Q9HBY8
SS
Gene name |
SGK2 |
Protein name |
Serine/threonine-protein kinase Sgk2 |
Names |
EC 2.7.11.1 , Serum/glucocorticoid-regulated kinase 2 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:10110 |
EC number |
2.7.11.-: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Akt is a serine/threonine kinase that belongs to a group of proteins called the AGC superfamily. It is involved in various biological responses through the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway. Akt2, in particular, is regulated by different regions of the protein.<br>The N-terminal PH domain of Akt2 plays a regulatory role in its activation. Phosphorylation of Ser474 in the C-terminal regulatory domain is also necessary for full activation of Akt2. These modifications help activate the kinase and enable it to carry out its functions.<br>The linker region between the N-lobe and C-lobe of Akt2 occupies the ATP binding site. Additionally, the activation loop within Akt2 aids in autoinhibition by blocking the binding of peptide substrates, while still allowing access to the ATP binding site.
Autoinhibitory domains (AIDs)
Target domain |
27-367 (Kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
176-199 (Activation loop from InterPro)
Target domain |
35-292 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Huang X et al. (2003) "Crystal structure of an inactive Akt2 kinase domain", Structure (London, England : 1993), 11, 21-30
- Truebestein L et al. (2021) "Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Lučić I et al. (2018) "Conformational sampling of membranes by Akt controls its activation and inactivation", Proceedings of the National Academy of Sciences of the United States of America, 115, E3940-E3949
Autoinhibited structure
Activated structure
1 structures for Q9HBY8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9HBY8-F1 | Predicted | AlphaFoldDB |
415 variants for Q9HBY8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs35187177 RCV001543614 |
127 | R>Q | Colorectal cancer [ClinVar] | Yes |
ClinVar ExAC TOPMed dbSNP gnomAD |
| rs771880699 | 6 | A>G | No |
ExAC gnomAD |
|
| rs1413171044 | 6 | A>S | No | gnomAD | |
| rs1979729751 | 7 | G>V | No | TOPMed | |
| rs2145533695 | 8 | T>S | No | Ensembl | |
| rs376003983 | 10 | S>C | No |
ESP ExAC TOPMed gnomAD |
|
| rs903526031 | 11 | P>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1433631652 | 12 | Q>* | No | gnomAD | |
| rs151094343 | 12 | Q>H | No |
ESP ExAC TOPMed gnomAD |
|
| rs1979777141 | 13 | P>L | No | Ensembl | |
| rs1979776809 | 13 | P>S | No | TOPMed | |
| rs1979777869 | 15 | R>G | No | Ensembl | |
| rs1051809537 | 17 | N>S | No | TOPMed | |
| rs1979778472 | 18 | G>R | No | Ensembl | |
| rs1050011775 | 21 | N>I | No |
TOPMed gnomAD |
|
| rs1050011775 | 21 | N>S | No |
TOPMed gnomAD |
|
| rs1472496923 | 23 | G>E | No | gnomAD | |
| rs200005007 | 24 | P>S | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs200005007 | 24 | P>T | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs141029147 | 28 | P>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs1388022431 | 29 | N>D | No | gnomAD | |
| rs1979818980 | 29 | N>K | No | TOPMed | |
| rs1264207084 | 30 | A>V | No | gnomAD | |
| rs769566731 | 31 | Q>* | No |
ExAC TOPMed gnomAD |
|
| rs2145536192 | 31 | Q>R | No | Ensembl | |
| COSM1483650 | 33 | T>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs771210039 | 34 | D>N | No |
ExAC gnomAD |
|
| rs774384018 | 35 | F>C | No |
ExAC gnomAD |
|
| rs759387934 | 35 | F>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs761088243 | 36 | D>E | No |
ExAC gnomAD |
|
| rs368110081 | 36 | D>G | No |
ESP ExAC TOPMed gnomAD |
|
| rs200530019 | 36 | D>N | No |
ESP ExAC TOPMed gnomAD |
|
| rs368110081 | 36 | D>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs200530019 | 36 | D>Y | No |
ESP ExAC TOPMed gnomAD |
|
| rs2145536241 | 38 | L>F | No | Ensembl | |
| rs750160588 | 39 | K>Q | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1388897484 | 39 | K>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1979822284 | 40 | V>F | No | TOPMed | |
| rs369824445 | 41 | I>N | No |
ESP TOPMed gnomAD |
|
| rs987632510 | 42 | G>R | No | gnomAD | |
| rs987632510 | 42 | G>S | No | gnomAD | |
| TCGA novel | 43 | K>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs762686366 | 45 | N>K | No |
ExAC gnomAD |
|
| rs1172172653 | 45 | N>S | No | gnomAD | |
| rs1979824985 | 47 | G>E | No | TOPMed | |
| rs535471043 | 47 | G>R | No |
1000Genomes ExAC TOPMed gnomAD |
|
| COSM3546714 | 48 | K>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs372782530 | 49 | V>I | No |
ESP TOPMed |
|
| rs369635262 | 49 | V>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1339072022 | 51 | L>Q | No | gnomAD | |
| COSM5857913 | 52 | A>Q | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM3546715 | 53 | K>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM1411913 | 53 | K>R | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs752217367 | 53 | K>T | No |
ExAC TOPMed gnomAD |
|
| rs756048017 | 54 | R>C | No |
ExAC TOPMed gnomAD |
|
| rs147953497 | 54 | R>L | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1600988958 | 56 | S>P | No | Ensembl | |
| rs753794614 | 57 | D>G | No |
ExAC gnomAD |
|
| rs1979839633 | 57 | D>N | No | Ensembl | |
| rs753794614 | 57 | D>V | No |
ExAC gnomAD |
|
| rs147035926 | 61 | Y>C | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1979840863 | 61 | Y>H | No | TOPMed | |
| COSM3911361 | 61 | Y>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs147035926 | 61 | Y>S | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1979841404 | 62 | A>V | No | TOPMed | |
| rs1267576874 | 63 | V>A | No |
TOPMed gnomAD |
|
|
COSM443849 rs778281277 |
63 | V>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD |
| rs746029910 | 63 | V>M | No |
ExAC TOPMed gnomAD |
|
|
COSM443848 rs1476667216 |
63 | V>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic NCI-TCGA gnomAD |
| rs1345925418 | 64 | K>N | No | gnomAD | |
| rs758675026 | 65 | V>L | No |
ExAC gnomAD |
|
| TCGA novel | 65 | V>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1218019427 | 68 | K>E | No |
TOPMed gnomAD |
|
| rs1367790703 | 68 | K>R | No | gnomAD | |
| rs1979843813 | 69 | K>N | No | Ensembl | |
| TCGA novel | 69 | K>Q | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 69 | K>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs267605942 | 70 | S>F | No | TOPMed | |
| rs1979844013 | 70 | S>P | No | TOPMed | |
| rs780174060 | 71 | I>V | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 73 | K>= | Variant assessed as Somatic; LOW impact. [NCI-TCGA] | No | NCI-TCGA |
| rs8183328 | 76 | E>G | No |
TOPMed gnomAD |
|
| rs8183328 | 76 | E>V | No |
TOPMed gnomAD |
|
| rs781438134 | 78 | S>I | No |
ExAC TOPMed gnomAD |
|
| rs781438134 | 78 | S>N | No |
ExAC TOPMed gnomAD |
|
| rs1206827133 | 79 | H>Q | No | gnomAD | |
| rs1979956824 | 80 | I>F | No | TOPMed | |
| rs770491904 | 81 | M>L | No |
ExAC TOPMed gnomAD |
|
| rs770491904 | 81 | M>V | No |
ExAC TOPMed gnomAD |
|
| rs749720747 | 82 | A>P | No |
ExAC TOPMed gnomAD |
|
| rs749720747 | 82 | A>S | No |
ExAC TOPMed gnomAD |
|
| COSM4913390 | 83 | E>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM723611 | 83 | E>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs569319046 | 84 | R>H | No |
ExAC TOPMed gnomAD |
|
| rs1436070727 | 85 | S>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1407966655 | 87 | L>P | No |
TOPMed gnomAD |
|
| rs761726709 | 91 | V>M | No |
ExAC gnomAD |
|
| rs140303557 | 93 | H>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
| rs1979960027 | 94 | P>L | No | TOPMed | |
| rs1415736322 | 96 | L>F | No |
TOPMed gnomAD |
|
| rs149168513 | 97 | V>L | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1304306746 | 100 | R>C | No | gnomAD | |
| rs367993196 | 100 | R>H | No |
1000Genomes ESP ExAC gnomAD |
|
| rs1363763474 | 101 | Y>C | No |
TOPMed gnomAD |
|
| rs754209529 | 103 | F>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs778374321 | 104 | Q>* | No |
ExAC gnomAD |
|
