AiPD: Autoinhibited Protein Database

Q9H2G4

Gene name	TSPYL2 (CDA1, DENTT, TSPX, HRIHFB2216)
Protein name	Testis-specific Y-encoded-like protein 2
Names	TSPY-like protein 2, Cell division autoantigen 1, Cutaneous T-cell lymphoma-associated antigen se20-4, CTCL-associated antigen se20-4, Differentially-expressed nucleolar TGF-beta1 target protein, Nuclear protein of 79 kDa, NP79
Species	Homo sapiens (Human)
KEGG Pathway	hsa:64061
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-56 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9H2G4

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9H2G4-F1	Predicted				AlphaFoldDB

482 variants for Q9H2G4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs782724184 CA10418503	2	D>V		No	ClinGen ExAC TOPMed gnomAD
CA413113208 rs1556807111	2	D>Y		No	ClinGen gnomAD
rs1556807114 CA413113236	3	R>S		No	ClinGen gnomAD
CA413113273 rs1556807116	4	P>S		No	ClinGen gnomAD
rs781914325 CA10418504	6	E>D		No	ClinGen ExAC TOPMed gnomAD
CA413113338 rs1556807120	6	E>G		No	ClinGen gnomAD
rs898527518 CA329168633	6	E>K		No	ClinGen Ensembl
CA413113355 rs1556807124	7	G>E		No	ClinGen gnomAD
CA413113393 rs1469158674	9	P>S		No	ClinGen TOPMed gnomAD
rs1469158674 CA413113385	9	P>T		No	ClinGen TOPMed gnomAD
CA413113498 rs1556807132	12	T>I		No	ClinGen gnomAD
TCGA novel	14	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413113597 rs1318359585	16	S>N		No	ClinGen TOPMed gnomAD
CA413113650 rs1284339555	17	S>R		No	ClinGen TOPMed gnomAD
rs183642206 CA413113652	18	S>A		No	ClinGen 1000Genomes gnomAD
rs1222766539 CA413113666	18	S>C		No	ClinGen TOPMed gnomAD
CA329168642 rs183642206	18	S>P		No	ClinGen 1000Genomes gnomAD
CA413113658 rs183642206	18	S>T		No	ClinGen 1000Genomes gnomAD
rs1556807146 CA413113689	19	E>G		No	ClinGen gnomAD
rs1556807145 CA413113672	19	E>K		No	ClinGen gnomAD
CA413113741 rs1556807147	21	P>A		No	ClinGen gnomAD
rs1556807148 CA413113772	22	Q>R		No	ClinGen gnomAD
CA10418507 rs781871680	23	R>L		No	ClinGen ExAC gnomAD
CA10418508 rs782504396	25	P>L		No	ClinGen ExAC gnomAD
rs1305586848 CA413113842	26	P>S		No	ClinGen TOPMed
CA413114990 rs1252690968	28	P>A		No	ClinGen TOPMed
CA413114995 rs1192226103	28	P>R		No	ClinGen TOPMed
rs1002926853 CA329168690	30	P>L		No	ClinGen gnomAD
CA413115029 rs1556807174	31	P>L		No	ClinGen gnomAD
rs781884842 RCV000999438	32	P>missing		No	ClinVar dbSNP
rs781884842 RCV000239202	33	P>missing		No	ClinVar dbSNP
CA413115050 rs1556807180	33	P>L		No	ClinGen gnomAD
CA413115076 rs1556807186	36	R>*		No	ClinGen gnomAD
rs1444736813 CA413115103	38	P>L		No	ClinGen TOPMed
rs1556807194 CA413115120	40	P>L		No	ClinGen gnomAD
rs1556807193 CA413115118	40	P>S		No	ClinGen gnomAD
CA413115128 rs1234857280	41	P>A		No	ClinGen TOPMed
rs1300971313 CA413115154	43	Q>R		No	ClinGen TOPMed
rs782451065 CA10418517	44	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA413115266 rs1602101717	51	E>K		No	ClinGen Ensembl
TCGA novel	54	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413115361 rs1602101724	56	Q>E		No	ClinGen Ensembl
TCGA novel	56	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413115371 rs1556807211	56	Q>R		No	ClinGen gnomAD
CA10418520 rs782544701	60	D>N		No	ClinGen ExAC TOPMed gnomAD
rs782223791 CA10418522	62	R>K		No	ClinGen ExAC gnomAD
rs1569227244 CA413115493	63	G>R		No	ClinGen Ensembl
CA413115532 rs1556807234	65	G>E		No	ClinGen gnomAD
rs1358640232 CA413115556	67	G>R		No	ClinGen TOPMed
rs1358640232 CA413115554	67	G>S		No	ClinGen TOPMed
rs1314844230 CA413115572	68	P>S		No	ClinGen TOPMed gnomAD
rs782412723 CA10418526	70	L>V		No	ClinGen ExAC TOPMed gnomAD
CA413115656 rs1556807246	72	P>L		No	ClinGen gnomAD
rs782760564 CA10418529	72	P>S		No	ClinGen ExAC gnomAD
TCGA novel	74	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781973800 CA10418530	75	P>S		No	ClinGen ExAC TOPMed gnomAD
CA413115722 rs1556807258	76	Y>C		No	ClinGen gnomAD
CA10418532 rs782716321	82	G>A		No	ClinGen ExAC TOPMed gnomAD
rs782716321 CA413115847	82	G>E		No	ClinGen ExAC TOPMed gnomAD
rs781793525 CA10418533	84	I>L		No	ClinGen ExAC gnomAD
rs1556807263	84	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868974991 CA413115920	86	A>S		No	ClinGen gnomAD
CA413115914 rs868974991	86	A>T		No	ClinGen gnomAD
rs1556807271 CA413115926	86	A>V		No	ClinGen gnomAD
rs1556807276 CA413115932	87	Y>H		No	ClinGen gnomAD
CA10418535 rs782790882	89	T>M		No	ClinGen ExAC TOPMed gnomAD
