AiPD: Autoinhibited Protein Database

Q9H1H9

Gene name	KIF13A (RBKIN)
Protein name	Kinesin-like protein KIF13A
Names	Kinesin-like protein RBKIN
Species	Homo sapiens (Human)
KEGG Pathway	hsa:63971
EC number
Protein Class

Descriptions

Kinesin-3 KIF13B autoinhibition involves the coiled-coil 1 (CC1) segment, which interacts with both the neck coil (NC) and the motor domain (MD). This interaction not only inhibits the NC-mediated dimerization, but also prevents the ADP release from the MD, effectively inhibiting the motor activity.

Autoinhibitory domains (AIDs)

389-431 (Coiled-coil 1) SS

Target domain	1-388 (Motor domain and neck coil)
Relief mechanism	Partner binding
Assay

AID

389-431 (Coiled-coil 1)

Target domain

1-388 (Motor domain and neck coil)

Relief mechanism

Partner binding (Cargo-mediated dimerization)

Assay

Accessory elements

No accessory elements

References

Ren J et al. (2018) "Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition", Proceedings of the National Academy of Sciences of the United States of America, 115, E11933-E11942

Autoinhibited structure

Activated structure

1 structures for Q9H1H9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9H1H9-F1	Predicted				AlphaFoldDB

