Q9FPR3
PR
Gene name |
EDR1 (STY10, At1g08720, F22O13.20) |
Protein name |
Serine/threonine-protein kinase EDR1 |
Names |
MAPKK kinase EDR1, Protein ENHANCED DISEASE RESISTANCE 1, AtEDR1, Serine/threonine/tyrosine-protein kinase 10 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G08720 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
809-817 (Activation loop from InterPro)
Target domain |
669-925 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
828-832 (Activation loop from InterPro)
Target domain |
669-925 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9FPR3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FPR3-F1 | Predicted | AlphaFoldDB |
63 variants for Q9FPR3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_2774150_A_G | 21 | N>S | No | 1000Genomes | |
| tmp_1_2774159_C_T | 24 | A>V | No | 1000Genomes | |
| tmp_1_2774161_C_A | 25 | P>T | No | 1000Genomes | |
| ENSVATH10803975 | 31 | R>W | No | 1000Genomes | |
| tmp_1_2774195_C_G | 36 | A>G | No | 1000Genomes | |
| ENSVATH01025799 | 47 | T>A | No | 1000Genomes | |
| ENSVATH01025801 | 51 | P>L | No | 1000Genomes | |
| ENSVATH01025802 | 53 | A>T | No | 1000Genomes | |
| tmp_1_2774263_A_T | 59 | M>L | No | 1000Genomes | |
| ENSVATH10803976 | 60 | A>V | No | 1000Genomes | |
| ENSVATH00012415 | 61 | S>C | No | 1000Genomes | |
| ENSVATH10803977 | 63 | A>S | No | 1000Genomes | |
| tmp_1_2774282_C_A | 65 | T>N | No | 1000Genomes | |
| tmp_1_2774366_C_T | 93 | S>L | No | 1000Genomes | |
| ENSVATH10803980 | 108 | T>M | No | 1000Genomes | |
| ENSVATH10803982 | 116 | Q>R | No | 1000Genomes | |
| tmp_1_2774462_C_T | 125 | S>L | No | 1000Genomes | |
| tmp_1_2774924_C_T | 162 | S>F | No | 1000Genomes | |
| ENSVATH10804072 | 191 | P>S | No | 1000Genomes | |
| ENSVATH10804126 | 243 | R>K | No | 1000Genomes | |
| tmp_1_2775189_G_C | 250 | E>D | No | 1000Genomes | |
| ENSVATH01025817 | 352 | A>V | No | 1000Genomes | |
| tmp_1_2775833_C_T | 355 | S>L | No | 1000Genomes | |
| ENSVATH10804214 | 369 | H>Q | No | 1000Genomes | |
| ENSVATH10804325 | 373 | A>T | No | 1000Genomes | |
| ENSVATH10804326 | 374 | N>D | No | 1000Genomes | |
| ENSVATH00012424 | 385 | A>G | No | 1000Genomes | |
| tmp_1_2775927_A_T | 386 | E>D | No | 1000Genomes | |
| ENSVATH04540915 | 386 | E>K | No | 1000Genomes | |
| ENSVATH00012426 | 395 | V>E | No | 1000Genomes | |
| ENSVATH10804327 | 399 | R>W | No | 1000Genomes | |
| ENSVATH00012427 | 405 | S>F | No | 1000Genomes | |
| ENSVATH00012428 | 407 | S>A | No | 1000Genomes | |
| ENSVATH10804329 | 418 | N>I | No | 1000Genomes | |
| ENSVATH10804330 | 421 | T>P | No | 1000Genomes | |
| ENSVATH10804332 | 432 | I>S | No | 1000Genomes | |
| ENSVATH10804334 | 446 | Q>R | No | 1000Genomes | |
| tmp_1_2776130_A_C | 454 | N>T | No | 1000Genomes | |
| ENSVATH10804425 | 475 | K>I | No | 1000Genomes | |
| ENSVATH00012429 | 491 | P>A | No | 1000Genomes | |
| ENSVATH04540916 | 492 | L>Q | No | 1000Genomes | |
| tmp_1_2776324_A_G | 519 | I>V | No | 1000Genomes | |
| tmp_1_2776351_C_T | 528 | R>C | No | 1000Genomes | |
| tmp_1_2776363_T_C | 532 | Y>H | No | 1000Genomes | |
| ENSVATH10804429 | 552 | V>M | No | 1000Genomes | |
| ENSVATH00012430 | 553 | H>P | No | 1000Genomes | |
| ENSVATH00012431 | 555 | R>K | No | 1000Genomes | |
| ENSVATH10804430 | 566 | V>A | No | 1000Genomes | |
| tmp_1_2776469_C_T | 567 | P>L | No | 1000Genomes | |
| tmp_1_2776484_C_T | 572 | S>F | No | 1000Genomes | |
| ENSVATH10804431 | 574 | E>G | No | 1000Genomes | |
| tmp_1_2776544_A_T | 592 | E>V | No | 1000Genomes | |
| ENSVATH10804433 | 598 | H>N | No | 1000Genomes | |
| ENSVATH10804434 | 599 | T>A | No | 1000Genomes | |
| ENSVATH13866657 | 606 | Q>R | No | 1000Genomes | |
| ENSVATH00012433 | 626 | T>A | No | 1000Genomes | |
| tmp_1_2776712_G_A | 648 | R>Q | No | 1000Genomes | |
| tmp_1_2776718_A_G | 650 | D>G | No | 1000Genomes | |
| tmp_1_2776784_C_A | 672 | A>E | No | 1000Genomes | |
| tmp_1_2777809_C_T | 716 | R>W | No | 1000Genomes | |
| tmp_1_2778048_G_T | 765 | R>L | No | 1000Genomes | |
| ENSVATH10804823 | 779 | N>S | No | 1000Genomes | |
| tmp_1_2779028_C_T | 918 | T>M | No | 1000Genomes |
No associated diseases with Q9FPR3
