AiPD: Autoinhibited Protein Database

Q9HCT0

Gene name	FGF22 (UNQ2500/PRO5800)
Protein name	Fibroblast growth factor 22
Names	FGF-22
Species	Homo sapiens (Human)
KEGG Pathway	hsa:27006
EC number
Protein Class

Descriptions

The mammalian fibroblast growth factor (FGF)1 family contains at least 22 distinct polypeptides (FGF1–FGF22) that are expressed in a specific spatial and temporal pattern. FGF9 was originally described as a glia-activating factor and is expressed in the nervous system as a potent mitogen for glia cells. FGF9 adopts a beta-trefoil fold similar to other FGFs, but the N- and C-terminal regions outside the beta-trefoil core are ordered (typical FGFs have disordered tails) and involved in reversible dimerization. Due to the dimerization, a significant surface area is buried in the dimer interface that occludes a major receptor binding site of FGF9 within the beta-trefoil core. Sequence alignment of FGFs shows that most of the residues that participate in this interface in FGF9 are conserved in FGF16, suggesting that FGF16 may also dimerize for autoinhibition.

Autoinhibitory domains (AIDs)

32-39 (N-terminal helix) SS

Target domain	42-167 (beta-trefoil core)
Relief mechanism
Assay

AID

32-39 (N-terminal helix)

Target domain

42-167 (beta-trefoil core)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Plotnikov AN et al. (2001) "Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition", The Journal of biological chemistry, 276, 4322-9

Autoinhibited structure

Activated structure

1 structures for Q9HCT0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9HCT0-F1	Predicted				AlphaFoldDB