CA413115992 rs1258920633	90	L>F		No	ClinGen TOPMed
rs200235910 CA10418537	91	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs868944420 CA413116031	92	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1206581888 CA413116049	93	E>D		No	ClinGen TOPMed gnomAD
CA413116041 rs1278158064	93	E>Q		No	ClinGen TOPMed
rs782596856 CA10418539	94	C>G		No	ClinGen ExAC gnomAD
rs782596856 CA10418538	94	C>R		No	ClinGen ExAC gnomAD
rs782431539 CA10418540	95	P>R		No	ClinGen ExAC TOPMed gnomAD
CA10418543 rs782391431	101	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1214136520 CA413116222 COSM3708664	101	I>V	liver [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1556807299 CA413116279	103	S>L		No	ClinGen gnomAD
rs1556807305 CA413116310	105	Y>D		No	ClinGen gnomAD
rs1295191118 CA413116425	109	P>S		No	ClinGen TOPMed
rs1375338128 CA413116476	111	P>T		No	ClinGen TOPMed gnomAD
rs1556807317 CA413116539	114	S>G		No	ClinGen gnomAD
CA413116547 rs1556807320	114	S>N		No	ClinGen gnomAD
rs1602101968 CA413116658	119	P>S		No	ClinGen Ensembl
rs781938963 CA10418547	120	T>I		No	ClinGen ExAC gnomAD
rs1556807329 CA413116679	120	T>P		No	ClinGen gnomAD
CA10418549 rs782426401	121	P>L		No	ClinGen ExAC TOPMed gnomAD
rs782053997 CA10418548	121	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	122	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782022963 CA10418550	122	E>G		No	ClinGen ExAC gnomAD
CA413116816 rs1188010467	124	S>L		No	ClinGen TOPMed gnomAD
CA10418557 rs201527496	125	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA413116842 rs200823725 CA10418555	125	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10418556 rs201527496	125	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs200823725 CA413116839	125	G>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782157673	127	S>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs782639859 CA10418559	127	S>I		No	ClinGen ExAC gnomAD
rs1250546800 CA413116969	130	I>V		No	ClinGen TOPMed gnomAD
rs782478654 CA10418562	131	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA10418563 rs782649574	133	Q>E		No	ClinGen ExAC gnomAD
rs782201620 CA10418564	134	V>F		No	ClinGen ExAC TOPMed gnomAD
CA413117047 rs782201620	134	V>I		No	ClinGen ExAC TOPMed gnomAD
rs782314641 CA10418565	136	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs188041795 CA10418566	137	S>L		No	ClinGen 1000Genomes ExAC gnomAD
CA10418568 rs782399753	138	S>G		No	ClinGen ExAC gnomAD
CA10418569 rs782793681	138	S>R		No	ClinGen ExAC gnomAD
CA10418570 rs782105353	139	S>C		No	ClinGen ExAC TOPMed gnomAD
rs782314089 CA10418571	140	F>C		No	ClinGen ExAC TOPMed gnomAD
rs1556807368 CA413117202	141	G>D		No	ClinGen gnomAD
rs1310674266 CA413117251	143	E>G		No	ClinGen TOPMed
CA10418573 rs782161959	148	T>I		No	ClinGen ExAC TOPMed gnomAD
CA413117433 rs782792077	149	C>F		No	ClinGen ExAC TOPMed gnomAD
rs782792077 CA10418574	149	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1556807383 CA413117458	150	S>N		No	ClinGen gnomAD
TCGA novel	151	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782759070 CA10418577	155	A>S		No	ClinGen ExAC
rs781820784 CA10418578	155	A>V		No	ClinGen ExAC TOPMed gnomAD
CA10418579 rs144264921	156	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413117705 rs1249791967	158	R>K		No	ClinGen TOPMed
rs1469615945 CA413117781	160	V>A		No	ClinGen TOPMed
CA413117766 rs1602102149	160	V>I		No	ClinGen Ensembl
rs782541253 CA10418582	161	D>G		No	ClinGen ExAC gnomAD
rs782653951 CA10418583	162	P>L		No	ClinGen ExAC gnomAD
CA329168991 rs147809315	162	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA413117882 rs1556807412	164	S>R		No	ClinGen gnomAD
TCGA novel	167	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782486858 CA10418585	169	I>F		No	ClinGen ExAC gnomAD
CA413118055 rs1263752143	171	I>V		No	ClinGen TOPMed
TCGA novel	173	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782013886 CA10418591	174	D>N		No	ClinGen ExAC TOPMed gnomAD
rs782314519 CA10418592	177	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1327004488 CA413118251	180	R>P		No	ClinGen TOPMed gnomAD
TCGA novel	184	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413118340 rs1556807436	184	R>K		No	ClinGen gnomAD
rs781855034 CA10418593	185	S>T		No	ClinGen ExAC TOPMed gnomAD
CA413118380 rs1388205721	187	R>W		No	ClinGen TOPMed
