Q9JJ40
PR
Gene name |
Pdzk1 (Clamp, Diphor1, Nherf3) |
Protein name |
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 |
Names |
NHERF-3, C-terminal-linking and modulating protein, Dietary Pi-regulated RNA-1, Diphor-1, Na(+)/H(+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, NaPi-Cap1, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:65144 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JJ40
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JJ40-F1 | Predicted | AlphaFoldDB |
4 variants for Q9JJ40
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3319647278 | 204 | G>E | No | EVA | |
| rs8174277 | 303 | G>S | No | EVA | |
| rs13452375 | 418 | E>K | No | EVA | |
| rs8174280 | 484 | A>E | No | EVA |
No associated diseases with Q9JJ40
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| brush border | The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. |
| brush border membrane | The portion of the plasma membrane surrounding the brush border. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| microvillus membrane | The portion of the plasma membrane surrounding a microvillus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| PDZ domain binding | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| protein-membrane adaptor activity | The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle. |
| scavenger receptor binding | Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| carnitine transport | The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. |
| cholesterol transport | The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| intracellular transport | The directed movement of substances within a cell. |
| positive regulation of cation transmembrane transport | Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. |
| positive regulation of ion transmembrane transporter activity | Any process that activates or increases the activity of an ion transporter. |
| positive regulation of protein localization to membrane | Any process that activates or increases the frequency, rate or extent of protein localization to membrane. |
| positive regulation of protein targeting to membrane | Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| regulation of anion transport | Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZK8 | NHERF1 | Na | Bos taurus (Bovine) | SS |
| Q5ZM14 | NHERF1 | Na | Gallus gallus (Chicken) | SS |
| Q24008 | inaD | Inactivation-no-after-potential D protein | Drosophila melanogaster (Fruit fly) | PR |
| Q9Y6N9 | USH1C | Harmonin | Homo sapiens (Human) | PR |
| O14745 | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Homo sapiens (Human) | EV |
| Q86UT5 | PDZD3 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 | Homo sapiens (Human) | PR |
| Q99MJ6 | Pdzd3 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 | Mus musculus (Mouse) | PR |
| Q0QWG9 | Grid2ip | Delphilin | Mus musculus (Mouse) | PR |
| P70441 | Slc9a3r1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Mus musculus (Mouse) | PR |
| Q9JIL4 | Pdzk1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | Mus musculus (Mouse) | PR |
| Q9JJ19 | Nherf1 | Na | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASTFNPREC | KLSKKEGQNY | GFFLRIEKDT | DGHLVRVIEE | GSPAEKAGLL | DGDRVLRING |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VFVDKEEHAQ | VVDLVRKSGN | SVTLLVLDGD | SYEKAVKHQV | DLKELDQSPR | EPALNEKKPD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LGMNGGVETC | AQPRLCYLVK | EGNSFGFSLK | TIQGKKGVFL | TDITPQGVAM | KAGVLADDHL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IEVNGENVEN | ASHEEVVEKV | TKSGSRIMFL | LVDKETARCH | SEQKTPFKRE | TASLKLLPHQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PRVVVIKKGS | NGYGFYLRAG | PEQKGQIIKD | IEPGSPAEAA | GLKNNDLVVA | VNGESVEALD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HDGVVEMIRN | GGDQTTLLVL | DKEADRIYSL | ARFSPLLYCQ | SQELPNGSVK | EAPAPISAPL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EAPGSATTED | VGDHKPKLCR | LIKEDDSYGF | HLNAIRGQPG | SFVKEVQQGG | PADKAGLENE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DIIIEVNGEN | VQDEPYDRVV | ERIKSSGEHV | TLLVCGKVAY | SYFQAKKIPI | LSSLADPLVA |
| 490 | 500 | 510 | 520 | ||
| GPDAKGETEH | DSAESTKDSS | HPARDRTLSA | ASHSSSNSED | TVM |