AiPD: Autoinhibited Protein Database

Q9HC98

Gene name	NEK6
Protein name	Serine/threonine-protein kinase Nek6
Names	Never in mitosis A-related kinase 6, NimA-related protein kinase 6, Protein kinase SID6-1512
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10783
EC number	2.7.11.34: Protein-serine/threonine kinases
Protein Class	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED (PTHR43289)

Descriptions

Nek6 is a NIMA-related kinase essential for proper mitotic spindle assembly and has a catalytic domain with a 30-40 amino acid N-terminal extension. Nek6 is subject to autoinhibition by the tyrosine motif, Tyr108. This is because the Y108A mutation is more active than wild-type Nek6. In addition, the activity of Nek6 is increased by interaction with the Nek9 noncatalytic C-terminal domain, which may release tyrosine from the autoinhibitory position.

Autoinhibitory domains (AIDs)

Target domain	31-41 (N-terminal extension of kinase domain)
Relief mechanism	Partner binding
Assay	Structural analysis, Mutagenesis experiment

AID

108-114 (Tyrosine motif)

Target domain

31-41 (N-terminal extension of kinase domain)

Relief mechanism

Partner binding (Interaction with C-terminal domain of Nek9)

Assay

Structural analysis, Mutagenesis experiment

Accessory elements

189-212 (Activation loop from InterPro)

Target domain	45-310 (Protein kinase domain)
Relief mechanism
Assay

References

Richards MW et al. (2009) "An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9", Molecular cell, 36, 560-70

Autoinhibited structure

Activated structure

1 structures for Q9HC98

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9HC98-F1	Predicted				AlphaFoldDB