rs368493284 CA413118428	189	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781920742 CA10418601	190	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs782707868 CA10418600	190	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1013022953 CA329169056	192	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10418604 rs781875909	193	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs192279149 CA413118482	193	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed
RCV000999439 rs1602102251	195	R>missing		No	ClinVar dbSNP
TCGA novel	199	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782374761 CA329169090	200	V>G		No	ClinGen 1000Genomes
rs782668342 CA10418610	200	V>M		No	ClinGen ExAC gnomAD
rs1238530279 CA413118660	202	R>M		No	ClinGen TOPMed gnomAD
CA413118675 rs1304609582	203	E>K		No	ClinGen TOPMed
rs782632847 CA10418613	204	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	206	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782342028 CA10418615	206	E>G		No	ClinGen ExAC gnomAD
rs782228545 CA10418614	206	E>K		No	ClinGen ExAC TOPMed gnomAD
CA329169110 rs963766645	210	E>A		No	ClinGen Ensembl
COSM1122904 rs782435988 CA10418618	210	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1556807486 CA413118833	212	M>L		No	ClinGen gnomAD
CA413118852 rs1295814650	213	E>Q		No	ClinGen TOPMed gnomAD
CA329169116 rs372826412	214	S>N		No	ClinGen ESP TOPMed
rs1556807496 CA413118958	219	L>V		No	ClinGen gnomAD
TCGA novel	220	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10418620 rs782133426	221	D>A		No	ClinGen ExAC gnomAD
rs782133426 CA10418621	221	D>V		No	ClinGen ExAC gnomAD
CA413119142 rs1556807503	228	A>T		No	ClinGen gnomAD
rs975255965 CA329169145	229	V>A		No	ClinGen Ensembl
TCGA novel	231	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375827801 CA10418622	235	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA10418623 rs782090845	237	F>L		No	ClinGen ExAC
CA413119495 rs1429346571	239	R>C		No	ClinGen TOPMed
rs782138092 CA10418626	242	R>H		No	ClinGen ExAC
TCGA novel	248	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413119865 rs1556807513	252	L>V		No	ClinGen gnomAD
rs782493555 CA10418629	254	R>H		No	ClinGen ExAC TOPMed gnomAD
rs782493555 CA413119927	254	R>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	256	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413119997 rs1556807524	257	L>H		No	ClinGen gnomAD
rs782601558 CA10418630	257	L>V		No	ClinGen ExAC TOPMed gnomAD
VAR_075536	262	I>M	found in patients with mild intellectual disability; unknown pathological significance [UniProt]	No	UniProt
CA413120198 rs1275739524	264	G>D		No	ClinGen TOPMed
CA413120289 rs1375956619	267	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1556807840 CA413120732	271	L>F		No	ClinGen gnomAD
CA413120766 rs1351157319	272	N>H		No	ClinGen TOPMed gnomAD
rs782321647 CA10418655	272	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	275	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1556807853 CA413120958	279	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1556807857 CA413121001	281	N>T		No	ClinGen gnomAD
rs1368644810 CA413121008	282	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10418658 rs782398266	282	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
CA413121024 rs1403222151	283	R>C		No	ClinGen TOPMed
rs781958730 CA10418659	283	R>H		No	ClinGen ExAC TOPMed gnomAD
CA413121085 rs1569228093	286	D>Y		No	ClinGen Ensembl
COSM1230717 rs782227977 CA10418660	289	R>C	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs199763926 CA10418661	289	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1556807871 CA413121174	292	T>S		No	ClinGen gnomAD
CA413123055 rs1305873504	297	Q>H		No	ClinGen TOPMed
CA10418703 rs782210338	300	R>K		No	ClinGen ExAC TOPMed
rs1229404836 CA413123193	302	I>T		No	ClinGen TOPMed
TCGA novel	309	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	312	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782355371 CA10418704	313	Q>H		No	ClinGen ExAC
CA10418705 rs782562823	314	T>I		No	ClinGen ExAC gnomAD
rs1556807962 CA413123584	316	P>H		No	ClinGen gnomAD
rs1556807962 CA413123585	316	P>R		No	ClinGen gnomAD
CA413123580 rs1556807960	316	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10418707 rs782394621	321	M>T		No	ClinGen ExAC gnomAD
CA10418706 rs782191661	321	M>V		No	ClinGen ExAC
CA413123903 rs1556807970	327	F>L		No	ClinGen gnomAD
CA10418708 rs781992684	329	R>C		No	ClinGen ExAC gnomAD
rs782133998 CA10418709	329	R>H		No	ClinGen ExAC TOPMed gnomAD