1681 variants for Q9H1H9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1201157053	2	S>*		No	gnomAD
rs897813029	3	D>G		No	TOPMed
rs1381065376	4	T>N		No	TOPMed
rs1781676157	5	K>R		No	Ensembl
rs1437827351	6	V>I		No	TOPMed
rs2150659318	11	R>Q		No	1000Genomes
rs367718683	12	V>I		No	ESP ExAC TOPMed gnomAD
rs367718683	12	V>L		No	ESP ExAC TOPMed gnomAD
rs763638959	14	P>A		No	ExAC TOPMed gnomAD
COSM1442411 COSM1442410 COSM4948347	14	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1338941852	15	M>K		No	gnomAD
rs774830525	15	M>L		No	ExAC TOPMed gnomAD
rs774830525	15	M>V		No	ExAC TOPMed gnomAD
rs1781673988	16	N>H		No	Ensembl
rs917131859	17	R>G		No	TOPMed gnomAD
rs1781673623	17	R>Q		No	gnomAD
rs1329668277	18	R>Q		No	gnomAD
rs774552274	19	E>A		No	ExAC gnomAD
rs1412092640	19	E>K		No	gnomAD
TCGA novel	22	L>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	24	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1781638354	24	T>P		No	TOPMed gnomAD
rs945806990	25	K>Q		No	TOPMed gnomAD
rs749637872	25	K>R		No	ExAC TOPMed gnomAD
rs749637872	25	K>T		No	ExAC TOPMed gnomAD
rs1781636832	26	C>G		No	TOPMed
rs1781636513	27	V>A		No	Ensembl
rs1393844940	29	E>V		No	TOPMed
rs769913734	30	M>I		No	ExAC TOPMed gnomAD
rs745933017	32	G>A		No	ExAC gnomAD
rs1781634843	33	N>H		No	TOPMed gnomAD
rs1781634520	33	N>I		No	Ensembl
rs1008730202	34	Q>E		No	Ensembl
rs757154920	34	Q>R		No	ExAC gnomAD
rs912944180	38	H>Y		No	TOPMed gnomAD
rs1781631229	39	P>L		No	Ensembl
COSM4812108 COSM420970 COSM1133768	39	P>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs777591110	39	P>S		No	ExAC TOPMed gnomAD
rs1198330965	40	P>L		No	gnomAD
rs1266700093	40	P>S		No	gnomAD
rs148788770	41	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1488489966	41	P>S		No	gnomAD
rs953588422	42	S>F		No	TOPMed
rs367921778 COSM1487496 COSM450954	42	S>P	breast [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs764935841	45	K>R		No	ExAC gnomAD
rs759323519	46	Q>R		No	ExAC TOPMed gnomAD
rs538767258	48	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs766030430	49	R>G		No	ExAC gnomAD
TCGA novel	51	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs748079081	52	P>L		No	ExAC TOPMed gnomAD
rs1472518432	52	P>S		No	TOPMed gnomAD
COSM4857674 COSM483721 COSM4857675	53	K>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1305886029	54	V>L		No	gnomAD
rs376963344	56	A>T		No	ESP ExAC TOPMed gnomAD
rs1459674149	59	Y>C		No	gnomAD
rs2150436022	60	C>F		No	Ensembl
rs1366748628	63	S>F		No	gnomAD
rs767798014	64	M>V		No	ExAC gnomAD
rs201865906	66	E>A		No	ESP ExAC TOPMed gnomAD
rs190798348	66	E>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs761732143	66	E>K		No	ExAC gnomAD
rs1770200244	67	S>T		No	Ensembl
rs750427547	68	N>K		No	ExAC TOPMed gnomAD
rs566106960	69	T>A		No	1000Genomes ExAC gnomAD
rs199883389	69	T>S		No	ESP ExAC TOPMed gnomAD
rs1770199277	70	T>*		No	Ensembl
rs868163134	70	T>A		No	TOPMed gnomAD
rs1012630170	71	K>I		No	gnomAD
rs1282096308	72	Y>*		No	TOPMed
rs745688584	72	Y>H		No	ExAC gnomAD
rs1286368039	73	A>S		No	TOPMed gnomAD
rs1227765830	74	G>S		No	TOPMed gnomAD
COSM261656 COSM3829736 COSM3829737	76	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1377472628	77	V>M		No	gnomAD
rs371912600	80	K>R		No	Ensembl
rs1262355882	81	C>Y		No	Ensembl
rs1768111691	84	E>K		No	Ensembl
rs1193421351	85	G>E		No	TOPMed gnomAD
rs763146358	87	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs769774239	90	A>S		No	ExAC gnomAD
rs769774239	90	A>T		No	ExAC gnomAD
rs1187400912	91	F>L		No	gnomAD
rs1768110240	94	Y>H		No	Ensembl
rs776543375	96	A>V		No	ExAC gnomAD
rs770464526	97	C>S		No	ExAC gnomAD
rs1768108883	98	I>S		No	TOPMed
rs777206426	98	I>V		No	Ensembl
COSM4815792 COSM450953 COSM1487495	99	F>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1562061166	101	Y>C		No	Ensembl
TCGA novel	101	Y>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1369154020	109	S>C		No	gnomAD
COSM3623121 COSM3623120 COSM3623122	109	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3921127 COSM3921129 COSM3921128	111	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs377604358	112	M>L		No	ESP TOPMed
rs377604358	112	M>V		No	ESP TOPMed
rs1307000538	113	M>I		No	gnomAD
rs1768063506	115	H>R		No	Ensembl
rs375275290	115	H>Y		No	ESP TOPMed
rs551855128	116	A>T		No	1000Genomes ExAC gnomAD
rs1650004805	117	E>V		No	Ensembl
rs770182316	118	Q>H		No	ExAC TOPMed gnomAD
rs1217732551	119	L>P		No	TOPMed gnomAD
rs1160973273	119	L>V		No	gnomAD
rs746430364	122	I>V		No	ExAC gnomAD
rs1364308552	124	R>K		No	gnomAD
rs781570360	125	L>F		No	ExAC TOPMed gnomAD
rs757635579	127	C>R		No	ExAC TOPMed gnomAD
rs1205042285	128	A>V		No	gnomAD
rs747378600	129	L>V		No	ExAC gnomAD
rs1204658061	130	F>L		No	gnomAD
TCGA novel	132	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs778132880	133	I>F		No	ExAC gnomAD
TCGA novel	133	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs778132880	133	I>V		No	ExAC gnomAD
COSM3777346 COSM3777347 COSM3777345	134	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs370495452	134	S>F		No	ESP gnomAD
rs758751233	135	L>V		No	ExAC TOPMed gnomAD
rs1455920973	137	Q>K		No	TOPMed gnomAD
rs1355811246	137	Q>P		No	TOPMed gnomAD
rs1355811246	137	Q>R		No	TOPMed gnomAD
rs752696019	138	N>I		No	ExAC TOPMed gnomAD
rs2150406119	138	N>K		No	Ensembl
rs752696019	138	N>S		No	ExAC TOPMed gnomAD
rs752696019	138	N>T		No	ExAC TOPMed gnomAD
rs1230823848	139	E>K		No	gnomAD
rs755042298	142	T>A		No	ExAC gnomAD
rs753761466	144	K>E		No	ExAC gnomAD
rs1351261913	145	V>A		No	gnomAD
rs766318604	146	E>K		No	ExAC gnomAD
rs1768057422	147	V>M		No	Ensembl
rs1768057021	148	S>C		No	Ensembl
rs773057861	149	Y>C		No	ExAC gnomAD
rs761579923	150	M>I		No	ExAC gnomAD
rs767147148	150	M>T		No	ExAC gnomAD
rs1768056295	154	N>S		No	gnomAD
rs1478438447	158	R>Q		No	TOPMed gnomAD
COSM282221 rs73726225	158	R>W	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
COSM4816178 COSM450952 COSM1134257	160	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150406050	164	K>Q		No	Ensembl
rs1219714287	165	G>E		No	TOPMed gnomAD
rs1768055145	165	G>R		No	TOPMed
rs1219714287	165	G>V		No	TOPMed gnomAD
rs1314279712	166	S>R		No	TOPMed gnomAD
rs1767701129	169	S>Y		No	Ensembl
rs1276991766	172	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1767700917	172	V>L		No	Ensembl
rs1218231290 COSM5709977 COSM5709978 COSM182140	173	R>*	Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated gnomAD
rs866507448	173	R>L		No	Ensembl
rs866507448	173	R>Q		No	Ensembl
rs369988431	174	E>K		No	ESP ExAC TOPMed gnomAD
rs892103843	175	H>R		No	TOPMed gnomAD
rs1767699312	176	K>N		No	gnomAD
rs1767699092	177	V>G		No	TOPMed
rs566406810	180	P>A		No	1000Genomes ExAC TOPMed gnomAD
rs566406810	180	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs2150401073	182	V>L		No	Ensembl
rs200098741	183	D>H		No	1000Genomes ExAC TOPMed gnomAD
rs536071727	184	G>S		No	1000Genomes ExAC gnomAD
rs1767697234	187	Q>E		No	TOPMed
TCGA novel	189	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1767696536	190	V>I		No	TOPMed
rs901138354	191	T>I		No	TOPMed
rs901138354	191	T>S		No	TOPMed
rs1031078336	191	T>S		No	TOPMed
rs1412262999	195	D>G		No	gnomAD
rs759136761	196	I>T		No	ExAC gnomAD
rs1281211512	196	I>V		No	TOPMed gnomAD
rs2150398963	198	S>*		No	Ensembl
rs1767526276	202	E>D		No	Ensembl
COSM3777343 COSM3777342 COSM3777344	202	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1767526508	202	E>Q		No	Ensembl
rs1202537616	207	R>*		No	gnomAD
COSM4857186 COSM1137483 COSM483720	207	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	207	R>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1581520319	207	R>Q		No	Ensembl
rs1480118113	208	T>M		No	TOPMed gnomAD
rs774636318	213	N>S		No	ExAC TOPMed gnomAD
rs1311891268	214	M>I		No	gnomAD
rs768904476	214	M>V		No	ExAC gnomAD
COSM2856159 COSM2856161 rs1038727795 COSM2856160	216	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs76740306	218	S>T		No	1000Genomes ExAC gnomAD
rs944453104	219	S>N		No	gnomAD
rs769818117	220	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs745949348	220	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM1285775 COSM1285774	220	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1459501990	222	H>R		No	gnomAD
rs1767522257	223	A>G		No	Ensembl
rs1767522021	224	V>L		No	TOPMed gnomAD
TCGA novel	229	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1348263906	230	T>A		No	gnomAD
rs569555938	230	T>I		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	230	T>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
RCV000972422 rs140337156	232	T>I		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1458260804	232	T>S		No	gnomAD
rs1418081522	233	L>I		No	gnomAD
rs1269058074	235	D>N		No	TOPMed gnomAD
rs1767519911	236	L>M		No	gnomAD
rs777468774	237	Q>H		No	ExAC gnomAD
rs375224761	238	S>F		No	ESP ExAC TOPMed gnomAD
rs1302679311	241	S>Y		No	gnomAD
rs753377526	242	G>E		No	ExAC TOPMed gnomAD
rs1367513260	242	G>R		No	TOPMed gnomAD
rs755685728	243	E>K		No	ExAC gnomAD
rs751964181	244	K>R		No	ExAC gnomAD
rs977569625	245	V>A		No	TOPMed gnomAD
rs1168895495	247	K>N		No	gnomAD
rs764678759	247	K>R		No	ExAC TOPMed gnomAD
rs1450766444	249	S>G		No	gnomAD
COSM595289 COSM1144126 COSM1650569	254	A>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4782865 COSM1442408 rs775888626 COSM1442409	254	A>V	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1767410613	257	E>K		No	TOPMed
rs759791058	258	R>S		No	ExAC gnomAD
rs1581516944	259	V>G		No	Ensembl
rs1734450669	259	V>L		No	TOPMed
TCGA novel	260	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs554852294	260	S>F		No	ExAC gnomAD
rs2150397602	265	A>G		No	1000Genomes
rs772954554	265	A>S		No	ExAC TOPMed gnomAD
rs747944740	266	G>R		No	ExAC gnomAD
rs778901339	267	E>G		No	ExAC gnomAD
rs1252953122	267	E>K		No	gnomAD
rs377524718	268	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ESP NCI-TCGA TOPMed gnomAD
rs1308235773	268	R>Q		No	TOPMed gnomAD
rs748855782	270	K>R		No	ExAC
rs1767405969	272	G>S		No	TOPMed
rs1767405484	273	S>G		No	Ensembl
rs779782546	273	S>R		No	ExAC gnomAD
COSM5061664 COSM267994 COSM5061663	278	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1392318617	280	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
TCGA novel	282	L>W	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1460876287	283	G>W		No	gnomAD
rs779508654	286	I>M		No	ExAC gnomAD
rs749123689	286	I>V		No	ExAC TOPMed gnomAD
rs1766080379	288	S>L		No	TOPMed
rs769541785	290	A>S		No	ExAC TOPMed gnomAD
rs769541785	290	A>T		No	ExAC TOPMed gnomAD
rs1766078881	291	D>G		No	TOPMed
rs1181417033	291	D>N		No	TOPMed gnomAD
rs745345224	292	Q>R		No	ExAC gnomAD
rs780716160	294	A>P		No	ExAC gnomAD
rs1175467159	297	G>C		No	TOPMed gnomAD
rs758508802	303	P>R		No	Ensembl
rs200179034	304	Y>F		No	ESP ExAC TOPMed gnomAD
rs1424182248	305	R>Q		No	TOPMed gnomAD
rs753152754	306	D>H		No	ExAC TOPMed gnomAD
rs1766075092	306	D>V		No	Ensembl
COSM4844971 COSM4844970 COSM4844972	307	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs868036391	309	L>F		No	Ensembl
rs1230619489	311	W>C		No	gnomAD
rs1322422211	316	N>T		No	TOPMed gnomAD
rs140191648	317	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs74782516	317	L>W		No	Ensembl
rs1334588650	318	G>W		No	gnomAD
COSM5153874 COSM1442406 COSM1442407	319	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1397117772	321	S>R		No	gnomAD
COSM3921125 COSM3921124 COSM3921126	324	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs780507229	325	M>I		No	ExAC gnomAD
rs375428169	325	M>L		No	ESP ExAC TOPMed gnomAD
rs375428169	325	M>V		No	ESP ExAC TOPMed gnomAD
rs2150380159	326	I>M		No	Ensembl
rs1766030427	326	I>V		No	TOPMed gnomAD
rs1581472551	329	I>T		No	Ensembl
rs1766030149	329	I>V		No	Ensembl
rs1581472541	330	S>N		No	TOPMed
rs1581472541	330	S>T		No	TOPMed
rs1562037576	331	P>L		No	Ensembl
rs750628331	333	A>S		No	ExAC TOPMed gnomAD
rs750628331	333	A>T		No	ExAC TOPMed gnomAD
rs1241822646	333	A>V		No	gnomAD
rs1211255199	334	D>N		No	gnomAD
COSM3623115 COSM3623116 COSM3623114	335	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1766025868	337	E>G		No	1000Genomes TOPMed
rs1277718786	337	E>K		No	gnomAD
rs910220165	339	T>A		No	Ensembl
rs1766024815	340	L>P		No	Ensembl
rs764098650	346	A>V		No	ExAC gnomAD
rs1449942004	348	R>G		No	gnomAD
rs955140378	348	R>Q		No	TOPMed gnomAD
rs1766022545	349	A>T		No	TOPMed
rs1403819560	350	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1301169091	353	V>M		No	TOPMed
rs1419407506	355	H>R		No	TOPMed gnomAD
