Q9JJZ8
PR
Gene name |
Cnga3 (Cng3) |
Protein name |
Cyclic nucleotide-gated cation channel alpha-3 |
Names |
Cone photoreceptor cGMP-gated channel subunit alpha, Cyclic nucleotide-gated channel alpha-3, CNG channel alpha-3, CNG-3, CNG3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12790 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JJZ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JJZ8-F1 | Predicted | AlphaFoldDB |
34 variants for Q9JJZ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3413107791 | 7 | Q>E | No | EVA | |
| rs3389860082 | 7 | Q>R | No | EVA | |
| rs3389805060 | 10 | Q>P* | No | EVA | |
| rs3388463457 | 18 | I>T | No | EVA | |
| rs108754013 | 20 | N>D | No | EVA | |
| rs3389850602 | 20 | N>I | No | EVA | |
| rs221461796 | 21 | A>T | No | EVA | |
| rs231590531 | 27 | H>Q | No | EVA | |
| rs3388464116 | 34 | R>T | No | EVA | |
| rs263456706 | 44 | A>S | No | EVA | |
| rs3388464023 | 95 | R>M | No | EVA | |
| rs1133455729 | 104 | P>S | No | EVA | |
| rs3388464335 | 123 | N>D | No | EVA | |
| rs3388466027 | 131 | A>T | No | EVA | |
| rs51771604 | 157 | L>V | No | EVA | |
| rs3388464171 | 161 | V>A | No | EVA | |
| rs3388464712 | 191 | K>M | No | EVA | |
| rs3389869263 | 202 | L>M | No | EVA | |
| rs3388463446 | 239 | P>H | No | EVA | |
| rs3388464437 | 269 | I>T | No | EVA | |
| rs3388464297 | 272 | G>E | No | EVA | |
| rs3388466024 | 303 | T>A | No | EVA | |
| rs3388466070 | 305 | T>S | No | EVA | |
| rs3389858249 | 314 | V>A | No | EVA | |
| rs3388464683 | 315 | K>R | No | EVA | |
| rs3388463797 | 393 | D>E | No | EVA | |
| rs3388463995 | 536 | K>Q | No | EVA | |
| rs261934433 | 580 | I>V | No | EVA | |
| rs3388464447 | 582 | Q>H | No | EVA | |
| rs223419581 | 624 | S>A | No | EVA | |
| rs236222150 | 624 | S>Y | No | EVA | |
| rs3388466008 | 629 | K>R | No | EVA | |
| rs3388464113 | 631 | D>H | No | EVA | |
| rs3388465135 | 631 | D>V | No | EVA |
No associated diseases with Q9JJZ8
5 regional properties for Q9JJZ8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 423 - 547 | IPR000595 |
| domain | Ion transport domain | 112 - 348 | IPR005821 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 450 - 466 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 488 - 511 | IPR018488-2 |
| domain | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | 539 - 609 | IPR032406 |
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon initial segment | Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. |
| cone photoreceptor outer segment | The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| glial cell projection | A prolongation or process extending from a glial cell. |
| intracellular cyclic nucleotide activated cation channel complex | A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| transmembrane transporter complex | A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| intracellular cAMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. |
| intracellular cGMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. |
| intracellular cyclic nucleotide activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| protein-containing complex binding | Binding to a macromolecular complex. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cation transmembrane transport | The process in which a cation is transported across a membrane. |
| cation transport | The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| inorganic cation import across plasma membrane | The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol. |
| ion transmembrane transport | A process in which an ion is transported across a membrane. |
| response to cAMP | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. |
| response to magnesium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. |
| retinal cone cell development | Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03041 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Bos taurus (Bovine) | PR |
| Q00194 | CNGA1 | cGMP-gated cation channel alpha-1 | Bos taurus (Bovine) | PR |
| Q29441 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Bos taurus (Bovine) | PR |
| Q90980 | Cyclic nucleotide-gated channel rod photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q90805 | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| P29973 | CNGA1 | cGMP-gated cation channel alpha-1 | Homo sapiens (Human) | PR |
| Q16280 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Homo sapiens (Human) | PR |
| Q16281 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Homo sapiens (Human) | PR |
| P29974 | Cnga1 | cGMP-gated cation channel alpha-1 | Mus musculus (Mouse) | PR |
| Q62398 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Mus musculus (Mouse) | PR |
| Q62927 | Cnga1 | cGMP-gated cation channel alpha-1 | Rattus norvegicus (Rat) | PR |
| Q00195 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Rattus norvegicus (Rat) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKVNTQCSQ | PSPTQLSIKN | ADRDLDHVEN | GLGRVSRLII | SIRAWASRHL | HDEDQTPDSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDRFHGSELK | EVSTRESNAQ | PNPGEQKPPD | GGEGRKEEPI | VVDPSSNIYY | RWLTAIALPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FYNWCLLVCR | ACFDELQSEH | LTLWLVLDYS | ADVLYVLDML | VRARTGFLEQ | GLMVRDTKRL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WKHYTKTLHF | KLDILSLIPT | DLAYLKLGVN | YPELRFNRLL | KFSRLFEFFD | RTETRTNYPN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VFRIGNLVLY | TLIIIHWNAC | IYFAISKFIG | FGTDSWVYPN | TSKPEYARLS | RKYIYSLYWS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TLTLTTIGET | PPPVKDEEYL | FVVIDFLVGI | LIFATIVGNV | GSMISNMNAP | RVEFQAKIDS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VKQYMQFRKV | TKDLETRVIR | WFDYLWANRK | TVDEKEVLKN | LPDKLKAEIA | INVHLDTLKK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VRIFQDCEAG | LLVELVLKLR | PTVFSPGDYI | CKKGDIGREM | YIIKEGKLAV | VADDGVTQFV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VLSDGSYFGE | ISILNIKGSK | SGNRRTANIR | SIGYSDLFCL | SKDDLMEALT | EYPDAKRALE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EKGRQILMKD | NLIDEDLVAA | RVDTRDVEEK | VEYLESSLDI | LQTRFARLLA | EYSASQMKLK |
| 610 | 620 | 630 | |||
| QRLTRLESQM | NRRCCGFSPD | RENSEDASKT | D |