Q9JHC9

PR
Gene name
Elf2
Protein name
ETS-related transcription factor Elf-2
Names
E74-like factor 2, New ETS-related factor
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:69257
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

147-224 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9JHC9

Entry ID Method Resolution Chain Position Source
AF-Q9JHC9-F1 Predicted AlphaFoldDB

42 variants for Q9JHC9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs226816906 4 A>T No EVA
rs237637534 18 D>G No EVA
rs30085541 18 D>N No EVA
rs218387223 28 T>S No EVA
rs30085525 32 C>Y No EVA
rs50714775 33 P>R No EVA
rs3388633636 49 Y>C No EVA
rs3392848421 99 A>P No EVA
rs3392838600 102 L>R No EVA
rs3393040061 102 L>V No EVA
rs3388625284 119 E>S No EVA
rs3388625202 131 F>Y No EVA
rs3388631117 146 V>L No EVA
rs3388633646 173 K>E No EVA
rs3388625676 196 I>N No EVA
rs3388628345 259 M>I No EVA
rs3388627628 287 Y>* No EVA
rs3388626240 302 D>N No EVA
rs3388627618 308 P>H No EVA
rs3388631144 308 P>T No EVA
rs3392927802 309 E>K No EVA
rs3392969927 312 A>S No EVA
rs3393057756 313 A>S No EVA
rs3393039012 316 D>A No EVA
rs3393128511 317 D>A No EVA
rs3393057698 320 L>S No EVA
rs3388627627 324 S>P No EVA
rs3388631879 330 L>I No EVA
rs3388617823 335 T>N No EVA
rs3388633574 363 S>F No EVA
rs3388633580 388 V>F No EVA
rs3388627591 404 K>Q No EVA
rs3388626164 407 A>P No EVA
rs3388630495 410 V>A No EVA
rs3388617834 431 S>I No EVA
rs3388625224 439 T>I No EVA
rs3388622923 459 A>T No EVA
rs3392848414 482 G>A No EVA
rs3392969903 482 G>R No EVA
rs3388630528 535 P>A No EVA
rs3388620314 535 P>E No EVA
rs3388612616 571 V>F No EVA

No associated diseases with Q9JHC9

3 regional properties for Q9JHC9

Type Name Position InterPro Accession
conserved_site 14-3-3 protein, conserved site 45 - 55 IPR023409-1
conserved_site 14-3-3 protein, conserved site 217 - 236 IPR023409-2
domain 14-3-3 domain 5 - 249 IPR023410

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

24 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58DT0 ELF5 ETS-related transcription factor Elf-5 Bos taurus (Bovine) SS
Q0VC65 ETV6 Transcription factor ETV6 Bos taurus (Bovine) SS
P32519 ELF1 ETS-related transcription factor Elf-1 Homo sapiens (Human) PR
Q9UKW6 ELF5 ETS-related transcription factor Elf-5 Homo sapiens (Human) EV
Q99607 ELF4 ETS-related transcription factor Elf-4 Homo sapiens (Human) PR
Q9Y603 ETV7 Transcription factor ETV7 Homo sapiens (Human) SS
P78545 ELF3 ETS-related transcription factor Elf-3 Homo sapiens (Human) SS
P41212 ETV6 Transcription factor ETV6 Homo sapiens (Human) SS
P97360 Etv6 Transcription factor ETV6 Mus musculus (Mouse) EV
Q8VDK3 Elf5 ETS-related transcription factor Elf-5 Mus musculus (Mouse) SS
Q60775 Elf1 ETS-related transcription factor Elf-1 Mus musculus (Mouse) PR
Q9Z2U4 Elf4 ETS-related transcription factor Elf-4 Mus musculus (Mouse) PR
Q00422 Gabpa GA-binding protein alpha chain Mus musculus (Mouse) EV
Q9WTP3 Spdef SAM pointed domain-containing Ets transcription factor Mus musculus (Mouse) PR
P70459 Erf ETS domain-containing transcription factor ERF Mus musculus (Mouse) PR
P81270 Erg Transcriptional regulator ERG Mus musculus (Mouse) SS
P28322 Etv4 ETS translocation variant 4 Mus musculus (Mouse) SS
Q9CXC9 Etv5 ETS translocation variant 5 Mus musculus (Mouse) SS
P41164 Etv1 ETS translocation variant 1 Mus musculus (Mouse) SS
P41971 Elk3 ETS domain-containing protein Elk-3 Mus musculus (Mouse) EV
P41158 Elk4 ETS domain-containing protein Elk-4 Mus musculus (Mouse) PR
P41969 Elk1 ETS domain-containing protein Elk-1 Mus musculus (Mouse) PR
P15037 Ets2 Protein C-ets-2 Mus musculus (Mouse) SS
P27577 Ets1 Protein C-ets-1 Mus musculus (Mouse) EV
10 20 30 40 50 60
MASAVVDSGG SALELPSDGG ENQEGGDTGP DCPAVIVEPV PSARLEQGYA AQVLVYDDET
70 80 90 100 110 120
YMMQDVAEEQ EVETENSETV EASVHSSNAH CTDKTIEAAE ALLHMESPTC LRDSRSPVEV
130 140 150 160 170 180
FVPPCISTPE FIHAAMRPDV ITETVVEVST EESEPMDASP IPTSPDSHEP MKKKKVGRKP
190 200 210 220 230 240
KTQQSPVSNG SPELGIKKKA REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL
250 260 270 280 290 300
VDSKAVSKLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID
310 320 330 340 350 360
DDKSETCPED LAAAADDKSL ERVSLSAESL LKAATAVRGG KNSSPLNCSR AEKGVARVVN
370 380 390 400 410 420
ITSPTHDGSS RSPTTTAPVS AAAAPRTVRV AMQVPVVMTS LGQKISAVAV QSVNAGTGSP
430 440 450 460 470 480
LITSTSPASA SSPKVVIQTV PTVMPASTEN GDRITMQPAK IITIPATQLA QCQLQAKSNL
490 500 510 520 530 540
TGSGSINIVG TPLAVRALTP VSIAHGTPVM RLSVPAQQAS GQTPPRVISA LLKGPEGKSE
550 560 570 580 590
AKKQEHDVKT LQLVEEKGAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK