AiPD: Autoinhibited Protein Database

Q9H8T0

Gene name	AKTIP
Protein name	AKT-interacting protein
Names	Ft1, Fused toes protein homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:64400
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-109 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-109 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9H8T0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9H8T0-F1	Predicted				AlphaFoldDB

178 variants for Q9H8T0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA395922361 rs1364147270	8	S>F		No	ClinGen gnomAD
CA395922322 rs1364897796	12	V>G		No	ClinGen gnomAD
CA8057095 COSM1378340 rs779924211	13	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA8057094 rs769566710	13	R>H		No	ClinGen ExAC gnomAD
rs1371166754 CA395922308	14	K>R		No	ClinGen gnomAD
rs764155782 CA8057078	15	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1429434344 CA395922192	16	S>F		No	ClinGen gnomAD
CA8057076 rs775441301	20	E>D		No	ClinGen ExAC gnomAD
rs919044600 CA281365467	20	E>K		No	ClinGen Ensembl
CA395922162 rs1250209537	21	K>E		No	ClinGen TOPMed gnomAD
rs61734118 CA8057075	21	K>N		No	ClinGen ExAC TOPMed gnomAD
CA395922151 rs1481856382	22	T>I		No	ClinGen gnomAD
CA281365457 rs973534183	25	G>R		No	ClinGen Ensembl
CA395922123 rs776539900	27	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8057072 rs776539900	27	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1225219264 CA395922100	30	S>I		No	ClinGen gnomAD
rs770900884 CA8057071	31	P>L		No	ClinGen ExAC gnomAD
rs1428326756 CA395922090	32	P>S		No	ClinGen TOPMed
rs141560947 CA8057070	33	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
COSM971479 CA8057069 rs141560947	33	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs747621138 CA8057067	37	K>E		No	ClinGen ExAC gnomAD
rs780558074 CA8057066	37	K>N		No	ClinGen ExAC TOPMed gnomAD
rs756609255 CA8057065	42	S>Y		No	ClinGen ExAC gnomAD
rs986386188 CA281365403	43	I>T		No	ClinGen Ensembl
TCGA novel	46	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8057063 rs767844319	50	I>V		No	ClinGen ExAC gnomAD
rs199669647 CA281365360 COSM3932365	51	T>A	urinary_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes
rs751715236 CA8057061	53	P>L		No	ClinGen ExAC gnomAD
rs533946422 CA8057062	53	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs764315195 CA8057060	54	T>K		No	ClinGen ExAC gnomAD
rs199548307 CA281365344	55	S>C		No	ClinGen 1000Genomes TOPMed gnomAD
CA395921951 rs1437597313	55	S>P		No	ClinGen TOPMed
rs775464421 CA8057058	56	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8057056 rs759373692	58	P>S		No	ClinGen ExAC gnomAD
CA8057055 rs759373692	58	P>T		No	ClinGen ExAC gnomAD
CA8057053 rs770843306	60	A>V		No	ClinGen ExAC gnomAD
rs908389472 CA281365313	62	S>A		No	ClinGen TOPMed gnomAD
rs1046908213 CA281365299	62	S>L		No	ClinGen TOPMed
CA281365290 rs1021665141	63	T>A		No	ClinGen TOPMed
rs1021665141 CA281365289	63	T>S		No	ClinGen TOPMed
rs746802147 CA8057052	64	N>D		No	ClinGen ExAC gnomAD
rs771641760 CA8057050	66	T>M		No	ClinGen ExAC gnomAD
CA8057048 rs778254783	68	A>V		No	ClinGen ExAC TOPMed gnomAD
rs746359591 CA8057046	72	P>L		No	ClinGen ExAC gnomAD
CA395921850 rs746359591	72	P>R		No	ClinGen ExAC gnomAD
TCGA novel	77	Y>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	80	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	81	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs980836688 CA281361831	86	V>I		No	ClinGen TOPMed
rs969422442 CA281361822	87	V>L		No	ClinGen TOPMed
TCGA novel	88	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA281361787 rs912559809	88	K>Q		No	ClinGen gnomAD
CA8057022 rs777982018	94	V>I		No	ClinGen ExAC gnomAD
rs1314598157 CA395921151	95	Y>C		No	ClinGen gnomAD
CA8057020 rs752861266	97	Q>P		No	ClinGen ExAC gnomAD