275 variants for Q9HCT0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1161116731	2	R>C		No	1000Genomes TOPMed
rs1161116731	2	R>G		No	1000Genomes TOPMed
rs1442591194	2	R>H		No	gnomAD
rs1985843586	3	R>C		No	TOPMed gnomAD
rs1160198107	3	R>H		No	gnomAD
rs1985843586	3	R>S		No	TOPMed gnomAD
rs1985843861	4	R>H		No	Ensembl
rs777555725	6	W>*		No	1000Genomes ExAC TOPMed gnomAD
rs901656218	6	W>C		No	TOPMed gnomAD
rs1985844332	8	G>D		No	Ensembl
TCGA novel	9	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1834125487	11	W>*		No	TOPMed
rs746745501	12	L>Q		No	ExAC gnomAD
rs1163364498	12	L>V		No	TOPMed gnomAD
rs770319170	15	A>S		No	ExAC gnomAD
rs1361630682	16	R>L		No	TOPMed gnomAD
rs2144740370	17	A>G		No	Ensembl
rs1985845674	17	A>T		No	TOPMed
rs1568183153	18	P>S		No	TOPMed gnomAD
rs2144740389	19	D>E		No	Ensembl
rs1390985989	19	D>G		No	TOPMed
rs2144740380	19	D>H		No	Ensembl
rs780807616	20	A>T		No	ExAC gnomAD
rs1371639623	21	A>T		No	TOPMed gnomAD
rs1985846388	21	A>V		No	TOPMed
rs1300264340	22	G>E		No	TOPMed gnomAD
rs745396212	23	T>I		No	ExAC TOPMed gnomAD
rs769081555	24	P>R		No	ExAC TOPMed gnomAD
rs774847960	25	S>C		No	ExAC TOPMed gnomAD
rs1398571872	25	S>N		No	gnomAD
rs957044085	25	S>R		No	TOPMed gnomAD
rs1985847433	26	A>T		No	Ensembl
rs1985847609	27	S>L		No	TOPMed
TCGA novel	29	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1985847904	30	P>Q		No	Ensembl
rs1020054868	31	R>C		No	TOPMed gnomAD
rs1020054868	31	R>S		No	TOPMed gnomAD
rs1426035775	32	S>N		No	TOPMed
rs1242182881	33	Y>*		No	1000Genomes TOPMed gnomAD
rs967153801	34	P>A		No	gnomAD
rs938547832	34	P>R		No	TOPMed gnomAD
rs967153801	34	P>S		No	gnomAD
rs868524749	35	H>N		No	Ensembl
rs1985849116	35	H>Q		No	gnomAD
rs574406266	35	H>R		No	1000Genomes ExAC TOPMed gnomAD
rs1156911841	38	G>D		No	TOPMed gnomAD
rs1266725231	38	G>S		No	TOPMed gnomAD
rs1985849720	39	D>Y		No	TOPMed
rs1431325577	40	V>M		No	TOPMed gnomAD
rs2144740533	41	R>H		No	1000Genomes
rs1985849989	44	R>G		No	Ensembl
rs1266044336	44	R>L		No	TOPMed gnomAD
rs1382706397	45	L>F		No	TOPMed gnomAD
rs1382706397	45	L>I		No	TOPMed gnomAD
rs1382706397	45	L>V		No	TOPMed gnomAD
rs867043655	46	F>S		No	Ensembl
rs1345226304	47	S>F		No	TOPMed gnomAD
rs150190794	48	S>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1304105130	50	H>Q		No	gnomAD
rs1348679178	50	H>R		No	TOPMed gnomAD
rs867554271	53	L>P		No	TOPMed gnomAD
rs867554271	53	L>R		No	TOPMed gnomAD
rs888478340	54	R>C		No	TOPMed gnomAD
rs888478340	54	R>S		No	TOPMed gnomAD
rs1223423096	55	V>M		No	gnomAD
rs1985851855	56	D>G		No	Ensembl
rs866479235	57	P>H		No	gnomAD
rs773273941	57	P>S		No	ExAC TOPMed gnomAD
rs1251516799	58	G>C		No	TOPMed gnomAD
rs766532254	58	G>D		No	1000Genomes ExAC TOPMed gnomAD
rs1251516799	58	G>R		No	TOPMed gnomAD
rs1251516799	58	G>S		No	TOPMed gnomAD
rs766532254	58	G>V		No	1000Genomes ExAC TOPMed gnomAD
rs1175232982	59	G>S		No	gnomAD
rs1985852608	60	R>C		No	TOPMed gnomAD
rs1480722494	60	R>L		No	TOPMed
rs776733729	62	Q>*		No	1000Genomes ExAC TOPMed gnomAD
rs1031139564	62	Q>R		No	TOPMed gnomAD
rs1427204057	64	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1985853309	68	H>L		No	TOPMed
rs1262744599	68	H>Y		No	TOPMed
rs1985853557	69	G>D		No	Ensembl
rs1411722302	69	G>S		No	gnomAD
rs956847925	70	Q>R		No	TOPMed gnomAD
rs2032949755	71	D>G		No	gnomAD
rs989756434	72	S>C		No	TOPMed gnomAD
rs989756434	72	S>G		No	TOPMed gnomAD
rs774209995	72	S>N		No	ExAC TOPMed gnomAD
rs1324520678	75	E>G		No	gnomAD
rs150121578	77	R>C		No	ESP ExAC TOPMed gnomAD
rs150121578	77	R>G		No	ESP ExAC TOPMed gnomAD
rs138373700	77	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs138373700	77	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs150121578	77	R>S		No	ESP ExAC TOPMed gnomAD
rs1985965856	78	S>C		No	TOPMed
rs1327255991	79	V>G		No	gnomAD
rs1201095741	79	V>I		No	TOPMed gnomAD
rs1201095741	79	V>L		No	TOPMed gnomAD
rs754498541	80	H>P		No	ExAC TOPMed gnomAD
rs142706038	80	H>Q		No	ESP ExAC TOPMed gnomAD
