Q9FN94

PR
Gene name
At5g59670 (MTH12.12)
Protein name
Receptor-like protein kinase At5g59670
Names
Leucine-rich repeat receptor-like protein kinase At5g59670
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G59670
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

502-580 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

706-713 (Activation loop from InterPro)

Target domain

564-837 (Protein kinase domain)

Relief mechanism

Assay

724-731 (Activation loop from InterPro)

Target domain

564-837 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9FN94

Entry ID Method Resolution Chain Position Source
AF-Q9FN94-F1 Predicted AlphaFoldDB

235 variants for Q9FN94

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH03453879 3 S>G No 1000Genomes
ENSVATH03453880 5 F>V No 1000Genomes
ENSVATH00743222 10 A>V No 1000Genomes
ENSVATH00743223 15 T>A No 1000Genomes
ENSVATH03453881 24 D>V No 1000Genomes
ENSVATH03453882 25 P>Q No 1000Genomes
ENSVATH08581389 26 Q>P No 1000Genomes
ENSVATH08581396 36 P>H No 1000Genomes
ENSVATH03453894 37 A>P No 1000Genomes
ENSVATH03453894 37 A>T No 1000Genomes
tmp_5_24041749_C_T 40 T>M No 1000Genomes
ENSVATH03453896 42 P>H No 1000Genomes
ENSVATH03453896 42 P>L No 1000Genomes
ENSVATH03453897 44 T>A No 1000Genomes
ENSVATH03453898 44 T>K No 1000Genomes
ENSVATH07451259 45 E>D No 1000Genomes
ENSVATH07451260 46 T>N No 1000Genomes
ENSVATH07451262 47 Q>H No 1000Genomes
tmp_5_24041769_C_A 47 Q>K No 1000Genomes
ENSVATH07451261 47 Q>R No 1000Genomes
ENSVATH03453900 50 L>M No 1000Genomes
ENSVATH03453902 51 L>S No 1000Genomes
ENSVATH03453902 51 L>W No 1000Genomes
ENSVATH07451263 55 D>N No 1000Genomes
ENSVATH09557640 56 A>E No 1000Genomes
ENSVATH14641165 56 A>S No 1000Genomes
ENSVATH03453907 67 V>I No 1000Genomes
ENSVATH03453908 71 Q>R No 1000Genomes
ENSVATH03453909 73 S>R No 1000Genomes
ENSVATH03453910 74 K>E No 1000Genomes
ENSVATH03453911 74 K>T No 1000Genomes
ENSVATH00743224 76 L>F No 1000Genomes
ENSVATH09557644 76 L>S No 1000Genomes
ENSVATH09557645 77 K>N No 1000Genomes
ENSVATH09557646 78 P>Q No 1000Genomes
ENSVATH08581400 79 Y>* No 1000Genomes
ENSVATH08581399 79 Y>S No 1000Genomes
ENSVATH07451264 86 P>S No 1000Genomes
ENSVATH03453913 87 E>D No 1000Genomes
ENSVATH03453914 89 V>E No 1000Genomes
ENSVATH00743225 89 V>I No 1000Genomes
ENSVATH03453916 96 S>I No 1000Genomes
ENSVATH03453919 106 A>G No 1000Genomes
ENSVATH03453918 106 A>T No 1000Genomes
ENSVATH03453921 108 S>C No 1000Genomes
ENSVATH07451265 108 S>N No 1000Genomes
ENSVATH03453922
ENSVATH03453921
 108 S>R No 1000Genomes
ENSVATH08581401 110 L>V No 1000Genomes
ENSVATH03453923 117 H>Q No 1000Genomes
ENSVATH14641167 117 H>R No 1000Genomes
ENSVATH03453924 119 I>T No 1000Genomes
tmp_5_24041988_G_A 120 A>T No 1000Genomes
ENSVATH03453926 134 K>N No 1000Genomes
ENSVATH03453927 138 Q>E No 1000Genomes
ENSVATH03453928 140 V>E No 1000Genomes
ENSVATH03453929 143 T>K No 1000Genomes
ENSVATH07451266 144 G>E No 1000Genomes
ENSVATH03453930 144 G>R No 1000Genomes
ENSVATH03453930 144 G>W No 1000Genomes
ENSVATH03453932 162 Q>K No 1000Genomes
ENSVATH07451267 165 E>K No 1000Genomes