| COSM3546716 | 104 | Q>E | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1323071785 | 104 | Q>H | No | gnomAD | |
| rs1979962374 | 105 | T>A | No | gnomAD | |
| rs1979962374 | 105 | T>S | No | gnomAD | |
| rs771132667 | 106 | P>A | No |
ExAC gnomAD |
|
| rs377612011 | 106 | P>H | No |
ExAC TOPMed gnomAD |
|
| rs377612011 | 106 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs377612011 | 106 | P>R | No |
ExAC TOPMed gnomAD |
|
| rs1240899725 | 107 | E>A | No |
TOPMed gnomAD |
|
| rs746625692 | 107 | E>K | No |
ExAC TOPMed gnomAD |
|
| rs1466884509 | 108 | K>* | No | Ensembl | |
| rs938843585 | 108 | K>N | No | TOPMed | |
| rs1979964520 | 109 | L>F | No | TOPMed | |
| rs1187488873 | 110 | Y>D | No | gnomAD | |
| COSM1411914 | 110 | Y>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1399643390 | 114 | D>G | No | gnomAD | |
|
COSM1411915 rs147953497 |
114 | D>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs369045712 | 114 | D>N | No |
ExAC TOPMed gnomAD |
|
| rs369045712 | 114 | D>Y | No |
ExAC TOPMed gnomAD |
|
| rs894730265 | 115 | Y>C | No |
TOPMed gnomAD |
|
| rs894730265 | 115 | Y>S | No |
TOPMed gnomAD |
|
| rs1568664724 | 116 | V>I | No | Ensembl | |
| rs773071898 | 117 | N>D | No |
ExAC TOPMed gnomAD |
|
| rs143273559 | 117 | N>K | No |
ESP ExAC TOPMed gnomAD |
|
| rs767901983 | 118 | G>V | No |
ExAC gnomAD |
|
| rs372059009 | 118 | G>W | No |
ESP ExAC TOPMed gnomAD |
|
| rs752991711 | 119 | G>* | No |
ExAC TOPMed gnomAD |
|
| COSM3546717 | 119 | G>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
rs1200346658 COSM1225516 |
119 | G>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic NCI-TCGA gnomAD |
| rs756221883 | 119 | G>V | No |
ExAC gnomAD |
|
| rs778005111 | 120 | E>K | No |
ExAC gnomAD |
|
| rs1395594924 | 121 | L>H | No | gnomAD | |
| COSM724556 | 124 | H>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1600991607 | 124 | H>P | No | Ensembl | |
|
TCGA novel rs1979842824 |
125 | L>A | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1327166599 | 125 | L>P | No | gnomAD | |
| rs777117678 | 127 | R>W | No |
ExAC TOPMed gnomAD |
|
| rs1980038865 | 128 | E>G | No | Ensembl | |
| rs1357905242 | 128 | E>K | No | gnomAD | |
| TCGA novel | 129 | R>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs915237238 | 129 | R>C | No |
TOPMed gnomAD |
|
| rs915237238 | 129 | R>G | No |
TOPMed gnomAD |
|
| rs570263979 | 130 | R>Q | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs148253360 | 130 | R>W | No |
ESP ExAC TOPMed gnomAD |
|
| rs775481466 | 134 | P>A | No |
ExAC TOPMed gnomAD |
|
| rs760973578 | 134 | P>R | No |
ExAC gnomAD |
|
| rs775481466 | 134 | P>T | No |
ExAC TOPMed gnomAD |
|
| rs141249005 | 135 | R>G | No |
ESP ExAC TOPMed gnomAD |
|
| rs199504693 | 135 | R>Q | No |
ESP ExAC TOPMed gnomAD |
|
| rs141249005 | 135 | R>W | No |
ESP ExAC TOPMed gnomAD |
|
| COSM419389 | 136 | A>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs56229314 | 137 | R>S | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1600991701 | 137 | R>T | No | Ensembl | |
| rs1980043440 | 139 | Y>C | No | TOPMed | |
| TCGA novel | 140 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1980043957 | 141 | A>V | No | TOPMed | |
| rs1166299206 | 143 | V>M | No | gnomAD | |
| rs763850331 | 144 | A>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs138125315 | 144 | A>G | No |
ESP TOPMed gnomAD |
|
| rs763850331 | 144 | A>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs138125315 | 144 | A>V | No |
ESP TOPMed gnomAD |
|
| rs755742423 | 145 | S>C | No |
ExAC gnomAD |
|
| rs755742423 | 145 | S>R | No |
ExAC gnomAD |
|
| rs756719391 | 146 | A>D | No |
ExAC gnomAD |
|
| rs766451038 | 146 | A>T | No |
ExAC TOPMed gnomAD |
|
| rs1980047251 | 147 | I>T | No | Ensembl | |
| rs745787170 | 149 | Y>* | No |
ExAC gnomAD |
|
| rs778297714 | 149 | Y>C | No |
ExAC gnomAD |
|
| TCGA novel | 149 | Y>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1600991758 | 150 | L>P | No | Ensembl | |
| rs1225705735 | 150 | L>V | No |
TOPMed gnomAD |
|