202 variants for Q9HC98

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA374875763 rs1247048658	2	A>V		No	ClinGen gnomAD
CA199686987 rs911139179	4	Q>E		No	ClinGen TOPMed
CA5234091 rs779271535	4	Q>R		No	ClinGen ExAC gnomAD
CA374875781 rs1167516898	5	P>L		No	ClinGen gnomAD
CA374875782 rs528727476	6	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5234093 rs528727476	6	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1365078463 CA374875792	7	H>L		No	ClinGen TOPMed gnomAD
CA374875791 rs1365078463	7	H>R		No	ClinGen TOPMed gnomAD
CA374875801 rs1326135942	8	M>I		No	ClinGen gnomAD
CA5234094 rs780230637	8	M>V		No	ClinGen ExAC gnomAD
CA374875807 rs1331996591	9	P>R		No	ClinGen gnomAD
rs377403028 CA5234095	10	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1366906036 CA374875816	11	G>R		No	ClinGen gnomAD
rs1588482166 CA374875835	13	S>R		No	ClinGen Ensembl
CA374875840 rs1465974668	14	S>C		No	ClinGen gnomAD
CA374875846 rs1454488440	15	N>S		No	ClinGen TOPMed
CA5234096 rs145488745	16	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA374875873 rs1290364170	18	C>Y		No	ClinGen gnomAD
rs747894737 CA5234098	21	L>V		No	ClinGen ExAC gnomAD
CA374875936 rs867678055	22	G>R		No	ClinGen TOPMed
CA199687059 rs867678055	22	G>W		No	ClinGen TOPMed
CA374875951 rs1290547838	23	P>L		No	ClinGen gnomAD
rs1446146786 CA374875953	24	V>M		No	ClinGen gnomAD
CA5234099 rs769478376	25	H>R		No	ClinGen ExAC gnomAD
CA199687064 rs140978005	26	P>S		No	ClinGen ESP gnomAD
CA199687068 rs910941666	27	P>L		No	ClinGen gnomAD
rs941098694 CA199687088	29	P>S		No	ClinGen Ensembl
CA374876051 rs1384634882	30	Q>R		No	ClinGen gnomAD
CA5234123 rs758964365	34	N>D		No	ClinGen ExAC gnomAD
CA374877205 rs1256928848	34	N>K		No	ClinGen gnomAD
CA5234124 rs769243779	35	T>A		No	ClinGen ExAC gnomAD
CA5234125 rs774694008	35	T>M		No	ClinGen ExAC TOPMed gnomAD
CA5234128 rs750746819	39	R>C		No	ClinGen ExAC gnomAD
rs1376354948 CA374877234	39	R>H		No	ClinGen TOPMed gnomAD
CA374877233 rs1376354948	39	R>L		No	ClinGen TOPMed gnomAD
CA374877238 rs1467238937	40	C>Y		No	ClinGen TOPMed gnomAD
rs763278157 CA5234129	41	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1409086630 CA374877248	42	L>M		No	ClinGen TOPMed gnomAD
CA374877252 rs1433128929	42	L>R		No	ClinGen gnomAD
rs1409086630 CA374877249	42	L>V		No	ClinGen TOPMed gnomAD
CA5234131 rs183673274	43	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs148262318 CA5234134	48	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs755980284 CA5234135	49	K>N		No	ClinGen ExAC gnomAD
rs777558111 CA5234136	52	G>S		No	ClinGen ExAC gnomAD
CA5234137 rs749069904	53	R>*		No	ClinGen ExAC TOPMed gnomAD
rs1341208772 CA374877344	56	F>Y		No	ClinGen TOPMed
rs745431350 CA5234140	58	E>A		No	ClinGen ExAC gnomAD
CA5234139 rs778399540	58	E>K		No	ClinGen ExAC TOPMed gnomAD
CA199696983 rs923279115	63	T>I		No	ClinGen TOPMed gnomAD
rs1588497542 CA374877391	63	T>P		No	ClinGen Ensembl
CA374877409 rs1265646448	66	L>M		No	ClinGen gnomAD
CA5234141 rs771504531	68	R>K		No	ClinGen ExAC TOPMed gnomAD
CA374877426 rs1377794796	68	R>S		No	ClinGen TOPMed
rs775022069 CA5234142	70	T>S		No	ClinGen ExAC TOPMed gnomAD
CA374877478 rs1427488678	76	V>A		No	ClinGen gnomAD
rs1372158895 CA374877475	76	V>L		No	ClinGen TOPMed gnomAD
CA374877474 rs1372158895	76	V>M		No	ClinGen TOPMed gnomAD
CA374877482 rs1370678576	77	Q>*		No	ClinGen gnomAD
CA374877484 rs1429957019	77	Q>R		No	ClinGen TOPMed
CA374877513 rs1386238966	79	F>L		No	ClinGen TOPMed gnomAD
rs1332109613 CA374877532	82	M>V		No	ClinGen TOPMed
rs779439151 CA5234159	84	A>T		No	ClinGen ExAC gnomAD
rs1386167089 CA374877565	86	A>V		No	ClinGen TOPMed gnomAD
CA199698616 rs987052518	88	Q>R		No	ClinGen Ensembl
CA374877581 rs1588499962	89	D>N		No	ClinGen Ensembl
rs183711992 CA199698654	92	K>R		No	ClinGen 1000Genomes gnomAD
rs183711992 CA374877606	92	K>T		No	ClinGen 1000Genomes gnomAD
rs1463842648 CA374877612	93	E>*		No	ClinGen gnomAD
