Q9FXF2

PR
Gene name
RKF1 (At1g29750, F1N18.19, T3M22.1)
Protein name
Probable LRR receptor-like serine/threonine-protein kinase RFK1
Names
Receptor-like kinase in flowers 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G29750
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

625-696 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

824-848 (Activation loop from InterPro)

Target domain

681-956 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9FXF2

Entry ID Method Resolution Chain Position Source
AF-Q9FXF2-F1 Predicted AlphaFoldDB

90 variants for Q9FXF2

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_10420456_T_A 5 Y>F No 1000Genomes
ENSVATH04668040 19 L>F No 1000Genomes
ENSVATH04668039 20 N>H No 1000Genomes
ENSVATH04668038 20 N>I No 1000Genomes
ENSVATH04668037 24 F>L No 1000Genomes
tmp_1_10420382_T_A 30 I>F No 1000Genomes
tmp_1_10420370_A_C 34 F>V No 1000Genomes
tmp_1_10419678_A_G 61 F>L No 1000Genomes
tmp_1_10419667_G_A,C 64 F>L No 1000Genomes
ENSVATH01125099 79 T>A No 1000Genomes
ENSVATH01125098 79 T>I No 1000Genomes
tmp_1_10419287_G_C 126 R>G No 1000Genomes
ENSVATH12316778 142 E>D No 1000Genomes
tmp_1_10419025_G_A 157 R>W No 1000Genomes
ENSVATH12316776 163 P>L No 1000Genomes
ENSVATH00050411 180 A>G No 1000Genomes
ENSVATH04668004 181 F>L No 1000Genomes
tmp_1_10418644_G_A 184 T>I No 1000Genomes
ENSVATH12316531 199 L>M No 1000Genomes
ENSVATH04667998 220 T>I No 1000Genomes
ENSVATH00050409 232 T>R No 1000Genomes
ENSVATH04667996 236 Y>C No 1000Genomes
ENSVATH14000392 244 E>K No 1000Genomes
ENSVATH04667993 248 M>I No 1000Genomes
ENSVATH04667991 260 V>F No 1000Genomes
ENSVATH12316530 263 V>A No 1000Genomes
tmp_1_10417940_C_T 290 G>S No 1000Genomes
tmp_1_10417824_T_C 300 N>S No 1000Genomes
ENSVATH12316527 307 T>I No 1000Genomes
ENSVATH04667981 333 A>V No 1000Genomes
tmp_1_10417414_A_T 351 D>E No 1000Genomes
tmp_1_10417206_C_A 381 R>L No 1000Genomes
tmp_1_10417200_T_A 383 N>I No 1000Genomes
ENSVATH12316453 398 K>I No 1000Genomes
ENSVATH12316452 398 K>N No 1000Genomes
tmp_1_10416885_T_G 401 K>Q No 1000Genomes
tmp_1_10416849_G_A 413 R>* No 1000Genomes
tmp_1_10416581_T_G 419 H>P No 1000Genomes
ENSVATH04667964 425 S>N No 1000Genomes
ENSVATH04667963 429 V>I No 1000Genomes
tmp_1_10416471_C_T 456 D>N No 1000Genomes
tmp_1_10416468_C_T 457 A>T No 1000Genomes
tmp_1_10416435_T_C 468 M>V No 1000Genomes
tmp_1_10416393_C_G 482 V>L No 1000Genomes
ENSVATH04667959 518 D>N No 1000Genomes
tmp_1_10416278_G_T 520 A>D No 1000Genomes
ENSVATH00050390 526 N>Y No 1000Genomes
ENSVATH00050389 531 N>D No 1000Genomes
ENSVATH04667955 561 Q>H No 1000Genomes
ENSVATH04667954 563 P>S No 1000Genomes
ENSVATH12316221 564 I>T No 1000Genomes
ENSVATH00050386 568 L>F No 1000Genomes
tmp_1_10415939_C_A 607 V>F No 1000Genomes
tmp_1_10415795_G_A 616 P>L No 1000Genomes
ENSVATH00050382 626 I>V No 1000Genomes
ENSVATH04667949 654 R>Q No 1000Genomes
ENSVATH14000388 655 Q>H No 1000Genomes
ENSVATH00050381 655 Q>R No 1000Genomes
tmp_1_10415675_C_T 656 R>Q No 1000Genomes
ENSVATH12316215 668 T>I No 1000Genomes
tmp_1_10415490_T_A 673 Q>H No 1000Genomes
tmp_1_10415472_A_T 679 D>E No 1000Genomes
ENSVATH00050379 684 T>A No 1000Genomes
ENSVATH00050378 685 N>K No 1000Genomes
tmp_1_10415319_G_T 701 A>E No 1000Genomes
ENSVATH01125040 710 Q>K No 1000Genomes
ENSVATH04667943 745 V>I No 1000Genomes
tmp_1_10415181_C_T 747 R>Q No 1000Genomes
ENSVATH00050376 753 A>V No 1000Genomes
ENSVATH14000387 755 E>K No 1000Genomes
ENSVATH14000386 763 S>C No 1000Genomes
ENSVATH04667938 776 M>V No 1000Genomes
ENSVATH00050374 782 F>Y No 1000Genomes
ENSVATH04667937 793 A>T No 1000Genomes
ENSVATH12316040 878 A>T No 1000Genomes
ENSVATH14904681 881 T>P No 1000Genomes
tmp_1_10414561_A_T 891 S>T No 1000Genomes
ENSVATH04667927 907 L>S No 1000Genomes
ENSVATH04667925 926 A>E No 1000Genomes
tmp_1_10414328_C_T 937 A>T No 1000Genomes
tmp_1_10414324_G_C 938 S>C No 1000Genomes
ENSVATH00050370 940 T>I No 1000Genomes
ENSVATH04667924 944 L>I No 1000Genomes
ENSVATH12316039 954 G>D No 1000Genomes
ENSVATH04667923 963 P>A No 1000Genomes
tmp_1_10414222_A_C 972 I>R No 1000Genomes
tmp_1_10414212_C_A 975 K>N No 1000Genomes
ENSVATH12316037 983 G>C No 1000Genomes
ENSVATH04667922 1015 K>N No 1000Genomes
tmp_1_10414087_T_G 1017 E>A No 1000Genomes

