Q9FNE1

PR
Gene name
CRK42 (At5g40380, MPO12.90)
Protein name
Cysteine-rich receptor-like protein kinase 42
Names
Cysteine-rich RLK42
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G40380
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

253-334 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

457-464 (Activation loop from InterPro)

Target domain

315-604 (Protein kinase domain)

Relief mechanism

Assay

475-481 (Activation loop from InterPro)

Target domain

315-604 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9FNE1

Entry ID Method Resolution Chain Position Source
AF-Q9FNE1-F1 Predicted AlphaFoldDB

101 variants for Q9FNE1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07278852 2 R>H No 1000Genomes
ENSVATH07278853 7 T>S No 1000Genomes
ENSVATH12277240 13 V>I No 1000Genomes
ENSVATH07278854 17 Y>H No 1000Genomes
tmp_5_16152173_CCTT_GCTT,C 18 S>C No 1000Genomes
ENSVATH12277241 21 F>I No 1000Genomes
tmp_5_16152205_T_G 29 S>A No 1000Genomes
tmp_5_16152206_C_A 29 S>Y No 1000Genomes
ENSVATH12277242 45 S>I No 1000Genomes
ENSVATH07278857 56 T>N No 1000Genomes
ENSVATH03300830 75 T>I No 1000Genomes
ENSVATH03300830 75 T>N No 1000Genomes
ENSVATH07278858 76 E>K No 1000Genomes
ENSVATH03300831 81 T>S No 1000Genomes
ENSVATH14555656 97 S>F No 1000Genomes
tmp_5_16152419_A_G 100 Q>R No 1000Genomes
ENSVATH03300832 110 I>L No 1000Genomes
tmp_5_16152506_G_A 129 R>H No 1000Genomes
tmp_5_16152520_G_C 134 E>Q No 1000Genomes
ENSVATH00690663 143 A>T No 1000Genomes
ENSVATH00690665 153 T>I No 1000Genomes
ENSVATH03300835 156 D>N No 1000Genomes
ENSVATH03300836 157 P>L No 1000Genomes
tmp_5_16152593_G_A 158 R>Q No 1000Genomes
ENSVATH12277244 168 A>V No 1000Genomes
ENSVATH03300837 170 V>L No 1000Genomes
ENSVATH14555658 173 R>K No 1000Genomes
ENSVATH00690666 183 N>S No 1000Genomes
tmp_5_16152673_G_A 185 V>I No 1000Genomes
ENSVATH12277277 205 E>D No 1000Genomes
tmp_5_16152733_G_A 205 E>K No 1000Genomes
ENSVATH12277278 222 A>V No 1000Genomes
tmp_5_16152794_C_G 225 T>R No 1000Genomes
ENSVATH07278863 230 R>K No 1000Genomes
ENSVATH14555659 232 S>P No 1000Genomes
ENSVATH12277279 243 H>R No 1000Genomes
tmp_5_16152857_A_G 246 H>R No 1000Genomes
ENSVATH00690668 248 L>H No 1000Genomes
ENSVATH07278882 254 I>V No 1000Genomes
tmp_5_16153182_C_T 261 T>M No 1000Genomes
tmp_5_16153205_C_G 269 L>V No 1000Genomes
ENSVATH03300860 270 L>S No 1000Genomes
ENSVATH00690669 274 V>A No 1000Genomes
ENSVATH03300861 277 T>I No 1000Genomes
ENSVATH03300863 280 S>L No 1000Genomes
tmp_5_16153494_A_G 285 E>G No 1000Genomes
ENSVATH07278890 288 N>S No 1000Genomes
ENSVATH00690673 294 R>K No 1000Genomes
ENSVATH03300882 295 K>N No 1000Genomes
tmp_5_16153541_A_G 301 T>A No 1000Genomes
ENSVATH07278891 304 K>R No 1000Genomes
ENSVATH14555665 311 A>G No 1000Genomes
ENSVATH12277349 312 T>S No 1000Genomes
ENSVATH07278892 313 D>Y No 1000Genomes
ENSVATH03300886 317 H>P No 1000Genomes
ENSVATH00690674 318 K>T No 1000Genomes
ENSVATH03300888 320 M>I No 1000Genomes
ENSVATH03300887 320 M>T No 1000Genomes
ENSVATH00690675 336 N>T No 1000Genomes
ENSVATH03300890 337 G>C No 1000Genomes
ENSVATH00690676 338 K>N No 1000Genomes
ENSVATH03300891 351 D>E No 1000Genomes
ENSVATH07278893 356 F>V No 1000Genomes
ENSVATH07278896 407 K>N No 1000Genomes
ENSVATH00690678 412 S>R No 1000Genomes
tmp_5_16154182_C_T 432 S>F No 1000Genomes
tmp_5_16154215_C_G 443 T>S No 1000Genomes
tmp_5_16154251_A_T 455 K>M No 1000Genomes
tmp_5_16154305_G_C 473 S>T No 1000Genomes
ENSVATH03300906 490 R>T No 1000Genomes
tmp_5_16154485_C_T 497 A>V No 1000Genomes
ENSVATH07278903 510 A>V No 1000Genomes
ENSVATH12277437 513 T>I No 1000Genomes
ENSVATH12277438 539 V>I No 1000Genomes
ENSVATH03300909 540 E>K No 1000Genomes
tmp_5_16154703_G_A 541 A>T No 1000Genomes
ENSVATH07278907 543 D>E No 1000Genomes
ENSVATH07278908 544 P>T No 1000Genomes
ENSVATH03300910 545 C>F No 1000Genomes
ENSVATH14555669 548 D>H No 1000Genomes
ENSVATH03300911 550 F>L No 1000Genomes
ENSVATH14555670 560 A>V No 1000Genomes
ENSVATH07278910 564 L>F No 1000Genomes
ENSVATH03300912 571 T>A No 1000Genomes
tmp_5_16154799_G_C 573 A>P No 1000Genomes
tmp_5_16154805_C_T 575 P>S No 1000Genomes
tmp_5_16154809_C_T 576 S>L No 1000Genomes
ENSVATH12277439 581 M>I No 1000Genomes
tmp_5_16154839_G_A 586 R>H No 1000Genomes
ENSVATH12277440 591 R>S No 1000Genomes
ENSVATH07278912 610 T>N No 1000Genomes
ENSVATH03300917 619 I>L No 1000Genomes
ENSVATH14555672 627 T>M No 1000Genomes
ENSVATH07278914 629 F>L No 1000Genomes
tmp_5_16154988_G_T 636 D>Y No 1000Genomes
tmp_5_16154992_A_C 637 Q>P No 1000Genomes
ENSVATH12277441 641 T>S No 1000Genomes
ENSVATH12277442 647 T>N No 1000Genomes
ENSVATH03300919 650 T>S No 1000Genomes
ENSVATH12277443 651 I>M No 1000Genomes
ENSVATH03300920 652 I>Y No 1000Genomes