rs781977698 CA10418711	330	N>K		No	ClinGen ExAC
CA10418710 rs782346892	330	N>S		No	ClinGen ExAC TOPMed gnomAD
CA10418712 rs782055951	331	R>C		No	ClinGen ExAC gnomAD
rs201895359 CA10418713	331	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781890138 CA10418714	332	S>L		No	ClinGen ExAC gnomAD
CA10418738 rs782740859	334	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA413124110 rs1556808020	334	R>W		No	ClinGen gnomAD
CA413124167 rs1293666952	337	S>F		No	ClinGen TOPMed
rs183690746 CA10418739	338	H>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413124252 rs1602103846	342	I>V		No	ClinGen Ensembl
CA10418741 rs782710737	343	R>C		No	ClinGen ExAC TOPMed gnomAD
CA413124285 rs1556808032	343	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA413124337 rs1160418050	345	H>L		No	ClinGen TOPMed gnomAD
rs782545023 CA10418743	346	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA329170317 COSM1491064 rs782709479	346	R>W	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1000151289 CA329170333	348	Q>R		No	ClinGen TOPMed
CA329170340 rs1033330656	350	P>T		No	ClinGen Ensembl
rs781829924 CA10418745	352	A>V		No	ClinGen ExAC gnomAD
rs376609801 CA10418746	353	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs369549099 CA10418747	353	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs782195059 CA10418748	354	R>C		No	ClinGen ExAC gnomAD
CA10418749 rs782539542	354	R>H		No	ClinGen ExAC gnomAD
CA10418751 rs782250059	356	G>R		No	ClinGen ExAC gnomAD
rs782391917 CA10418752	358	Q>R		No	ClinGen ExAC gnomAD
rs781950604 CA10418753	360	A>G		No	ClinGen ExAC TOPMed gnomAD
rs781950604 CA10418754	360	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA413124743 rs1556808059	362	H>Q		No	ClinGen gnomAD
TCGA novel	365	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10418756 rs781934817	368	F>I		No	ClinGen ExAC gnomAD
rs1556808067 CA413124969	370	N>S		No	ClinGen gnomAD
rs782138409 CA10418757	371	H>Q		No	ClinGen ExAC gnomAD
CA413125020 rs1602103967	372	S>I		No	ClinGen Ensembl
CA10418758 rs782804078	373	L>F		No	ClinGen ExAC TOPMed gnomAD
CA413125029 rs782804078	373	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1556808077 CA413125160	378	R>G		No	ClinGen gnomAD
CA413125166 rs1236415661	378	R>K		No	ClinGen TOPMed
CA413125171 rs1332513949	378	R>S		No	ClinGen TOPMed
TCGA novel	379	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10418759 rs781976001	379	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1172975380 CA413125330	382	I>V		No	ClinGen TOPMed
rs1556808136 CA413125346	383	I>F		No	ClinGen gnomAD
rs1556808138 CA413125360	383	I>M		No	ClinGen gnomAD
CA10418780 rs145074661	384	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA413125389 rs1191695472	385	N>K		No	ClinGen TOPMed
rs1556808142 CA413125405	386	D>H		No	ClinGen gnomAD
rs1257310880 CA413125463	388	W>L		No	ClinGen TOPMed
CA10418783 rs373147193	393	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs782777372 CA10418784	393	R>H		No	ClinGen ExAC gnomAD
rs1556808160 CA413125605	395	Y>D		No	ClinGen gnomAD
CA329170526 rs782371895	395	Y>S		No	ClinGen gnomAD
CA413125692 rs1556808164	399	R>G		No	ClinGen gnomAD
rs782082499 CA10418786	399	R>S		No	ClinGen ExAC gnomAD
rs1556808168 CA413125705	400	G>S		No	ClinGen gnomAD
rs782744344 CA10418787	401	S>F		No	ClinGen ExAC TOPMed gnomAD
rs781788409 CA10418788	402	R>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	405	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1246916510 CA413125779	405	R>K		No	ClinGen TOPMed gnomAD
rs782652162 CA413125814	407	K>E		No	ClinGen ExAC gnomAD
rs782652162 CA10418790	407	K>Q		No	ClinGen ExAC gnomAD
rs1569228559 CA413125840	408	Q>*		No	ClinGen Ensembl
rs782488550 CA413125894	410	M>K		No	ClinGen ExAC gnomAD
rs782488550 CA10418792	410	M>T		No	ClinGen ExAC gnomAD
rs1556808185 CA413125881	410	M>V		No	ClinGen gnomAD
CA413125919 rs1340777042	411	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	412	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10418793 rs782653091	413	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1556808306 CA413126076	414	K>N		No	ClinGen gnomAD
CA10418814 rs782251414	414	K>T		No	ClinGen ExAC TOPMed gnomAD
CA10418815 rs200525147	417	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1556808313 CA413126122	418	R>I		No	ClinGen gnomAD
rs1267565173 CA413126150	419	C>Y		No	ClinGen TOPMed gnomAD