rs1433784545	80	H>Y		No	TOPMed gnomAD
rs781460338	81	V>A		No	ExAC TOPMed gnomAD
rs757612208	81	V>M		No	ExAC TOPMed gnomAD
rs147002397	82	G>A		No	ESP ExAC TOPMed gnomAD
rs1985966652	82	G>S		No	Ensembl
rs147002397	82	G>V		No	ESP ExAC TOPMed gnomAD
rs1263137106	83	V>A		No	gnomAD
rs369452453	83	V>I		No	ESP ExAC TOPMed gnomAD
rs377152236	84	V>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1387909111	86	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1985967507	86	I>V		No	Ensembl
rs1163938244	90	S>F		No	gnomAD
rs1339269585	91	S>A		No	TOPMed gnomAD
rs143583963	91	S>L		No	ESP ExAC TOPMed gnomAD
rs1456274684	92	G>D		No	TOPMed gnomAD
COSM340129 rs1568184636	92	G>S	lung [Cosmic]	No	cosmic curated TOPMed
rs1290559142	93	F>L		No	gnomAD
rs761703237	94	Y>*		No	ExAC TOPMed gnomAD
rs1385835984	94	Y>H		No	gnomAD
TCGA novel	94	Y>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1318831416	95	V>M		No	TOPMed gnomAD
rs376452466	96	A>G		No	ESP ExAC TOPMed gnomAD
rs760467518	96	A>P		No	ExAC TOPMed gnomAD
rs760467518	96	A>T		No	ExAC TOPMed gnomAD
COSM4985776 rs376452466	96	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1470380231	97	M>I		No	TOPMed gnomAD
rs759084167	97	M>T		No	ExAC TOPMed gnomAD
rs1260048800	97	M>V		No	TOPMed gnomAD
rs752087141	98	N>K		No	ExAC TOPMed gnomAD
rs1600617968	98	N>T		No	Ensembl
rs764696073	98	N>Y		No	ExAC TOPMed gnomAD
rs562313940	99	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs562313940	99	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs369429141	99	R>H		No	ESP ExAC TOPMed gnomAD
rs369429141	99	R>L		No	ESP ExAC TOPMed gnomAD
rs780416005	100	R>P		No	ExAC gnomAD
rs780416005	100	R>Q		No	ExAC gnomAD
rs529828160	100	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs199657035	101	G>A		No	1000Genomes ExAC TOPMed gnomAD
rs768756945	101	G>S		No	ExAC gnomAD
rs199657035	101	G>V		No	1000Genomes ExAC TOPMed gnomAD
rs527326025	102	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs771837744	102	R>H		No	ExAC gnomAD
rs1445616382	103	L>F		No	TOPMed
rs746793067	104	Y>*		No	ExAC TOPMed gnomAD
rs1985971115	104	Y>C		No	Ensembl
rs552154203	104	Y>H		No	1000Genomes ExAC gnomAD
rs201725343	105	G>R		No	1000Genomes ExAC TOPMed gnomAD
rs373208428	106	S>*		No	ESP ExAC TOPMed gnomAD
rs373208428	106	S>L		No	ESP ExAC TOPMed gnomAD
rs2144745279	106	S>P		No	Ensembl
rs768439708	107	R>*		No	ExAC TOPMed gnomAD
rs768439708	107	R>G		No	ExAC TOPMed gnomAD
rs199848240	107	R>Q		No	ExAC TOPMed gnomAD
rs1985976506	108	L>H		No	TOPMed
rs761442443	108	L>I		No	ExAC TOPMed gnomAD
rs1293894631	109	Y>C		No	gnomAD
rs1985976644	109	Y>H		No	gnomAD
rs144025975	110	T>I		No	ESP ExAC TOPMed gnomAD
rs1187385928	111	V>A		No	TOPMed gnomAD
rs1187385928	111	V>E		No	TOPMed gnomAD
rs148675872 COSM1002917	111	V>M	endometrium [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs374379884	112	D>A		No	ESP ExAC TOPMed gnomAD
rs1165810457	112	D>E		No	gnomAD
rs1600618450	112	D>N		No	Ensembl
rs367985651	114	R>G		No	ESP ExAC TOPMed gnomAD
rs1405224576	114	R>S		No	TOPMed gnomAD
COSM4855889	115	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs141882459	116	R>G		No	ESP ExAC TOPMed gnomAD
rs780966247	116	R>Q		No	ExAC TOPMed gnomAD
rs141882459	116	R>W		No	ESP ExAC TOPMed gnomAD
rs943141177	117	E>G		No	TOPMed
rs1320855481	117	E>K		No	gnomAD
rs750445158	118	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs371851054	118	R>H		No	ESP ExAC TOPMed gnomAD
rs371851054	118	R>P		No	ESP ExAC TOPMed gnomAD
rs750445158	118	R>S		No	1000Genomes ExAC TOPMed gnomAD
rs199913782	119	I>M		No	1000Genomes ExAC TOPMed gnomAD
rs749102468	119	I>T		No	ExAC gnomAD
rs1985978507	119	I>V		No	gnomAD
rs201800861	120	E>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1321911259	120	E>A		No	TOPMed gnomAD
rs201800861	120	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1321911259	120	E>V		No	TOPMed gnomAD
rs771748957	121	E>D		No	1000Genomes ExAC TOPMed gnomAD
rs747640110	121	E>K		No	ExAC gnomAD