rs772803256	356	A>D		No	ExAC TOPMed gnomAD
rs772803256	356	A>V		No	ExAC TOPMed gnomAD
rs561202901	358	V>A		No	1000Genomes ExAC gnomAD
rs776198139	358	V>M		No	ExAC TOPMed gnomAD
rs1766019003	359	N>S		No	TOPMed
TCGA novel	361	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs972725145	362	P>L		No	Ensembl
rs1278722927	363	N>D		No	TOPMed gnomAD
rs1278722927	363	N>H		No	TOPMed gnomAD
rs199847865	363	N>K		No	1000Genomes ExAC TOPMed gnomAD
rs1252489635	363	N>S		No	TOPMed gnomAD
COSM450951 rs368453026 COSM1487494	364	A>T	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1766017188	364	A>V		No	Ensembl
rs780449304	365	K>E		No	ExAC gnomAD
rs1766016713	367	I>F		No	TOPMed
rs1004220316	368	R>*		No	TOPMed
rs1004220316	368	R>G		No	TOPMed
COSM4786501 COSM1442405 COSM1442404	368	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs376646474	368	R>Q		No	ESP ExAC TOPMed gnomAD
rs1766015421	369	E>D		No	TOPMed
rs1353286062	369	E>K		No	gnomAD
rs781564779	371	R>Q		No	ExAC TOPMed gnomAD
rs746241908	371	R>W		No	ExAC TOPMed gnomAD
rs371586560	373	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs764189371	374	V>I		No	ExAC TOPMed gnomAD
rs764189371	374	V>L		No	ExAC TOPMed gnomAD
rs765089174	375	E>A		No	ExAC gnomAD
rs201673713	375	E>D		No	ExAC TOPMed gnomAD
rs765089174	375	E>G		No	ExAC gnomAD
COSM6106234 COSM6106236 COSM6106235 rs752618857 COSM1650570 COSM595290 COSM1144125	375	E>K	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1416065098	378	R>G		No	gnomAD
TCGA novel	379	E>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1766011677	379	E>Q		No	TOPMed gnomAD
rs1473163877	380	Q>*		No	gnomAD
rs1473163877	380	Q>K		No	gnomAD
rs1252217511	380	Q>L		No	gnomAD
rs776467254	381	L>V		No	ExAC gnomAD
rs905388243	382	S>C		No	TOPMed gnomAD
rs905388243	382	S>F		No	TOPMed gnomAD
rs1215435208	383	Q>E		No	gnomAD
TCGA novel	383	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs765993037	383	Q>R		No	ExAC gnomAD
COSM6173566 COSM6173568 COSM6173567	384	A>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs760361283	384	A>T		No	ExAC gnomAD
rs771562734	385	E>K		No	ExAC gnomAD
rs771360881	387	M>V		No	ExAC gnomAD
rs1377828752	388	K>Q		No	TOPMed gnomAD
rs1452000005	389	A>S		No	TOPMed gnomAD
rs1452000005	389	A>T		No	TOPMed gnomAD
rs1765707226	390	P>S		No	TOPMed
rs1393987610	392	L>P		No	gnomAD
TCGA novel	393	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2150376301	393	K>T		No	Ensembl
rs778050727	396	L>F		No	ExAC gnomAD
rs184385862	397	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs184385862	397	E>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs35188434	399	S>A		No	Ensembl
rs867493334	399	S>F		No	Ensembl
rs1027014590	403	I>M		No	TOPMed
COSM1442402 COSM4786328 COSM1442403	404	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1765704912	405	E>G		No	Ensembl
rs2150376263	406	L>Q		No	Ensembl
rs1302795878	407	T>I		No	TOPMed gnomAD
rs1353521768	410	W>*		No	TOPMed
rs1002184263	411	E>G		No	Ensembl
rs4716190	415	R>S		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM224680 COSM3829731 COSM3829732	418	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1381985985	420	I>L		No	TOPMed gnomAD
rs1376485977	420	I>R		No	gnomAD
rs1374259000	421	A>E		No	gnomAD
rs1432498590	421	A>T		No	gnomAD
rs1212476382	422	Q>*		No	gnomAD
rs761425219	422	Q>H		No	ExAC
TCGA novel	426	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM1212347 rs763841192 COSM1212346	426	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs757974953	427	Q>R		No	ExAC TOPMed gnomAD
rs752311361	428	L>F		No	ExAC TOPMed gnomAD
rs752311361	428	L>V		No	ExAC TOPMed gnomAD
rs1765418570	430	S>N		No	TOPMed
rs1195668940	431	M>V		No	gnomAD
COSM1442399 rs1336109030 COSM1442398	432	G>E	large_intestine [Cosmic]	No	cosmic curated gnomAD
rs972114894	434	S>P		No	gnomAD
rs369179322	435	L>M		No	ESP ExAC TOPMed gnomAD
rs1765417184	436	E>D		No	TOPMed
TCGA novel	436	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1456722627	437	M>V		No	TOPMed gnomAD
COSM1137482 COSM483719	439	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs762252182	441	K>R		No	ExAC gnomAD
rs1333431547	443	G>E		No	gnomAD
rs768936416	444	D>A		No	ExAC TOPMed gnomAD
rs146614687	444	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs569310446	444	D>N		No	1000Genomes ExAC gnomAD
rs569310446	444	D>Y		No	1000Genomes ExAC gnomAD
rs369108069	445	D>G		No	Ensembl
rs370056121	446	K>R		No	ESP TOPMed gnomAD
rs769743376	447	C>F		No	ExAC gnomAD
rs775600287	447	C>R		No	ExAC TOPMed gnomAD
rs912763037	447	C>W		No	TOPMed gnomAD
rs769743376	447	C>Y		No	ExAC gnomAD
rs1765411999	449	L>V		No	Ensembl
rs1765411696	451	N>D		No	Ensembl
rs1765411401	451	N>S		No	Ensembl
rs1471287927	452	L>P		No	TOPMed gnomAD
rs745739374	452	L>V		No	ExAC gnomAD
rs1181164813	456	P>S		No	gnomAD
COSM2856121 COSM2856122 COSM2856120	458	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756933415	459	N>H		No	ExAC gnomAD
rs746886160	459	N>S		No	ExAC TOPMed gnomAD
rs377226069	460	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP NCI-TCGA
rs1468289329	461	L>H		No	gnomAD
rs1362562310	469	H>Y		No	gnomAD
rs1765154025	470	T>S		No	Ensembl
rs772022917	471	R>T		No	ExAC gnomAD
rs1428355504	473	G>D		No	gnomAD
rs1765153217	475	D>H		No	gnomAD
rs1449617517	477	S>C		No	gnomAD
rs1765152593	478	Q>E		No	TOPMed
COSM4393384 COSM4393383 COSM4393382	479	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1765152416	479	D>N		No	TOPMed
COSM1596128 COSM1076354 COSM1596127	480	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1164036242	481	Q>R		No	TOPMed
rs747753942	484	G>D		No	ExAC
rs778641370	485	I>V		No	ExAC TOPMed gnomAD
rs1765151188	487	I>T		No	TOPMed
rs949707104	489	P>L		No	Ensembl
rs754379361	489	P>S		No	ExAC gnomAD
COSM4937948 COSM4937949 COSM4937950	490	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	490	Q>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1414045157	492	C>S		No	gnomAD
rs1184765054	493	E>K		No	TOPMed gnomAD
rs1765149721	494	I>T		No	Ensembl
rs1420834303	496	I>V		No	gnomAD
rs1474607783	497	A>T		No	TOPMed gnomAD
rs1765148546	498	S>P		No	Ensembl
rs1262947285	499	D>H		No	gnomAD
rs1765148156	499	D>V		No	gnomAD
rs1486450824	502	V>I		No	TOPMed gnomAD
rs1765146639	503	T>I		No	TOPMed gnomAD
rs764406869	503	T>S		No	ExAC gnomAD
rs2150368454	504	L>V		No	Ensembl
rs2150368451	505	T>A		No	Ensembl
rs1209506776	505	T>I		No	TOPMed gnomAD
rs1765145785	506	P>A		No	gnomAD
rs752846173	506	P>L		No	ExAC gnomAD
rs934877720	507	K>N		No	TOPMed
rs1360956670	510	A>S		No	TOPMed gnomAD
rs1360956670	510	A>T		No	TOPMed gnomAD
rs759518782	511	R>G		No	ExAC TOPMed gnomAD
rs914476784	512	S>F		No	TOPMed gnomAD
rs1209022824	513	C>S		No	TOPMed gnomAD
rs1209022824	513	C>Y		No	TOPMed gnomAD
rs868601077	516	G>D		No	gnomAD
rs1018752418	516	G>R		No	TOPMed gnomAD
rs1018752418	516	G>S		No	TOPMed gnomAD
rs1764939304	517	T>A		No	gnomAD
rs368788633	517	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs368788633	517	T>N		No	ESP ExAC TOPMed gnomAD
rs1764938628	518	L>V		No	TOPMed
TCGA novel	519	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1764938067	521	S>G		No	gnomAD
rs1764937840	521	S>N		No	Ensembl
rs1764937637	522	T>I		No	Ensembl
rs1419320894	523	T>S		No	gnomAD
rs753115739	524	Q>E		No	ExAC
rs1174973931	524	Q>R		No	TOPMed gnomAD
rs35635947	525	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1303793917	525	L>Q		No	gnomAD
COSM3860654 COSM3860653 COSM3860652	526	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1253528325	526	W>C		No	gnomAD
rs1764936054	527	H>Y		No	Ensembl
COSM3860651 COSM3860650 rs866916195 COSM3860649	530	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
COSM275727 rs1764935495	530	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
COSM3410816 COSM3410815 COSM3410817	532	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1264650135	534	G>R		No	gnomAD
COSM2856113 COSM1442397 COSM1442396	539	F>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1764934824	539	F>L		No	TOPMed
rs754033269	541	I>T		No	ExAC gnomAD
rs1764924566	544	P>R		No	TOPMed gnomAD
rs1383109527	544	P>T		No	gnomAD
rs111458322	545	K>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1374321464	547	K>E		No	gnomAD
rs200546188	548	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs767541977	548	R>H		No	ExAC TOPMed gnomAD
TCGA novel	548	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs200546188	548	R>S		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM5515116 COSM282220 COSM5515117 rs1489727131	549	R>*	Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs868551894	549	R>Q		No	TOPMed gnomAD
rs1463211990	550	D>V		No	Ensembl
rs761883927	551	W>C		No	ExAC gnomAD
rs1562022687	552	L>F		No	Ensembl
rs962986544	554	D>G		No	Ensembl
rs962986544	554	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs774189643	555	F>L		No	ExAC TOPMed gnomAD
rs1764921958	555	F>L		No	Ensembl
rs763904226	556	E>G		No	ExAC gnomAD
rs370847942	559	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1581434176	559	T>P		No	Ensembl
rs745356933	561	P>L		No	ExAC TOPMed gnomAD
rs1281400011	564	H>R		No	gnomAD
rs1581434087	565	D>A		No	Ensembl
rs770457657	566	L>P		No	ExAC TOPMed gnomAD
rs748638232	567	D>A		No	ExAC gnomAD
rs967700130	568	A>T		No	TOPMed
TCGA novel	569	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1764918757	570	S>C		No	TOPMed gnomAD
rs1255894708	570	S>R		No	gnomAD
rs1764918387	572	A>T		No	gnomAD
rs1391936531	573	S>C		No	TOPMed gnomAD
rs1391936531	573	S>F		No	TOPMed gnomAD
rs866509249	574	S>Y		No	Ensembl
rs999980303	575	E>D		No	TOPMed gnomAD
rs1228838176	576	P>L		No	gnomAD
rs1764916661	577	D>G		No	Ensembl
rs1256498250	577	D>H		No	gnomAD
rs749682554	578	Y>C		No	ExAC TOPMed gnomAD
rs1399852443	579	N>S		No	TOPMed gnomAD
rs1483476338	580	Y>C		No	TOPMed gnomAD
rs780411887	580	Y>H		No	ExAC gnomAD
rs756454963	581	E>K		No	ExAC
COSM1154624 COSM4870797 COSM1076352	581	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	583	A>C	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	583	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2150365417	584	Q>E		No	Ensembl
rs750501727	585	M>I		No	ExAC TOPMed gnomAD
rs1412348036	585	M>K		No	gnomAD
rs781383135	588	I>T		No	ExAC TOPMed gnomAD
rs1223453963	588	I>V		No	TOPMed gnomAD
rs902524477	589	M>I		No	Ensembl
rs1253178495	589	M>L		No	gnomAD
rs1253178495	589	M>V		No	gnomAD
rs771102186	597	P>L		No	ExAC
rs192358685	597	P>T		No	1000Genomes ExAC
rs1417042238	598	V>A		No	TOPMed
rs1165077870	598	V>L		No	TOPMed
rs187906244	599	Q>E		No	1000Genomes ExAC
rs1052153695	599	Q>R		No	gnomAD
rs777668774	600	N>D		No	ExAC gnomAD
rs1764027781	600	N>K		No	TOPMed
COSM3994742 COSM3994743 COSM3994744 rs1210948997	602	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1764027420	603	Q>H		No	Ensembl
COSM1076350 COSM1596130 COSM1596129	606	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1390884154	608	Q>R		No	TOPMed gnomAD
rs754754776	609	Y>H		No	ExAC TOPMed gnomAD
COSM2856100 COSM1196653 COSM1196652 rs753700328	610	L>V	lung Variant assessed as Somatic; MODERATE impact. large_intestine [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1338695019	613	K>R		No	gnomAD
rs1581403731	614	R>S		No	gnomAD
rs369577474	619	E>Q		No	ESP ExAC gnomAD
rs761409991	621	R>Q		No	ExAC TOPMed gnomAD
rs1764023441	621	R>W		No	TOPMed gnomAD
rs1246843671	623	M>T		No	Ensembl
COSM3623104 COSM3623102 COSM3623103	623	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765898617	624	Y>C		No	ExAC gnomAD
rs1764022192	625	E>K		No	TOPMed
COSM3860646 rs776913211 COSM3860647 COSM3860648	626	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs2150355029 COSM1621238 COSM1621237 COSM1621236	626	R>W	liver [Cosmic]	No	cosmic curated Ensembl
rs773490796	627	E>D		No	ExAC gnomAD
rs199545656	627	E>K		No	ExAC TOPMed gnomAD
rs748286787	630	Q>E		No	ExAC gnomAD
rs1050493386	630	Q>H		No	gnomAD
rs1581403493	631	L>P		No	Ensembl
rs778818169	632	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs754947976	632	R>H		No	ExAC TOPMed gnomAD
rs754947976	632	R>P		No	ExAC TOPMed gnomAD
rs1764019791	633	Q>H		No	TOPMed
rs1243179671	634	Q>H		No	TOPMed
rs903296544	634	Q>R		No	TOPMed gnomAD
rs1581403413	635	L>P		No	Ensembl
rs1216547371	636	S>C		No	gnomAD
rs1581403395	636	S>P		No	Ensembl
rs749059679	637	P>S		No	ExAC gnomAD
rs749059679	637	P>T		No	ExAC gnomAD
rs749973962	638	D>N		No	ExAC TOPMed gnomAD
rs1581403320	639	R>G		No	Ensembl
rs1381359093	639	R>K		No	gnomAD
rs1204925012	639	R>S		No	TOPMed gnomAD
rs1301176260	640	Q>H		No	TOPMed gnomAD
rs1581403264	641	P>A		No	Ensembl
