Q9I8X3
Gene name |
fgfr3 |
Protein name |
Fibroblast growth factor receptor 3 |
Names |
FGFR-3 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
|
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with P22607)
Fibroblast growth factor receptor 3 (FGFR3) is one of the members of FGFR family belonging to the receptor tyrosine kinases (RTK) in cell proliferation, differentiation, migration, and maintenance of cellular homeostasis. FGFR3 consists of the ligand-binding region (immunoglobulin (Ig) domain 1-like domains) designated D1, D2, and D3, and a kinase domain. The D1 domain and the acid box (AB)-containing linker between D1 and D2 are involved in autoinhibition. Loss of D1 or the linker enhances the affinity of FGFR for FGF and HS and increases the signaling capacity of FGFR. Specifically, the AB region blocks the heparan sulfate (HS)-binding site on the D2 domain in cis to suppress HS-binding affinity of EGFR. D1 is dispensable for autoinhibition but plays a minor role in autoinhibition.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
622-647 (Activation loop from InterPro)
Target domain |
460-739 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9I8X3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9I8X3-F1 | Predicted | AlphaFoldDB |
No variants for Q9I8X3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9I8X3 | |||||
No associated diseases with Q9I8X3
15 regional properties for Q9I8X3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 460 - 739 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 460 - 734 | IPR001245 |
| domain | Immunoglobulin subtype 2 | 46 - 108 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 160 - 228 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 259 - 339 | IPR003598-3 |
| domain | Immunoglobulin subtype | 40 - 118 | IPR003599-1 |
| domain | Immunoglobulin subtype | 154 - 239 | IPR003599-2 |
| domain | Immunoglobulin subtype | 253 - 350 | IPR003599-3 |
| domain | Immunoglobulin-like domain | 16 - 122 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 144 - 237 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 246 - 348 | IPR007110-3 |
| domain | Immunoglobulin I-set | 37 - 102 | IPR013098-1 |
| domain | Immunoglobulin I-set | 159 - 238 | IPR013098-2 |
| domain | Immunoglobulin I-set | 253 - 349 | IPR013098-3 |
| binding_site | Protein kinase, ATP binding site | 466 - 496 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| fibroblast growth factor binding | Binding to a fibroblast growth factor. |
| fibroblast growth factor receptor activity | Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of kinase activity | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| regulation of hematopoietic stem cell differentiation | Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| Q8VYA3 | WAKL10 | Wall-associated receptor kinase-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M092 | WAKL17 | Wall-associated receptor kinase-like 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| E7F3X9 | ddr1 | receptor protein-tyrosine kinase | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1QVU0 | ltk | Tyrosine-protein kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9YI66 | tyro3 | Tyrosine-protein kinase receptor TYRO3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVPLCLLLYL | ATLVFPPVYS | AHLLSPEPTD | WVSSEVEVFL | EDYVAGVGDT | VVLSCTPQDF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLPIVWQKDG | DAVSSSNRTR | VGQKALRIIN | VSYEDSGVYS | CRHAHKSMLL | SNYTVKVIDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSSGDDEDYD | EDEDEAGNGN | AEAPYWTRSD | RMEKKLLAVP | AANTVKFRCP | AAGNPTPSIH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WLKNGKEFKG | EQRMGGIKLR | HQQWSLVMES | AVPSDRGNYT | CVVQNKYGSI | KHTYQLDVLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RSPHRPILQA | GLPANQTVVV | GSDVEFHCKV | YSDAQPHIQW | LKHIEVNGSQ | YGPNGAPYVN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLKTAGINTT | DKELEILYLT | NVSFEDAGQY | TCLAGNSIGY | NHHSAWLTVL | PAVEMEREDD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YADILIYVTS | CVLFILTMVI | IILCRMWINT | QKTLPAPPVQ | KLSKFPLKRQ | VSLESNSSMN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SNTPLVRIAR | LSSSDGPMLP | NVSELELPSD | PKWEFTRTKL | TLGKPLGEGC | FGQVVMAEAI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GIDKEKPNKP | LTVAVKMLKD | DGTDKDLSDL | VSEMEMMKMI | GKHKNIINLL | GACTQDGPLY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VLVEYASKGN | LREYLRARRP | PGMDYSFDTC | KIPNETLTFK | DLVSCAYQVA | RGMEYLASKK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CIHRDPAARN | VLVTEDNVMK | IADFGLARDV | HNIDYYKKTT | NGRLPVKWMA | PEALFDRVYT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HQSDVWSYGV | LLWEIFTLGG | SPYPGIPVEE | LFKLLKEGHR | MDKPANCTHE | LYMIMRECWH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AVPSQRPTFR | QLVEDHDRVL | SMTSTDEYLD | LSVPFEQYSP | TCPDSNSTCS | SGDDSVFAHD |
| 790 | |||||
| PLPEEPCLPK | HHHSNGVIRT |