rs774713096 CA5234165	95	G>D		No	ClinGen ExAC gnomAD
rs768754460 CA5234188	100	L>M		No	ClinGen ExAC gnomAD
CA374869994 rs1209363432	101	N>S		No	ClinGen TOPMed
rs1271939785 CA374870054	109	L>W		No	ClinGen gnomAD
CA199658042 rs1031164724	111	S>L		No	ClinGen TOPMed
CA374870074 rs1182869786	112	F>C		No	ClinGen gnomAD
CA374870080 rs1267853445	113	I>V		No	ClinGen gnomAD
rs370008827 CA5234193	114	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs750249273 CA5234192	114	E>K		No	ClinGen ExAC TOPMed gnomAD
rs370008827 CA374870088	114	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA374870093 rs1415316825	115	D>N		No	ClinGen TOPMed gnomAD
rs1168037323 CA374870100	116	N>D		No	ClinGen gnomAD
CA5234195 rs143094065	117	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA5234197 rs780863742	119	N>S		No	ClinGen ExAC gnomAD
CA374870173 rs1417581726	127	A>T		No	ClinGen TOPMed
CA5234204 rs747235761	132	Q>H		No	ClinGen ExAC gnomAD
rs780356311 CA5234203	132	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA374870223 rs1449600656	134	I>N		No	ClinGen gnomAD
rs1223479281 CA374870228	135	K>E		No	ClinGen gnomAD
rs868482996 CA199660864	136	Y>H		No	ClinGen TOPMed gnomAD
rs1472585159 CA374870530	138	K>R		No	ClinGen gnomAD
rs1157394651 CA374870555	140	Q>R		No	ClinGen gnomAD
CA199660870 rs759138170	142	R>Q		No	ClinGen TOPMed
rs767329239 CA374870578	142	R>W		No	ClinGen ExAC gnomAD
rs775228582 CA5234232	143	L>V		No	ClinGen ExAC gnomAD
CA374870596 rs1454102379	144	I>V		No	ClinGen TOPMed
CA5234233 rs368466543	145	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1395923597 CA374870621	146	E>Q		No	ClinGen TOPMed
CA199660891 rs552985155	149	V>A		No	ClinGen 1000Genomes TOPMed
rs1588517960 CA374870697	152	Y>D		No	ClinGen Ensembl
CA374871106 rs1588517996	154	V>A		No	ClinGen Ensembl
rs1407961158 CA374871100	154	V>L		No	ClinGen gnomAD
CA374871099 rs1407961158	154	V>M		No	ClinGen gnomAD
CA374871113 rs1289955664	155	Q>*		No	ClinGen gnomAD
CA374871137 rs1483225181	157	C>Y		No	ClinGen TOPMed
rs200565078 CA5234238	158	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA199660913 rs879292381	159	A>T		No	ClinGen gnomAD
rs751958560 CA5234241	160	V>L		No	ClinGen ExAC TOPMed gnomAD
CA5234240 rs751958560	160	V>M		No	ClinGen ExAC TOPMed gnomAD
CA5234243 rs748409240	165	S>L		No	ClinGen ExAC TOPMed gnomAD
rs369950028 CA5234244	166	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1420088183 CA374871249	166	R>H		No	ClinGen gnomAD
CA374871244 rs369950028	166	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs777970915 CA5234245	167	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1461941868 CA374871256	167	R>W		No	ClinGen TOPMed gnomAD
CA5234247 rs771033424	171	R>*		No	ClinGen ExAC gnomAD
CA374871305 rs1369451980	171	R>Q		No	ClinGen gnomAD
CA5234282 rs760926146	175	P>A		No	ClinGen ExAC gnomAD
rs553709380 CA374871493	177	N>K		No	ClinGen gnomAD
CA374871497 rs1482758201	178	V>M		No	ClinGen gnomAD
rs1162626313 CA374871542	182	A>T		No	ClinGen gnomAD
CA5234284 rs754146573	183	T>M		No	ClinGen ExAC TOPMed gnomAD
CA5234286 rs779146612	185	V>I		No	ClinGen ExAC TOPMed gnomAD
CA5234288 rs758428107	186	V>G		No	ClinGen ExAC gnomAD
CA5234287 rs775352569	186	V>M		No	ClinGen ExAC gnomAD
rs779821672 CA374871617	189	G>C		No	ClinGen ExAC TOPMed gnomAD
rs779821672 CA5234289	189	G>S		No	ClinGen ExAC TOPMed gnomAD
CA5234291 rs768356782	195	R>C		No	ClinGen ExAC gnomAD
CA374871678 rs768356782	195	R>S		No	ClinGen ExAC gnomAD
rs200086787 CA199661854	196	F>C		No	ClinGen Ensembl
rs201207004 CA199661861	197	F>L		No	ClinGen gnomAD
rs747816154 CA5234293	200	E>G		No	ClinGen ExAC gnomAD
rs1588519923 CA374871751	201	T>P		No	ClinGen Ensembl
rs1588519942 CA374871761	202	T>P		No	ClinGen Ensembl
rs772780677 CA5234296	203	A>V		No	ClinGen ExAC gnomAD
rs751648398 CA5234330	215	S>L		No	ClinGen ExAC gnomAD
CA5234331 rs555077914	216	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA5234332 rs767414917	216	P>L		No	ClinGen ExAC TOPMed gnomAD