rs767209431	641	P>L		No	ExAC TOPMed gnomAD
rs767209431	641	P>Q		No	ExAC TOPMed gnomAD
rs1418673915	643	S>N		No	TOPMed gnomAD
rs751158530	643	S>R		No	ExAC TOPMed gnomAD
rs1253744102	645	G>D		No	gnomAD
rs371481890	645	G>S		No	ESP ExAC TOPMed gnomAD
rs1764015491	646	P>L		No	TOPMed
rs777228908	646	P>S		No	ExAC gnomAD
rs766587571	647	D>A		No	ExAC gnomAD
rs766587571	647	D>G		No	ExAC gnomAD
rs1764014888	648	R>C		No	TOPMed gnomAD
rs932259103	648	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs932259103	648	R>P		No	TOPMed gnomAD
rs1239902675	650	A>T		No	TOPMed gnomAD
rs772348284	651	Y>C		No	ExAC TOPMed gnomAD
rs773294233	651	Y>H		No	ExAC gnomAD
rs1764013529	652	S>G		No	Ensembl
rs761849509	653	S>R		No	ExAC TOPMed gnomAD
rs1764012978	655	T>A		No	TOPMed
rs769462021	656	A>T		No	Ensembl
rs768744386	656	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1227791929	657	Q>R		No	TOPMed gnomAD
rs780042277	659	K>Q		No	ExAC gnomAD
rs1581402971	660	V>G		No	Ensembl
rs769414007	660	V>L		No	ExAC TOPMed gnomAD
rs745729592	661	T>N		No	ExAC gnomAD
rs745729592	661	T>S		No	ExAC gnomAD
rs757023213	664	A>P		No	ExAC TOPMed gnomAD
rs757023213	664	A>S		No	ExAC TOPMed gnomAD
rs757023213	664	A>T		No	ExAC TOPMed gnomAD
rs1764010441	666	E>*		No	Ensembl
rs757989336	666	E>D		No	ExAC gnomAD
rs575782974	666	E>G		No	1000Genomes ExAC gnomAD
rs575782974	666	E>V		No	1000Genomes ExAC gnomAD
rs754242420	667	R>T		No	ExAC gnomAD
rs780376924	669	E>D		No	ExAC gnomAD
rs1217645186	669	E>K		No	TOPMed gnomAD
rs1388089444	671	F>L		No	TOPMed
rs1314241716	672	R>*		No	gnomAD
rs746859406	672	R>P		No	ExAC TOPMed gnomAD
rs746859406	672	R>Q		No	ExAC TOPMed gnomAD
rs549732971	676	A>E		No	1000Genomes ExAC gnomAD
rs549732971	676	A>G		No	1000Genomes ExAC gnomAD
rs1282088227	677	K>E		No	gnomAD
rs771797492	679	R>*		No	ExAC TOPMed gnomAD
rs747590404	679	R>Q		No	ExAC TOPMed gnomAD
rs1763200900	681	Q>R		No	Ensembl
rs1390996248	686	N>S		No	TOPMed
rs1189693919	687	T>N		No	gnomAD
TCGA novel rs370516567	688	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA ESP ExAC TOPMed gnomAD
rs377660043	689	V>L		No	ESP TOPMed gnomAD
rs1432845228	692	A>T		No	TOPMed gnomAD
rs1235817660	692	A>V		No	TOPMed
rs1275839559	693	N>D		No	TOPMed gnomAD
rs1459323073	693	N>K		No	TOPMed gnomAD
rs1256559133	695	L>M		No	gnomAD
rs1324550631	696	A>G		No	gnomAD
rs751985111	696	A>T		No	ExAC gnomAD
COSM3777339 COSM3777340 COSM3777341	697	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1356593399	700	S>G		No	gnomAD
rs1763197203	700	S>N		No	TOPMed
rs764265841	701	K>E		No	ExAC TOPMed gnomAD
rs1241944704	701	K>I		No	gnomAD
COSM3921123 COSM3921122 COSM3921121	703	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs370174871	704	D>H		No	ESP ExAC TOPMed gnomAD
rs370174871	704	D>N		No	ESP ExAC TOPMed gnomAD
rs370174871	704	D>Y		No	ESP ExAC TOPMed gnomAD
rs766492554	708	T>A		No	ExAC gnomAD
rs1165263482	708	T>I		No	gnomAD
rs766492554	708	T>S		No	ExAC gnomAD
rs760515749 COSM3393990 COSM3393992 COSM3393991	710	Q>R	pancreas [Cosmic]	No	cosmic curated ExAC gnomAD
rs773191114	711	I>M		No	ExAC gnomAD
rs973933871	712	P>L		No	TOPMed gnomAD
rs973933871	712	P>R		No	TOPMed gnomAD
rs2150344209	712	P>T		No	Ensembl
rs1442077923	713	A>T		No	gnomAD
rs1175798971	714	A>E		No	gnomAD
rs1175798971	714	A>V		No	gnomAD
rs1236942436	716	L>F		No	gnomAD
rs747797233	718	A>T		No	ExAC gnomAD
rs1452587260	719	N>D		No	gnomAD
rs1245952704	719	N>S		No	Ensembl
rs373203654	720	R>K		No	ESP ExAC TOPMed gnomAD
rs373203654	720	R>T		No	ESP ExAC TOPMed gnomAD
rs1762870549	722	R>G		No	gnomAD
rs767276586	724	A>S		No	ExAC gnomAD
rs767276586	724	A>T		No	ExAC gnomAD
rs545311161	726	V>G		No	1000Genomes ExAC gnomAD
rs1358726104	727	S>R		No	gnomAD
rs1168382464	728	E>A		No	Ensembl
rs774038439	730	A>T		No	ExAC gnomAD
rs1427947280	731	I>F		No	gnomAD
rs768256939	731	I>S		No	ExAC TOPMed gnomAD
rs1581361645	735	R>K		No	TOPMed
rs1762868746	737	G>E		No	TOPMed gnomAD
rs1423859782	739	S>C		No	TOPMed gnomAD
rs1423859782	739	S>G		No	TOPMed gnomAD
rs201227106	742	V>A		No	gnomAD
rs775025708	745	I>L		No	ExAC TOPMed gnomAD
rs769312626	745	I>T		No	ExAC TOPMed gnomAD
rs775025708	745	I>V		No	ExAC TOPMed gnomAD
rs1210287245	746	E>V		No	gnomAD
rs747452757	749	E>D		No	ExAC TOPMed gnomAD
rs2150340038	749	E>V		No	Ensembl
rs1762866642	753	I>T		No	TOPMed gnomAD
rs1279018298	754	D>G		No	gnomAD
COSM1596133 COSM1596134 COSM1076344	755	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1220710304	757	D>Y		No	gnomAD
rs755300488	758	L>F		No	ExAC gnomAD
rs780240346	759	Y>C		No	ExAC TOPMed gnomAD
rs754136335	759	Y>N		No	ExAC TOPMed gnomAD
rs1332818199	763	K>E		No	gnomAD
rs750314357	764	E>D		No	ExAC gnomAD
rs201426866	764	E>G		No	1000Genomes ExAC TOPMed gnomAD
rs767411948	765	K>E		No	ExAC gnomAD
TCGA novel	766	V>F	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs761661761	766	V>I		No	ExAC gnomAD
rs751348105	767	P>A		No	ExAC gnomAD
COSM3410813 COSM3410814 COSM3410812	768	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs567873540	770	K>E		No	1000Genomes ExAC gnomAD
rs9358140	771	R>K		No	ExAC TOPMed gnomAD
rs9358140	771	R>T		No	ExAC TOPMed gnomAD
rs756248183	772	L>I		No	ExAC TOPMed gnomAD
rs1176522355	774	G>A		No	gnomAD
rs764497166	774	G>R		No	ExAC gnomAD
COSM5154412 COSM1442394 COSM1442395	775	K>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1232479730	776	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs961791795	777	G>D		No	TOPMed
rs1222620222	777	G>R		No	gnomAD
rs1222620222	777	G>S		No	gnomAD
rs1323522887	778	D>N		No	gnomAD
rs1287824852	779	P>A		No	gnomAD
rs1762757868	779	P>R		No	Ensembl
COSM4947817 COSM1442392 COSM1442393	780	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs757188997	781	Y>C		No	ExAC gnomAD
rs1024140355	781	Y>H		No	TOPMed gnomAD
rs751533445	783	A>P		No	ExAC TOPMed gnomAD
rs751533445	783	A>T		No	ExAC TOPMed gnomAD
TCGA novel	785	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs969121555	786	N>D		No	Ensembl
rs1444971735	787	H>R		No	gnomAD
rs758205572	788	N>D		No	ExAC TOPMed gnomAD
rs758205572	788	N>H		No	ExAC TOPMed gnomAD
rs1392808385	788	N>K		No	TOPMed
rs377522532	788	N>S		No	ESP ExAC TOPMed gnomAD
rs764940401	789	L>V		No	ExAC gnomAD
rs776055042	790	I>T		No	ExAC gnomAD
rs537563876	790	I>V		No	1000Genomes ExAC gnomAD
rs1382070598	791	G>A		No	gnomAD
rs865883552	791	G>R		No	Ensembl
rs865883552	791	G>W		No	Ensembl
rs991788242	792	V>L		No	TOPMed gnomAD
rs1267793518	793	A>S		No	gnomAD
rs774925806	795	V>I		No	ExAC TOPMed gnomAD
rs1221818829	796	F>S		No	gnomAD
rs1762752736	798	E>K		No	TOPMed
rs1031228689	800	L>F		No	TOPMed gnomAD
rs1031228689	800	L>V		No	TOPMed gnomAD
rs1316643164	801	F>L		No	TOPMed gnomAD
rs775849508	801	F>L		No	ExAC TOPMed gnomAD
rs377260168	802	C>R		No	ESP TOPMed gnomAD
rs1365012546	803	D>G		No	TOPMed gnomAD
rs1365012546	803	D>V		No	TOPMed gnomAD
rs1435615603	804	V>G		No	gnomAD
rs1233687923	805	K>T		No	TOPMed gnomAD
rs764895482	807	Q>H		No	gnomAD
rs778278248	808	Y>*		No	ExAC
TCGA novel	808	Y>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs745933985	810	V>G		No	ExAC gnomAD
rs1452979067	812	I>V		No	TOPMed gnomAD
rs373449548	813	I>T		No	ESP ExAC TOPMed gnomAD
rs1762749270	814	S>T		No	Ensembl
rs776043267	819	V>L		No	ExAC gnomAD
rs1561988766	820	A>V		No	gnomAD
rs770300082	822	R>C		No	ExAC gnomAD
rs1226003141	822	R>H		No	TOPMed gnomAD
rs770905756	825	V>L		No	ExAC TOPMed gnomAD
rs770905756	825	V>M		No	ExAC TOPMed gnomAD
rs1762356543	827	V>A		No	TOPMed
rs1762356226	828	M>T		No	TOPMed gnomAD
rs1450377000	828	M>V		No	gnomAD
rs747183114	829	R>G		No	ExAC gnomAD
rs373766807	829	R>H		No	ESP ExAC TOPMed gnomAD
rs758382026	831	T>A		No	ExAC TOPMed gnomAD
rs1166393503	832	G>R		No	gnomAD
rs1156776569	833	A>T		No	gnomAD
rs748106972	834	V>I		No	ExAC TOPMed gnomAD
rs1369130811	835	P>R		No	gnomAD
rs1367448908	835	P>T		No	TOPMed gnomAD
rs1479781957	837	R>C		No	Ensembl
rs1479781957	837	R>G		No	Ensembl
rs778640625	837	R>H		No	ExAC TOPMed gnomAD
rs778640625	837	R>L		No	ExAC TOPMed gnomAD
rs1443309884	838	V>M		No	TOPMed gnomAD
rs753372514	839	V>L		No	ExAC gnomAD
rs753372514	839	V>M		No	ExAC gnomAD
rs1459390704	840	E>G		No	gnomAD
rs1302368508	840	E>Q		No	TOPMed
rs1194880481	841	D>A		No	gnomAD
rs532695204	841	D>H		No	1000Genomes gnomAD
rs1194880481	841	D>V		No	gnomAD
COSM3381532 COSM3381533 COSM3381534 rs1581337635	842	D>E	pancreas [Cosmic]	No	cosmic curated Ensembl
rs1762352732	842	D>N		No	Ensembl
rs779813008	843	S>F		No	ExAC TOPMed gnomAD
rs1356370675	843	S>P		No	gnomAD
rs1356370675	843	S>T		No	gnomAD
rs779813008	843	S>Y		No	ExAC TOPMed gnomAD
COSM4872273 rs565377483 COSM1154622 COSM1076342	844	S>L	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes NCI-TCGA TOPMed
rs1385343377	847	S>T		No	TOPMed gnomAD
rs749992718	848	S>G		No	ExAC TOPMed gnomAD
COSM3410807 COSM3410808 rs749992718 COSM3410806	848	S>R	central_nervous_system [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1448656729	848	S>T		No	gnomAD
rs764673066	850	S>G		No	ExAC TOPMed gnomAD
rs1561988484	851	G>R		No	Ensembl
rs1327019605	852	S>C		No	gnomAD
rs940196144	853	L>F		No	TOPMed gnomAD
rs940196144	853	L>V		No	TOPMed gnomAD
TCGA novel	854	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1391795171	855	V>D		No	gnomAD
rs547042809 COSM3697694 COSM3697696 COSM3697695	856	V>I	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs201527270	857	D>H		No	ESP ExAC TOPMed gnomAD
rs201527270	857	D>N		No	ESP ExAC TOPMed gnomAD
rs1159821821	858	S>G		No	gnomAD
TCGA novel	858	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs374346705	858	S>N		No	1000Genomes ExAC gnomAD
rs771229208	859	S>G		No	ExAC gnomAD
rs202026754	860	G>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs202026754	860	G>W		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1621235 COSM1621234 COSM1621233 rs778836721	862	I>V	liver [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
COSM1596137 COSM1596138 COSM1076338 rs768322177	865	R>*	endometrium [Cosmic]	No	cosmic curated ExAC gnomAD
rs749172071	865	R>L		No	ExAC TOPMed gnomAD
rs749172071	865	R>Q		No	ExAC TOPMed gnomAD
rs1348202782	866	V>F		No	TOPMed gnomAD
rs1348202782	866	V>I		No	TOPMed gnomAD
rs755839052	870	T>A		No	ExAC gnomAD
rs1762345642	870	T>I		No	TOPMed
rs950024611	872	R>Q		No	TOPMed gnomAD
rs780804691	872	R>W		No	ExAC TOPMed gnomAD
rs749013206	873	V>L		No	ExAC gnomAD
TCGA novel	875	I>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1278918131	877	E>K		No	TOPMed gnomAD
rs1433031486	878	A>T		No	gnomAD
rs1442452108	879	T>A		No	TOPMed gnomAD
rs769503676	879	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs769503676	879	T>R		No	ExAC TOPMed gnomAD
rs1408762555	883	L>V		No	gnomAD
rs976895510	884	N>H		No	Ensembl
rs1173861716	884	N>S		No	TOPMed gnomAD
COSM1487493 COSM4815277 COSM450950	887	N>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1762298254	887	N>H		No	Ensembl
rs1762297698	891	C>R		No	Ensembl
rs1762296943	895	F>L		No	TOPMed
rs1309539426	896	W>R		No	TOPMed gnomAD
rs781002633	897	D>G		No	ExAC gnomAD
rs756826675	898	Q>R		No	ExAC gnomAD
rs202231672	899	C>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs755466789	900	E>A		No	ExAC gnomAD
rs766700241	901	S>C		No	ExAC gnomAD
rs756486869	902	T>A		No	ExAC TOPMed gnomAD
rs532977529	902	T>M		No	1000Genomes ExAC TOPMed gnomAD
rs1449412775	905	A>T		No	gnomAD
rs1452416193	906	P>L		No	TOPMed gnomAD
rs1452416193	906	P>Q		No	TOPMed gnomAD
rs1335134210	906	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1581334781	907	V>G		No	Ensembl
rs1243640289	907	V>L		No	gnomAD
rs1581334735	908	V>G		No	Ensembl
rs541125345	908	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs905344128	909	D>G		No	TOPMed
rs1762292529	909	D>N		No	Ensembl
COSM3623095 COSM3623094 COSM3623093 rs770759632	911	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
COSM3623092 COSM3623091 COSM3623090	912	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs201026056	913	P>S		No	ESP ExAC TOPMed gnomAD
rs1762291355	914	S>L		No	TOPMed
rs777300692	915	P>R		No	ExAC gnomAD
rs749746390	918	K>R		No	ExAC gnomAD
rs1762290359	919	D>G		No	Ensembl
COSM3623087 COSM3623089 COSM3623088	919	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1762290517	919	D>N		No	TOPMed
rs1206895453	920	A>T		No	TOPMed gnomAD
rs866985103	920	A>V		No	TOPMed gnomAD
rs1762289305	921	Q>R		No	TOPMed
rs1762288781	926	F>I		No	Ensembl
TCGA novel rs1762288598	926	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1362180764	927	S>F		No	TOPMed gnomAD
rs1316290150	927	S>P		No	TOPMed
rs1362180764	927	S>Y		No	TOPMed gnomAD