CA413126189 rs1602104587	421	V>M		No	ClinGen Ensembl
rs1556808320 CA413126248	424	M>V		No	ClinGen gnomAD
CA413126275 rs1556808325	425	E>G		No	ClinGen gnomAD
CA329170759 rs199605770	425	E>K		No	ClinGen gnomAD
rs186095471 CA10418818	426	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10418817 rs782224348	426	D>G		No	ClinGen ExAC TOPMed gnomAD
CA413126284 rs1489265950	426	D>N		No	ClinGen TOPMed
rs782418192 CA10418821	427	A>G		No	ClinGen ExAC gnomAD
CA10418820 rs782148691	427	A>T		No	ClinGen ExAC TOPMed gnomAD
CA413126322 rs1221166474	428	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	428	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1556808336 CA413126341	429	D>E		No	ClinGen gnomAD
CA413126354 rs1324285451	430	Y>C		No	ClinGen TOPMed
rs1556808344 CA413126404	433	V>A		No	ClinGen gnomAD
CA413126396 rs1282801783	433	V>L		No	ClinGen TOPMed
rs1222207205 CA413126513	439	E>D		No	ClinGen TOPMed
CA10418823 rs782123120	439	E>K		No	ClinGen ExAC gnomAD
TCGA novel	440	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413126574 rs1430398506	443	I>M		No	ClinGen TOPMed
rs1290001720 CA413126568	443	I>S		No	ClinGen TOPMed
CA413126563 rs1342988999	443	I>V		No	ClinGen TOPMed
rs1556808357 CA413126576	444	D>N		No	ClinGen gnomAD
TCGA novel	448	H>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782506300 CA10418829	450	I>M		No	ClinGen ExAC gnomAD
CA413126746 rs1556808374	453	S>F		No	ClinGen gnomAD
rs782211234 CA329170803	457	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1556808386 CA413126838	460	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1424197283 CA413126855	461	Y>C		No	ClinGen TOPMed
CA10418831 rs781827520	461	Y>D		No	ClinGen ExAC gnomAD
rs985376172 CA329170826	462	F>L		No	ClinGen Ensembl
rs782495382 CA10418832	462	F>Y		No	ClinGen ExAC gnomAD
TCGA novel	463	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	464	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10418834 rs782190267	468	E>G		No	ClinGen ExAC
rs1556808394 CA413126982	471	D>V		No	ClinGen gnomAD
COSM613041 CA413127005 rs1556808397	472	I>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs149102271 CA10418835	472	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs782676402 CA10418836	473	N>D		No	ClinGen ExAC gnomAD
rs143195586 CA10418837	473	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1556808406 CA413127031	474	E>K		No	ClinGen gnomAD
TCGA novel	476	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782152487 CA10418839	476	I>V		No	ClinGen ExAC TOPMed gnomAD
rs962609843 CA329170888	478	D>H		No	ClinGen TOPMed gnomAD
CA413127132 rs962609843	478	D>N		No	ClinGen TOPMed gnomAD
CA10418842 rs148286087	480	E>K		No	ClinGen ESP ExAC gnomAD
rs782167100 CA10418843	481	N>H		No	ClinGen ExAC TOPMed gnomAD
CA10418844 rs782765922	482	P>S		No	ClinGen ExAC gnomAD
rs377693568 CA10418845	483	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA413127308 rs1556808422	484	H>L		No	ClinGen gnomAD
CA413127320 rs1452883994	485	N>D		No	ClinGen TOPMed
rs1556808425 CA413127329	485	N>S		No	ClinGen gnomAD
rs201683434 CA10418849	489	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1556808440 COSM3780513 CA413127438	490	N>S	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1169578163 CA413127454	491	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	492	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10418851 rs140520453	492	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1556808447 CA413127498	492	T>S		No	ClinGen gnomAD
rs782807185 CA10418852	493	T>I		No	ClinGen ExAC gnomAD
rs782642668 CA10418855	494	D>G		No	ClinGen ExAC gnomAD
CA329171007 rs782705108	495	N>D		No	ClinGen ExAC TOPMed gnomAD
rs782705108 CA10418857	495	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs375540357 CA10418858	496	N>D		No	ClinGen ESP ExAC
CA413127573 rs1556808459	496	N>S		No	ClinGen gnomAD
rs782278185 CA10418860	497	E>K		No	ClinGen ExAC gnomAD
rs138367420 CA329171048	498	S>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10418861 RCV000961815 rs138367420	498	S>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs781992463 CA10418864	500	D>N		No	ClinGen ExAC gnomAD
CA329171057 rs979846106	501	D>N		No	ClinGen gnomAD
COSM1190553 CA10418866 rs782344893	503	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs781969830 CA10418867	504	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1054706191 CA329171065	505	T>A		No	ClinGen Ensembl