CA5234334 rs755926840	220	H>Y		No	ClinGen ExAC gnomAD
CA5234336 rs543844372	224	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
CA199668393 rs201833354	230	I>M		No	ClinGen ExAC gnomAD
rs1042477188 CA199668386	230	I>V		No	ClinGen TOPMed gnomAD
CA5234339 rs779050538	232	S>A		No	ClinGen ExAC gnomAD
CA374873314 rs10760354	233	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5234341 rs771906905	237	L>V		No	ClinGen ExAC gnomAD
CA374873377 rs1288821162	239	E>K		No	ClinGen gnomAD
CA374874481 rs1190475979	242	A>T		No	ClinGen gnomAD
rs1419093540 CA374874497	243	L>F		No	ClinGen gnomAD
CA5234366 rs151138282	252	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs919717766 CA199675081	252	M>K		No	ClinGen Ensembl
CA5234365 rs749637388	252	M>V		No	ClinGen ExAC gnomAD
rs1338625653 CA374874674	255	F>L		No	ClinGen gnomAD
CA374874669 rs1588554508	255	F>S		No	ClinGen Ensembl
rs774656051 CA5234367	256	S>C		No	ClinGen ExAC TOPMed gnomAD
rs774656051 CA5234368	256	S>F		No	ClinGen ExAC TOPMed gnomAD
rs772144294 CA5234369	259	Q>K		No	ClinGen ExAC gnomAD
CA5234372 rs764086271	262	E>K		No	ClinGen ExAC gnomAD
CA5234373 rs753614385	263	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA374874733 rs1315306769	264	C>F		No	ClinGen TOPMed
CA5234374 rs761645776	264	C>R		No	ClinGen ExAC TOPMed gnomAD
CA5234375 rs764888197	265	D>N		No	ClinGen ExAC gnomAD
CA5234376 rs750118016	266	Y>F		No	ClinGen ExAC
CA374874746 rs750118016	266	Y>S		No	ClinGen ExAC
rs779720887 CA5234379	267	P>H		No	ClinGen ExAC gnomAD
CA5234382 rs778322409	268	P>L		No	ClinGen ExAC gnomAD
rs1564666860 CA374874774	271	G>E		No	ClinGen Ensembl
CA5234385 rs779084313 COSM1597960	271	G>R	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1564666865 CA374874777	272	E>K		No	ClinGen Ensembl
CA374874794 rs1301876690	274	Y>H		No	ClinGen TOPMed
CA5234386 rs746106299	275	S>Y		No	ClinGen ExAC gnomAD
rs144052872 CA5234388	276	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs144052872 CA374874806	276	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs760711060 CA5234389	277	K>E		No	ClinGen ExAC gnomAD
rs768520677 CA5234390	277	K>M		No	ClinGen ExAC gnomAD
rs200398623 CA5234408	279	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1469571292 CA374874934	280	E>*		No	ClinGen gnomAD
CA374874941 rs1193711970	281	L>V		No	ClinGen gnomAD
rs758656747 CA5234409	283	S>G		No	ClinGen ExAC gnomAD
CA199677586 rs201113183	284	M>T		No	ClinGen Ensembl
CA5234410 rs780223937	284	M>V		No	ClinGen ExAC
CA5234411 rs747180914	285	C>S		No	ClinGen ExAC gnomAD
CA374874968 rs747180914	285	C>Y		No	ClinGen ExAC gnomAD
rs776507491 CA5234413	287	C>R		No	ClinGen ExAC gnomAD
rs748129024 CA5234415	289	D>E		No	ClinGen ExAC TOPMed gnomAD
CA374875002 rs1248451252	290	P>A		No	ClinGen TOPMed
CA5234417 rs146443565	291	H>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5234418 rs762820475	292	Q>R		No	ClinGen ExAC gnomAD
rs1298408686 CA374875034	295	D>N		No	ClinGen gnomAD
rs1271742411 CA374875053	297	G>A		No	ClinGen gnomAD
rs774178334 CA5234420	297	G>R		No	ClinGen ExAC gnomAD
rs200235098 CA374875062	299	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5234422 rs200235098	299	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs542509176 CA5234424	300	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs376476122 CA5234425	301	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA374875084 rs1423213989	302	V>A		No	ClinGen gnomAD
CA199677681 rs954971092	302	V>L		No	ClinGen TOPMed
rs1414669747 CA374875122	307	H>R		No	ClinGen TOPMed
CA199677696 rs915086313	309	W>*		No	ClinGen Ensembl
rs1395201958 CA374875134	309	W>G		No	ClinGen TOPMed
CA374875142 rs1165927187	310	M>L		No	ClinGen gnomAD
CA374875162 rs1344640329	312	S>R		No	ClinGen TOPMed gnomAD
CA374875168 rs1451744753	313	T>I		No	ClinGen gnomAD
rs1290755558 CA374875170	314	T>R		No	ClinGen gnomAD
CA374875175 rs1363269245	314	T>W		No	ClinGen gnomAD