No associated diseases with Q9FXF2

5 regional properties for Q9FXF2

Type Name Position InterPro Accession
domain Protein kinase domain 681 - 956 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 684 - 952 IPR001245
active_site Serine/threonine-protein kinase, active site 803 - 815 IPR008271
binding_site Protein kinase, ATP binding site 687 - 709 IPR017441
domain Malectin domain 417 - 604 IPR021720

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

33 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
Q07407 htl Fibroblast growth factor receptor homolog 1 Drosophila melanogaster (Fruit fly) PR
P54756 EPHA5 Ephrin type-A receptor 5 Homo sapiens (Human) SS
P54764 EPHA4 Ephrin type-A receptor 4 Homo sapiens (Human) SS
P29322 EPHA8 Ephrin type-A receptor 8 Homo sapiens (Human) SS
P29320 EPHA3 Ephrin type-A receptor 3 Homo sapiens (Human) PR
Q15375 EPHA7 Ephrin type-A receptor 7 Homo sapiens (Human) SS
Q9UF33 EPHA6 Ephrin type-A receptor 6 Homo sapiens (Human) SS
P29323 EPHB2 Ephrin type-B receptor 2 Homo sapiens (Human) EV
P54762 EPHB1 Ephrin type-B receptor 1 Homo sapiens (Human) SS
P54753 EPHB3 Ephrin type-B receptor 3 Homo sapiens (Human) SS
P29317 EPHA2 Ephrin type-A receptor 2 Homo sapiens (Human) SS
P54760 EPHB4 Ephrin type-B receptor 4 Homo sapiens (Human) SS
Q5JZY3 EPHA10 Ephrin type-A receptor 10 Homo sapiens (Human) SS
P21709 EPHA1 Ephrin type-A receptor 1 Homo sapiens (Human) SS
O15197 EPHB6 Ephrin type-B receptor 6 Homo sapiens (Human) SS
Q02763 TEK Angiopoietin-1 receptor Homo sapiens (Human) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MISLYQILAE KKKKKKNDLN IFAFSVFAII CFKFYSVNAI KLPQQEVDAL QQIATTLGSK
70 80 90 100 110 120
FWKFDAENCK IEMVGLTETP PPTAKQEIEC ECSPTNDTDC HVVKFAFKDH NLPGTLPQIV
130 140 150 160 170 180
KLPYLREIDL AYNYINGTLP REWASSNLTF ISLLVNRLSG EIPKEFGNSS LTYLDLESNA
190 200 210 220 230 240
FSGTIPQELG NLVHLKKLLL SSNKLTGTLP ASLARLQNMT DFRINDLQLS GTIPSYIQNW
250 260 270 280 290 300
KQLERLEMIA SGLTGPIPSV ISVLSNLVNL RISDIRGPVQ PFPSLKNVTG LTKIILKNCN
310 320 330 340 350 360
ISGQIPTYLS HLKELETLDL SFNKLVGGIP SFAQAENLRF IILAGNMLEG DAPDELLRDG
370 380 390 400 410 420
ITVDLSYNNL KWQSPESRAC RPNMNLNLNL FQSTSTKKSS KFLPCIKDFK CPRYSSCLHV
430 440 450 460 470 480
NCGGSDMYVK EKKTKELYEG DGNVEGGAAK YFLKPDANWG FSSTGDFMDD NNFQNTRFTM
490 500 510 520 530 540
FVPASNQSDL YKSARIAPVS LTYFHACLEN GNYTINLDFA EIRFTNDENY NRLGRRLFDI
550 560 570 580 590 600
YIQEKLVAKD FNIMDEAKGA QTPIIKPLTA YVTNHFLTIR LSWAGKGTTR IPTRGVYGPI
610 620 630 640 650 660
ISAISIVSDS KPCERPKTGM SPGAYIAIGI GAPCLIIFIL GFLWICGCLP RCGRQRKDPY
670 680 690 700 710 720
EEELPSGTFT LRQIKFATDD FNPTNKIGEG GFGAVFKGVL ADGRVVAVKQ LSSKSRQGNR
730 740 750 760 770 780
EFLNEIGAIS CLQHPNLVKL HGFCVERAQL LLAYEYMENN SLSSALFSPK HKQIPMDWPT
790 800 810 820 830 840
RFKICCGIAK GLAFLHEESP LKFVHRDIKA TNILLDKDLT PKISDFGLAR LDEEEKTHIS
850 860 870 880 890 900
TKVAGTIGYM APEYALWGYL TFKADVYSFG VLVLEIVAGI TNSNFMGAGD SVCLLEFANE
910 920 930 940 950 960
CVESGHLMQV VDERLRPEVD RKEAEAVIKV ALVCSSASPT DRPLMSEVVA MLEGLYPVPE
970 980 990 1000 1010 1020
STPGVSRNAG DIRFKAFKDL RRGMENNSKT QCSVKSYPSS SSTSSGAGQA VQERKKEESR
P