rs140007905	123	G>R		No	ESP ExAC TOPMed gnomAD
rs140007905	123	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs775856232	124	H>L		No	ExAC TOPMed gnomAD
rs775856232	124	H>P		No	ExAC TOPMed gnomAD
rs763336425	124	H>Q		No	ExAC TOPMed gnomAD
rs1010746586	125	N>T		No	TOPMed gnomAD
rs764247800	126	T>P		No	ExAC gnomAD
rs751825478	127	Y>*		No	ExAC TOPMed gnomAD
rs1429356212	127	Y>C		No	TOPMed gnomAD
rs1667061318	127	Y>H		No	gnomAD
rs143615127	128	A>S		No	ESP ExAC TOPMed gnomAD
rs143615127	128	A>T		No	ESP ExAC TOPMed gnomAD
rs1186900086	128	A>V		No	TOPMed
rs1985980589	129	S>L		No	TOPMed
rs756015532	130	Q>*		No	ExAC gnomAD
rs1455256374	130	Q>R		No	gnomAD
rs1338288913	131	R>C		No	1000Genomes gnomAD
rs200251395	131	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs1338288913	131	R>S		No	1000Genomes gnomAD
rs1985981441	132	W>C		No	gnomAD
rs753640996	132	W>G		No	ExAC TOPMed gnomAD
rs753640996	132	W>R		No	ExAC TOPMed gnomAD
rs778678657	133	R>C		No	ExAC TOPMed gnomAD
rs747876693	133	R>H		No	ExAC gnomAD
rs146864547	134	R>C		No	ESP ExAC TOPMed gnomAD
COSM1396258 rs139763814	134	R>H	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs746504991	135	R>C		No	ExAC TOPMed gnomAD
rs143239645	135	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143239645	135	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs973273475	136	G>S		No	TOPMed gnomAD
rs1235120634	137	Q>*		No	TOPMed gnomAD
rs1182273436	137	Q>H		No	TOPMed gnomAD
rs749626445	137	Q>R		No	ExAC gnomAD
rs994761584	138	P>L		No	Ensembl
rs1985982892	139	M>V		No	Ensembl
rs1425397173	140	F>L		No	TOPMed gnomAD
rs145347220	142	A>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs145347220	142	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1198157646	144	D>G		No	TOPMed gnomAD
rs1331887181	144	D>Y		No	TOPMed gnomAD
rs760693654	145	R>G		No	ExAC TOPMed gnomAD
rs1228406503	145	R>K		No	TOPMed gnomAD
rs1228406503	145	R>M		No	TOPMed gnomAD
rs868293802	145	R>S		No	Ensembl
rs200820027	146	R>G		No	Ensembl
rs527353913	146	R>K		No	1000Genomes ExAC TOPMed gnomAD
rs527353913	146	R>M		No	1000Genomes ExAC TOPMed gnomAD
rs752552471	146	R>S		No	ExAC TOPMed gnomAD
rs527353913	146	R>T		No	1000Genomes ExAC TOPMed gnomAD
rs200820027	146	R>W		No	Ensembl
rs780503701	147	G>E		No	ExAC TOPMed gnomAD
rs746475694	147	G>R		No	ExAC TOPMed gnomAD
rs746475694	147	G>W		No	ExAC TOPMed gnomAD
rs552215752	148	G>A		No	1000Genomes ExAC gnomAD
rs552215752	148	G>E		No	1000Genomes ExAC gnomAD
rs552215752	148	G>V		No	1000Genomes ExAC gnomAD
rs1199104315	148	G>W		No	gnomAD
COSM2727578 rs1053327160	149	P>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs760109035 COSM5057048	150	R>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs892963018	150	R>Q		No	TOPMed gnomAD
COSM714010 rs748495939	150	R>W	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1170442261	151	P>L		No	gnomAD
rs1477454344	151	P>S		No	gnomAD
rs1176673072	152	G>S		No	TOPMed
rs760779668	153	G>S		No	ExAC TOPMed gnomAD
rs776696707	154	R>Q		No	ExAC TOPMed gnomAD
rs766633544	154	R>W		No	ExAC TOPMed gnomAD
rs1985986416	155	T>A		No	Ensembl
rs759489041	155	T>M		No	ExAC TOPMed gnomAD
rs1272129614	156	R>Q		No	TOPMed gnomAD
rs202173750	156	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs763778299	157	R>L		No	ExAC TOPMed gnomAD
rs763778299	157	R>Q		No	ExAC TOPMed gnomAD
rs373233901	157	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs751206913	158	Y>D		No	ExAC gnomAD
rs756783248	159	H>Y		No	ExAC gnomAD
rs1985987579	161	S>Y		No	1000Genomes
rs755440550	162	A>S		No	ExAC TOPMed gnomAD
rs755440550	162	A>T		No	ExAC TOPMed gnomAD
rs1985987903	162	A>V		No	Ensembl
rs1985988221	166	P>H		No	Ensembl
rs1196368310	166	P>S		No	gnomAD
rs772365209	167	V>I		No	1000Genomes ExAC TOPMed gnomAD
rs1167673006	168	L>P		No	gnomAD
rs1985988806	169	V>A		No	Ensembl
rs778052684	169	V>I		No	ExAC TOPMed gnomAD
rs778052684	169	V>L		No	ExAC TOPMed gnomAD
rs761366792	171	S>R		No	ExAC gnomAD
rs1826317541	171	S>R		No	TOPMed gnomAD

