AiPD: Autoinhibited Protein Database

Q9H074

Gene name	PAIP1
Protein name	Polyadenylate-binding protein-interacting protein 1
Names	PABP-interacting protein 1, PAIP-1, Poly(A)-binding protein-interacting protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10605
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-202 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-202 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for Q9H074

Entry ID	Method	Resolution	Chain	Position	Source
1JH4	NMR	-	B	123-144	PDB
3NTW	X-ray	260 A	B/D	123-144	PDB
3RK6	X-ray	200 A	A/B	157-373	PDB
6YXJ	X-ray	350 A	B	157-375	PDB
AF-Q9H074-F1	Predicted				AlphaFoldDB

336 variants for Q9H074

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA3257581 rs566674929	2	S>A		No	ClinGen 1000Genomes ExAC gnomAD
CA359665834 rs988094289	3	D>E		No	ClinGen TOPMed gnomAD
rs1342768887 CA359665838	3	D>G		No	ClinGen TOPMed
rs1430919939 CA359665828	4	G>C		No	ClinGen TOPMed gnomAD
rs1430919939 CA359665830	4	G>R		No	ClinGen TOPMed gnomAD
CA117932913 rs1028926898	6	D>H		No	ClinGen TOPMed
CA359665806 rs1028926898	6	D>N		No	ClinGen TOPMed
CA359665797 rs74693632	7	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA117932905 rs931505645	8	A>D		No	ClinGen TOPMed
CA117932906 rs1048625328	8	A>T		No	ClinGen TOPMed gnomAD
CA117932904 rs931505645	8	A>V		No	ClinGen TOPMed
CA359665782 rs1162800470	9	P>T		No	ClinGen TOPMed gnomAD
rs1391714812 CA359665755	10	G>S		No	ClinGen gnomAD
rs1186907599 CA359665732	11	A>V		No	ClinGen TOPMed gnomAD
CA359665730 rs1486311166	12	G>S		No	ClinGen gnomAD
rs1376294353 CA359665719	13	R>Q		No	ClinGen TOPMed
CA117932879 rs972838868	15	R>G		No	ClinGen gnomAD
CA117932878 rs970460707	15	R>Q		No	ClinGen TOPMed
CA359665702 rs972838868	15	R>W		No	ClinGen gnomAD
rs1292614689 CA359665695	16	S>C		No	ClinGen gnomAD
rs1456090989 CA359665693	16	S>N		No	ClinGen TOPMed
rs775224454 CA3257577	17	R>P		No	ClinGen ExAC TOPMed gnomAD
CA3257578 rs368538352	17	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769283075 CA117932867	18	G>D		No	ClinGen ExAC gnomAD
rs769283075 CA3257576	18	G>V		No	ClinGen ExAC gnomAD
CA359665675 rs1357390834	19	L>M		No	ClinGen gnomAD
rs895596832 CA117932862	20	G>S		No	ClinGen TOPMed gnomAD
rs1294179842 CA359665657	21	R>C		No	ClinGen gnomAD
rs1365618324 CA359665655	21	R>H		No	ClinGen gnomAD
rs1294179842 CA359665660	21	R>S		No	ClinGen gnomAD
CA3257575 rs747434396	23	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1301994523 CA359665642	23	G>R		No	ClinGen gnomAD
rs1275191945 CA359665624	24	G>V		No	ClinGen TOPMed
CA359665621 rs1372397633	25	G>R		No	ClinGen TOPMed gnomAD
rs1170876904 CA359665607	26	P>L		No	ClinGen TOPMed gnomAD
CA359665613 rs1579933853	26	P>T		No	ClinGen Ensembl
CA117932824 rs905552801	27	E>K		No	ClinGen TOPMed
CA359665589 rs1427749729	28	G>D		No	ClinGen gnomAD
rs1265612116 CA359665595	28	G>S		No	ClinGen TOPMed
rs1184950507 CA359665585	29	G>S		No	ClinGen gnomAD
rs947155577 CA117932808	30	G>S		No	ClinGen TOPMed
CA359665553 rs1410819960	32	P>L		No	ClinGen gnomAD
CA117932806 rs1032703598	32	P>S		No	ClinGen TOPMed gnomAD
CA359665536 rs1390686316	34	G>R		No	ClinGen gnomAD
CA359665526 rs1471914791	35	A>P		No	ClinGen TOPMed
rs1158989982 CA359665520	35	A>V		No	ClinGen TOPMed
rs1489999072 CA359665503	37	P>L		No	ClinGen gnomAD
rs912983908 CA359665497	38	A>P		No	ClinGen TOPMed gnomAD
rs912983908 CA117932803	38	A>S		No	ClinGen TOPMed gnomAD