3 regional properties for Q9FPR3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclin, N-terminal | 36 - 177 | IPR006671 |
| domain | Cyclin-like domain | 68 - 170 | IPR013763-1 |
| domain | Cyclin-like domain | 183 - 268 | IPR013763-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
| trans-Golgi network transport vesicle membrane | The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| abscisic acid-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription. |
| cell death | Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). |
| defense response to oomycetes | Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism. |
| ethylene-activated signaling pathway | The series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| negative regulation of abscisic acid-activated signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of defense response to bacterium | Any process that modulates the frequency, rate or extent of defense response to bacterium. |
| regulation of defense response to fungus | Any process that modulates the frequency, rate or extent of defense response to fungus. |
| regulation of salicylic acid mediated signaling pathway | Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| response to ethylene | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. |
| response to fungus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. |
| response to water deprivation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
52 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A2VDU3 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Bos taurus (Bovine) | SS |
| Q4TVR5 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Bos taurus (Bovine) | PR |
| Q3SZJ2 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Bos taurus (Bovine) | PR |
| A7E3S4 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Bos taurus (Bovine) | SS |
| Q6XUX0 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Gallus gallus (Chicken) | PR |
| P05625 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Gallus gallus (Chicken) | PR |
| Q04982 | BRAF | Serine/threonine-protein kinase B-raf | Gallus gallus (Chicken) | SS |
| P83104 | Takl1 | Putative mitogen-activated protein kinase kinase kinase 7-like | Drosophila melanogaster (Fruit fly) | PR |
| Q95UN8 | slpr | Mitogen-activated protein kinase kinase kinase | Drosophila melanogaster (Fruit fly) | EV |
| P11346 | Raf | Raf homolog serine/threonine-protein kinase Raf | Drosophila melanogaster (Fruit fly) | PR |
| O43353 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Homo sapiens (Human) | PR |
| Q02779 | MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 | Homo sapiens (Human) | SS |
| Q8NB16 | MLKL | Mixed lineage kinase domain-like protein | Homo sapiens (Human) | EV |
| Q16584 | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | Homo sapiens (Human) | EV |
| P00540 | MOS | Proto-oncogene serine/threonine-protein kinase mos | Homo sapiens (Human) | PR |
| Q5TCX8 | MAP3K21 | Mitogen-activated protein kinase kinase kinase 21 | Homo sapiens (Human) | PR |
| Q6XUX3 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Homo sapiens (Human) | PR |
| O43318 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens (Human) | SS |
| Q9NYL2 | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20 | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| P80192 | MAP3K9 | Mitogen-activated protein kinase kinase kinase 9 | Homo sapiens (Human) | SS |
| P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens (Human) | EV |
| P10398 | ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens (Human) | PR |
| P15056 | BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens (Human) | EV |
| Q80XI6 | Map3k11 | Mitogen-activated protein kinase kinase kinase 11 | Mus musculus (Mouse) | PR |
| Q8VDG6 | Map3k21 | Mitogen-activated protein kinase kinase kinase 21 | Mus musculus (Mouse) | PR |
| P58801 | Ripk2 | Receptor-interacting serine/threonine-protein kinase 2 | Mus musculus (Mouse) | PR |
| Q62073 | Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | Mus musculus (Mouse) | EV |
| Q3U1V8 | Map3k9 | Mitogen-activated protein kinase kinase kinase 9 | Mus musculus (Mouse) | SS |
