Q9GLW0

SS
Gene name
PGR (NR3C3)
Protein name
Progesterone receptor
Names
PR , Nuclear receptor subfamily 3 group C member 3
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:403621
EC number
Protein Class

Descriptions

Human progesterone receptor A (PR-A) and B (PR-B) isoforms are members of the nuclear receptor family of ligand-activated transcription factors. The two PR proteins are identical except that PR-B contains an additional 164 N-terminal amino acids in the B upstream segment (BUS). <br>In PR-B, the deletion of the autoinhibitory region increases the transcriptional activity. In PR-A, deletion of the same region also increases its transcriptional activity. The autoinhibitory region contains a SUMO-1 binding motif (IKEE) and mutation within the motif leads to loss of autoinhibitory function.

Autoinhibitory domains (AIDs)

379-401 (Autoinhibitory region) SS

Target domain

693-939 (hormone binding domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9GLW0

Entry ID Method Resolution Chain Position Source
AF-Q9GLW0-F1 Predicted AlphaFoldDB

No variants for Q9GLW0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9GLW0

No associated diseases with Q9GLW0

2 regional properties for Q9GLW0

Type Name Position InterPro Accession
domain Nuclear hormone receptor, ligand-binding domain 685 - 919 IPR000536
domain Zinc finger, nuclear hormone receptor-type 570 - 645 IPR001628

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Nucleoplasmic shuttling is both hormone- and cell cycle-dependent
  • On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
estrogen response element binding Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen.
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
nuclear steroid receptor activity Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
steroid binding Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
intracellular steroid hormone receptor signaling pathway The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A7X8B3 PGR Progesterone receptor Pan troglodytes (Chimpanzee) SS
P06401 PGR Progesterone receptor Homo sapiens (Human) EV
Q00175 Pgr Progesterone receptor Mus musculus (Mouse) SS
Q63449 Pgr Progesterone receptor Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MTERTGKDAR APHVAGGAPS PAPAAEPESR RRDGGRLRAS QTSDAPRVAA AAAAAAAAAS
70 80 90 100 110 120
AAPSAPSDRL LFSRRGQGAD PGGKAQDAQP RPDVARADPR LEAASGAGAD SPGPPRQDRG
130 140 150 160 170 180
PLHGAPSTAL RPAGPGQGRS SPAWEPRSPR CPSGPEPPED PRGARSSQGA ACPLMSRPEG
190 200 210 220 230 240
KAGDGCGTAG AHKGPPRGLS PSRQPLPLCP GAHAWPGAAG KAATQPAALG VEDEGGFAAE
250 260 270 280 290 300
GSPGPLLKGK PRPPAGPAAA AGAAPAAPGT APGGTAPVPK EDSRLPAPKG SLAEQDAPAP
310 320 330 340 350 360
GCSPLATTMM DFIHVPILPL GSAFLAARTR QLLEAETYDA GAFAPPRGSP SAPCAPLAAG
370 380 390 400 410 420
DFPDCAYPSD AEPKDDAFPL YGDFQPPALK IKEEEEGAEA AARSPRPYLA AGPHSCVFAD
430 440 450 460 470 480
APPALPALPP LPPRAPSSRP GEGAPAAAAA AGCSASSASS PGPALECVLY KAEGAPPPQG
490 500 510 520 530 540
PFAAAPCRVP GAGACLLPRD GAAAAASAGA AGASPALYQP LGLGALPQLG YQAAVLKEGL
550 560 570 580 590 600
PQVYQPYLNY LRPDSDASQS PQYSFESLPQ KICLICGDEA SGCHYGVLTC GSCKVFFKRA
610 620 630 640 650 660
MEGQHNYLCA GRNDCIVDKI RRKNCPACRL RKCCQAGMVL GGRKFKKFNK VRVMRTLDAV
670 680 690 700 710 720
ALPQPVGIPN ESQALSQRIS FSPSQDIQLI PPLINLLMSI EPDVIYAGHD NTKPDTSSSL
730 740 750 760 770 780
LTSLNQLGER QLLSVVKWSK SLPGFRNLHI DDQITLIQYS WMSLMVFGLG WRSYKHVSGQ
790 800 810 820 830 840
MLYFAPDLIL NEQRMKESSF YSLCLTMWQI PQEFVKLQVS QEEFLCMKVL LLLNTIPLEG
850 860 870 880 890 900
LRSQNQFEEM RSSYIRELIK AIGLRQKGVV SSSQRFYQLT KLLDNLHDLV KQLHLYCLNT
910 920 930
FIQSRALSVE FPEMMSEVIA AQLPKILAGM VKPLLFHKK