No associated diseases with Q9HCT0

No regional properties for Q9HCT0

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9HCT0

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name	Definition
fibroblast growth factor receptor binding	Binding to a fibroblast growth factor receptor (FGFR).
growth factor activity	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

7 GO annotations of biological process

Name	Definition
animal organ morphogenesis	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cell differentiation	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
fibroblast growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of cell migration	Any process that modulates the frequency, rate or extent of cell migration.

28 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P48801	FGF3	Fibroblast growth factor 3	Gallus gallus (Chicken)	SS
O15520	FGF10	Fibroblast growth factor 10	Homo sapiens (Human)	SS
O43320	FGF16	Fibroblast growth factor 16	Homo sapiens (Human)	EV SS
P10767	FGF6	Fibroblast growth factor 6	Homo sapiens (Human)	SS
P11487	FGF3	Fibroblast growth factor 3	Homo sapiens (Human)	SS
P31371	FGF9	Fibroblast growth factor 9	Homo sapiens (Human)	EV
Q92914	FGF11	Fibroblast growth factor 11	Homo sapiens (Human)	SS
Q9NP95	FGF20	Fibroblast growth factor 20	Homo sapiens (Human)	SS
Q9NSA1	FGF21	Fibroblast growth factor 21	Homo sapiens (Human)	PR
P08620	FGF4	Fibroblast growth factor 4	Homo sapiens (Human)	PR
P21658	Fgf6	Fibroblast growth factor 6	Mus musculus (Mouse)	SS
O35565	Fgf10	Fibroblast growth factor 10	Mus musculus (Mouse)	SS
P54130	Fgf9	Fibroblast growth factor 9	Mus musculus (Mouse)	SS
Q9JJN1	Fgf21	Fibroblast growth factor 21	Mus musculus (Mouse)	PR
Q9ESL8	Fgf16	Fibroblast growth factor 16	Mus musculus (Mouse)	SS
Q9ESL9	Fgf20	Fibroblast growth factor 20	Mus musculus (Mouse)	SS
P11403	Fgf4	Fibroblast growth factor 4	Mus musculus (Mouse)	PR
P61329	Fgf12	Fibroblast growth factor 12	Mus musculus (Mouse)	PR
P05524	Fgf3	Fibroblast growth factor 3	Mus musculus (Mouse)	SS
Q9ESS2	Fgf22	Fibroblast growth factor 22	Mus musculus (Mouse)	SS
Q95L12	FGF9	Fibroblast growth factor 9	Sus scrofa (Pig)	SS
Q9EST9	Fgf20	Fibroblast growth factor 20	Rattus norvegicus (Rat)	SS
O54769	Fgf16	Fibroblast growth factor 16	Rattus norvegicus (Rat)	SS
P36364	Fgf9	Fibroblast growth factor 9	Rattus norvegicus (Rat)	SS
P70492	Fgf10	Fibroblast growth factor 10	Rattus norvegicus (Rat)	SS
Q6PBT8	fgf1	Putative fibroblast growth factor 1	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q2HXK8	fgf16	Fibroblast growth factor 16	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
P48802	fgf3	Fibroblast growth factor 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MRRRLWLGLA	WLLLARAPDA	AGTPSASRGP	RSYPHLEGDV	RWRRLFSSTH	FFLRVDPGGR
70	80	90	100	110	120
VQGTRWRHGQ	DSILEIRSVH	VGVVVIKAVS	SGFYVAMNRR	GRLYGSRLYT	VDCRFRERIE
130	140	150	160
ENGHNTYASQ	RWRRRGQPMF	LALDRRGGPR	PGGRTRRYHL	SAHFLPVLVS