rs779196597 CA281361742	100	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs755048837 CA8057018	101	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8057017 COSM3818093 rs753984711	101	R>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs755048837 CA395921096	101	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	102	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395921034 rs1200188293	105	M>T		No	ClinGen gnomAD
CA281361654 rs753201275	108	G>A		No	ClinGen TOPMed gnomAD
CA395920995 rs1473245954	109	V>L		No	ClinGen gnomAD
CA395920982 rs1156378312	110	I>T		No	ClinGen TOPMed
CA281361652 rs1032844543	113	R>Q		No	ClinGen Ensembl
rs769347114 CA8057006	113	R>W		No	ClinGen ExAC TOPMed gnomAD
CA395920926 rs1191455290	116	L>F		No	ClinGen TOPMed gnomAD
CA8057005 rs747506016	119	D>N		No	ClinGen ExAC gnomAD
COSM971478 CA8057003 rs373752479	121	V>I	Variant assessed as Somatic; 0.0 impact. central_nervous_system endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	128	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8057000 rs755278060	130	D>A		No	ClinGen ExAC TOPMed gnomAD
CA395920750 rs1405384807	133	P>A		No	ClinGen gnomAD
rs1177246282 CA395920725	135	G>C		No	ClinGen gnomAD
CA8056999 rs370289246	137	C>G		No	ClinGen ESP ExAC gnomAD
rs1427164346 CA395920699	137	C>Y		No	ClinGen gnomAD
rs781311887 COSM971477 CA8056952	139	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA8056951 rs757341232	139	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA395920082 rs1158115486	140	L>W		No	ClinGen TOPMed
rs953034676 CA281360946	141	V>L		No	ClinGen TOPMed
rs1394013364 CA395920056	143	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs758135917 CA8056948	144	I>S		No	ClinGen ExAC gnomAD
rs1300948018 CA395920036	146	V>I		No	ClinGen TOPMed
CA8056947 rs752514939	148	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA281360927 rs995013998	149	P>A		No	ClinGen TOPMed
CA8056946 rs778493299	149	P>L		No	ClinGen ExAC gnomAD
rs754625474 CA8056945	154	T>A		No	ClinGen ExAC gnomAD
TCGA novel	156	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1567757016 CA395919889	158	L>M		No	ClinGen Ensembl
rs765897827 CA8056943	160	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	162	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1347930660 CA395919832	162	R>T		No	ClinGen TOPMed
rs760168557 CA8056942	165	A>T		No	ClinGen ExAC gnomAD
CA281360715 rs1044968841	169	R>Q		No	ClinGen TOPMed
CA395919708 rs1478076012	174	I>T		No	ClinGen TOPMed gnomAD
CA281360693 rs61731846	175	W>*		No	ClinGen Ensembl
CA281360697 rs61731847	175	W>L		No	ClinGen Ensembl
rs995190946 CA281360685	176	Q>*		No	ClinGen Ensembl
CA8056920 rs753316244	177	V>I		No	ClinGen ExAC gnomAD
rs963725014 CA281360672	178	L>I		No	ClinGen TOPMed
CA395919680 rs1244858630	179	M>V		No	ClinGen TOPMed gnomAD
rs759826964 CA8056918	183	R>G		No	ClinGen ExAC gnomAD
TCGA novel	185	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776857155 CA8056917	189	D>H		No	ClinGen ExAC gnomAD
rs771085637 CA8056916	190	T>R		No	ClinGen ExAC gnomAD
rs150593359 CA281360609	191	A>T		No	ClinGen ESP TOPMed
rs1259542641 CA395919585	192	S>N		No	ClinGen TOPMed
CA395919580 rs1340502168	193	P>S		No	ClinGen TOPMed
rs773241653 CA8056915	194	L>P		No	ClinGen ExAC gnomAD
rs773241653 CA8056914	194	L>R		No	ClinGen ExAC gnomAD
rs772184838 CA8056913	196	P>A		No	ClinGen ExAC gnomAD
CA281360562 rs1012088845	196	P>L		No	ClinGen TOPMed
rs748061956 CA8056912	198	A>T		No	ClinGen ExAC gnomAD
CA8056911 rs778887599	200	V>G		No	ClinGen ExAC gnomAD
TCGA novel	204	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395919489 rs1313357996	205	D>E		No	ClinGen TOPMed
TCGA novel	205	D>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1354301019 CA395919484	206	I>T		No	ClinGen TOPMed
