Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FUY6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FUY6-F1 | Predicted | AlphaFoldDB |
23 variants for Q9FUY6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| vcZ1WRPG3 | 99 | K>M | No | Ensembl | |
| vcZ1WRPG5 | 107 | R>Q | No | Ensembl | |
| vcZ1WRPH1 | 129 | R>K | No | Ensembl | |
| vcZ1WRPI5 | 159 | H>Q | No | Ensembl | |
| vcZ1WRPJB | 171 | V>A | No | Ensembl | |
| vcZ1WRPJC | 173 | E>K | No | Ensembl | |
| vcZ1WRPJE | 186 | R>K | No | Ensembl | |
| vcZ1WRPJF | 193 | F>V | No | Ensembl | |
| vcZ1WRPJG | 195 | P>S | No | Ensembl | |
| vcZ1WRPJI | 200 | N>K | No | Ensembl | |
| vcZ1WRPJJ | 204 | N>D | No | Ensembl | |
| vcZ1WRPJK | 206 | D>E | No | Ensembl | |
| vcZ1WRPJN | 218 | N>H | No | Ensembl | |
| vcZ1WRPOA | 240 | T>A | No | Ensembl | |
| vcZ1WRPOB | 242 | L>F | No | Ensembl | |
| vcZ1WRPOD | 243 | R>G | No | Ensembl | |
| vcZ1WRPOD | 243 | R>W | No | Ensembl | |
| vcZ1WRPOE | 246 | R>K | No | Ensembl | |
| vcZ1WRPOF | 249 | A>T | No | Ensembl | |
| vcZ1WRPOH | 250 | R>G | No | Ensembl | |
| vcZ1WRPOJ | 259 | E>* | No | Ensembl | |
| vcZ1WRPOK | 260 | E>G | No | Ensembl | |
| vcZ1WRPOM | 263 | K>R | No | Ensembl |
No associated diseases with Q9FUY6
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A2VDZ3 | MEF2A | Myocyte-specific enhancer factor 2A | Bos taurus (Bovine) | SS |
| Q9W6U8 | MEF2A | Myocyte-specific enhancer factor 2A | Gallus gallus (Chicken) | SS |
| Q06413 | MEF2C | Myocyte-specific enhancer factor 2C | Homo sapiens (Human) | EV |
| Q02078 | MEF2A | Myocyte-specific enhancer factor 2A | Homo sapiens (Human) | SS |
| Q8CFN5 | Mef2c | Myocyte-specific enhancer factor 2C | Mus musculus (Mouse) | SS |
| Q60929 | Mef2a | Myocyte-specific enhancer factor 2A | Mus musculus (Mouse) | SS |
| A4UTP7 | MEF2C | Myocyte-specific enhancer factor 2C | Sus scrofa (Pig) | SS |
| A2ICN5 | MEF2A | Myocyte-specific enhancer factor 2A | Sus scrofa (Pig) | SS |
| A0A096MJY4 | Mef2c | Myocyte-specific enhancer factor 2C | Rattus norvegicus (Rat) | SS |
| Q2MJT0 | Mef2a | Myocyte-specific enhancer factor 2A | Rattus norvegicus (Rat) | SS |
| Q40702 | MADS2 | MADS-box transcription factor 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q5K4R0 | MADS47 | MADS-box transcription factor 47 | Oryza sativa subsp japonica (Rice) | PR |
| Q655V4 | MADS30 | MADS-box transcription factor 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q1PFA4 | AGL30 | Agamous-like MADS-box protein AGL30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P29383 | AGL3 | Agamous-like MADS-box protein AGL3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P35632 | AP3 | Floral homeotic protein APETALA 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q683D7 | MAF5 | Protein MADS AFFECTING FLOWERING 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAREKIQIKK | IDNSTARQVT | FSKRRRGLFK | KAEELSVLCD | ADVALIIFSS | TGKLFDYSSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SMKQILERRD | LHSKNLEKLD | QPSLELQLVE | NSNYSRLSKE | ISEKSHRLRQ | MRGEELQGLN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IEELQQLERS | LETGLSRVIE | RKGDKIMREI | NQLQQKGMHL | MEENEKLRQQ | VMEISNNNNN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NNNGYREAGV | VIFEPENGFN | NNNNEDGQSS | ESVTNPCNSI | DPPPQDDDSS | DTSLKLGLAT |
| 250 | 260 | ||||
| LLRLKRSKAR | CGYFCMLLEE | GEKKK |