No associated diseases with Q9HC98

6 regional properties for Q9HC98

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	45 - 310	IPR000719
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	122 - 135	IPR001245-1
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	162 - 180	IPR001245-2
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	228 - 250	IPR001245-3
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	274 - 296	IPR001245-4
active_site	Serine/threonine-protein kinase, active site	168 - 180	IPR008271

Functions

		Description
EC Number	2.7.11.34	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus Nucleus speckle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole	Colocalizes with APBB1 at the nuclear speckles Colocalizes with PIN1 in the nucleus Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis
PANTHER Family	PTHR43289	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED
PANTHER Subfamily	PTHR43289:SF13	SERINE_THREONINE-PROTEIN KINASE NEK6
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
centriolar satellite	A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
spindle pole	Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

10 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
kinesin binding	Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
magnesium ion binding	Binding to a magnesium (Mg) ion.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
transcription corepressor binding	Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

13 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromosome segregation	The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
mitotic nuclear membrane disassembly	The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.
mitotic spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of I-kappaB kinase/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of cellular senescence	Any process that modulates the frequency, rate or extent of cellular senescence.
regulation of mitotic cell cycle	Any process that modulates the rate or extent of progress through the mitotic cell cycle.
regulation of mitotic metaphase/anaphase transition	Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
spindle assembly	The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8TDX7	NEK7	Serine/threonine-protein kinase Nek7	Homo sapiens (Human)	EV
Q00526	CDK3	Cyclin-dependent kinase 3	Homo sapiens (Human)	PR
Q9ES74	Nek7	Serine/threonine-protein kinase Nek7	Mus musculus (Mouse)	SS
Q9ES70	Nek6	Serine/threonine-protein kinase Nek6	Mus musculus (Mouse)	SS
A2BD05	NEK6	Serine/threonine-protein kinase Nek6	Sus scrofa (Pig)	SS
D3ZBE5	Nek7	Serine/threonine-protein kinase Nek7	Rattus norvegicus (Rat)	SS
P59895	Nek6	Serine/threonine-protein kinase Nek6	Rattus norvegicus (Rat)	SS
G5EFM9	nekl-3	Serine/threonine-protein kinase nekl-3	Caenorhabditis elegans	PR

10	20	30	40	50	60
MAGQPGHMPH	GGSSNNLCHT	LGPVHPPDPQ	RHPNTLSFRC	SLADFQIEKK	IGRGQFSEVY
70	80	90	100	110	120
KATCLLDRKT	VALKKVQIFE	MMDAKARQDC	VKEIGLLKQL	NHPNIIKYLD	SFIEDNELNI
130	140	150	160	170	180
VLELADAGDL	SQMIKYFKKQ	KRLIPERTVW	KYFVQLCSAV	EHMHSRRVMH	RDIKPANVFI
190	200	210	220	230	240
TATGVVKLGD	LGLGRFFSSE	TTAAHSLVGT	PYYMSPERIH	ENGYNFKSDI	WSLGCLLYEM
250	260	270	280	290	300
AALQSPFYGD	KMNLFSLCQK	IEQCDYPPLP	GEHYSEKLRE	LVSMCICPDP	HQRPDIGYVH
310
QVAKQMHIWM	SST