No associated diseases with Q9FNE1

5 regional properties for Q9FNE1

Type Name Position InterPro Accession
domain Protein kinase domain 315 - 604 IPR000719
domain Gnk2-homologous domain 35 - 135 IPR002902-1
domain Gnk2-homologous domain 137 - 236 IPR002902-2
active_site Serine/threonine-protein kinase, active site 436 - 448 IPR008271
binding_site Protein kinase, ATP binding site 321 - 343 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8AXY6 MUSK Muscle, skeletal receptor tyrosine protein kinase Gallus gallus (Chicken) SS
Q24488 Ror Tyrosine-protein kinase transmembrane receptor Ror Drosophila melanogaster (Fruit fly) SS
Q9V6K3 Nrk Tyrosine-protein kinase transmembrane receptor Ror2 Drosophila melanogaster (Fruit fly) SS
P30530 AXL Tyrosine-protein kinase receptor UFO Homo sapiens (Human) PR
Q01973 ROR1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Homo sapiens (Human) PR
Q01974 ROR2 Tyrosine-protein kinase transmembrane receptor ROR2 Homo sapiens (Human) EV
P18910 Npr1 Atrial natriuretic peptide receptor 1 Rattus norvegicus (Rat) PR
P51842 Gucy2f Retinal guanylyl cyclase 2 Rattus norvegicus (Rat) PR
P16067 Npr2 Atrial natriuretic peptide receptor 2 Rattus norvegicus (Rat) PR
O13146 epha3 Ephrin type-A receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MRCLTKTRSF HYVIIFYSFF FLPFLSSSSD DQRTTVSGLF CGGRSKSSAD PNYIPTFVED
70 80 90 100 110 120
MHSLSLKLTT RRFATESLNS TTSIYALIQC HDDLSPSDCQ LCYAIARTRI PRCLPSSSAR
130 140 150 160 170 180
IFLDGCFLRY ETYEFYDESV SDASDSFSCS NDTVLDPRFG FQVSETAARV AVRKGGFGVA
190 200 210 220 230 240
GENGVHALAQ CWESLGKEDC RVCLEKAVKE VKRCVSRREG RAMNTGCYLR YSDHKFYNGD
250 260 270 280 290 300
GHHKFHVLFN KGVIVAIVLT TSAFVMLILL ATYVIMTKVS KTKQEKRNLG LVSRKFNNSK
310 320 330 340 350 360
TKFKYETLEK ATDYFSHKKM LGQGGNGTVF LGILPNGKNV AVKRLVFNTR DWVEEFFNEV
370 380 390 400 410 420
NLISGIQHKN LVKLLGCSIE GPESLLVYEY VPNKSLDQFL FDESQSKVLN WSQRLNIILG
430 440 450 460 470 480
TAEGLAYLHG GSPVRIIHRD IKTSNVLLDD QLNPKIADFG LARCFGLDKT HLSTGIAGTL
490 500 510 520 530 540
GYMAPEYVVR GQLTEKADVY SFGVLVLEIA CGTRINAFVP ETGHLLQRVW NLYTLNRLVE
550 560 570 580 590 600
ALDPCLKDEF LQVQGSEAEA CKVLRVGLLC TQASPSLRPS MEEVIRMLTE RDYPIPSPTS
610 620 630 640 650
PPFLRVSSLT TDLEGSSTIS HSTNSTTTFN TMVKTDQASY TSSESSTTRT I