rs1052815812 CA117932794	39	E>A		No	ClinGen TOPMed gnomAD
CA3257574 rs550677463	40	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1385858763 CA359665468	41	A>V		No	ClinGen TOPMed
rs571448156 CA359665447	43	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3257572 rs748648834	43	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1287709801 CA359665441	44	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA359665433 rs1402636760	44	Q>H		No	ClinGen gnomAD
CA117932758 rs1020794727	45	P>Q		No	ClinGen Ensembl
rs1263734925 CA359665402	47	Q>H		No	ClinGen TOPMed
CA117932747 rs997321863	48	P>L		No	ClinGen gnomAD
CA359665391 rs1210618464	49	K>E		No	ClinGen TOPMed
CA359665376 rs1482245240	50	A>D		No	ClinGen TOPMed
rs1482245240 CA359665373	50	A>V		No	ClinGen TOPMed
CA117932746 rs562875256	51	P>L		No	ClinGen TOPMed gnomAD
CA117932735 rs953738506	52	G>S		No	ClinGen TOPMed gnomAD
CA117932729 rs1019690700	53	F>L		No	ClinGen Ensembl
rs921963831 CA117932728	53	F>L		No	ClinGen TOPMed
CA359665264 rs1579933677	57	P>Q		No	ClinGen Ensembl
CA359665267 rs1160724489	57	P>S		No	ClinGen TOPMed
CA359665251 rs1561241131	58	P>L		No	ClinGen Ensembl
CA359665220 rs1006923335	61	Q>H		No	ClinGen TOPMed gnomAD
rs1457125451 CA359665213	62	P>R		No	ClinGen TOPMed
rs1579933646 CA359665171	66	P>L		No	ClinGen Ensembl
CA359665178 rs1407836314	66	P>T		No	ClinGen TOPMed
CA359665138 rs1450781688	70	A>S		No	ClinGen gnomAD
rs1245815878 CA359665119	72	C>G		No	ClinGen TOPMed
CA359665051 rs1340298906	78	P>L		No	ClinGen TOPMed
CA359665034 rs1177968468	80	R>W		No	ClinGen gnomAD
rs1005340018 COSM3787062 CA117932695	83	R>L	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA359664988 rs1561241070	84	P>L		No	ClinGen Ensembl
CA117932688 rs1035915839	85	G>R		No	ClinGen TOPMed
CA359664947 rs1273877500	87	L>P		No	ClinGen gnomAD
rs755434574	89	E>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1430315681 CA359664923	89	E>K		No	ClinGen gnomAD
CA3257550 rs749422672	90	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA359664622 rs749422672	90	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs562316321 CA117931956	91	T>M		No	ClinGen 1000Genomes ExAC TOPMed
CA3257549 rs562316321	91	T>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed
CA117931944 rs955226708	92	R>K		No	ClinGen TOPMed
rs767785421 CA117931940	93	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1002403168 CA117931927	93	P>L		No	ClinGen TOPMed gnomAD
rs767785421 CA3257546	93	P>S		No	ClinGen ExAC TOPMed gnomAD
rs767785421 CA3257547	93	P>T		No	ClinGen ExAC TOPMed gnomAD
CA3257543 rs764160098	94	L>P		No	ClinGen ExAC gnomAD
rs962431319 CA117931860	95	R>K		No	ClinGen TOPMed gnomAD
rs190101953 CA3257540	97	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA3257539 rs759019019	98	P>T		No	ClinGen ExAC gnomAD
rs776279823 CA3257538	99	S>T		No	ClinGen ExAC gnomAD
CA359664557 rs1579932559	102	D>G		No	ClinGen Ensembl
CA3257535 rs774663961	102	D>N		No	ClinGen ExAC gnomAD
rs548754300 CA117931788	103	K>N		No	ClinGen Ensembl
rs1362547839 CA359664534	105	P>L		No	ClinGen gnomAD
rs1165971006 CA359664532	106	Q>E		No	ClinGen gnomAD
CA3257534 rs769196105	107	Q>E		No	ClinGen ExAC gnomAD
rs1246902869 CA359664522	107	Q>P		No	ClinGen TOPMed
CA3257533 rs748499230	108	N>S		No	ClinGen ExAC TOPMed gnomAD
rs769772392 CA3257531	112	A>T		No	ClinGen ExAC gnomAD
CA359664457 rs1204002761	113	M>T		No	ClinGen gnomAD
