Q9JHG7

PR
Gene name
Pik3cg (Pi3kg1)
Protein name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Names
PI3-kinase subunit gamma, PI3K-gamma, PI3Kgamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p110gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, Serine/threonine protein kinase PIK3CG, p120-PI3K
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:30955
EC number
2.7.1.137: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

964-988 (Activation loop from InterPro)

Target domain

797-1094 (Phosphatidylinositol 3-/4-kinase, catalytic domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9JHG7

Entry ID Method Resolution Chain Position Source
AF-Q9JHG7-F1 Predicted AlphaFoldDB

46 variants for Q9JHG7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs49039292 20 R>C No EVA
rs3389244569 40 I>T No EVA
rs3389235150 44 L>V No EVA
rs3389210677 79 L>P No EVA
rs3402475806 106 W>R No EVA
rs3389229009 149 A>T No EVA
rs3389233791 161 D>E No EVA
rs3389245945 185 M>V No EVA
rs29216533 262 S>P No EVA
rs3389244530 267 E>G No EVA
rs3389232672 309 T>M No EVA
rs3403140122 310 P>S No EVA
rs3389250140 343 G>D No EVA
rs3389250094 361 F>* No EVA
rs108525518 405 A>T No EVA
rs3389222637 424 P>S No EVA
rs3389168707 490 K>E No EVA
rs3389250093 496 S>I No EVA
rs108531174 561 T>A No EVA
rs3389232670 593 F>S No EVA
rs3389205655 594 S>I No EVA
rs3389210606 603 I>N No EVA
rs3389233840 616 I>F No EVA
rs3389233813 616 I>N No EVA
rs107601557 640 V>A No EVA
rs3389235202 672 Y>* No EVA
rs3389232673 683 K>M No EVA
rs3389250157 690 R>G No EVA
rs3402735203 693 H>D No EVA
rs3403117030 697 W>* No EVA
rs3389239541 706 S>T No EVA
rs3389236463 710 Q>* No EVA
rs3389250175 718 E>D No EVA
rs3389234092 770 K>R No EVA
rs3389237749 805 A>V No EVA
rs3412564307 822 V>L No EVA
rs3389210637 843 L>M No EVA
rs3389233792 887 T>R No EVA
rs3389222672 925 V>E No EVA
rs3389210667 958 G>* No EVA
rs3389237803 961 F>L No EVA
rs3389231093 975 F>E No EVA
rs108636709 987 L>I No EVA
rs3389229028 1067 Y>S No EVA
rs3389233854 1070 D>Y No EVA
rs3403131315 1095 K>RSAFLLV* No EVA

No associated diseases with Q9JHG7

2 regional properties for Q9JHG7

Type Name Position InterPro Accession
domain Protein kinase domain 195 - 533 IPR000719
active_site Serine/threonine-protein kinase, active site 316 - 328 IPR008271

Functions

Description
EC Number 2.7.1.137 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
phosphatidylinositol 3-kinase complex A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
phosphatidylinositol 3-kinase complex, class IA A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.
phosphatidylinositol 3-kinase complex, class IB A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

11 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
1-phosphatidylinositol-4-phosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ephrin receptor binding Binding to an ephrin receptor.
identical protein binding Binding to an identical protein or proteins.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.
phosphatidylinositol-3,4-bisphosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

28 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
hepatocyte apoptotic process Any apoptotic process in a hepatocyte, the main structural component of the liver.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
negative regulation of fibroblast apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.
negative regulation of triglyceride catabolic process Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
phosphatidylinositol 3-kinase signaling A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of acute inflammatory response Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
positive regulation of catalytic activity Any process that activates or increases the activity of an enzyme.
positive regulation of cytosolic calcium ion concentration Any process that increases the concentration of calcium ions in the cytosol.
positive regulation of endothelial cell migration Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of MAP kinase activity Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
positive regulation of protein kinase B signaling Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of Rac protein signal transduction Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of calcium ion transmembrane transport Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport.
regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
secretory granule localization Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.
sphingosine-1-phosphate receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32871 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Bos taurus (Bovine) PR
P42336 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Homo sapiens (Human) PR
P42338 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Homo sapiens (Human) PR
O00329 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Homo sapiens (Human) PR
P48736 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (Human) PR
P42337 Pik3ca Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Mus musculus (Mouse) PR
Q8BTI9 Pik3cb Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Mus musculus (Mouse) PR
Q8BKC8 Pi4kb Phosphatidylinositol 4-kinase beta Mus musculus (Mouse) PR
Q61194 Pik3c2a Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Mus musculus (Mouse) PR
O35904 Pik3cd Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Mus musculus (Mouse) PR
O02697 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Sus scrofa (Pig) PR
Q9Z1L0 Pik3cb Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Rattus norvegicus (Rat) PR
Q94125 age-1 Phosphatidylinositol 3-kinase age-1 Caenorhabditis elegans PR
10 20 30 40 50 60
MELENYEQPV VLREDNLRRR RRMKPRSAAG SLSSMELIPI EFVLPTSQRI SKTPETALLH
70 80 90 100 110 120
VAGHGNVEQM KAQVWLRALE TSVAAEFYHR LGPDQFLLLY QKKGQWYEIY DRYQVVQTLD
130 140 150 160 170 180
CLHYWKLMHK SPGQIHVVQR HVPSEETLAF QKQLTSLIGY DVTDISNVHD DELEFTRRRL
190 200 210 220 230 240
VTPRMAEVAG RDAKLYAMHP WVTSKPLPDY LSKKIANNCI FIVIHRGTTS QTIKVSADDT
250 260 270 280 290 300
PGTILQSFFT KMAKKKSLMN ISESQSEQDF VLRVCGRDEY LVGETPLKNF QWVRQCLKNG
310 320 330 340 350 360
DEIHLVLDTP PDPALDEVRK EEWPLVDDCT GVTGYHEQLT IHGKDHESVF TVSLWDCDRK
370 380 390 400 410 420
FRVKIRGIDI PVLPRNTDLT VFVEANIQHG QQVLCQRRTS PKPFAEEVLW NVWLEFGIKI
430 440 450 460 470 480
KDLPKGALLN LQIYCCKTPS LSSKASAETP GSESKGKAQL LYYVNLLLID HRFLLRHGDY
490 500 510 520 530 540
VLHMWQISGK AEEQGSFNAD KLTSATNPDK ENSMSISILL DNYCHPIALP KHRPTPDPEG
550 560 570 580 590 600
DRVRAEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKHPKAYP KLFSSVKWGQ
610 620 630 640 650 660
QEIVAKTYQL LARREIWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL
670 680 690 700 710 720
LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY
730 740 750 760 770 780
LRGCGTAMLQ DFTQQVHVIE MLQKVTIDIK SLSAEKYDVS SQVISQLKQK LESLQNSNLP
790 800 810 820 830 840
ESFRVPYDPG LKAGTLVIEK CKVMASKKKP LWLEFKCADP TVLSNETIGI IFKHGDDLRQ
850 860 870 880 890 900
DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAQ IQQSTVGNTG
910 920 930 940 950 960
AFKDEVLNHW LKEKCPIEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMISETGNL
970 980 990 1000 1010 1020
FHIDFGHILG NYKSFLGINK ERVPFVLTPD FLFVMGSSGK KTSPHFQKFQ DVCVRAYLAL
1030 1040 1050 1060 1070 1080
RHHTNLLIIL FSMMLMTGMP QLTSKEDIEY IRDALTVGKS EEDAKKYFLD QIEVCRDKGW
1090 1100
TVQFNWFLHL VLGIKQGEKH SA