rs1260668126 CA395919488	206	I>V		No	ClinGen Ensembl
CA8056894 rs760860184	210	K>R		No	ClinGen ExAC TOPMed gnomAD
CA395919432 rs1194237105	213	V>A		No	ClinGen gnomAD
TCGA novel	213	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395919435 rs1279710988	213	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA281360360 rs767578006	214	V>A		No	ClinGen ExAC TOPMed gnomAD
rs767578006 CA8056892	214	V>D		No	ClinGen ExAC TOPMed gnomAD
CA8056893 rs773479084	214	V>I		No	ClinGen ExAC gnomAD
rs761884339 CA8056891	216	S>G		No	ClinGen ExAC gnomAD
rs1193762457 CA395919395	219	V>A		No	ClinGen gnomAD
rs911361305 CA281360351	219	V>L		No	ClinGen TOPMed gnomAD
rs911361305 CA395919397	219	V>M		No	ClinGen TOPMed gnomAD
rs151134332 CA281360343	221	T>A		No	ClinGen 1000Genomes
CA8056890 rs774284749	223	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8056889 rs528168629 COSM1378338	223	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA395919372 rs528168629	223	R>P		No	ClinGen ExAC TOPMed gnomAD
rs749069548 CA8056888	224	L>S		No	ClinGen ExAC gnomAD
rs1437625343 CA395919360	225	F>S		No	ClinGen gnomAD
rs1347301445	225	F>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA281360319 rs559351790	227	Q>E		No	ClinGen Ensembl
CA395919341 rs1598150377	228	P>S		No	ClinGen Ensembl
CA8056886 rs769769588	229	K>T		No	ClinGen ExAC
rs780998485 CA395919302	233	P>H		No	ClinGen ExAC gnomAD
CA8056884 rs780998485	233	P>L		No	ClinGen ExAC gnomAD
rs748916763 CA281360288	234	Y>C		No	ClinGen Ensembl
CA8056881 RCV000900067 rs118126947	235	A>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA395919287 rs1427104315	236	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	237	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8056859 rs374819167	240	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA395918589 rs1216332913	243	P>A		No	ClinGen gnomAD
CA8056856 rs767877058	246	H>P		No	ClinGen ExAC gnomAD
rs750806890 CA8056855	247	D>H		No	ClinGen ExAC gnomAD
TCGA novel	251	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395918480 rs1284857214	251	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	252	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395918453 rs1448593027	254	L>M		No	ClinGen TOPMed gnomAD
CA395918439 rs1390158105	255	T>I		No	ClinGen TOPMed
rs760290777	258	K>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs551631734 CA8056832	258	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1327909463 CA395918313	261	E>K		No	ClinGen TOPMed
TCGA novel	261	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770316581 CA8056830	262	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA8056829 rs770316581	262	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs746414525 CA8056828	263	H>Y		No	ClinGen ExAC gnomAD
CA8056827 rs143575360	265	K>E		No	ClinGen ESP ExAC TOPMed
rs1208224739 CA395918236	266	S>N		No	ClinGen gnomAD
CA8056826 rs757708234	267	V>G		No	ClinGen ExAC gnomAD
rs751667313 CA8056825	268	H>Y		No	ClinGen ExAC
rs758363858 CA8056823	270	A>T		No	ClinGen ExAC
CA395918182 rs1488397374	271	G>S		No	ClinGen gnomAD
CA395918159 rs1598146921	273	S>*		No	ClinGen Ensembl
rs201981579 CA8056821	276	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8056818 rs145847118	280	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1280086197 CA395918082	281	Q>E		No	ClinGen gnomAD
rs1384861610 CA395918073	281	Q>H		No	ClinGen gnomAD
rs568156696 CA8056816	289	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA281358661 rs1034577709	289	T>K		No	ClinGen Ensembl
CA8056815 rs772679190	290	V>L		No	ClinGen ExAC TOPMed gnomAD
rs772679190 CA395917965	290	V>M		No	ClinGen ExAC TOPMed gnomAD
rs771776966 CA8056814 COSM3421035	291	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1426404310 CA395917930	293	T>K		No	ClinGen gnomAD