rs868992844 CA413127789	507	N>D		No	ClinGen gnomAD
rs1556808484 CA413127798	507	N>S		No	ClinGen gnomAD
rs891589662 CA329171083	508	N>D		No	ClinGen TOPMed gnomAD
TCGA novel	510	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs377587714 CA10418869	510	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA10418870 rs782072659	512	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413127935 rs1351587070	514	N>D		No	ClinGen TOPMed gnomAD
TCGA novel	514	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413128000 rs1556808501	516	E>G		No	ClinGen gnomAD
CA10418873 rs370449744	516	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA413127985 rs370449744	516	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10418874 rs782747918	517	N>S		No	ClinGen ExAC TOPMed gnomAD
rs782080298 CA10418876	518	P>A		No	ClinGen ExAC TOPMed gnomAD
CA413128037 rs782080298	518	P>S		No	ClinGen ExAC TOPMed gnomAD
rs782080298 CA413128040	518	P>T		No	ClinGen ExAC TOPMed gnomAD
CA413128068 rs868928234	519	E>D		No	ClinGen Ensembl
CA413128092 COSM1122912 rs1556808508	521	N>D	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA10418878 rs146112253	521	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10418879 rs781815242 CA413128130	522	N>K		No	ClinGen ExAC TOPMed gnomAD
CA413128138 rs1248917220	523	K>E		No	ClinGen TOPMed
CA10418880 rs782543175	525	T>A		No	ClinGen ExAC TOPMed gnomAD
CA413128191 rs1359091165	525	T>I		No	ClinGen TOPMed
CA10418882 rs374502411	529	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413128328 rs1556808519	531	N>K		No	ClinGen gnomAD
CA413128359 rs1241854521	533	N>D		No	ClinGen TOPMed
CA10418884 rs782532031	533	N>K		No	ClinGen ExAC gnomAD
TCGA novel	533	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1028963655 CA329171122	535	N>D		No	ClinGen TOPMed
CA413128402 rs887866076	535	N>K		No	ClinGen TOPMed gnomAD
CA413128406 rs1369119886	536	E>K		No	ClinGen TOPMed gnomAD
CA10418885 rs782594117	538	T>I		No	ClinGen ExAC gnomAD
CA10418888 rs367714830	539	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	540	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1556808535 CA413128496	540	G>S		No	ClinGen gnomAD
CA413128542 rs1404330334	542	N>S		No	ClinGen TOPMed
CA413128563 rs1363467745	543	F>Y		No	ClinGen TOPMed gnomAD
rs1006265626 CA329171139	545	K>R		No	ClinGen Ensembl
CA413128638 rs879997017	547	G>D		No	ClinGen Ensembl
rs1160285011 CA413128635	547	G>S		No	ClinGen TOPMed
TCGA novel	548	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782652782 CA10418889	549	W>S		No	ClinGen 1000Genomes ExAC gnomAD
CA413128709 rs1556808560	550	G>D		No	ClinGen gnomAD
rs1455511030 CA413128787	553	G>A		No	ClinGen TOPMed
rs868986922 CA413128860	556	Q>H		No	ClinGen Ensembl
rs781874099 CA329171146	560	D>H		No	ClinGen Ensembl
CA413128960 rs1556808575	561	S>G		No	ClinGen gnomAD
rs782276508 CA10418890	563	N>S		No	ClinGen ExAC gnomAD
rs1158678572 CA413129042	564	E>D		No	ClinGen TOPMed
rs1556808582 CA413129057	565	A>E		No	ClinGen gnomAD
CA413129078 rs1431551843	566	D>G		No	ClinGen TOPMed gnomAD
rs1490346927 CA413129273	572	E>D		No	ClinGen TOPMed gnomAD
CA329171159 rs782548409	578	E>K		No	ClinGen gnomAD
TCGA novel	579	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA329171183 rs371667688	583	G>D		No	ClinGen ESP TOPMed gnomAD
rs782334662 CA10418897	584	S>T		No	ClinGen ExAC
rs1313435123 CA413129604	586	D>G		No	ClinGen TOPMed
CA10418898 rs781962409	587	D>E		No	ClinGen ExAC TOPMed gnomAD
CA329171197 rs782463233	588	G>D		No	ClinGen 1000Genomes
CA413129660 rs1602105201	589	N>D		No	ClinGen Ensembl
CA329171198 rs962228566	589	N>S		No	ClinGen TOPMed gnomAD
CA413129732 rs1556808608	593	N>D		No	ClinGen gnomAD
CA10418900 rs782047479	593	N>S		No	ClinGen ExAC TOPMed gnomAD
rs782799577 CA10418901	595	G>S		No	ClinGen ExAC TOPMed gnomAD
rs782124596 CA10418904 COSM1122917	597	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1556808619 CA413129826	598	D>Y		No	ClinGen gnomAD
CA10418908 rs781824070	600	D>N		No	ClinGen ExAC gnomAD
CA413129913 rs1556808626	603	I>L		No	ClinGen gnomAD
rs782480459 CA10418909	604	E>K		No	ClinGen ExAC gnomAD
rs149418485 CA10418912	607	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA413130094 rs1556808640	610	I>T		No	ClinGen gnomAD
