Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9FX60

Entry ID Method Resolution Chain Position Source
AF-Q9FX60-F1 Predicted AlphaFoldDB

24 variants for Q9FX60

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04570371 2 A>V No 1000Genomes
ENSVATH00021695 7 S>T No 1000Genomes
ENSVATH13890674 10 K>Q No 1000Genomes
ENSVATH04570370 12 H>Q No 1000Genomes
tmp_1_4588473_G_A 17 P>L No 1000Genomes
tmp_1_4588432_G_A 31 P>S No 1000Genomes
tmp_1_4588417_C_T 36 V>I No 1000Genomes
ENSVATH11141474 41 R>H No 1000Genomes
ENSVATH04570368 43 R>C No 1000Genomes
tmp_1_4588389_C_T 45 G>E No 1000Genomes
ENSVATH04570366 64 R>H No 1000Genomes
ENSVATH00021694 67 P>R No 1000Genomes
tmp_1_4588219_T_C,G 75 I>L No 1000Genomes
tmp_1_4588219_T_C,G 75 I>V No 1000Genomes
ENSVATH11141473 79 F>S No 1000Genomes
ENSVATH04570365 80 K>E No 1000Genomes
tmp_1_4588069_C_T 90 V>M No 1000Genomes
ENSVATH04570363 97 A>G No 1000Genomes
ENSVATH11141471 105 F>S No 1000Genomes
ENSVATH11141470 110 L>F No 1000Genomes
tmp_1_4587997_G_T 114 H>N No 1000Genomes
ENSVATH04570362 117 R>K No 1000Genomes
ENSVATH01046629 121 M>V No 1000Genomes
ENSVATH01046628 123 K>N No 1000Genomes

No associated diseases with Q9FX60

1 regional properties for Q9FX60

Type Name Position InterPro Accession
domain Histone H2A/H2B/H3 1 - 132 IPR007125

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
structural constituent of chromatin The action of a molecule that contributes to the structural integrity of chromatin.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P68428 Histone H3.2 Triticum aestivum (Wheat) PR
P68432 Histone H3.1 Bos taurus (Bovine) PR
P84227 Histone H3.2 Bos taurus (Bovine) PR
Q5E9F8 H3-3B Histone H3.3 Bos taurus (Bovine) PR
P84229 H3-VIII Histone H3.2 Gallus gallus (Chicken) PR
P84247 H3-X Histone H3.3 Gallus gallus (Chicken) PR
P02299 His3 Histone H3 Drosophila melanogaster (Fruit fly) PR
Q71H73 Histone H3.3 Vitis vinifera (Grape) PR
Q71DI3 H3C13 Histone H3.2 Homo sapiens (Human) PR
P68431 H3C12 Histone H3.1 Homo sapiens (Human) PR
Q16695 H3-4 Histone H3.1t Homo sapiens (Human) PR
P84243 H3-3B Histone H3.3 Homo sapiens (Human) PR
P69246 H3C4 Histone H3.2 Zea mays (Maize) PR
P84228 H3c15 Histone H3.2 Mus musculus (Mouse) PR
P68433 H3c11 Histone H3.1 Mus musculus (Mouse) PR
P84244 H3-3b Histone H3.3 Mus musculus (Mouse) PR
P02301 H3-5 Histone H3.3C Mus musculus (Mouse) PR
Q71LE2 H3-3A Histone H3.3 Sus scrofa (Pig) PR
O35799 Hfe Hereditary hemochromatosis protein homolog Rattus norvegicus (Rat) PR
Q6LED0 Histone H3.1 Rattus norvegicus (Rat) PR
P84245 H3-3b Histone H3.3 Rattus norvegicus (Rat) PR
Q2RAD9 H3R-21 Histone H3.2 Oryza sativa subsp japonica (Rice) PR
Q0JCT1 H3 Histone H3.3 Oryza sativa subsp japonica (Rice) PR
P08898 his-2 Histone H3 Caenorhabditis elegans PR
Q10453 his-71 Histone H3.3 type 1 Caenorhabditis elegans PR
Q27490 his-70 Histone H3.3-like type 1 Caenorhabditis elegans PR
Q27532 his-74 Histone H3.3-like type 2 Caenorhabditis elegans PR
Q9U281 his-72 Histone H3.3 type 2 Caenorhabditis elegans PR
P59226 HTR2 Histone H3.1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FKQ3 At5g65350 Histone H3-like 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FXI7 MGH3 Histone H3-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LR02 At1g75600 Histone H3-like 3 Arabidopsis thaliana (Mouse-ear cress) PR
P59169 HTR4 Histone H3.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q28D37 TGas081o10.1 Histone H3.2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6P823 TGas113e22.1 Histone H3.3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q4QRF4 zgc:113984; Histone H3.2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6PI20 h3f3a Histone H3.3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MARTKQSARK SHGGKAPTKQ LATKAARKSA PTTGGVKKPH RFRPGTVALR EIRKYQKSTE
70 80 90 100 110 120
LLNRKLPFQR LVREIAQDFK TDLRFQSHAV LALQEAAEAY LVGLFEDTNL CAIHAKRVTI
130
MPKDVQLARR IRAERA