rs745905117 CA3257530	114	A>T		No	ClinGen ExAC gnomAD
rs1293344317 CA359664434	115	K>M		No	ClinGen gnomAD
rs781589612 CA3257529	116	P>L		No	ClinGen ExAC gnomAD
CA117931703 rs892183888	117	Q>R		No	ClinGen Ensembl
CA359664409 rs1312630839	118	V>L		No	ClinGen gnomAD
rs1340417445 CA359664400	119	V>L		No	ClinGen TOPMed
rs1328395337 CA359664374	121	A>V		No	ClinGen gnomAD
CA3257525 rs758420058	122	P>L		No	ClinGen ExAC
rs752581221 CA3257524	123	V>I		No	ClinGen ExAC gnomAD
rs765163438 CA3257523	124	L>F		No	ClinGen ExAC gnomAD
TCGA novel	124	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3257522 rs367757021	125	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA117931661 rs944333142	125	M>V		No	ClinGen Ensembl
CA3257521 rs374480379	127	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1365565019 CA359664320	127	K>Q		No	ClinGen gnomAD
CA3257520 rs374480379	127	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1301683689 CA359664308	128	L>P		No	ClinGen gnomAD
rs1460624136 CA359664290	130	V>M		No	ClinGen TOPMed
CA359664268 rs1426398904	132	A>G		No	ClinGen gnomAD
TCGA novel	134	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1490164975 CA359664203	139	G>D		No	ClinGen gnomAD
rs774753530 CA3257518	139	G>S		No	ClinGen ExAC gnomAD
CA359664201 rs1490164975	139	G>V		No	ClinGen gnomAD
rs768894743 CA3257517	141	S>F		No	ClinGen ExAC gnomAD
rs1320421758 CA359664161	142	S>F		No	ClinGen TOPMed gnomAD
rs1372365110 CA359664167	142	S>T		No	ClinGen TOPMed gnomAD
COSM177137 CA359664144 rs1339777441	143	S>R	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA3257515 rs540649575	144	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	144	Y>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3257514 rs370971947	145	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA359664106 rs370971947	145	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA3257492 rs201581258	148	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs201581258 CA359662816	148	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs1462523269 CA359662793	151	G>D		No	ClinGen TOPMed gnomAD
CA3257491 rs772298149	152	C>F		No	ClinGen ExAC gnomAD
rs147428438 CA3257490	154	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA3257489 rs778743590	156	P>S		No	ClinGen ExAC gnomAD
rs1225606316 CA359662755	157	T>A		No	ClinGen gnomAD
rs1346442585 CA359662721	162	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA359662712 rs1236996091	163	Q>R		No	ClinGen gnomAD
rs754923991 CA3257488	164	D>N		No	ClinGen ExAC gnomAD
CA359662687 rs1402790064	166	L>F		No	ClinGen TOPMed
rs1302070069 CA359662685	167	N>D		No	ClinGen TOPMed
CA117924122 rs1025162380	167	N>K		No	ClinGen TOPMed
rs779896134 CA3257486	172	Q>K		No	ClinGen ExAC gnomAD
rs989975853 CA117924098	174	G>A		No	ClinGen Ensembl
rs989975853 CA359662635	174	G>D		No	ClinGen Ensembl
CA3257485 rs755638110	179	E>A		No	ClinGen ExAC gnomAD
CA359662562 rs1319709352	184	A>T		No	ClinGen gnomAD
rs1400821137 CA359662552	184	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3257484 rs749889316	189	G>S		No	ClinGen ExAC gnomAD
rs756906120 CA3257482	191	V>L		No	ClinGen ExAC gnomAD
CA359662391 rs1319938159	198	Q>E		No	ClinGen TOPMed
rs1447607766 CA359662361	200	L>F		No	ClinGen gnomAD
rs1285442912 CA359662350	201	V>G		No	ClinGen TOPMed gnomAD
rs765621661 CA3257480	202	E>D		No	ClinGen ExAC gnomAD
rs1269814753 CA359662328	203	L>R		No	ClinGen TOPMed
