Q9H8S9-1

EV
Gene name
MOB1A (C2orf6, MOB4B, MOBK1B, MOBKL1B)
Protein name
MOB kinase activator 1A
Names
Mob1 alpha, Mob1A, Mob1 homolog 1B, Mps one binder kinase activator-like 1B
Species
Homo sapiens (Human)
KEGG Pathway
hsa:55233
EC number
Protein Class
MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB (PTHR22599)

Descriptions

Mob1 is an activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Mob1 adopts an autoinhibited, closed conformation, with its N-terminal FXFx5KxF motif. Phosphorylation of Mob1 at T35 relieves this autoinhibition and stimulates Lats1 binding in part.

Autoinhibitory domains (AIDs)

1-52 (N-terminal autoinhibitory element) EV

Target domain

31-204 (Mob1/phocein family)

Relief mechanism

PTM

Assay

Structural analysis, Deletion assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

12 structures for Q9H8S9-1

Entry ID Method Resolution Chain Position Source
1PI1 X-ray 200 A A 33-216 PDB
4J1V X-ray 195 A A/C 33-216 PDB
4JIZ X-ray 210 A A 40-211 PDB
5BRK X-ray 230 A A 1-216 PDB
5BRM X-ray 265 A A/B/C/D/E/F 41-216 PDB
5TWF X-ray 314 A A/B 1-216 PDB
5TWG X-ray 230 A A 1-216 PDB
5TWH X-ray 250 A A 1-216 PDB
5XQZ X-ray 210 A A/B 33-216 PDB
6MCP X-ray 250 A B/D 33-216 PDB
6MCQ X-ray 257 A B/D 33-216 PDB
AF-Q9H8S9-F1 Predicted AlphaFoldDB

No variants for Q9H8S9-1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9H8S9-1

No associated diseases with Q9H8S9-1

3 regional properties for Q9H8S9-1

Type Name Position InterPro Accession
domain PDZ domain 14 - 94 IPR001478-1
domain PDZ domain 154 - 234 IPR001478-2
domain EBP50, C-terminal 235 - 358 IPR015098

Functions

Description
EC Number
Subcellular Localization
PANTHER Family PTHR22599 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB
PANTHER Subfamily PTHR22599:SF30 MOB KINASE ACTIVATOR 1A
PANTHER Protein Class kinase modulator
kinase activator
PANTHER Pathway Category CCKR signaling map
MOB1
CCKR signaling map
MOB1

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

2 GO annotations of biological process

Name Definition
hippo signaling The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG EDLNEWIAVN
70 80 90 100 110 120
TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG TNIKKPIKCS APKYIDYLMT
130 140 150 160 170 180
WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN
190 200 210
TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LGSKDR