| rs1252643805 | 151 | H>R | No | gnomAD | |
| TCGA novel | 152 | S>A | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs762618711 | 152 | S>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs750192641 | 152 | S>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA gnomAD |
| rs886678200 | 155 | I>F | No |
TOPMed gnomAD |
|
| rs779959970 | 155 | I>N | No |
ExAC gnomAD |
|
| rs779959970 | 155 | I>T | No |
ExAC gnomAD |
|
| rs886678200 | 155 | I>V | No |
TOPMed gnomAD |
|
| rs149168513 | 157 | Y>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs1980050646 | 158 | R>G | No | TOPMed | |
| rs371001587 | 158 | R>K | No |
ESP ExAC TOPMed gnomAD |
|
| rs1315099459 | 159 | D>Y | No |
TOPMed gnomAD |
|
| COSM346612 | 160 | L>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs2145542643 | 160 | L>P | No | Ensembl | |
| COSM3546719 | 162 | P>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1980078860 | 163 | E>D | No | Ensembl | |
| rs780086868 | 165 | I>F | No |
ExAC TOPMed gnomAD |
|
| rs561214757 | 166 | L>I | No |
TOPMed gnomAD |
|
| rs1361521693 | 166 | L>P | No | gnomAD | |
| rs561214757 | 166 | L>V | No |
TOPMed gnomAD |
|
| rs1300832300 | 167 | L>F | No | gnomAD | |
| rs1219511423 | 168 | D>A | No |
TOPMed gnomAD |
|
| rs1346987516 | 168 | D>Y | No |
TOPMed gnomAD |
|
| rs1305632607 | 169 | C>F | No |
TOPMed gnomAD |
|
| rs1454211118 | 170 | Q>H | No | TOPMed | |
| rs868779424 | 170 | Q>R | No | Ensembl | |
|
COSM3939356 rs776084733 |
172 | H>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
| rs762941685 | 173 | V>M | No |
ExAC TOPMed gnomAD |
|
| rs368717593 | 174 | V>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs368717593 | 174 | V>M | No |
ESP ExAC TOPMed gnomAD |
|
| rs1314858957 | 175 | L>P | No | gnomAD | |
| rs766423421 | 176 | T>M | No |
TOPMed gnomAD |
|
| rs1980173071 | 177 | D>G | No | TOPMed | |
| rs372059009 | 178 | F>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs1379535899 | 179 | G>D | No | gnomAD | |
| COSM3546720 | 179 | G>E | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1317091376 | 179 | G>S | No |
TOPMed gnomAD |
|
| rs1213803491 | 180 | L>I | No | gnomAD | |
| rs754940218 | 181 | C>Y | No |
ExAC gnomAD |
|
| rs1318573456 | 183 | E>D | No |
TOPMed gnomAD |
|
| rs1258783590 | 184 | G>D | No | gnomAD | |
| rs1220236205 | 185 | V>A | No | gnomAD | |
| rs1980175045 | 185 | V>I | No | gnomAD | |
| TCGA novel | 186 | E>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1202259412 | 186 | E>D | No |
TOPMed gnomAD |
|
| rs1460940728 | 186 | E>G | No | gnomAD | |
| rs1255932006 | 187 | P>R | No | gnomAD | |
| rs1239756395 | 187 | P>T | No | gnomAD | |
| rs1473303077 | 188 | E>K | No | gnomAD | |
|
rs559824768 COSM6093621 |
189 | D>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
| rs1980176622 | 189 | D>N | No | TOPMed | |
| rs1186271204 | 190 | T>P | No |
TOPMed gnomAD |
|
| rs1417864160 | 191 | T>K | No | gnomAD | |
| rs781014007 | 193 | T>K | No |
ExAC gnomAD |
|
| rs1980178370 | 194 | F>L | No | Ensembl | |
| TCGA novel | 196 | G>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1467775669 | 197 | T>A | No | gnomAD | |
| rs1338575408 | 197 | T>I | No | gnomAD | |
| COSM3991715 | 198 | P>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1429989109 | 198 | P>S | No | gnomAD | |
| rs1268198757 | 199 | E>D | No | gnomAD | |
| VAR_041074 | 199 | E>K | a lung adenocarcinoma sample; somatic mutation [UniProt] | No | UniProt |
| rs1980179604 | 199 | E>V | No | Ensembl | |
| rs552024157 | 200 | Y>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
| rs1489720061 | 201 | L>V | No |
TOPMed gnomAD |
|
| rs1460299750 | 202 | A>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs1980371220 | 203 | P>L | No | TOPMed | |
| rs1200631547 | 203 | P>S | No | gnomAD | |
| COSM478176 | 206 | L>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1012760297 | 207 | R>G | No |
TOPMed gnomAD |
|
| rs371549338 | 207 | R>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs1012760297 | 207 | R>W | No |
TOPMed gnomAD |