rs760188858 CA117924027	204	I>M		No	ClinGen ExAC gnomAD
CA117924031 rs1000281930	204	I>S		No	ClinGen TOPMed
rs955157098 CA117924041	204	I>V		No	ClinGen Ensembl
CA3257478 rs776583259	205	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA359662301 rs776583259	205	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA359662310 rs1180522936	205	Y>H		No	ClinGen TOPMed
CA3257456 rs749328612	208	A>T		No	ClinGen ExAC TOPMed gnomAD
rs950869337 CA117919942	209	T>I		No	ClinGen TOPMed
rs1004196277 CA117919925	210	S>F		No	ClinGen Ensembl
rs761729968 CA3257454	210	S>T		No	ClinGen ExAC gnomAD
CA3257453 rs774643854	211	I>V		No	ClinGen ExAC TOPMed gnomAD
CA3257452 rs768820165	212	P>R		No	ClinGen ExAC gnomAD
rs775238326 CA3257450	213	N>D		No	ClinGen ExAC gnomAD
rs1224989549 CA359660877	214	F>V		No	ClinGen gnomAD
rs200898020 CA3257447	217	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA359660816 rs1299999029	217	M>T		No	ClinGen TOPMed gnomAD
rs1561233981 CA359660722	223	N>D		No	ClinGen Ensembl
CA359660718 rs1217351323	223	N>S		No	ClinGen gnomAD
TCGA novel	223	N>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3257445 rs770481346	227	H>Q		No	ClinGen ExAC gnomAD
TCGA novel	228	H>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA359660633 rs1579919162	228	H>N		No	ClinGen Ensembl
rs777598536 CA3257443	230	T>A		No	ClinGen ExAC TOPMed gnomAD
rs140990754 CA3257442	231	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359660550 rs1429994280	233	P>A		No	ClinGen TOPMed gnomAD
rs1429994280 CA359660552	233	P>T		No	ClinGen TOPMed gnomAD
rs1175467418 CA359660532	234	Q>H		No	ClinGen TOPMed gnomAD
rs780551266 CA3257440	235	S>N		No	ClinGen ExAC gnomAD
rs767850266 CA3257438	237	N>I		No	ClinGen ExAC TOPMed gnomAD
rs767850266 CA3257437	237	N>S		No	ClinGen ExAC TOPMed gnomAD
rs767850266 CA3257439	237	N>T		No	ClinGen ExAC TOPMed gnomAD
CA3257436 rs17851362	239	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs751556168 CA3257435	239	R>H		No	ClinGen ExAC TOPMed gnomAD
CA117919844 rs751556168	239	R>L		No	ClinGen ExAC TOPMed gnomAD
CA359660497 rs1461503885	240	Q>L		No	ClinGen gnomAD
rs1294792325 CA359660491	241	L>S		No	ClinGen gnomAD
CA359660480 rs1307673341	243	L>F		No	ClinGen TOPMed gnomAD
CA359659717 rs752921741	247	R>G		No	ClinGen ExAC TOPMed gnomAD
rs199828948 CA3257413	247	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3257414 rs752921741	247	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA558865324 rs1364087769	249	E>*		No	ClinGen gnomAD
CA359659688 rs759399679	249	E>D		No	ClinGen ExAC gnomAD
TCGA novel	258	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3257411 rs377594386	258	K>R		No	ClinGen ESP ExAC gnomAD
rs1359264575 CA359659567	259	G>E		No	ClinGen TOPMed gnomAD
CA359659558 rs1165832398	260	D>V		No	ClinGen gnomAD
CA3257409 rs760516043	264	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs922298642 CA117915753	264	R>Q		No	ClinGen TOPMed gnomAD
rs377433433 CA359659499	266	R>P		No	ClinGen ESP ExAC gnomAD
rs377433433 CA3257408	266	R>Q		No	ClinGen ESP ExAC gnomAD
CA3257407 rs771708331	268	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA359659417 rs1265011095	274	L>V		No	ClinGen TOPMed
rs746287460 CA3257403	275	G>R		No	ClinGen ExAC gnomAD
CA3257402 rs781392602	278	Y>C		No	ClinGen ExAC gnomAD
rs1263461989 CA359659376	278	Y>H		No	ClinGen gnomAD