rs1762287614	928	H>R		No	TOPMed
rs1245635512	930	K>T		No	gnomAD
rs1762075727	931	D>H		No	Ensembl
rs781496280	932	Y>H		No	ExAC TOPMed gnomAD
rs1275096365	932	Y>S		No	gnomAD
rs1406204595	933	V>A		No	TOPMed gnomAD
rs1188385719	933	V>M		No	TOPMed
rs1420216008	935	N>K		No	gnomAD
rs566354052	935	N>S		No	1000Genomes ExAC gnomAD
rs867482809	936	V>L		No	gnomAD
COSM1596140 COSM1596139 COSM1076336	939	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs777912527	941	L>R		No	ExAC TOPMed gnomAD
rs1191596184	947	G>E		No	TOPMed gnomAD
rs548160058	950	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs1266876591	950	A>V		No	TOPMed gnomAD
rs1038175034	951	I>V		No	TOPMed gnomAD
rs778797717	955	G>D		No	Ensembl
rs1435803579	956	H>R		No	TOPMed gnomAD
COSM3860644 COSM3860645 rs377225601 COSM3860643	957	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs759509689	957	R>W		No	ExAC TOPMed gnomAD
rs371840880	958	C>Y		No	ESP ExAC TOPMed gnomAD
rs1263307875	960	G>R		No	gnomAD
rs1762069717	961	N>S		No	TOPMed
rs367717609	962	G>S		No	ESP ExAC TOPMed gnomAD
rs771660259	963	S>I		No	ExAC TOPMed gnomAD
rs761363264	963	S>R		No	ExAC TOPMed gnomAD
rs1360581996	963	S>R		No	TOPMed gnomAD
rs771660259	963	S>T		No	ExAC TOPMed gnomAD
rs773800441	965	I>L		No	ExAC gnomAD
rs1313154357	966	W>*		No	gnomAD
rs1363961771	967	E>G		No	gnomAD
rs1400123113	967	E>K		No	gnomAD
rs746302478	968	V>G		No	ExAC gnomAD
rs201596924	968	V>I		No	1000Genomes ExAC
rs771310891	969	D>E		No	ExAC gnomAD
rs1359528903	969	D>H		No	TOPMed gnomAD
rs1359528903	969	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs200248913	970	S>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM450948 COSM4812866 COSM1134256	972	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1421638722	975	T>K		No	TOPMed gnomAD
rs1264427318	977	T>A		No	1000Genomes TOPMed gnomAD
COSM3994739 COSM3994741 COSM3994740	977	T>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1264427318	977	T>S		No	1000Genomes TOPMed gnomAD
rs779073192	979	H>P		No	ExAC gnomAD
rs755122590	979	H>Q		No	ExAC gnomAD
rs779073192	979	H>R		No	ExAC gnomAD
rs753814401	981	R>K		No	ExAC gnomAD
rs1761882989	983	N>D		No	Ensembl
rs1486751512	984	E>D		No	TOPMed gnomAD
rs768564251	986	T>M		No	ExAC TOPMed gnomAD
rs1317110266	987	R>*		No	gnomAD
rs1333688304	987	R>*		No	gnomAD
rs1317110266	987	R>G		No	gnomAD
rs779969750	987	R>Q		No	ExAC TOPMed gnomAD
rs755106049	988	R>S		No	ExAC TOPMed gnomAD
rs1267538316	989	I>M		No	TOPMed gnomAD
rs749421370	991	M>I		No	ExAC TOPMed gnomAD
rs780021482	992	W>*		No	ExAC TOPMed gnomAD
rs780021482	992	W>C		No	ExAC TOPMed gnomAD
rs1386350732	994	S>C		No	TOPMed gnomAD
COSM3623086 COSM3623084 COSM3623085	994	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1761879754 COSM1329198 COSM1329199	995	I>M	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs1761879939	995	I>V		No	TOPMed gnomAD
rs750404304	999	N>S		No	ExAC TOPMed gnomAD
rs936651146	1000	E>D		No	TOPMed gnomAD
COSM231071 rs1561980933	1001	L>S	skin [Cosmic]	No	cosmic curated Ensembl
rs2150324267	1002	G>*		No	Ensembl
rs1183055763	1003	E>D		No	gnomAD
rs1385016290	1003	E>G		No	gnomAD
rs902513906	1003	E>K		No	Ensembl
rs902513906	1003	E>Q		No	Ensembl
rs1761877957	1005	A>V		No	TOPMed
TCGA novel	1008	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2150324246	1008	E>Q		No	1000Genomes
rs751195710	1010	H>Y		No	ExAC gnomAD
rs201793412	1014	D>G		No	ESP ExAC TOPMed gnomAD
rs1490380826	1014	D>N		No	gnomAD
rs201793412	1014	D>V		No	ESP ExAC TOPMed gnomAD
rs1490380826	1014	D>Y		No	gnomAD
rs1581946204	1016	N>S		No	TOPMed gnomAD
rs1761875964	1018	G>E		No	TOPMed gnomAD
rs1761875964	1018	G>V		No	TOPMed gnomAD
rs1358716716	1020	I>V		No	gnomAD
rs376231863	1024	R>K		No	ESP ExAC TOPMed gnomAD
rs1363923270	1025	Q>R		No	TOPMed gnomAD
COSM483717 COSM4857294 COSM1137480	1026	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758007445	1028	S>P		No	ExAC gnomAD
rs1039150543	1029	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1447855174	1030	R>G		No	TOPMed gnomAD
COSM3860641 COSM3860640 COSM3860642	1030	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1761854259	1033	V>I		No	TOPMed gnomAD
rs373262206	1034	T>M		No	ESP ExAC TOPMed gnomAD
rs1761853676	1035	V>M		No	TOPMed gnomAD
rs1761853120	1039	Q>K		No	Ensembl
rs1189716618	1040	H>L		No	gnomAD
rs1761851778	1047	M>T		No	TOPMed gnomAD
rs189201100	1048	V>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs762249432	1051	I>M		No	ExAC gnomAD
rs1336988363	1051	I>T		No	TOPMed gnomAD
rs1296480722	1051	I>V		No	TOPMed
rs774810280	1052	L>Q		No	ExAC gnomAD
rs774810280	1052	L>R		No	ExAC gnomAD
rs769171168	1053	S>L		No	ExAC gnomAD
TCGA novel	1054	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1761849878	1054	V>L		No	TOPMed
rs1761849500	1055	S>C		No	TOPMed
rs1265260343	1055	S>T		No	gnomAD
rs763197579	1056	I>V		No	ExAC TOPMed gnomAD
rs1278632122	1057	G>S		No	TOPMed gnomAD
rs769749811	1058	C>W		No	ExAC gnomAD
rs746025544	1059	V>G		No	ExAC
rs780960120	1061	A>S		No	ExAC
rs1201762550	1064	T>I		No	TOPMed
rs746982399	1065	K>I		No	ExAC gnomAD
rs746982399	1065	K>R		No	ExAC gnomAD
rs777480189	1067	Q>K		No	ExAC gnomAD
rs758203518	1069	G>E		No	ExAC gnomAD
rs1761846804	1069	G>R		No	TOPMed
rs3734234	1070	L>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs3734234	1070	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1419629108	1071	D>N		No	gnomAD
rs1481022523	1073	Y>H		No	gnomAD
COSM268228	1074	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs777746220	1076	D>A		No	ExAC gnomAD
rs746892812	1076	D>N		No	ExAC gnomAD
COSM3777337 COSM3777338	1077	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1383146587	1077	D>V		No	gnomAD
rs1181135084	1079	D>G		No	gnomAD
rs1233716913	1082	D>Y		No	gnomAD
rs748018940	1083	M>I		No	ExAC TOPMed gnomAD
rs1648263432	1083	M>T		No	Ensembl
rs1761387101	1086	Y>*		No	Ensembl
rs1761386668	1087	Q>E		No	TOPMed
rs1274464108	1087	Q>H		No	gnomAD
rs79653168	1088	E>D		No	Ensembl
rs760811127	1088	E>G		No	ExAC gnomAD
rs772049995	1089	E>D		No	ExAC TOPMed gnomAD
rs773106750	1089	E>G		No	ExAC gnomAD
TCGA novel	1089	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1091	L>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1092	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1160217254	1093	C>Y		No	TOPMed gnomAD
COSM1076334 rs192133963 COSM1596141 COSM1596142	1094	V>I	endometrium [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs192133963 RCV000975103	1094	V>L		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs768338454	1096	E>K		No	ExAC gnomAD
COSM4947499 COSM4947498 COSM86222 rs1761189899	1097	R>T	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated gnomAD
rs748909909	1099	S>L		No	ExAC gnomAD
rs1221703921	1100	D>E		No	gnomAD
rs1761189517	1100	D>G		No	Ensembl
rs1761189167	1101	A>T		No	TOPMed
rs779906738	1101	A>V		No	ExAC TOPMed gnomAD
rs1761188810	1103	I>V		No	TOPMed
rs755676744	1104	K>R		No	ExAC TOPMed gnomAD
TCGA novel	1105	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs745411489	1106	R>Q		No	ExAC TOPMed gnomAD
rs1273519098	1107	E>*		No	TOPMed gnomAD
rs1761187646	1110	D>E		No	gnomAD
rs112367304	1111	E>K		No	Ensembl
rs112367304	1111	E>Q		No	Ensembl
rs1050210080	1113	I>L		No	Ensembl
rs2150315577	1115	K>R		No	Ensembl
rs1561972286	1116	V>I		No	Ensembl
COSM1442389 COSM2856011 COSM2856008 COSM1442388 rs1346755993 COSM2856010 COSM2856009	1116	V>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs1455836418	1117	S>G		No	gnomAD
rs753174132	1117	S>I		No	ExAC TOPMed gnomAD
rs1561972250	1118	N>K		No	Ensembl
TCGA novel	1119	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs765582187	1120	T>I		No	ExAC TOPMed gnomAD
rs368765608	1121	E>A		No	ESP ExAC TOPMed gnomAD
rs1309161633	1124	E>K		No	TOPMed gnomAD
rs1403988480	1125	D>Y		No	TOPMed
rs780806668	1126	D>H		No	ExAC TOPMed gnomAD
rs780806668	1126	D>N		No	ExAC TOPMed gnomAD
rs2150312937	1127	V>M		No	Ensembl
rs748676840	1128	E>K		No	ExAC TOPMed gnomAD
rs1012385455	1129	R>Q		No	TOPMed
rs755339587	1131	A>T		No	ExAC TOPMed gnomAD
COSM272864	1131	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1462585050	1134	V>A		No	gnomAD
rs754253648	1135	E>Q		No	ExAC
rs1581915430	1136	Q>R		No	Ensembl
rs1386232775	1138	V>A		No	gnomAD
rs1449184730	1138	V>I		No	gnomAD
rs1449184730	1138	V>L		No	gnomAD
rs1389775006	1139	G>E		No	TOPMed gnomAD
TCGA novel	1142	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1272301877	1150	P>S		No	gnomAD
rs767573213	1151	A>G		No	ExAC gnomAD
rs1204335649	1151	A>T		No	TOPMed gnomAD
rs767573213	1151	A>V		No	ExAC gnomAD
rs1760983640	1154	S>G		No	TOPMed
rs751506792	1155	G>R		No	ExAC gnomAD
rs1760983214	1159	A>S		No	TOPMed gnomAD
COSM4786309 COSM1442387 COSM1442386	1162	D>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1760982313	1162	D>E		No	Ensembl
rs547479559	1162	D>N		No	1000Genomes ExAC TOPMed gnomAD
rs547479559	1162	D>Y		No	1000Genomes ExAC TOPMed gnomAD
rs1391973898	1163	W>L		No	gnomAD
rs556247264	1164	I>N		No	1000Genomes ExAC gnomAD
rs750627392	1166	P>L		No	ExAC TOPMed gnomAD
rs1326147197	1167	P>L		No	gnomAD
TCGA novel	1167	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1137479 COSM1137478 COSM4858279	1169	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1385384449	1169	M>T		No	gnomAD
rs537497725	1171	T>I		No	1000Genomes ExAC TOPMed gnomAD
rs1760803187	1173	I>M		No	TOPMed
rs1157711566	1173	I>T		No	gnomAD
rs570438110	1173	I>V		No	1000Genomes ExAC TOPMed gnomAD
rs1196686610	1179	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1196686610	1179	D>Y		No	TOPMed gnomAD
rs762942389	1182	A>S		No	ExAC gnomAD
rs200192784	1182	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs886158517	1183	D>A		No	Ensembl
rs1397069126	1183	D>E		No	gnomAD
COSM3829724 COSM3829722 COSM3829723	1184	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765307051	1186	S>C		No	ExAC gnomAD
COSM6173576 COSM6173577 COSM6173575	1187	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs377483649	1187	A>T		No	ESP ExAC TOPMed gnomAD
rs372713505	1188	N>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201386556	1190	Q>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1760549018	1191	L>I		No	Ensembl
rs760182991	1192	V>L		No	ExAC TOPMed gnomAD
rs1373234653	1193	G>S		No	TOPMed gnomAD
rs1185459475	1194	P>L		No	gnomAD
COSM4695886 COSM4695885 COSM4695887	1195	H>M	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1441922128	1195	H>P		No	gnomAD
rs1441922128	1195	H>R		No	gnomAD
rs1760547269	1197	S>Y		No	TOPMed
rs1340752220	1198	G>A		No	TOPMed gnomAD
rs1340752220	1198	G>D		No	TOPMed gnomAD
rs1207908162	1198	G>S		No	TOPMed gnomAD
rs1340752220	1198	G>V		No	TOPMed gnomAD
TCGA novel	1199	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1581901120	1199	V>G		No	Ensembl
rs374802927	1199	V>M		No	ESP ExAC TOPMed gnomAD
rs1581901107	1200	N>T		No	Ensembl
rs746405854	1207	H>D		No	ExAC gnomAD
rs776820595	1207	H>L		No	ExAC gnomAD
rs988950601	1208	G>C		No	gnomAD
rs956157720	1208	G>V		No	gnomAD
rs771329476	1209	S>N		No	ExAC gnomAD
rs2150307638	1212	F>C		No	Ensembl
rs1406908946	1212	F>L		No	gnomAD
COSM1487491 COSM450947 COSM4815345	1213	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758523339	1213	Y>C		No	ExAC TOPMed gnomAD
rs778208739	1213	Y>H		No	ExAC TOPMed gnomAD
rs1303042403	1215	P>A		No	TOPMed
rs1472628107	1215	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1218892982	1216	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1482345909	1217	I>R		No	gnomAD
rs34296471	1217	I>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1251754428	1218	K>Q		No	gnomAD
rs1485839101	1219	H>R		No	TOPMed
rs1222717904	1220	S>R		No	gnomAD
rs754834948	1221	D>G		No	ExAC TOPMed gnomAD
rs753823485	1222	D>N		No	ExAC gnomAD
rs780108694	1226	A>S		No	ExAC gnomAD
rs780108694	1226	A>T		No	ExAC gnomAD
rs559223242	1227	T>I		No	1000Genomes ExAC TOPMed gnomAD
rs1365459038	1228	A>T		No	gnomAD
rs780983796	1231	D>H		No	ExAC gnomAD
TCGA novel	1232	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1596147 COSM1076326 rs1760502234 COSM1596148	1233	S>L	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated gnomAD
rs1455653081	1235	H>P		No	gnomAD
rs1760501218	1239	H>D		No	Ensembl
TCGA novel	1241	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs200009476	1243	V>I		No	ESP ExAC TOPMed gnomAD
rs1760500597	1245	P>S		No	TOPMed gnomAD
rs1760500309	1246	Q>R		No	Ensembl
rs762581033	1247	N>S		No	ExAC TOPMed gnomAD
rs1760499178	1248	E>G		No	Ensembl
rs1760499369	1248	E>K		No	TOPMed
rs754270600	1250	I>M		No	ExAC TOPMed gnomAD