|
| rs1980371895 | 208 | K>R | No | Ensembl | |
| rs751073833 | 211 | Y>H | No |
ExAC TOPMed gnomAD |
|
| rs767312138 | 213 | R>L | No |
ExAC TOPMed gnomAD |
|
| rs767312138 | 213 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs562801174 | 214 | A>G | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs562801174 | 214 | A>V | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs777560138 | 215 | V>L | No |
ExAC gnomAD |
|
| rs200466252 | 216 | D>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs1980374519 | 217 | W>* | No | gnomAD | |
| rs1441601495 | 217 | W>* | No | gnomAD | |
| rs747970827 | 217 | W>G | No | TOPMed | |
| rs576244474 | 218 | W>* | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs576244474 | 218 | W>C | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs545256210 | 219 | C>F | No |
1000Genomes ExAC TOPMed gnomAD |
|
| COSM5523791 | 219 | C>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1980375438 | 220 | L>W | No | Ensembl | |
| rs772212410 | 221 | G>V | No |
ExAC gnomAD |
|
| rs775816146 | 222 | A>S | No |
ExAC TOPMed gnomAD |
|
|
TCGA novel rs747552762 |
223 | V>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC gnomAD NCI-TCGA |
| rs1363366717 | 223 | V>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs1239508965 | 225 | Y>H | No |
TOPMed gnomAD |
|
| COSM3546724 | 226 | E>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1980376994 | 226 | E>G | No | TOPMed | |
| rs1980376744 | 226 | E>K | No |
TOPMed gnomAD |
|
| rs762666063 | 227 | M>K | No |
ExAC TOPMed gnomAD |
|
| rs762666063 | 227 | M>T | No |
ExAC TOPMed gnomAD |
|
| rs763436249 | 228 | L>F | No |
TOPMed gnomAD |
|
| rs774078730 | 230 | G>S | No | ExAC | |
| TCGA novel | 231 | L>E | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1391749452 | 231 | L>V | No |
TOPMed gnomAD |
|
| rs1466239240 | 232 | P>L | No | gnomAD | |
| rs769330436 | 234 | F>L | No |
ExAC TOPMed gnomAD |
|
| rs1223391275 | 235 | Y>H | No |
TOPMed gnomAD |
|
| rs1332216134 | 235 | Y>S | No |
TOPMed gnomAD |
|
| rs139082826 | 237 | Q>P | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1980453555 | 238 | D>E | No | TOPMed | |
| rs748478154 | 238 | D>G | No |
ExAC TOPMed gnomAD |
|
| rs773809237 | 240 | S>F | No |
ExAC TOPMed gnomAD |
|
| rs770318092 | 240 | S>P | No |
ExAC gnomAD |
|
| rs1279705095 | 241 | Q>* | No | gnomAD | |
| rs1263290289 | 241 | Q>H | No |
TOPMed gnomAD |
|
| rs1980454446 | 241 | Q>P | No | Ensembl | |
| rs771470286 | 242 | M>I | No | ExAC | |
| rs775134419 | 243 | Y>* | No | ExAC | |
| rs1980455255 | 243 | Y>H | No | Ensembl | |
| rs760573886 | 244 | E>* | No |
ExAC TOPMed |
|
| rs760573886 | 244 | E>K | No |
ExAC TOPMed |
|
| rs765081617 | 246 | I>F | No | ExAC | |
| rs750551120 | 247 | L>M | No |
ExAC TOPMed gnomAD |
|
| rs758702684 | 247 | L>P | No |
ExAC gnomAD |
|
| rs758702684 | 247 | L>Q | No |
ExAC gnomAD |
|
| rs758702684 | 247 | L>R | No |
ExAC gnomAD |
|
| rs201107079 | 248 | H>P | No |
ExAC gnomAD |
|
| rs781753057 | 250 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs781753057 | 250 | P>Q | No |
ExAC TOPMed gnomAD |
|
| rs778259364 | 252 | Q>* | No |
ExAC TOPMed gnomAD |
|
| rs144484426 | 252 | Q>R | No |
ESP ExAC gnomAD |
|
| rs1393992024 | 253 | I>F | No |
TOPMed gnomAD |
|
| rs1393992024 | 253 | I>V | No |
TOPMed gnomAD |
|
| rs373606723 | 256 | G>R | No |
ESP TOPMed gnomAD |
|
| rs373606723 | 256 | G>S | No |
ESP TOPMed gnomAD |
|
| rs768185787 | 257 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs148779761 | 257 | R>W | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1980460033 | 258 | T>R | No | gnomAD | |
| TCGA novel | 259 | V>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs776480411 | 259 | V>M | No |
ExAC TOPMed gnomAD |
|
| rs764925044 | 261 | A>S | No |
ExAC TOPMed gnomAD |
|
| rs764925044 | 261 | A>T | No |
ExAC TOPMed gnomAD |
|
| rs77604620 | 262 | C>S | No | Ensembl | |
| rs1298549200 | 263 | D>N | No | gnomAD | |
| rs773122788 | 264 | L>F | No |
ExAC gnomAD |
|
|
TCGA novel rs1980371402 |