TCGA novel	279	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1309548016 CA359659349	280	N>I		No	ClinGen gnomAD
CA359659344 rs1278918018	280	N>K		No	ClinGen gnomAD
rs1579911948 CA359658845	284	K>R		No	ClinGen Ensembl
CA359658775 rs1375901890	289	Q>R		No	ClinGen gnomAD
rs751142862 CA3257367	298	V>D		No	ClinGen ExAC TOPMed gnomAD
rs375053699 CA3257368	298	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs751142862 CA359658661	298	V>G		No	ClinGen ExAC TOPMed gnomAD
CA359658667 rs375053699	298	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs763511432 CA3257366	299	G>A		No	ClinGen ExAC gnomAD
rs1344884861 CA359658634	301	R>*		No	ClinGen gnomAD
rs140543083 COSM738709 CA3257365	301	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA117913899 rs923942364	305	N>S		No	ClinGen TOPMed gnomAD
rs1378024442 CA359658528	309	S>C		No	ClinGen gnomAD
CA3257364 rs775020225	311	P>A		No	ClinGen ExAC gnomAD
rs1444109582 CA359658501	312	M>V		No	ClinGen gnomAD
CA359658468 rs1305944324	314	D>N		No	ClinGen TOPMed
rs1334215477 CA359658406	318	C>S		No	ClinGen gnomAD
rs1413463127 CA359658393	319	A>S		No	ClinGen gnomAD
CA359658383 rs1160188699	320	V>I		No	ClinGen gnomAD
rs1440237382 CA359658350 CA359658352	322	L>F		No	ClinGen TOPMed gnomAD
rs1197045775 CA359658149	327	G>E		No	ClinGen Ensembl
rs1193617875 CA359658140	328	S>L		No	ClinGen gnomAD
rs375297911 CA3257332	331	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	332	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1398257099 CA359658093	333	A>T		No	ClinGen TOPMed
rs559313668 CA3257331	336	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs969485953 CA117912719	340	M>T		No	ClinGen gnomAD
CA359658006 rs1400125520	340	M>V		No	ClinGen gnomAD
CA359657994 rs1296216167	341	D>H		No	ClinGen TOPMed gnomAD
CA3257330 rs775615322	342	M>L		No	ClinGen ExAC gnomAD
CA117912707 rs1023419694	347	Q>R		No	ClinGen Ensembl
rs770201798 CA3257329	348	R>K		No	ClinGen ExAC gnomAD
rs746087575 CA3257328	349	I>V		No	ClinGen ExAC gnomAD
rs143500985 CA3257326	352	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	353	V>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1423042327 CA359657807	356	A>T		No	ClinGen gnomAD
CA3257323 rs758327466	358	C>G		No	ClinGen ExAC gnomAD
rs752205210 CA3257322	360	R>K		No	ClinGen ExAC gnomAD
rs1579909644 CA359657702	361	D>G		No	ClinGen Ensembl
rs1274165130 CA359657708	361	D>Y		No	ClinGen TOPMed
CA117912154 rs922377691	362	V>I		No	ClinGen TOPMed gnomAD
CA117912083 rs866284057	370	V>I		No	ClinGen Ensembl
rs1240450190 CA359657594	371	E>Q		No	ClinGen gnomAD
rs777604242 CA3257306	372	L>I		No	ClinGen ExAC gnomAD
rs748118672 CA117912070	373	R>L		No	ClinGen ExAC TOPMed gnomAD
rs748118672 CA3257304	373	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3257305 rs537292836	373	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1211668780 CA359657528	377	W>C		No	ClinGen gnomAD
CA359657520 rs1312678357	378	G>D		No	ClinGen gnomAD
rs963790802 CA117912068	379	R>K		No	ClinGen TOPMed
CA3257302 rs754502613	380	V>F		No	ClinGen ExAC TOPMed gnomAD
CA359657506 rs754502613	380	V>I		No	ClinGen ExAC TOPMed gnomAD
rs762696122 CA117912026	381	H>N		No	ClinGen Ensembl
rs1447773425 CA359657486	381	H>Q		No	ClinGen gnomAD
CA117912008 rs199834392	381	H>R		No	ClinGen gnomAD
rs540684238 CA117911977	382	A>S		No	ClinGen TOPMed gnomAD
rs540684238 CA359657483	382	A>T		No	ClinGen TOPMed gnomAD
rs766058654 CA3257300	382	A>V		No	ClinGen ExAC gnomAD