| Q9D2Y4 | Mlkl | Mixed lineage kinase domain-like protein | Mus musculus (Mouse) | SS |
| Q9ESL4 | Map3k20 | Mitogen-activated protein kinase kinase kinase 20 | Mus musculus (Mouse) | PR |
| P00536 | Mos | Proto-oncogene serine/threonine-protein kinase mos | Mus musculus (Mouse) | PR |
| Q66L42 | Map3k10 | Mitogen-activated protein kinase kinase kinase 10 | Mus musculus (Mouse) | SS |
| P28028 | Braf | Serine/threonine-protein kinase B-raf | Mus musculus (Mouse) | SS |
| Q99N57 | Raf1 | RAF proto-oncogene serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| P04627 | Araf | Serine/threonine-protein kinase A-Raf | Mus musculus (Mouse) | PR |
| P0C8E4 | Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | Rattus norvegicus (Rat) | SS |
| Q66HA1 | Map3k11 | Mitogen-activated protein kinase kinase kinase 11 | Rattus norvegicus (Rat) | PR |
| D3ZG83 | Map3k10 | Mitogen-activated protein kinase kinase kinase 10 | Rattus norvegicus (Rat) | SS |
| P00539 | Mos | Proto-oncogene serine/threonine-protein kinase mos | Rattus norvegicus (Rat) | PR |
| P11345 | Raf1 | RAF proto-oncogene serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| P32577 | Csk | Tyrosine-protein kinase CSK | Rattus norvegicus (Rat) | SS |
| P41243 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Rattus norvegicus (Rat) | SS |
| P14056 | Araf | Serine/threonine-protein kinase A-Raf | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q07292 | lin-45 | Raf homolog serine/threonine-protein kinase | Caenorhabditis elegans | PR |
| O22558 | STY8 | Serine/threonine-protein kinase STY8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWL6 | STY17 | Serine/threonine-protein kinase STY17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4JTP5 | STY46 | Serine/threonine-protein kinase STY46 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q05609 | CTR1 | Serine/threonine-protein kinase CTR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q2MHE4 | HT1 | Serine/threonine/tyrosine-protein kinase HT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q67E00 | dstyk | Dual serine/threonine and tyrosine protein kinase | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKHIFKKLHR | GGNQEQQNRT | NDAAPPSDQN | RIHVSANPPQ | ATPSSVTETL | PVAGATSSMA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SPAPTAASNR | ADYMSSEEEY | QVQLALAISA | SNSQSSEDPE | KHQIRAATLL | SLGSHQRMDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRDSSEVVAQ | RLSRQYWEYG | VLDYEEKVVD | SFYDVYSLST | DSAKQGEMPS | LEDLESNHGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PGFEAVVVNR | PIDSSLHELL | EIAECIALGC | STTSVSVLVQ | RLAELVTEHM | GGSAEDSSIV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LARWTEKSSE | FKAALNTCVF | PIGFVKIGIS | RHRALLFKVL | ADSVRLPCRL | VKGSHYTGNE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DDAVNTIRLE | DEREYLVDLM | TDPGTLIPAD | FASASNNTVE | PCNSNGNKFP | TAQFSNDVPK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSEGEGSSHS | SMANYSSSLD | RRTEAERTDS | SYPKVGPLRN | IDYSSPSSVT | SSTQLENNSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TAIGKGSRGA | IIECSRTNMN | IVPYNQNSEE | DPKNLFADLN | PFQNKGADKL | YMPTKSGLNN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VDDFHQQKNN | PLVGRSPAPM | MWKNYSCNEA | PKRKENSYIE | NLLPKLHRDP | RYGNTQSSYA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TSSSNGAISS | NVHGRDNVTF | VSPVAVPSSF | TSTENQFRPS | IVEDMNRNTN | NELDLQPHTA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AVVHGQQNDE | SHIHDHRKYT | SDDISTGCDP | RLKDHESTSS | SLDSTSYRND | PQVLDDADVG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ECEIPWNDLV | IAERIGLGSY | GEVYHADWHG | TEVAVKKFLD | QDFSGAALAE | FRSEVRIMRR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LRHPNVVFFL | GAVTRPPNLS | IVTEFLPRGS | LYRILHRPKS | HIDERRRIKM | ALDVAMGMNC |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LHTSTPTIVH | RDLKTPNLLV | DNNWNVKVGD | FGLSRLKHNT | FLSSKSTAGT | PEWMAPEVLR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NEPSNEKCDV | YSFGVILWEL | ATLRLPWRGM | NPMQVVGAVG | FQNRRLEIPK | ELDPVVGRII |
| 910 | 920 | 930 | |||
| LECWQTDPNL | RPSFAQLTEV | LKPLNRLVLP | TPQ |