rs375418655 CA413130134	612	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM488455 CA10418915 rs375418655	612	D>Y	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	613	F>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	614	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413130196 rs1556808648	614	D>H		No	ClinGen gnomAD
rs782368578 CA10418916	615	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA413130284 rs1261552631	616	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs782300852 CA10418918	619	D>E		No	ClinGen ExAC
CA10418919 rs782023215	621	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10418921 rs782382894	623	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10418922 rs782382894	623	V>M		No	ClinGen ExAC TOPMed gnomAD
CA413130557 rs1569229209	624	I>M		No	ClinGen Ensembl
rs1320826290 CA413130531	624	I>V		No	ClinGen TOPMed
RCV000513236 CA413130613 rs1556808667	626	I>F		No	ClinGen ClinVar Ensembl dbSNP
rs782761093 CA10418924	627	I>V		No	ClinGen ExAC gnomAD
rs371990751 CA413130735	629	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA10418927 rs782784563	630	E>G		No	ClinGen ExAC
rs375123038 CA10418926	630	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs375123038 CA413130746	630	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs147753284 CA10418929	632	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10418932 rs368159646	637	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs781817389 CA10418933	639	E>K		No	ClinGen ExAC gnomAD
CA10418980 rs147373370	640	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs959621239 CA329155878	642	Q>E		No	ClinGen TOPMed
CA413098510 rs1602106274	643	Q>R		No	ClinGen Ensembl
CA329155879 rs989601893 COSM3844984	645	E>K	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs782342167 CA10418981	646	D>H		No	ClinGen ExAC TOPMed gnomAD
rs782342167 CA10418982	646	D>N		No	ClinGen ExAC TOPMed gnomAD
rs145146062 CA10418985	648	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413098565 rs1556809163	651	G>R		No	ClinGen gnomAD
rs782115678 CA10418987	653	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA413098583 rs782013838	653	Y>C		No	ClinGen ExAC gnomAD
CA10418986 rs782013838	653	Y>F		No	ClinGen ExAC gnomAD
TCGA novel	655	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1263344785 CA413098609	657	G>R		No	ClinGen TOPMed
TCGA novel	660	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375981547 CA10418990	663	E>V		No	ClinGen ESP ExAC gnomAD
CA10418991 rs150975914	664	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413098671 rs1556809182	665	G>E		No	ClinGen gnomAD
rs1556809181 CA413098670	665	G>R		No	ClinGen gnomAD
CA10418993 rs781811512	668	S>L		No	ClinGen ExAC TOPMed gnomAD
CA413098694 rs781811512	668	S>W		No	ClinGen ExAC TOPMed gnomAD
CA10418994 rs369016861	669	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA413098702 rs1437283793	670	D>N		No	ClinGen TOPMed gnomAD
rs868919123 CA413098714	671	S>F		No	ClinGen Ensembl
rs377270693 CA10418997	677	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs781788384 CA10418998	678	Q>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781788384 CA413098775	678	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	681	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782609393 CA10418999	681	N>H		No	ClinGen ExAC TOPMed gnomAD
rs934271226 CA329155899	682	G>S		No	ClinGen TOPMed gnomAD
CA413098849 rs868980048	684	A>T		No	ClinGen Ensembl
rs1050424399 CA329155901	685	N>S		No	ClinGen gnomAD
rs370419229 CA10419002	686	P>A		No	ClinGen ExAC TOPMed gnomAD
CA10419003 rs782276407	686	P>L		No	ClinGen ExAC gnomAD
rs200976056 CA10419004	687	G>E		No	ClinGen ExAC TOPMed gnomAD
CA413098907 rs782004401	688	K>N		No	ClinGen ExAC TOPMed gnomAD
CA10419006 rs181418147	689	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782361864 CA10419007	689	R>K		No	ClinGen ExAC gnomAD
rs782361864 CA413098916	689	R>T		No	ClinGen ExAC gnomAD
CA329155915 rs201621148	691	K>E		No	ClinGen gnomAD
CA413098959 rs1230959790	692	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	692	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413098961 rs1365995949	693	G>R		No	ClinGen TOPMed

No associated diseases with Q9H2G4

No regional properties for Q9H2G4

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9H2G4

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Enriched in transcriptionally active regions of chromatin in neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
rDNA binding	Binding to a DNA sequence encoding a ribosomal RNA.