rs761108518	1253	I>L		No	ExAC gnomAD
rs1425682608	1253	I>M		No	Ensembl
rs773672086	1256	T>A		No	ExAC gnomAD
rs1760497501	1256	T>I		No	Ensembl
rs61729950	1257	T>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs61729950	1257	T>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs774773858	1258	V>I		No	ExAC gnomAD
rs768616701	1259	Q>H		No	ExAC gnomAD
rs749422448	1261	S>N		No	ExAC TOPMed gnomAD
rs1581899438	1262	H>P		No	Ensembl
COSM275726	1262	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1760496114	1262	H>Y		No	Ensembl
rs779829915	1263	P>L		No	ExAC gnomAD
rs2150307050	1265	A>T		No	Ensembl
rs1295199486	1265	A>V		No	gnomAD
rs780897761	1266	M>I		No	ExAC TOPMed gnomAD
rs1356232950	1266	M>R		No	TOPMed gnomAD
rs1356232950	1266	M>T		No	TOPMed gnomAD
rs879733612	1266	M>V		No	TOPMed gnomAD
rs1760494080	1268	L>F		No	TOPMed
rs555103615	1269	V>I		No	1000Genomes ExAC gnomAD
rs370736619	1270	L>I		No	ESP ExAC TOPMed gnomAD
COSM1621227 COSM1621228 COSM1621229 rs1175994839	1271	R>*	Variant assessed as Somatic; HIGH impact. liver [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs757826120	1273	R>*		No	ExAC gnomAD
rs1187113656	1273	R>L		No	gnomAD
rs1187113656	1273	R>Q		No	gnomAD
rs1448485038	1274	I>F		No	gnomAD
rs752203553	1275	A>P		No	ExAC TOPMed gnomAD
rs752203553	1275	A>S		No	ExAC TOPMed gnomAD
rs764686226	1276	A>T		No	ExAC gnomAD
rs761198847	1277	N>D		No	ExAC TOPMed gnomAD
rs750983159	1277	N>S		No	ExAC TOPMed gnomAD
rs761198847	1277	N>Y		No	ExAC TOPMed gnomAD
rs767983765	1279	Y>C		No	ExAC gnomAD
rs1344313006	1280	N>I		No	TOPMed gnomAD
COSM3697693 COSM3697692 rs751899598 COSM3697691	1285	T>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1581894076	1287	S>R		No	Ensembl
rs763165837	1292	I>L		No	ExAC gnomAD
rs763165837	1292	I>V		No	ExAC gnomAD
TCGA novel	1293	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1410543711	1293	S>Y		No	gnomAD
rs775587225	1294	L>V		No	ExAC gnomAD
rs1233703663	1297	I>M		No	TOPMed
rs1037611621	1298	F>S		No	Ensembl
TCGA novel	1299	Y>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs759678854	1303	V>L		No	ExAC gnomAD
rs776517852	1305	Y>C		No	ExAC gnomAD
COSM3921115 COSM3921116 COSM3921117	1306	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1273040881	1307	I>M		No	TOPMed gnomAD
rs1283345614	1307	I>V		No	Ensembl
rs948560314	1309	S>C		No	Ensembl
rs746980328	1310	N>S		No	ExAC TOPMed gnomAD
rs1367580203	1311	I>V		No	gnomAD
TCGA novel	1314	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs761557970	1317	E>D		No	ExAC gnomAD
rs1748280803	1318	I>V		No	TOPMed
rs1277150364	1319	E>G		No	gnomAD
rs1346266279	1319	E>K		No	TOPMed gnomAD
rs1346266279	1319	E>Q		No	TOPMed gnomAD
rs748974986	1320	D>E		No	ExAC gnomAD
rs2150303620	1320	D>N		No	Ensembl
rs1019753708	1321	R>Q		No	Ensembl
rs1760248796	1321	R>W		No	TOPMed
rs769438850	1323	T>M		No	ExAC gnomAD
rs769438850	1323	T>R		No	ExAC gnomAD
TCGA novel	1325	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs774472191	1326	L>F		No	ExAC TOPMed gnomAD
rs774472191	1326	L>V		No	ExAC TOPMed gnomAD
rs1760246979	1327	L>M		No	TOPMed
TCGA novel	1328	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1404185087	1333	N>S		No	gnomAD
rs779282508	1334	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1300082220	1335	G>D		No	TOPMed
rs987952505	1337	S>A		No	gnomAD
rs1190314631	1339	G>E		No	gnomAD
rs1760244649	1339	G>R		No	TOPMed
rs545140596	1341	T>A		No	1000Genomes
rs766435113	1341	T>M		No	ExAC TOPMed gnomAD
rs750346645	1342	Y>C		No	ExAC gnomAD
rs1278410006	1343	I>T		No	gnomAD
rs1760242039	1346	Y>*		No	TOPMed
rs1347843766	1347	T>A		No	gnomAD
rs1347843766	1347	T>S		No	gnomAD
rs761835838	1347	T>S		No	ExAC TOPMed gnomAD
rs774244288	1348	R>*		No	ExAC TOPMed gnomAD
COSM1596151 COSM1596152 rs1339590903 COSM1076322	1348	R>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs762633563	1350	V>L		No	ExAC gnomAD
rs762633563	1350	V>M		No	ExAC gnomAD
rs769341668	1352	Q>H		No	ExAC gnomAD
rs775338214	1352	Q>R		No	ExAC TOPMed gnomAD
rs1248252707	1353	V>M		No	TOPMed
rs1760239087	1355	N>D		No	Ensembl
rs1448365880	1355	N>I		No	TOPMed
rs1226851833	1356	I>N		No	gnomAD
COSM261655	1357	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1760237394	1358	S>G		No	Ensembl
rs772409670	1358	S>N		No	ExAC gnomAD
rs1167569315	1359	L>F		No	gnomAD
rs1473287463	1359	L>P		No	gnomAD
rs748695121	1360	E>D		No	ExAC TOPMed gnomAD
COSM1442385 rs1322814372 COSM1442384	1361	R>Q	large_intestine [Cosmic]	No	cosmic curated TOPMed gnomAD
rs1760236184	1361	R>W		No	1000Genomes gnomAD
rs1207661849	1363	R>Q		No	gnomAD
rs1253211513	1363	R>W		No	TOPMed gnomAD
rs1760084844	1365	A>T		No	TOPMed gnomAD
rs1275172590 COSM1311831 COSM4812447 COSM1311832	1366	V>I	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs748642534	1367	T>A		No	ExAC TOPMed gnomAD
rs1760083659	1369	K>*		No	gnomAD
rs774907074	1371	A>G		No	ExAC gnomAD
TCGA novel	1371	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1461179076	1374	T>A		No	TOPMed gnomAD
COSM4811058 COSM1133767 COSM420971	1375	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1760082424	1375	K>N		No	TOPMed
rs780492891	1377	R>G		No	ExAC TOPMed gnomAD
rs756255302	1377	R>Q		No	ExAC TOPMed gnomAD
rs780492891	1377	R>W		No	ExAC TOPMed gnomAD
rs746103151	1379	I>V		No	ExAC TOPMed gnomAD
rs757413284	1380	R>Q		No	ExAC TOPMed gnomAD
rs372857233	1380	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1760079371	1382	S>N		No	gnomAD
rs961422777	1384	S>C		No	Ensembl
COSM4877763 rs961422777 COSM4877762 COSM4877761	1384	S>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs751536244	1384	S>N		No	ExAC TOPMed gnomAD
rs1269454988	1385	T>I		No	TOPMed gnomAD
rs764164486	1385	T>S		No	ExAC gnomAD
rs1316227376	1386	P>L		No	gnomAD
rs752490875	1387	N>D		No	ExAC gnomAD
TCGA novel	1387	N>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs368584415	1388	V>A		No	ESP ExAC TOPMed gnomAD
rs1402813931	1388	V>I		No	TOPMed
rs1044421319	1389	H>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1044421319	1389	H>R		No	TOPMed
rs1391569000	1391	V>D		No	gnomAD
rs753403109	1391	V>F		No	ExAC gnomAD
rs753403109	1391	V>I		No	ExAC gnomAD
rs756978744	1393	S>F		No	Ensembl
rs900971113	1395	R>*		No	TOPMed gnomAD
rs200901764	1395	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200833262	1396	P>L		No	ESP ExAC TOPMed gnomAD
rs200833262	1396	P>Q		No	ESP ExAC TOPMed gnomAD
rs767024112	1397	D>E		No	ExAC TOPMed gnomAD
rs1162974804	1398	L>V		No	TOPMed gnomAD
rs1759824492	1399	S>F		No	TOPMed
rs763389412	1400	G>D		No	ExAC gnomAD
rs1759824208	1400	G>S		No	Ensembl
rs569146131	1401	F>L		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	1402	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs886653773	1403	E>D		No	TOPMed gnomAD
rs770047708	1404	D>G		No	ExAC gnomAD
rs1307176389	1405	D>V		No	gnomAD
rs1759678163	1408	W>*		No	Ensembl
rs1332254381	1408	W>R		No	TOPMed gnomAD
rs866549736	1409	P>S		No	Ensembl
rs1433570518	1410	E>D		No	gnomAD
rs771426174	1412	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs140293391	1413	L>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs140293391	1413	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs773637052	1414	D>G		No	ExAC gnomAD
COSM3623081 COSM3623082 COSM3623083	1414	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
VAR_029389 rs17689215	1415	M>V		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1259496367	1417	D>E		No	gnomAD
rs768601692	1418	Y>C		No	ExAC TOPMed gnomAD
rs866918817	1418	Y>H		No	gnomAD
rs2150295298	1420	S>F		No	Ensembl
rs1261076233	1422	Y>C		No	TOPMed gnomAD
rs1759674605	1423	Q>H		No	Ensembl
rs779771179	1424	D>V		No	ExAC TOPMed gnomAD
rs373092082	1426	A>E		No	ESP ExAC TOPMed gnomAD
rs755957437	1426	A>S		No	ExAC TOPMed gnomAD
rs373092082	1426	A>V		No	ESP ExAC TOPMed gnomAD
rs1581869106	1428	Y>F		No	Ensembl
TCGA novel	1429	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs751030387	1429	G>R		No	ExAC TOPMed gnomAD
rs1759672489	1430	T>I		No	TOPMed gnomAD
rs1759671841	1431	L>F		No	TOPMed gnomAD
rs763542054	1431	L>S		No	ExAC TOPMed gnomAD
rs755445981	1432	P>R		No	ExAC gnomAD
COSM4813150 COSM1487490 COSM1487489	1433	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3860635 COSM3860636 COSM3860634	1433	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1452755139	1434	D>G		No	gnomAD
rs754313942	1436	P>S		No	ExAC TOPMed gnomAD
rs761162305	1437	R>*		No	ExAC gnomAD
rs78281954	1437	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs78281954	1437	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs1205057852	1439	N>I		No	gnomAD
rs1047635332	1440	K>E		No	Ensembl
rs1346376943	1441	E>A		No	gnomAD
rs761975221	1442	G>S		No	ExAC gnomAD
rs1357219791	1443	C>Y		No	TOPMed gnomAD
rs1311012993	1444	T>A		No	gnomAD
rs367994814	1447	T>I		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	1448	P>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1313098182	1448	P>L		No	gnomAD
rs762033876	1448	P>S		No	ExAC gnomAD
rs1467194992	1449	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1330691192	1451	L>V		No	gnomAD
rs569875205	1452	T>A		No	1000Genomes
rs372447677	1453	V>F		No	ExAC TOPMed gnomAD
COSM1596153 COSM1596154 COSM1076317 rs372447677	1453	V>I	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1475583862	1454	S>G		No	TOPMed gnomAD
rs775387752	1455	P>H		No	ExAC gnomAD
rs775387752	1455	P>R		No	ExAC gnomAD
rs769673178	1456	F>L		No	ExAC gnomAD
rs1759537916	1456	F>S		No	TOPMed
rs1475189598	1458	A>V		No	TOPMed gnomAD
rs1759537212	1460	S>A		No	TOPMed
rs182962682	1460	S>C		No	1000Genomes TOPMed gnomAD
rs182962682	1460	S>F		No	1000Genomes TOPMed gnomAD
rs1199398005	1461	P>S		No	TOPMed gnomAD
rs1199398005	1461	P>T		No	TOPMed gnomAD
rs1175300473	1464	P>Q		No	gnomAD
rs776345807	1464	P>S		No	ExAC gnomAD
rs1430301170	1465	K>E		No	TOPMed gnomAD
rs770646228	1468	K>Q		No	ExAC gnomAD
rs746659694	1469	P>S		No	ExAC gnomAD
rs2150293010	1470	L>P		No	Ensembl
rs201979416	1471	M>I		No	1000Genomes ExAC TOPMed gnomAD
rs559728824	1473	V>I		No	1000Genomes TOPMed
rs534596564	1476	E>D		No	ExAC gnomAD
rs747611407	1477	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs778595043	1478	K>R		No	ExAC TOPMed gnomAD
rs1759532754	1483	L>P		No	TOPMed
rs1447468499	1485	A>E		No	TOPMed gnomAD
rs1447468499	1485	A>V		No	TOPMed gnomAD
rs375333105	1486	R>T		No	ESP TOPMed gnomAD
rs1281025424	1487	P>H		No	gnomAD
rs1377517558	1487	P>S		No	TOPMed gnomAD
COSM3623070 COSM3623071 COSM3623069	1488	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756620344	1488	L>P		No	ExAC gnomAD
rs756620344	1488	L>R		No	ExAC gnomAD
rs868522948	1490	S>C		No	Ensembl
rs1759530842	1491	Q>R		No	gnomAD
rs1051708893	1493	S>G		No	TOPMed gnomAD
rs781594811	1495	P>L		No	ExAC TOPMed gnomAD
rs757622676	1496	P>L		No	ExAC gnomAD
rs751824702	1497	P>L		No	ExAC TOPMed gnomAD
rs751824702	1497	P>R		No	ExAC TOPMed gnomAD
COSM1311829 COSM1311830 rs1759465050	1498	Q>E	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed gnomAD
rs1279484894	1498	Q>R		No	TOPMed gnomAD
rs778234437	1499	A>E		No	ExAC TOPMed gnomAD
rs778234437	1499	A>V		No	ExAC TOPMed gnomAD
rs758551418	1500	H>R		No	ExAC gnomAD
rs1362747960	1501	N>K		No	TOPMed gnomAD
rs1581861580	1501	N>T		No	Ensembl
rs765288895	1504	C>F		No	ExAC gnomAD
rs766177992	1505	I>T		No	ExAC gnomAD
rs753791221	1505	I>V		No	ExAC gnomAD
rs537340041	1507	P>A		No	1000Genomes ExAC gnomAD
rs537340041	1507	P>S		No	1000Genomes ExAC gnomAD
rs756267833	1509	G>E		No	Ensembl
rs1759461700	1509	G>R		No	gnomAD
rs142518339	1510	S>N		No	1000Genomes ExAC TOPMed gnomAD
rs772004378	1511	N>K		No	ExAC gnomAD
rs1420999888	1513	S>G		No	TOPMed gnomAD
rs776177971	1513	S>N		No	Ensembl
rs1561950826	1514	S>I		No	TOPMed gnomAD
rs1561950826	1514	S>N		No	TOPMed gnomAD
rs868120397	1515	M>I		No	TOPMed
rs761540530	1515	M>V		No	ExAC gnomAD
rs1581861305	1516	P>A		No	Ensembl
rs774209178	1517	V>I		No	ExAC gnomAD
rs774209178	1517	V>L		No	ExAC gnomAD
rs931897567	1519	H>Y		No	TOPMed
rs768253903	1520	N>S		No	ExAC TOPMed gnomAD
rs374548485	1521	S>N		No	ESP ExAC TOPMed gnomAD
COSM282219 rs989994318	1523	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs565980274	1523	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs1581861147	1524	E>K		No	Ensembl
rs777943369	1525	K>N		No	ExAC TOPMed gnomAD
rs984023682	1526	K>R		No	TOPMed gnomAD
rs1561950741	1527	I>V		No	Ensembl
rs752024775	1528	D>E		No	ExAC gnomAD
rs747459627	1528	D>G		No	ExAC gnomAD
rs747459627	1528	D>V		No	ExAC gnomAD
rs1296997380	1528	D>Y		No	Ensembl
rs772395057	1530	E>*		No	ExAC TOPMed gnomAD