CA359657461 rs1467694235	384	S>A		No	ClinGen gnomAD
rs755767615 CA3257299	384	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs763161379 CA3257298	385	T>A		No	ClinGen ExAC TOPMed gnomAD
rs763161379 CA3257297	385	T>P		No	ClinGen ExAC TOPMed gnomAD
CA3257296 rs763161379	385	T>S		No	ClinGen ExAC TOPMed gnomAD
rs571425260 CA359657429	386	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA359657434 rs776154087	386	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA3257295 rs776154087	386	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1179727783 CA359657427	387	R>G		No	ClinGen gnomAD
rs1441796314 CA359657360	394	D>G		No	ClinGen gnomAD
rs771110275 CA3257291	399	M>L		No	ClinGen ExAC gnomAD
rs765888476 CA3257276	402	P>A		No	ClinGen ExAC gnomAD
rs754032069 CA3257274	406	T>I		No	ClinGen ExAC
CA359657212 rs1179671189	407	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs113833560 CA117910947	410	V>A		No	ClinGen TOPMed
rs766481788 CA3257273	411	P>L		No	ClinGen ExAC gnomAD
CA359657179 rs1423001735	411	P>S		No	ClinGen TOPMed
CA3257272 rs760610345	415	A>G		No	ClinGen ExAC gnomAD
CA3257271 rs773501499	417	P>R		No	ClinGen ExAC gnomAD
rs1215838940 CA359657140	417	P>S		No	ClinGen gnomAD
CA359657095 rs1265034344	418	D>E		No	ClinGen gnomAD
rs1320007326 CA359657091	419	Y>C		No	ClinGen TOPMed gnomAD
CA3257254 rs779410324	419	Y>H		No	ClinGen ExAC gnomAD
CA3257252 rs754406394	425	E>A		No	ClinGen ExAC gnomAD
rs930144885 CA359657004	431	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs930144885 CA117903342	431	D>N		No	ClinGen TOPMed
rs1390498170 CA359656973	435	D>Y		No	ClinGen TOPMed gnomAD
TCGA novel	436	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3257251 rs547385153	436	Y>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3257250 rs760835280	436	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA359656966 rs547385153	436	Y>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	437	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA117903289 rs961095978	437	E>K		No	ClinGen Ensembl
rs1169413260 CA359656943	439	N>S		No	ClinGen gnomAD
CA359656905 rs1379342059	445	G>R		No	ClinGen TOPMed gnomAD
CA359656898 rs1279113828	446	A>P		No	ClinGen gnomAD
CA3257247 rs762007079	447	G>S		No	ClinGen ExAC gnomAD
rs149920694 CA3257246	449	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA3257243 rs775521136	449	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3257244 rs775521136	449	P>R		No	ClinGen ExAC TOPMed gnomAD
rs149920694 CA3257245	449	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs149920694 CA359656880	449	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs757259103 CA3257225	450	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA359656575 rs1353945897	451	L>F		No	ClinGen gnomAD
CA359656558 rs1308026266	453	D>N		No	ClinGen TOPMed gnomAD
CA3257224 rs751795197	454	I>T		No	ClinGen ExAC TOPMed gnomAD
CA359656502 rs1342262762	456	D>E		No	ClinGen TOPMed
rs764253665 CA3257223	458	M>I		No	ClinGen ExAC gnomAD
rs573216023 CA3257221	468	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1373596830 CA359656371	468	K>T		No	ClinGen gnomAD
TCGA novel	471	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1158147214 CA359656318	473	S>L		No	ClinGen gnomAD
rs919475254 CA117901155	473	S>P		No	ClinGen Ensembl
