AiPD: Autoinhibited Protein Database

Gene name	ASK4 (SK42)
Protein name	Shaggy-related protein kinase delta
Names	ASK-delta, Shaggy-related protein kinase 42, AtSK42
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G57870
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-72 (Predicted disordered autoinhibitory region) PR

1-72 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9FVS6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH14342261	15	A>V	No	1000Genomes
tmp_1_21434825_G_A	18	T>I	No	1000Genomes
ENSVATH13615831	46	E>K	No	1000Genomes
ENSVATH04986171	53	I>V	No	1000Genomes
ENSVATH00102767	66	T>K	No	1000Genomes
ENSVATH00102767	66	T>R	No	1000Genomes
tmp_1_21434538_C_T	71	G>E	No	1000Genomes
tmp_1_21434532_T_A	73	N>I	No	1000Genomes
ENSVATH14342258	76	S>L	No	1000Genomes
ENSVATH04986169	79	T>P	No	1000Genomes
tmp_1_21434406_C_T	87	V>I	No	1000Genomes
tmp_1_21434403_C_G	88	V>L	No	1000Genomes
tmp_1_21434397_T_C	90	T>A	No	1000Genomes
ENSVATH13615813	95	M>I	No	1000Genomes
tmp_1_21434269_C_G	108	V>L	No	1000Genomes
tmp_1_21434238_C_T	118	R>H	No	1000Genomes
ENSVATH13615811	125	Q>P	No	1000Genomes
tmp_1_21434204_C_G	129	M>I	No	1000Genomes
tmp_1_21434107_C_T	162	E>K	No	1000Genomes
ENSVATH13615810	180	L>F	No	1000Genomes
tmp_1_21434038_G_T	185	L>I	No	1000Genomes
tmp_1_21433604_G_A	206	R>C	No	1000Genomes
ENSVATH01386611	217	P>S	No	1000Genomes
ENSVATH14342238	229	S>N	No	1000Genomes
ENSVATH13615772	264	I>T	No	1000Genomes
ENSVATH14342237	280	Q>*	No	1000Genomes
tmp_1_21432603_C_T	293	V>I	No	1000Genomes
tmp_1_21432394_G_A	302	P>S	No	1000Genomes
tmp_1_21432361_T_G	313	N>H	No	1000Genomes
ENSVATH00102754	332	Q>H	No	1000Genomes
tmp_1_21431766_A_C	355	C>W	No	1000Genomes
ENSVATH04986134	362	I>S	No	1000Genomes
ENSVATH13615720	371	D>G	No	1000Genomes
ENSVATH01386579	371	D>N	No	1000Genomes
tmp_1_21431583_G_C	378	N>K	No	1000Genomes
tmp_1_21431578_C_T	380	R>Q	No	1000Genomes
tmp_1_21431440_G_C	394	S>C	No	1000Genomes
tmp_1_21431390_T_A	411	K>*	No	1000Genomes
tmp_1_21431374_A_G	416	M>T	No	1000Genomes
ENSVATH13615711	417	A>T	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	82 - 366	IPR000719
active_site	Serine/threonine-protein kinase, active site	203 - 215	IPR008271
binding_site	Protein kinase, ATP binding site	88 - 112	IPR017441
domain	Glycogen synthase kinase 3, catalytic domain	77 - 369	IPR039192

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Name	Definition
protein phosphorylation	The process of introducing a phosphate group on to a protein.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P18431	sgg	Protein kinase shaggy	Drosophila melanogaster (Fruit fly)	SS
P49840	GSK3A	Glycogen synthase kinase-3 alpha	Homo sapiens (Human)	PR
P49841	GSK3B	Glycogen synthase kinase-3 beta	Homo sapiens (Human)	EV
Q80YS9	Stkld1	Serine/threonine kinase-like domain-containing protein STKLD1	Mus musculus (Mouse)	PR
Q2NL51	Gsk3a	Glycogen synthase kinase-3 alpha	Mus musculus (Mouse)	SS
Q9WV60	Gsk3b	Glycogen synthase kinase-3 beta	Mus musculus (Mouse)	EV
P18265	Gsk3a	Glycogen synthase kinase-3 alpha	Rattus norvegicus (Rat)	PR
P18266	Gsk3b	Glycogen synthase kinase-3 beta	Rattus norvegicus (Rat)	PR
Q09595	R03D7.5	Putative serine/threonine-protein kinase R03D7.5	Caenorhabditis elegans	PR
Q9U2Q9	gsk-3	Glycogen synthase kinase-3	Caenorhabditis elegans	PR
Q39019	ASK10	Shaggy-related protein kinase kappa	Arabidopsis thaliana (Mouse-ear cress)	PR