266 | Q>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1305807279 | 266 | Q>K | No | Ensembl | |
| rs371549338 | 267 | S>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs1233803756 | 267 | S>R | No | gnomAD | |
| COSM1026983 | 270 | H>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1251941393 | 270 | H>Q | No |
TOPMed gnomAD |
|
| rs997424393 | 270 | H>R | No |
TOPMed gnomAD |
|
| rs763065323 | 271 | K>Q | No |
ExAC gnomAD |
|
| rs1351174814 | 271 | K>R | No | gnomAD | |
| rs1980462802 | 272 | D>N | No |
TOPMed gnomAD |
|
| rs1218495423 | 273 | Q>* | No | gnomAD | |
| rs754924930 | 273 | Q>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs1980463219 | 273 | Q>R | No | Ensembl | |
| rs1263685545 | 274 | R>G | No | gnomAD | |
| rs1376129286 | 274 | R>K | No |
TOPMed gnomAD |
|
| rs766577734 | 275 | Q>R | No |
ExAC gnomAD |
|
| rs751865521 | 276 | R>G | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 278 | G>G | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| COSM4098625 | 278 | G>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1200148764 | 281 | A>V | No | gnomAD | |
| COSM724555 | 282 | D>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs753243279 | 283 | F>S | No |
ExAC TOPMed gnomAD |
|
| rs1980464828 | 283 | F>V | No | gnomAD | |
| rs1440232558 | 285 | E>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1222666729 | 285 | E>K | No |
TOPMed gnomAD |
|
| rs780648362 | 286 | I>V | No |
ExAC TOPMed gnomAD |
|
| rs200797550 | 289 | H>R | No |
1000Genomes ExAC TOPMed gnomAD |
|
|
VAR_041075 rs35793869 |
289 | H>Y | No |
UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| TCGA novel | 293 | S>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1416496403 | 294 | P>S | No | gnomAD | |
| rs1416496403 | 294 | P>T | No | gnomAD | |
| rs1980694542 | 297 | W>R | No | gnomAD | |
| rs1379248803 | 298 | D>G | No | TOPMed | |
| rs1479848720 | 301 | Y>S | No | Ensembl | |
| rs1405236690 | 303 | K>N | No | gnomAD | |
| rs772473297 | 303 | K>R | No |
ExAC gnomAD |
|
| rs1980696265 | 304 | R>K | No | gnomAD | |
| rs891003647 | 305 | L>V | No | TOPMed | |
| rs1272741825 | 308 | P>S | No |
TOPMed gnomAD |
|
| rs1304361697 | 311 | P>L | No | gnomAD | |
| rs1304361697 | 311 | P>Q | No | gnomAD | |
| TCGA novel | 312 | N>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1040192580 | 314 | T>I | No | gnomAD | |
| rs1040192580 | 314 | T>K | No | gnomAD | |
| rs1981004404 | 315 | G>E | No | Ensembl | |
|
COSM1483651 rs774838630 |
315 | G>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
|
COSM1483651 rs763238680 |
315 | G>R | breast [Cosmic] | No |
cosmic curated ExAC TOPMed gnomAD |
| rs766744287 | 318 | D>H | No | ExAC | |
| rs1981005411 | 322 | F>I | No | TOPMed | |
| rs866568183 | 325 | E>* | No | Ensembl | |
| rs755794346 | 327 | T>I | No |
ExAC gnomAD |
|
| rs755794346 | 327 | T>N | No |
ExAC gnomAD |
|
| rs777308952 | 328 | Q>R | No |
ExAC gnomAD |
|
| rs1353819680 | 329 | E>D | No | gnomAD | |
| rs200184491 | 330 | A>G | No |
1000Genomes ExAC gnomAD |
|
| rs1229736864 | 330 | A>P | No | gnomAD | |
| rs200184491 | 330 | A>V | No |
1000Genomes ExAC gnomAD |
|
| rs200888984 | 331 | V>M | No | Ensembl | |
|
COSM3972558 rs1218495423 |
333 | K>E | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic NCI-TCGA gnomAD |
| rs1456934348 | 333 | K>Q | No | gnomAD | |
| rs1981007333 | 336 | G>A | No |
TOPMed gnomAD |
|
|
rs755045211 COSM4390057 |
336 | G>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
|
rs751865521 COSM289606 |
336 | G>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
| rs1178032411 | 337 | C>R | No |
TOPMed gnomAD |
|
| rs1196634252 | 337 | C>S | No | gnomAD | |
| rs1196634252 | 337 | C>Y | No | gnomAD | |
| rs1601004794 | 338 | T>P | No | Ensembl | |
| rs778952371 | 340 | D>A | No |
ExAC gnomAD |
|
| rs778952371 | 340 | D>V | No |
ExAC gnomAD |
|
| rs777516703 | 342 | V>A | No | gnomAD | |
| rs771931070 | 342 | V>M | No |
ExAC gnomAD |
|
| COSM1026984 | 342 | V>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs147672588 | 343 | A>T | No |
ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 345 | S>G | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1471924861 | 346 | S>C | No | gnomAD | |
| rs1165235304 | 348 | A>D | No | gnomAD | |
| rs1981009608 | 348 | A>T | No | Ensembl | |
| rs747250493 | 350 | S>G | No |
ExAC gnomAD |
|
| rs996045856 | 351 | A>T | No |
TOPMed gnomAD |
|
| rs368731800 | 352 | F>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs1981011040 | 352 | F>L | No | TOPMed | |
| COSM3991716 | 355 | F>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1981011754 | 356 | S>F | No | TOPMed | |
| TCGA novel | 356 | S>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs748188805 | 356 | S>P | No |
ExAC TOPMed gnomAD |
|
| rs904631892 | 357 | Y>C | No | Ensembl | |
| COSM97805 | 359 | P>G | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs766765898 | 360 | E>G | No |
ExAC TOPMed gnomAD |
|
| rs1223273825 | 360 | E>K | No |
TOPMed gnomAD |
|
| rs1295347295 | 361 | D>V | No | Ensembl | |
| rs2145564468 | 362 | D>G | No | Ensembl | |
| rs1216231388 | 362 | D>N | No | gnomAD | |
| rs1416453658 | 365 | L>W | No | TOPMed | |
| rs760355928 | 367 | C>F | No |
ExAC TOPMed gnomAD |
|
| rs760355928 | 367 | C>Y | No |
ExAC TOPMed gnomAD |
5 associated diseases with Q9HBY8
[MIM: 133540]: Cockayne syndrome B (CSB)
A rare disorder characterized by cutaneous sensitivity to sunlight, abnormal and slow growth, cachectic dwarfism, progeroid appearance, progressive pigmentary retinopathy and sensorineural deafness. There is delayed neural development and severe progressive neurologic degeneration resulting in intellectual disability. Two clinical forms are recognized
[MIM: 214150]: Cerebro-oculo-facio-skeletal syndrome 1 (COFS1)
A disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome. . Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 278800]: De Sanctis-Cacchione syndrome (DSC)
An autosomal recessive syndrome consisting of xeroderma pigmentosum associated with severe neurological and developmental involvement. In addition to the clinical signs of xeroderma pigmentosum, patients present with intellectual disability, dwarfism, gonadal hypoplasia, microcephaly and various neurologic complications of early onset. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 613761]: Macular degeneration, age-related, 5 (ARMD5)
A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. . Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
[MIM: 600630]: UV-sensitive syndrome 1 (UVSS1)
An autosomal recessive disorder characterized by cutaneous photosensitivity and mild freckling in the absence of neurological abnormalities or skin tumors. . Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A rare disorder characterized by cutaneous sensitivity to sunlight, abnormal and slow growth, cachectic dwarfism, progeroid appearance, progressive pigmentary retinopathy and sensorineural deafness. There is delayed neural development and severe progressive neurologic degeneration resulting in intellectual disability. Two clinical forms are recognized
- A disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome. . Note=The disease is caused by variants affecting the gene represented in this entry.
- An autosomal recessive syndrome consisting of xeroderma pigmentosum associated with severe neurological and developmental involvement. In addition to the clinical signs of xeroderma pigmentosum, patients present with intellectual disability, dwarfism, gonadal hypoplasia, microcephaly and various neurologic complications of early onset. Note=The disease is caused by variants affecting the gene represented in this entry.
- A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. . Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
- An autosomal recessive disorder characterized by cutaneous photosensitivity and mild freckling in the absence of neurological abnormalities or skin tumors. . Note=The disease is caused by variants affecting the gene represented in this entry.