7 GO annotations of biological process

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
negative regulation of cell cycle	Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
negative regulation of cell growth	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of DNA replication	Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.
nucleosome assembly	The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
regulation of protein kinase activity	Any process that modulates the frequency, rate or extent of protein kinase activity.
regulation of signal transduction	Any process that modulates the frequency, rate or extent of signal transduction.

15 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O19110	TSPY1	Testis-specific Y-encoded protein 1	Bos taurus (Bovine)	PR
P0DME0	SETSIP	Protein SETSIP	Homo sapiens (Human)	SS
Q8N831	TSPYL6	Testis-specific Y-encoded-like protein 6	Homo sapiens (Human)	PR
Q99457	NAP1L3	Nucleosome assembly protein 1-like 3	Homo sapiens (Human)	PR
P55209	NAP1L1	Nucleosome assembly protein 1-like 1	Homo sapiens (Human)	PR
Q01534	TSPY1	Testis-specific Y-encoded protein 1	Homo sapiens (Human)	PR
P0CV99	TSPY4	Testis-specific Y-encoded protein 4	Homo sapiens (Human)	PR
P0CV98	TSPY3	Testis-specific Y-encoded protein 3	Homo sapiens (Human)	PR
P0CW00	TSPY8	Testis-specific Y-encoded protein 8	Homo sapiens (Human)	PR
P0CW01	TSPY10	Testis-specific Y-encoded protein 10	Homo sapiens (Human)	PR
A6NKD2	TSPY2	Testis-specific Y-encoded protein 2	Homo sapiens (Human)	PR
Q01105	SET	Protein SET	Homo sapiens (Human)	SS
Q9H489	TSPY26P	Putative testis-specific Y-encoded-like protein 3	Homo sapiens (Human)	PR
Q9EQU5	Set	Protein SET	Mus musculus (Mouse)	EV
Q63945	Set	Protein SET	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MDRPDEGPPA	KTRRLSSSES	PQRDPPPPPP	PPPLLRLPLP	PPQQRPRLQE	ETEAAQVLAD
70	80	90	100	110	120
MRGVGLGPAL	PPPPPYVILE	EGGIRAYFTL	GAECPGWDST	IESGYGEAPP	PTESLEALPT
130	140	150	160	170	180
PEASGGSLEI	DFQVVQSSSF	GGEGALETCS	AVGWAPQRLV	DPKSKEEAII	IVEDEDEDER
190	200	210	220	230	240
ESMRSSRRRR	RRRRRKQRKV	KRESRERNAE	RMESILQALE	DIQLDLEAVN	IKAGKAFLRL
250	260	270	280	290	300
KRKFIQMRRP	FLERRDLIIQ	HIPGFWVKAF	LNHPRISILI	NRRDEDIFRY	LTNLQVQDLR
310	320	330	340	350	360
HISMGYKMKL	YFQTNPYFTN	MVIVKEFQRN	RSGRLVSHST	PIRWHRGQEP	QARRHGNQDA
370	380	390	400	410	420
SHSFFSWFSN	HSLPEADRIA	EIIKNDLWVN	PLRYYLRERG	SRIKRKKQEM	KKRKTRGRCE
430	440	450	460	470	480
VVIMEDAPDY	YAVEDIFSEI	SDIDETIHDI	KISDFMETTD	YFETTDNEIT	DINENICDSE
490	500	510	520	530	540
NPDHNEVPNN	ETTDNNESAD	DHETTDNNES	ADDNNENPED	NNKNTDDNEE	NPNNNENTYG
550	560	570	580	590	600
NNFFKGGFWG	SHGNNQDSSD	SDNEADEASD	DEDNDGNEGD	NEGSDDDGNE	GDNEGSDDDD
610	620	630	640	650	660
RDIEYYEKVI	EDFDKDQADY	EDVIEIISDE	SVEEEGIEEG	IQQDEDIYEE	GNYEEEGSED
670	680	690
VWEEGEDSDD	SDLEDVLQVP	NGWANPGKRG	KTG