AiPD: Autoinhibited Protein Database

Gene name	Pals2
Protein name	Protein PALS2
Names	Dlgh4 protein, MAGUK p55 subfamily member 6, P55T protein, Protein associated with Lin-7 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:56524
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

72-147 (Predicted disordered autoinhibitory region) PR

72-147 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9JLB0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388812964	134	K>I	No	EVA
rs3388816911	144	F>I	No	EVA
rs3388835903	145	R>I	No	EVA
rs1133823446	162	I>T	No	EVA
rs3388807980	187	K>R	No	EVA
rs3396733428	204	I>T	No	EVA
rs3388807966	210	D>E	No	EVA
rs1134656673	219	V>I	No	EVA
rs3388812949	220	N>S	No	EVA
rs1133431418	221	M>I	No	EVA
rs1134448959	222	E>K	No	EVA
rs3388796950	332	F>I	No	EVA
rs3388823300	335	H>Q	No	EVA
rs3388826274	347	P>Q	No	EVA
rs3388835091	392	E>D	No	EVA
rs3388828670	392	E>Q	No	EVA
rs3388829973	438	V>D	No	EVA
rs3388830404	447	L>S	No	EVA
rs3396582454	447	L>V	No	EVA
rs3388820005	449	V>I	No	EVA
rs3388826265	481	H>Q	No	EVA
rs3388828582	535	T>I	No	EVA
rs3388813012	537	I>T	No	EVA

Type	Name	Position	InterPro Accession
domain	Helicase, C-terminal	305 - 473	IPR001650
domain	DEAD/DEAH box helicase domain	116 - 280	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	110 - 309	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	91 - 119	IPR014014

		Description
EC Number
Subcellular Localization	Membrane; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell-cell junction	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
guanylate kinase activity	Catalysis of the reaction: ATP + GMP = ADP + GDP.

Name	Definition
No GO annotations for biological process

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q24210	CASK	Peripheral plasma membrane protein CASK	Drosophila melanogaster (Fruit fly)	SS
Q00013	MPP1	55 kDa erythrocyte membrane protein	Homo sapiens (Human)	PR
O14936	CASK	Peripheral plasma membrane protein CASK	Homo sapiens (Human)	EV
Q96JB8	MPP4	MAGUK p55 subfamily member 4	Homo sapiens (Human)	PR
Q14168	MPP2	MAGUK p55 subfamily member 2	Homo sapiens (Human)	PR
Q9NZW5	PALS2	Protein PALS2	Homo sapiens (Human)	PR
P70290	Mpp1	55 kDa erythrocyte membrane protein	Mus musculus (Mouse)	PR
O70589	Cask	Peripheral plasma membrane protein CASK	Mus musculus (Mouse)	SS
Q9WV34	Mpp2	MAGUK p55 subfamily member 2	Mus musculus (Mouse)	PR
Q6P7F1	Mpp4	MAGUK p55 subfamily member 4	Mus musculus (Mouse)	PR
Q8BVD5	Mpp7	MAGUK p55 subfamily member 7	Mus musculus (Mouse)	PR
O88910	Mpp3	MAGUK p55 subfamily member 3	Mus musculus (Mouse)	PR
Q9QYH1	Mpp4	MAGUK p55 subfamily member 4	Rattus norvegicus (Rat)	PR
P54936	lin-2	Protein lin-2	Caenorhabditis elegans	SS