPGNGSEP | APGSVAQPKK | IRGIGFGDIF | KEGSVKLRTR | TSSSETEEKK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TEKPLILQPL | GSRTQNVEVT | KPDVDGKIKA | KEYCRTLFPY | TGTNEDELTF | REGEIIHLIS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KETGEAGWWK | GELNGKEGVF | PDNFAVQISE | LDKDFPKPKK | PPPPAKGPAP | KPDLSAAEKK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFPLKAEEKD | EKSLLEQKPS | KPAAPQVPPK | KPTAPTKASN | LLRSPGAVYP | KRPEKPVPPP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPAAKINGEV | SIISSKIDTE | PVSKPKLDPE | QLPVRPKSVD | LDAFVARNSK | ETDDVNFDDI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ASSENLLHLT | ANRPKMPGRR | LPGRFNGGHS | PTQSPEKTLK | LPKEDDSGNL | KPLEFKKDAS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YSSKSSLSTP | SSASKVNTAA | FLTPLELKAK | AEADDGKRNS | VDELRAQIIE | LLCIVDALKK |
| 610 | 620 | 630 | |||
| DHGKELEKLR | KELEEEKAMR | SNLEVEIAKL | KKAVLLS |