Q9JKV2
Gene name |
Cilk1 (Ick) |
Protein name |
Serine/threonine-protein kinase ICK |
Names |
Intestinal cell kinase, mICK, MAK-related kinase, MRK |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56542 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
142-164 (Activation loop from InterPro)
Target domain |
4-284 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9JKV2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JKV2-F1 | Predicted | AlphaFoldDB |
50 variants for Q9JKV2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389061290 | 10 | L>F | No | EVA | |
| rs3389063778 | 38 | K>* | No | EVA | |
| rs3389067955 | 94 | N>K | No | EVA | |
| rs864293638 | 126 | L>S | No | EVA | |
| rs864261050 | 126 | L>V | No | EVA | |
| rs3389034763 | 142 | A>T | No | EVA | |
| rs3389057723 | 143 | D>H | No | EVA | |
| rs3389059634 | 148 | R>G | No | EVA | |
| rs3389057923 | 182 | D>E | No | EVA | |
| rs3389027051 | 202 | G>W | No | EVA | |
| rs3389054218 | 215 | V>E | No | EVA | |
| rs3389047412 | 225 | P>S | No | EVA | |
| rs3400374895 | 270 | K>E | No | EVA | |
| rs3389063719 | 317 | A>D | No | EVA | |
| rs3389057800 | 333 | R>* | No | EVA | |
| rs249783263 | 360 | H>R | No | EVA | |
| rs3400509647 | 365 | K>* | No | EVA | |
| rs3400374860 | 365 | K>M | No | EVA | |
| rs3399842223 | 366 | P>A | No | EVA | |
| rs3400376203 | 367 | S>C | No | EVA | |
| rs239084944 | 371 | F>C | No | EVA | |
| rs3389057758 | 384 | L>P | No | EVA | |
| rs3389061306 | 397 | K>M | No | EVA | |
| rs3389068521 | 409 | T>S | No | EVA | |
| rs3389053757 | 417 | D>N | No | EVA | |
| rs3389057778 | 426 | S>F | No | EVA | |
| rs255060310 | 457 | S>P | No | EVA | |
| rs3389057735 | 480 | S>F | No | EVA | |
| rs223698346 | 481 | S>A | No | EVA | |
| rs3400509643 | 484 | Q>H | No | EVA | |
| rs3399842249 | 485 | H>Q | No | EVA | |
| rs3389068021 | 514 | N>T | No | EVA | |
| rs3389062598 | 518 | S>G | No | EVA | |
| rs3389063777 | 519 | S>F | No | EVA | |
| rs3400470334 | 521 | L>W | No | EVA | |
| rs3400616707 | 522 | S>T | No | EVA | |
| rs3389063732 | 529 | V>I | No | EVA | |
| rs3389040187 | 530 | S>P | No | EVA | |
| rs3389040150 | 531 | V>L | No | EVA | |
| rs3389063740 | 540 | S>* | No | EVA | |
| rs3389068603 | 558 | K>E | No | EVA | |
| rs3400291732 | 558 | K>R | No | EVA | |
| rs3399329221 | 561 | I>M | No | EVA | |
| rs3389004916 | 567 | R>M | No | EVA | |
| rs3400616738 | 568 | V>K | No | EVA | |
| rs3410610806 | 571 | A>V | No | EVA | |
| rs247314453 | 574 | A>V | No | EVA | |
| rs3400385081 | 577 | P>H | No | EVA | |
| rs3400385130 | 578 | P>R | No | EVA | |
| rs256514070 | 603 | P>A | No | EVA |
No associated diseases with Q9JKV2
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| ciliary base | Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. |
| ciliary tip | Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| intraciliary anterograde transport | The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins. |
| intraciliary retrograde transport | The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins. |
| intraciliary transport | The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20794 | MAK | Serine/threonine-protein kinase MAK | Homo sapiens (Human) | PR |
| Q9UQ07 | MOK | MAPK/MAK/MRK overlapping kinase | Homo sapiens (Human) | PR |
| Q04859 | Mak | Serine/threonine-protein kinase MAK | Mus musculus (Mouse) | PR |
| Q9WVS4 | Mok | MAPK/MAK/MRK overlapping kinase | Mus musculus (Mouse) | PR |
| Q80Y86 | Mapk15 | Mitogen-activated protein kinase 15 | Mus musculus (Mouse) | SS |
| Q9WTU6 | Mapk9 | Mitogen-activated protein kinase 9 | Mus musculus (Mouse) | PR |
| Q91Y86 | Mapk8 | Mitogen-activated protein kinase 8 | Mus musculus (Mouse) | PR |
| Q63844 | Mapk3 | Mitogen-activated protein kinase 3 | Mus musculus (Mouse) | SS |
| P63085 | Mapk1 | Mitogen-activated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q6P5G0 | Mapk4 | Mitogen-activated protein kinase 4 | Mus musculus (Mouse) | SS |
| Q61532 | Mapk6 | Mitogen-activated protein kinase 6 | Mus musculus (Mouse) | SS |
| Q9WVS8 | Mapk7 | Mitogen-activated protein kinase 7 | Mus musculus (Mouse) | SS |
| O08911 | Mapk12 | Mitogen-activated protein kinase 12 | Mus musculus (Mouse) | SS |
| Q9Z1B7 | Mapk13 | Mitogen-activated protein kinase 13 | Mus musculus (Mouse) | SS |
| Q9WUI1 | Mapk11 | Mitogen-activated protein kinase 11 | Mus musculus (Mouse) | SS |
| P47811 | Mapk14 | Mitogen-activated protein kinase 14 | Mus musculus (Mouse) | SS |
| P20793 | Mak | Serine/threonine-protein kinase MAK | Rattus norvegicus (Rat) | PR |
| P43294 | MHK | Serine/threonine-protein kinase MHK | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRYTTIKQL | GDGTYGSVLL | GRSIESGELI | AIKKMKRKFY | SWEECMNLRE | VKSLKKLNHA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NIVKLKEVIR | ENDHLYFIFE | YMKENLYQLI | KERNKLFPES | AIRNIMYQIL | QGLAFIHKHG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FFHRDLKPEN | LLCMGPELVK | IADFGLAREI | RSRPPYTDYV | STRWYRAPEV | LLRSTNYSSP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IDIWAVGCIM | AEVYTLRPLF | PGASEIDTIF | KICQVLGTPK | KTDWPEGYQL | SSAMNFLWPQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CIPNNLKTLI | PNASSEAIQL | LRDLLQWDPK | KRPTASQALR | YPYFQIGHPL | GIISKDSGKP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QREVQDKTGP | PPYIKPAPPA | QAPAKAYTLI | SSRPSQASQP | PQHSVHPYKG | DVSRTEQLSH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VQEGKPSPPF | FPSLHNKNLQ | PKILASLEQK | NGEIKPKSRR | RWGLISRSTK | GSDDWADLDD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LDFSPSLTRI | DVKNKKRQSD | DTLCRFESVL | DLKPSESVGT | GTTVSTQASS | QRRDTPTLQS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SAKQHYLKHS | RYLPGINIRN | GVLPNPGKDF | LPSNSWSSSG | LSGKSSGTVS | VVSKITSVGS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GSASSSGLTG | SYIPSFLKKE | IGSVMQRVQL | APLAAPPPGY | SSLKAVRPHP | GRPFFHTQPR |
| 610 | 620 | ||||
| STPGLIPRPP | AAQPVHGRID | WSSKYPSRR |