No associated diseases with Q9H8T0

1 regional properties for Q9H8T0

Type	Name	Position	InterPro Accession
domain	Ubiquitin-conjugating enzyme E2	74 - 222	IPR000608

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
FHF complex	A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex).
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
ubiquitin conjugating enzyme activity	Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

10 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
early endosome to late endosome transport	The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
endosome organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
endosome to lysosome transport	The directed movement of substances from endosomes to lysosomes.
lysosome organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
positive regulation of protein binding	Any process that activates or increases the frequency, rate or extent of protein binding.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
protein localization to perinuclear region of cytoplasm	A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm.
protein polyubiquitination	Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

18 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZJJ5	AKTIP	AKT-interacting protein	Gallus gallus (Chicken)	PR
Q7K4V4	CG46338	Protein crossbronx	Drosophila melanogaster (Fruit fly)	PR
P25867	eff	Ubiquitin-conjugating enzyme E2-17 kDa	Drosophila melanogaster (Fruit fly)	PR
Q9Y385	UBE2J1	Ubiquitin-conjugating enzyme E2 J1	Homo sapiens (Human)	PR
P61086	UBE2K	Ubiquitin-conjugating enzyme E2 K	Homo sapiens (Human)	PR
Q9NPD8	UBE2T	Ubiquitin-conjugating enzyme E2 T	Homo sapiens (Human)	PR
O00762	UBE2C	Ubiquitin-conjugating enzyme E2 C	Homo sapiens (Human)	PR
O14933	UBE2L6	Ubiquitin/ISG15-conjugating enzyme E2 L6	Homo sapiens (Human)	PR
Q96LR5	UBE2E2	Ubiquitin-conjugating enzyme E2 E2	Homo sapiens (Human)	PR
Q969T4	UBE2E3	Ubiquitin-conjugating enzyme E2 E3	Homo sapiens (Human)	PR
Q7Z7E8	UBE2Q1	Ubiquitin-conjugating enzyme E2 Q1	Homo sapiens (Human)	PR
A1L167	UBE2QL1	Ubiquitin-conjugating enzyme E2Q-like protein 1	Homo sapiens (Human)	PR
Q16763	UBE2S	Ubiquitin-conjugating enzyme E2 S	Homo sapiens (Human)	EV
Q64362	Aktip	AKT-interacting protein	Mus musculus (Mouse)	PR
Q5FVH4	Aktip	AKT-interacting protein	Rattus norvegicus (Rat)	PR
P35129	let-70	Ubiquitin-conjugating enzyme E2 2	Caenorhabditis elegans	PR
Q9SLE4	UBC29	Ubiquitin-conjugating enzyme E2 29	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C8X7	UBC31	Probable ubiquitin-conjugating enzyme E2 31	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MNPFWSMSTS	SVRKRSEGEE	KTLTGDVKTS	PPRTAPKKQL	PSIPKNALPI	TKPTSPAPAA
70	80	90	100	110	120
QSTNGTHASY	GPFYLEYSLL	AEFTLVVKQK	LPGVYVQPSY	RSALMWFGVI	FIRHGLYQDG
130	140	150	160	170	180
VFKFTVYIPD	NYPDGDCPRL	VFDIPVFHPL	VDPTSGELDV	KRAFAKWRRN	HNHIWQVLMY
190	200	210	220	230	240
ARRVFYKIDT	ASPLNPEAAV	LYEKDIQLFK	SKVVDSVKVC	TARLFDQPKI	EDPYAISFSP
250	260	270	280	290
WNPSVHDEAR	EKMLTQKKPE	EQHNKSVHVA	GLSWVKPGSV	QPFSKEEKTV	AT