rs759381679 COSM1068436 CA3257219	475	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs202074856 CA3257218	475	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3257217 rs201359614	477	R>*		No	ClinGen ExAC TOPMed gnomAD
CA3257216 rs200129628	477	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA359656257 rs1219473715	479	Q>R		No	ClinGen gnomAD

No associated diseases with Q9H074

13 regional properties for Q9H074

Type	Name	Position	InterPro Accession
domain	B-box-type zinc finger	92 - 133	IPR000315
domain	Zinc finger, RING-type	16 - 57	IPR001841
domain	B30.2/SPRY domain	276 - 468	IPR001870
domain	SPRY domain	346 - 465	IPR003877
domain	Butyrophylin-like, SPRY domain	292 - 309	IPR003879-1
domain	Butyrophylin-like, SPRY domain	309 - 326	IPR003879-2
domain	Butyrophylin-like, SPRY domain	331 - 355	IPR003879-3
domain	Butyrophylin-like, SPRY domain	361 - 374	IPR003879-4
domain	Butyrophylin-like, SPRY domain	404 - 428	IPR003879-5
domain	Butyrophylin-like, SPRY domain	434 - 452	IPR003879-6
domain	SPRY-associated	293 - 345	IPR006574
conserved_site	Zinc finger, RING-type, conserved site	31 - 40	IPR017907
domain	TRIM75, PRY/SPRY domain	276 - 462	IPR035785

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mCRD-mediated mRNA stability complex	A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP.

2 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.
translation activator activity	Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.

7 GO annotations of biological process

Name	Definition
CRD-mediated mRNA stabilization	An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
mRNA stabilization	Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
positive regulation by host of viral process	A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected.
positive regulation of cytoplasmic translation	Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
regulation of translational initiation	Any process that modulates the frequency, rate or extent of translational initiation.
translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q95L46	EIF4G2	Eukaryotic translation initiation factor 4 gamma 2	Bos taurus (Bovine)	PR
O43432	EIF4G3	Eukaryotic translation initiation factor 4 gamma 3	Homo sapiens (Human)	EV
Q04637	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1	Homo sapiens (Human)	EV
P78344	EIF4G2	Eukaryotic translation initiation factor 4 gamma 2	Homo sapiens (Human)	PR
Q6NZJ6	Eif4g1	Eukaryotic translation initiation factor 4 gamma 1	Mus musculus (Mouse)	SS
Q80XI3	Eif4g3	Eukaryotic translation initiation factor 4 gamma 3	Mus musculus (Mouse)	SS
Q62448	Eif4g2	Eukaryotic translation initiation factor 4 gamma 2	Mus musculus (Mouse)	PR
Q8VE62	Paip1	Polyadenylate-binding protein-interacting protein 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSDGFDRAPG	AGRGRSRGLG	RGGGGPEGGG	FPNGAGPAER	ARHQPPQPKA	PGFLQPPPLR
70	80	90	100	110	120
QPRTTPPPGA	QCEVPASPQR	PSRPGALPEQ	TRPLRAPPSS	QDKIPQQNSE	SAMAKPQVVV
130	140	150	160	170	180
APVLMSKLSV	NAPEFYPSGY	SSSYTESYED	GCEDYPTLSE	YVQDFLNHLT	EQPGSFETEI
190	200	210	220	230	240
EQFAETLNGC	VTTDDALQEL	VELIYQQATS	IPNFSYMGAR	LCNYLSHHLT	ISPQSGNFRQ
250	260	270	280	290	300
LLLQRCRTEY	EVKDQAAKGD	EVTRKRFHAF	VLFLGELYLN	LEIKGTNGQV	TRADILQVGL
310	320	330	340	350	360
RELLNALFSN	PMDDNLICAV	KLLKLTGSVL	EDAWKEKGKM	DMEEIIQRIE	NVVLDANCSR
370	380	390	400	410	420
DVKQMLLKLV	ELRSSNWGRV	HATSTYREAT	PENDPNYFMN	EPTFYTSDGV	PFTAADPDYQ
430	440	450	460	470
EKYQELLERE	DFFPDYEENG	TDLSGAGDPY	LDDIDDEMDP	EIEEAYEKFC	LESERKRKQ