14 regional properties for Q9HBY8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Receptor L-domain | 52 - 163 | IPR000494-1 |
| domain | Receptor L-domain | 359 - 468 | IPR000494-2 |
| domain | Protein kinase domain | 1023 - 1298 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 1023 - 1290 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class II, conserved site | 1183 - 1191 | IPR002011 |
| domain | Fibronectin type III | 492 - 600 | IPR003961-1 |
| domain | Fibronectin type III | 622 - 831 | IPR003961-2 |
| domain | Fibronectin type III | 851 - 947 | IPR003961-3 |
| domain | Furin-like cysteine-rich domain | 179 - 340 | IPR006211 |
| repeat | Furin-like repeat | 231 - 321 | IPR006212 |
| active_site | Tyrosine-protein kinase, active site | 1155 - 1167 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 1029 - 1057 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 1023 - 1290 | IPR020635 |
| domain | Insulin receptor, trans-membrane domain | 940 - 987 | IPR040969 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.- | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| potassium channel regulator activity | Binds to and modulates the activity of a potassium channel. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| sodium channel regulator activity | Binds to and modulates the activity of a sodium channel. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| positive regulation of transporter activity | Any process that activates or increases the activity of a transporter. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of cell growth | Any process that modulates the frequency, rate, extent or direction of cell growth. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6TJY3 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Bos taurus (Bovine) | SS |
| P23443 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens (Human) | EV SS |
| Q9UBS0 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens (Human) | PR |
| O15530 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens (Human) | EV |
| Q05513 | PRKCZ | Protein kinase C zeta type | Homo sapiens (Human) | SS |
| P41743 | PRKCI | Protein kinase C iota type | Homo sapiens (Human) | EV |
| Q16512 | PKN1 | Serine/threonine-protein kinase N1 | Homo sapiens (Human) | EV |
| Q6P5Z2 | PKN3 | Serine/threonine-protein kinase N3 | Homo sapiens (Human) | SS |
| Q16513 | PKN2 | Serine/threonine-protein kinase N2 | Homo sapiens (Human) | EV |
| P24723 | PRKCH | Protein kinase C eta type | Homo sapiens (Human) | SS |
| Q02156 | PRKCE | Protein kinase C epsilon type | Homo sapiens (Human) | SS |
| Q04759 | PRKCQ | Protein kinase C theta type | Homo sapiens (Human) | PR |
| Q05655 | PRKCD | Protein kinase C delta type | Homo sapiens (Human) | SS |
| P17252 | PRKCA | Protein kinase C alpha type | Homo sapiens (Human) | EV |
| P05129 | PRKCG | Protein kinase C gamma type | Homo sapiens (Human) | SS |
| P05771 | PRKCB | Protein kinase C beta type | Homo sapiens (Human) | SS |
| P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens (Human) | EV SS |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens (Human) | EV |
| Q9Y243 | AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens (Human) | SS |
| Q96BR1 | SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens (Human) | SS |
| O00141 | SGK1 | Serine/threonine-protein kinase Sgk1 | Homo sapiens (Human) | PR |
| Q15208 | STK38 | Serine/threonine-protein kinase 38 | Homo sapiens (Human) | EV |
| Q9Y2H1 | STK38L | Serine/threonine-protein kinase 38-like | Homo sapiens (Human) | EV |
| Q6A1A2 | PDPK2P | Putative 3-phosphoinositide-dependent protein kinase 2 | Homo sapiens (Human) | PR |
| Q8QZV4 | Stk32c | Serine/threonine-protein kinase 32C | Mus musculus (Mouse) | PR |
| Q9Z1M4 | Rps6kb2 | Ribosomal protein S6 kinase beta-2 | Mus musculus (Mouse) | SS |
| Q8BSK8 | Rps6kb1 | Ribosomal protein S6 kinase beta-1 | Mus musculus (Mouse) | SS |
| Q9ERE3 | Sgk3 | Serine/threonine-protein kinase Sgk3 | Mus musculus (Mouse) | PR |
| P67999 | Rps6kb1 | Ribosomal protein S6 kinase beta-1 | Rattus norvegicus (Rat) | EV SS |
| Q9SUA3 | D6PKL1 | Serine/threonine-protein kinase D6PKL1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48963 | PHOT1 | Phototropin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64682 | PID | Protein kinase PINOID | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUL2 | WAG2 | Serine/threonine-protein kinase WAG2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5BKK4 | sgk1 | Serine/threonine-protein kinase Sgk1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNSSPAGTPS | PQPSRANGNI | NLGPSANPNA | QPTDFDFLKV | IGKGNYGKVL | LAKRKSDGAF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YAVKVLQKKS | ILKKKEQSHI | MAERSVLLKN | VRHPFLVGLR | YSFQTPEKLY | FVLDYVNGGE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFFHLQRERR | FLEPRARFYA | AEVASAIGYL | HSLNIIYRDL | KPENILLDCQ | GHVVLTDFGL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CKEGVEPEDT | TSTFCGTPEY | LAPEVLRKEP | YDRAVDWWCL | GAVLYEMLHG | LPPFYSQDVS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QMYENILHQP | LQIPGGRTVA | ACDLLQSLLH | KDQRQRLGSK | ADFLEIKNHV | FFSPINWDDL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YHKRLTPPFN | PNVTGPADLK | HFDPEFTQEA | VSKSIGCTPD | TVASSSGASS | AFLGFSYAPE |
| DDDILDC |