rs772395057	1530	E>Q		No	ExAC TOPMed gnomAD
rs748462859	1532	E>D		No	ExAC gnomAD
rs1758809178	1534	N>S		No	TOPMed
rs1305323943	1535	E>G		No	TOPMed gnomAD
rs897163028	1539	I>V		No	Ensembl
rs779280594	1541	R>K		No	ExAC gnomAD
COSM261654	1541	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1044961267	1542	K>R		No	TOPMed gnomAD
rs1044961267	1542	K>T		No	TOPMed gnomAD
rs1420668773	1543	L>I		No	gnomAD
rs373629019	1544	I>M		No	ESP TOPMed gnomAD
rs749536928	1544	I>V		No	ExAC gnomAD
rs1208591821	1545	S>T		No	TOPMed
TCGA novel	1546	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1758806128	1547	Q>L		No	Ensembl
rs1254178585	1548	P>L		No	gnomAD
rs1265089488	1551	P>A		No	TOPMed gnomAD
rs1265089488	1551	P>S		No	TOPMed gnomAD
rs1265089488	1551	P>T		No	TOPMed gnomAD
rs1480994008	1552	V>M		No	gnomAD
rs1758804650	1553	E>G		No	Ensembl
rs370868446	1553	E>K		No	ESP ExAC TOPMed gnomAD
rs370868446	1553	E>Q		No	ESP ExAC TOPMed gnomAD
rs1419066877	1557	F>L		No	TOPMed
rs756281554	1557	F>S		No	ExAC TOPMed gnomAD
rs1265381064	1561	N>D		No	gnomAD
rs767615649	1561	N>S		No	ExAC TOPMed gnomAD
rs757287995	1564	L>S		No	ExAC TOPMed gnomAD
rs909114227	1565	E>K		No	Ensembl
rs1172267769	1567	R>S		No	TOPMed gnomAD
rs988030455	1568	E>K		No	TOPMed gnomAD
rs991309411	1569	W>*		No	Ensembl
rs1758799603	1570	F>*		No	TOPMed gnomAD
rs751362648	1570	F>V		No	ExAC gnomAD
TCGA novel	1571	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1581840298	1572	S>A		No	Ensembl
rs1758799066	1572	S>F		No	Ensembl
rs1758798757	1574	V>A		No	Ensembl
rs1758798473	1575	D>N		No	Ensembl
rs1445557288	1576	L>V		No	gnomAD
rs1371309973	1578	N>D		No	gnomAD
rs1758796898	1580	R>Q		No	TOPMed gnomAD
rs201753966	1580	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs762457372	1581	V>I		No	ExAC TOPMed gnomAD
rs1442514320	1582	L>S		No	TOPMed gnomAD
rs1455344325	1583	E>K		No	TOPMed gnomAD
rs1758795941	1584	K>E		No	TOPMed
rs775273707	1585	E>A		No	ExAC TOPMed gnomAD
rs775273707	1585	E>G		No	ExAC TOPMed gnomAD
rs530891053	1586	V>A		No	1000Genomes ExAC gnomAD
rs759127355	1586	V>M		No	ExAC TOPMed gnomAD
rs377613904	1588	R>C		No	ESP ExAC TOPMed gnomAD
COSM4942710 rs184686655 COSM4942711 COSM4942709	1588	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1485000035	1589	S>N		No	Ensembl
rs1487166736	1591	T>I		No	TOPMed gnomAD
rs1758793480	1592	T>I		No	TOPMed
rs967495966	1593	S>I		No	Ensembl
rs780359848	1598	G>D		No	ExAC TOPMed gnomAD
rs780359848	1598	G>V		No	ExAC TOPMed gnomAD
rs745897585	1599	Y>*		No	ExAC TOPMed gnomAD
rs12211658 VAR_049699	1600	F>S		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1758792125	1600	F>V		No	Ensembl
rs757196364	1601	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1758791662	1601	S>P		No	Ensembl
rs758282538	1602	H>L		No	ExAC gnomAD
rs758282538	1602	H>P		No	ExAC gnomAD
rs752260591	1602	H>Q		No	ExAC
rs1758790451	1603	S>R		No	gnomAD
rs1297281131	1606	N>H		No	TOPMed gnomAD
rs369581592	1606	N>S		No	ESP ExAC TOPMed gnomAD
rs1758789485	1608	T>A		No	TOPMed gnomAD
rs201648357	1608	T>N		No	ESP ExAC TOPMed gnomAD
rs765885011	1609	L>M		No	ExAC gnomAD
rs765885011	1609	L>V		No	ExAC gnomAD
rs1343761626	1612	M>L		No	TOPMed gnomAD
rs768868179	1612	M>R		No	ExAC TOPMed gnomAD
rs768868179	1612	M>T		No	ExAC TOPMed gnomAD
rs891298408	1613	V>A		No	Ensembl
rs763420555	1613	V>L		No	ExAC gnomAD
rs1581839759	1614	V>G		No	Ensembl
rs1282997735	1615	P>T		No	gnomAD
COSM6173579 COSM6173580 COSM6173578	1616	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1343879993	1617	S>C		No	TOPMed gnomAD
rs770021543	1617	S>R		No	ExAC gnomAD
rs1343879993	1617	S>R		No	TOPMed gnomAD
rs1758785253	1619	S>N		No	gnomAD
rs1758785069	1620	S>*		No	TOPMed
TCGA novel	1620	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs41267712 RCV000885252	1621	D>E		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1228979076	1621	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1277467697	1622	Q>*		No	gnomAD
rs1277467697	1622	Q>E		No	gnomAD
rs781366500	1623	L>P		No	ExAC gnomAD
rs1281928299	1624	A>V		No	TOPMed
rs771194983	1625	I>V		No	ExAC gnomAD
rs1310895032	1626	Q>H		No	TOPMed gnomAD
rs541281370	1627	T>M		No	1000Genomes ExAC gnomAD
rs541281370	1627	T>R		No	1000Genomes ExAC gnomAD
rs1758782431	1628	K>E		No	TOPMed gnomAD
rs1758781781	1631	D>H		No	Ensembl
rs1440441635	1632	S>F		No	gnomAD
rs1476442640	1633	T>I		No	gnomAD
rs1476442640	1633	T>N		No	gnomAD
rs1406256146	1634	E>D		No	TOPMed
rs754599022	1634	E>G		No	ExAC TOPMed gnomAD
rs778577385	1634	E>K		No	ExAC gnomAD
rs1260024724	1635	H>D		No	TOPMed gnomAD
rs1260024724	1635	H>Y		No	TOPMed gnomAD
rs543574521	1636	S>A		No	1000Genomes ExAC TOPMed gnomAD
rs543574521	1636	S>P		No	1000Genomes ExAC TOPMed gnomAD
rs760216131	1638	P>L		No	ExAC TOPMed gnomAD
COSM1596156 COSM1076315 COSM1596155 rs1273285610	1639	S>L	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs764608480	1640	L>F		No	ExAC
rs199734807	1640	L>P		No	1000Genomes ExAC gnomAD
rs1256909832	1642	H>P		No	TOPMed gnomAD
TCGA novel	1644	F>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1645	R>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs765535914	1646	P>L		No	ExAC TOPMed gnomAD
rs1291170687	1647	S>F		No	gnomAD
rs1239283315	1648	S>L		No	gnomAD
rs201057801	1649	N>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs771105332	1650	K>E		No	ExAC TOPMed gnomAD
rs1329780094	1650	K>T		No	TOPMed gnomAD
rs1208245848	1651	E>A		No	TOPMed gnomAD
rs747135197	1653	T>I		No	ExAC TOPMed gnomAD
rs1758774990	1654	E>K		No	Ensembl
rs1204445362	1655	V>I		No	TOPMed gnomAD
rs1758773996	1656	E>G		No	Ensembl
rs41267710	1656	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1758773996	1656	E>V		No	Ensembl
rs1161765004	1657	K>Q		No	TOPMed gnomAD
rs374013859	1658	G>A		No	ESP ExAC TOPMed gnomAD
rs374013859	1658	G>D		No	ESP ExAC TOPMed gnomAD
rs374013859	1658	G>V		No	ESP ExAC TOPMed gnomAD
rs1183493987	1661	K>T		No	gnomAD
rs777530318	1662	D>G		No	Ensembl
rs1474040160	1663	K>Q		No	TOPMed gnomAD
rs1169239313	1664	I>L		No	TOPMed
rs1758771826	1664	I>M		No	TOPMed
rs1758771376	1667	V>M		No	TOPMed
rs1758770970	1668	P>L		No	Ensembl
COSM3860631 COSM3860632 COSM3860633 rs1384933070	1669	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs910852221	1670	K>R		No	Ensembl
rs985719006	1673	S>N		No	gnomAD
rs1326835041	1673	S>R		No	TOPMed
rs1758769358	1673	S>R		No	TOPMed
rs985719006	1673	S>T		No	gnomAD
TCGA novel	1674	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs755781422	1676	A>P		No	ExAC TOPMed gnomAD
rs755781422	1676	A>T		No	ExAC TOPMed gnomAD
rs1312082314	1676	A>V		No	TOPMed
TCGA novel	1678	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3860628 COSM3860630 COSM3860629	1679	S>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1281111784	1680	P>A		No	gnomAD
COSM3393988 COSM3393989 COSM3393987 rs374088011	1680	P>L	pancreas [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs567547421	1682	S>C		No	1000Genomes TOPMed gnomAD
rs567547421	1682	S>F		No	1000Genomes TOPMed gnomAD
rs867394754	1684	S>G		No	gnomAD
rs1441751005	1685	I>F		No	gnomAD
rs753204968	1686	P>L		No	ExAC gnomAD
rs1758766056	1688	K>E		No	Ensembl
rs1437391549	1691	K>R		No	TOPMed gnomAD
rs1437391549	1691	K>T		No	TOPMed gnomAD
rs1273167863	1693	L>P		No	TOPMed gnomAD
rs766660123	1697	G>D		No	ExAC TOPMed gnomAD
rs766660123	1697	G>V		No	ExAC TOPMed gnomAD
rs773284985	1698	S>L		No	ExAC gnomAD
TCGA novel	1698	S>Y	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1286029834	1699	C>R		No	TOPMed gnomAD
rs772099608	1700	S>L		No	ExAC gnomAD
COSM1650574 COSM595297 COSM1144118	1701	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1308784030	1703	D>G		No	TOPMed gnomAD
rs1758762008	1703	D>H		No	TOPMed
rs1758761358	1704	A>T		No	Ensembl
rs774191820	1705	C>R		No	ExAC TOPMed
rs1758760702	1705	C>Y		No	TOPMed
rs1235384224	1706	P>H		No	gnomAD
rs1758760394	1706	P>T		No	Ensembl
TCGA novel	1707	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1378782668	1709	I>M		No	gnomAD
rs1291909729	1710	S>I		No	TOPMed gnomAD
rs1291909729	1710	S>N		No	TOPMed gnomAD
rs749029069	1710	S>R		No	ExAC TOPMed gnomAD
rs1758758538	1714	R>T		No	TOPMed
rs2150281432	1715	G>*		No	Ensembl
rs755699796	1717	C>R		No	ExAC gnomAD
rs1758756946	1718	P>R		No	Ensembl
rs780742333	1722	T>K		No	ExAC TOPMed gnomAD
rs780742333	1722	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1758756045	1723	V>L		No	gnomAD
rs1758755619	1724	E>D		No	gnomAD
rs1758755820	1724	E>K		No	TOPMed gnomAD
TCGA novel	1725	H>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs369011113	1727	T>A		No	ESP ExAC TOPMed gnomAD
rs199705906	1727	T>I		No	ESP ExAC TOPMed gnomAD
rs766863284	1728	N>D		No	ExAC TOPMed gnomAD
rs1758754529	1728	N>T		No	TOPMed
rs1373396594	1729	I>S		No	Ensembl
rs1214430412	1731	E>G		No	TOPMed gnomAD
rs2150281375	1731	E>Q		No	Ensembl
rs1487835075	1732	D>A		No	gnomAD
rs1487835075	1732	D>G		No	gnomAD
rs750676792	1734	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs761844305	1735	F>L		No	ExAC gnomAD
rs1216931794	1736	T>A		No	TOPMed gnomAD
TCGA novel	1736	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs774507101	1737	E>G		No	ExAC TOPMed gnomAD
rs1489030576	1740	G>A		No	TOPMed gnomAD
rs1023461761	1740	G>R		No	TOPMed gnomAD
rs575520875	1741	V>L		No	TOPMed gnomAD
rs575520875	1741	V>M		No	TOPMed gnomAD
rs189438984	1742	S>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1327225774	1742	S>P		No	TOPMed
TCGA novel	1743	E>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1436146284	1746	D>N		No	gnomAD
rs1436146284	1746	D>Y		No	gnomAD
TCGA novel	1747	F>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs200658625	1747	F>Y		No	Ensembl
rs867622242	1749	G>A		No	TOPMed
rs867622242	1749	G>D		No	TOPMed
rs375235800	1749	G>S		No	ESP
rs745533373	1751	T>A		No	ExAC gnomAD
rs371892687	1751	T>I		No	ESP ExAC TOPMed gnomAD
COSM3860623 COSM3860624 COSM3860622	1752	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150281280	1753	S>Y		No	Ensembl
rs2150281275	1754	S>A		No	Ensembl
rs746457444	1756	G>A		No	ExAC gnomAD
rs746457444	1756	G>E		No	ExAC gnomAD
rs200385751	1757	E>D		No	ESP ExAC TOPMed gnomAD
rs777457626	1757	E>G		No	ExAC gnomAD
TCGA novel	1757	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs890421022	1759	S>C		No	TOPMed
rs1189836947	1760	S>I		No	gnomAD
rs1484320249	1762	R>K		No	gnomAD
rs1254500237	1762	R>S		No	gnomAD
rs1209753964	1763	S>R		No	gnomAD
rs374594635	1765	P>A		No	ESP TOPMed
rs201854187	1765	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201854187	1765	P>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs756474302	1767	K>N		No	ExAC gnomAD
rs750632162	1769	G>C		No	ExAC gnomAD
rs750632162	1769	G>S		No	ExAC gnomAD
rs73721713	1770	G>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs764175933	1771	K>N		No	ExAC gnomAD
rs762867292	1772	T>A		No	ExAC gnomAD
rs762867292	1772	T>S		No	ExAC gnomAD
rs1193004215	1773	V>L		No	gnomAD
rs370748706	1775	D>H		No	ESP ExAC TOPMed gnomAD
rs370748706	1775	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1758742043	1775	D>V		No	TOPMed gnomAD
rs1455199739	1776	G>E		No	TOPMed gnomAD
rs1418489603	1776	G>R		No	gnomAD
COSM6106247 COSM6106248 COSM6106246	1778	H>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1758741213	1778	H>R		No	TOPMed
rs1758740791	1779	H>R		No	TOPMed
rs1045600266	1780	P>L		No	TOPMed gnomAD
rs1758740545	1780	P>S		No	TOPMed gnomAD
rs1758740545	1780	P>T		No	TOPMed gnomAD
rs759299890	1781	S>N		No	ExAC gnomAD
rs1318722581	1782	Q>H		No	gnomAD
rs1400367407	1782	Q>R		No	TOPMed
rs770452075	1785	S>F		No	ExAC gnomAD
rs1481110315	1785	S>P		No	TOPMed gnomAD
rs777406906	1787	L>S		No	ExAC gnomAD
rs746679833	1787	L>V		No	ExAC TOPMed gnomAD
rs1303395967	1788	E>*		No	TOPMed gnomAD
rs200447171	1788	E>D		No	ESP ExAC TOPMed gnomAD
rs1320255937	1791	Q>P		No	TOPMed gnomAD
rs1320255937	1791	Q>R		No	TOPMed gnomAD
rs1758736901	1793	I>M		No	gnomAD
rs749780350	1793	I>V		No	ExAC gnomAD
rs1241749514	1795	P>T		No	TOPMed
rs2150281042	1796	E>D		No	Ensembl
rs780755258	1797	A>T		No	ExAC
rs938940904	1797	A>V		No	TOPMed gnomAD
rs1758735631	1798	A>P		No	Ensembl
COSM4925802 COSM4925803	1798	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1445418822	1798	A>V		No	gnomAD
rs202230300	1800	W>*		No	ExAC gnomAD
rs750709636	1800	W>*		No	ExAC gnomAD
rs1758734716	1801	V>F		No	TOPMed
rs1758734716	1801	V>I		No	TOPMed
rs370967470	1802	L>P		No	ESP ExAC TOPMed gnomAD
rs1212497603	1803	C>Y		No	TOPMed gnomAD
COSM3928245 COSM3928244	1805	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic

No associated diseases with Q9H1H9

8 regional properties for Q9H1H9

Type	Name	Position	InterPro Accession
domain	Zinc finger, RING-type	138 - 189	IPR001841-1
domain	Zinc finger, RING-type	299 - 339	IPR001841-2
domain	IBR domain	207 - 269	IPR002867-1
domain	IBR domain	277 - 339	IPR002867-2
domain	TRIAD supradomain	134 - 343	IPR044066
domain	Ariadne domain	352 - 469	IPR045840
domain	E3 ubiquitin-protein ligase ARIH2, BRcat domain	216 - 287	IPR047555
domain	E3 ubiquitin-protein ligase TRIAD1, Rcat domain	291 - 346	IPR047556

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Endosome membrane Golgi apparatus membrane	Recruited to the midbody during cytokinesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
centriole	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
endosome membrane	The lipid bilayer surrounding an endosome.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
kinesin complex	Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
trans-Golgi network membrane	The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity	A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

11 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cytoskeleton-dependent intracellular transport	The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
endosome to lysosome transport	The directed movement of substances from endosomes to lysosomes.
Golgi to plasma membrane protein transport	The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
melanosome organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
microtubule-based movement	A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
plus-end-directed vesicle transport along microtubule	The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.
regulation of cytokinesis	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
spindle assembly	The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
vesicle cargo loading	The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P33176	KIF5B	Kinesin-1 heavy chain	Homo sapiens (Human)	EV
O60282	KIF5C	Kinesin heavy chain isoform 5C	Homo sapiens (Human)	EV
Q12840	KIF5A	Kinesin heavy chain isoform 5A	Homo sapiens (Human)	EV
Q2M1P5	KIF7	Kinesin-like protein KIF7	Homo sapiens (Human)	EV
Q86VH2	KIF27	Kinesin-like protein KIF27	Homo sapiens (Human)	SS
Q7Z4S6	KIF21A	Kinesin-like protein KIF21A	Homo sapiens (Human)	EV
O75037	KIF21B	Kinesin-like protein KIF21B	Homo sapiens (Human)	EV
Q9P2E2	KIF17	Kinesin-like protein KIF17	Homo sapiens (Human)	EV
O00139	KIF2A	Kinesin-like protein KIF2A	Homo sapiens (Human)	PR
Q9NQT8	KIF13B	Kinesin-like protein KIF13B	Homo sapiens (Human)	EV
O43896	KIF1C	Kinesin-like protein KIF1C	Homo sapiens (Human)	SS
Q9EQW7	Kif13a	Kinesin-like protein KIF13A	Mus musculus (Mouse)	SS
Q70AM4	Kif13b	Kinesin 13B	Rattus norvegicus (Rat)	EV

10	20	30	40	50	60
MSDTKVKVAV	RVRPMNRREL	ELNTKCVVEM	EGNQTVLHPP	PSNTKQGERK	PPKVFAFDYC
70	80	90	100	110	120
FWSMDESNTT	KYAGQEVVFK	CLGEGILEKA	FQGYNACIFA	YGQTGSGKSF	SMMGHAEQLG
130	140	150	160	170	180
LIPRLCCALF	KRISLEQNES	QTFKVEVSYM	EIYNEKVRDL	LDPKGSRQSL	KVREHKVLGP
190	200	210	220	230	240
YVDGLSQLAV	TSFEDIESLM	SEGNKSRTVA	ATNMNEESSR	SHAVFNIIIT	QTLYDLQSGN
250	260	270	280	290	300
SGEKVSKVSL	VDLAGSERVS	KTGAAGERLK	EGSNINKSLT	TLGLVISSLA	DQAAGKGKSK
310	320	330	340	350	360
FVPYRDSVLT	WLLKDNLGGN	SQTSMIATIS	PAADNYEETL	STLRYADRAK	RIVNHAVVNE
370	380	390	400	410	420
DPNAKVIREL	REEVEKLREQ	LSQAEAMKAP	ELKEKLEESE	KLIKELTVTW	EEKLRKTEEI
430	440	450	460	470	480
AQERQRQLES	MGISLEMSGI	KVGDDKCYLV	NLNADPALNE	LLVYYLKDHT	RVGADTSQDI
490	500	510	520	530	540
QLFGIGIQPQ	HCEIDIASDG	DVTLTPKENA	RSCVNGTLVC	STTQLWHGDR	ILWGNNHFFR
550	560	570	580	590	600
INLPKRKRRD	WLKDFEKETG	PPEHDLDAAS	EASSEPDYNY	EFAQMEVIMK	TLNSNDPVQN
610	620	630	640	650	660
VVQVLEKQYL	EEKRSALEEQ	RLMYERELEQ	LRQQLSPDRQ	PQSSGPDRLA	YSSQTAQQKV
670	680	690	700	710	720
TQWAEERDEL	FRQSLAKLRE	QLVKANTLVR	EANFLAEEMS	KLTDYQVTLQ	IPAANLSANR
730	740	750	760	770	780
KRGAIVSEPA	IQVRRKGKST	QVWTIEKLEN	KLIDMRDLYQ	EWKEKVPEAK	RLYGKRGDPF
790	800	810	820	830	840
YEAQENHNLI	GVANVFLECL	FCDVKLQYAV	PIISQQGEVA	GRLHVEVMRV	TGAVPERVVE
850	860	870	880	890	900
DDSSENSSES	GSLEVVDSSG	EIIHRVKKLT	CRVKIKEATG	LPLNLSNFVF	CQYTFWDQCE
910	920	930	940	950	960
STVAAPVVDP	EVPSPQSKDA	QYTVTFSHCK	DYVVNVTEEF	LEFISDGALA	IEVWGHRCAG
970	980	990	1000	1010	1020
NGSSIWEVDS	LHAKTRTLHD	RWNEVTRRIE	MWISILELNE	LGEYAAVELH	QAKDVNTGGI
1030	1040	1050	1060	1070	1080
FQLRQGHSRR	VQVTVKPVQH	SGTLPLMVEA	ILSVSIGCVT	ARSTKLQRGL	DSYQRDDEDG
1090	1100	1110	1120	1130	1140
DDMDSYQEED	LNCVRERWSD	ALIKRREYLD	EQIKKVSNKT	EKTEDDVERE	AQLVEQWVGL
1150	1160	1170	1180	1190	1200
TEERNAVLVP	APGSGIPGAP	ADWIPPPGME	THIPVLFLDL	NADDLSANEQ	LVGPHASGVN
1210	1220	1230	1240	1250	1260
SILPKEHGSQ	FFYLPIIKHS	DDEVSATASW	DSSVHDSVHL	NRVTPQNERI	YLIVKTTVQL
1270	1280	1290	1300	1310	1320
SHPAAMELVL	RKRIAANIYN	KQSFTQSLKR	RISLKNIFYS	CGVTYEIVSN	IPKATEEIED
1330	1340	1350	1360	1370	1380
RETLALLAAR	SENEGTSDGE	TYIEKYTRGV	LQVENILSLE	RLRQAVTVKE	ALSTKARHIR
1390	1400	1410	1420	1430	1440
RSLSTPNVHN	VSSSRPDLSG	FDEDDKGWPE	NQLDMSDYSS	SYQDVACYGT	LPRDSPRRNK
1450	1460	1470	1480	1490	1500
EGCTSETPHA	LTVSPFKAFS	PQPPKFFKPL	MPVKEEHKKR	IALEARPLLS	QESMPPPQAH
1510	1520	1530	1540	1550	1560
NPGCIVPSGS	NGSSMPVEHN	SKREKKIDSE	EEENELEAIN	RKLISSQPYV	PVEFADFSVY
1570	1580	1590	1600	1610	1620
NASLENREWF	SSKVDLSNSR	VLEKEVSRSP	TTSSITSGYF	SHSASNATLS	DMVVPSSDSS
1630	1640	1650	1660	1670	1680
DQLAIQTKDA	DSTEHSTPSL	VHDFRPSSNK	ELTEVEKGLV	KDKIIVVPLK	ENSALAKGSP
1690	1700	1710	1720	1730	1740
SSQSIPEKNS	KSLCRTGSCS	ELDACPSKIS	QPARGFCPRE	VTVEHTTNIL	EDHSFTEFMG
1750	1760	1770	1780	1790	1800
VSEGKDFDGL	TDSSAGELSS	RRSLPNKTGG	KTVSDGLHHP	SQLHSKLEND	QVIIPEAAFW

VLCCQ