ENSVATH03453933 165 E>V No 1000Genomes
ENSVATH07451269 166 T>A No 1000Genomes
ENSVATH14641170 170 I>T No 1000Genomes
ENSVATH03453937 174 E>V No 1000Genomes
ENSVATH03453938 175 L>I No 1000Genomes
tmp_5_24042166_G_A 179 R>K No 1000Genomes
ENSVATH03453939 181 G>R No 1000Genomes
ENSVATH00743227 182 S>R No 1000Genomes
ENSVATH00743228 182 S>T No 1000Genomes
ENSVATH03453940 185 T>I No 1000Genomes
ENSVATH00743229 186 V>E No 1000Genomes
ENSVATH07451270 187 S>P No 1000Genomes
ENSVATH07451271 192 T>I No 1000Genomes
ENSVATH07451271 192 T>K No 1000Genomes
ENSVATH03453941 193 Y>F No 1000Genomes
ENSVATH03453942 194 R>K No 1000Genomes
tmp_5_24042212_G_C 194 R>S No 1000Genomes
ENSVATH08581403 194 R>W No 1000Genomes
ENSVATH07451273 195 R>C No 1000Genomes
ENSVATH12863275 195 R>H No 1000Genomes
ENSVATH03453943 196 L>F No 1000Genomes
ENSVATH07451274 198 F>I No 1000Genomes
ENSVATH03453944 199 K>N No 1000Genomes
tmp_5_24042232_C_T 201 S>F No 1000Genomes
ENSVATH00743230 204 R>G No 1000Genomes
ENSVATH03453946 204 R>K No 1000Genomes
ENSVATH03453947 206 R>L No 1000Genomes
tmp_5_24042539_A_C 207 Y>S No 1000Genomes
ENSVATH03453959 215 S>L No 1000Genomes
ENSVATH03453958 215 S>T No 1000Genomes
ENSVATH03453960 217 F>I No 1000Genomes
ENSVATH03453961 217 F>L No 1000Genomes
ENSVATH00743236 219 R>G No 1000Genomes
ENSVATH09557659 219 R>H No 1000Genomes
ENSVATH03453963 221 M>K No 1000Genomes
ENSVATH03453962 221 M>V No 1000Genomes
ENSVATH00743237 231 L>V No 1000Genomes
ENSVATH08581425 234 I>N No 1000Genomes
ENSVATH00743238 241 P>L No 1000Genomes
ENSVATH00743239 243 E>D No 1000Genomes
ENSVATH00743240 248 N>T No 1000Genomes
ENSVATH00743241 254 D>N No 1000Genomes
ENSVATH03453967 257 A>E No 1000Genomes
ENSVATH03453970 261 F>I No 1000Genomes
ENSVATH03453970 261 F>V No 1000Genomes
ENSVATH09557668 262 K>E No 1000Genomes
ENSVATH07451283 262 K>I No 1000Genomes
ENSVATH03453971 264 N>D No 1000Genomes
ENSVATH03453971 264 N>H No 1000Genomes
ENSVATH03453972 264 N>I No 1000Genomes
ENSVATH03453973 264 N>K No 1000Genomes
ENSVATH03453972 264 N>S No 1000Genomes
ENSVATH03453972 264 N>T No 1000Genomes
ENSVATH03453974 266 E>K No 1000Genomes
ENSVATH12863315 267 K>E No 1000Genomes
ENSVATH03453975 267 K>N No 1000Genomes
ENSVATH03453976 268 L>F No 1000Genomes
ENSVATH12863316 268 L>W No 1000Genomes
ENSVATH03453977 270 V>D No 1000Genomes
tmp_5_24042734_A_T 272 Y>F No 1000Genomes
ENSVATH14641174 278 Y>F No 1000Genomes
ENSVATH08581432 285 Q>R No 1000Genomes
ENSVATH08581434 289 T>I No 1000Genomes
ENSVATH03453979 294 I>F No 1000Genomes
tmp_5_24042801_C_G 294 I>M No 1000Genomes
tmp_5_24042800_T_G 294 I>S No 1000Genomes
ENSVATH03453981 304 T>P No 1000Genomes
ENSVATH07451288 305 G>S No 1000Genomes
ENSVATH03453982 306 P>T No 1000Genomes
ENSVATH03453983 310 D>E No 1000Genomes
ENSVATH09557671 310 D>N No 1000Genomes
ENSVATH09557673 313 S>R No 1000Genomes
ENSVATH03453984 314 I>L No 1000Genomes
ENSVATH03453986 315 K>N No 1000Genomes
ENSVATH03453985 315 K>T No 1000Genomes
ENSVATH03453987 317 F>V No 1000Genomes
ENSVATH07451289 318 Q>E No 1000Genomes
ENSVATH09557674 319 S>G No 1000Genomes
ENSVATH09557675 319 S>R No 1000Genomes
ENSVATH09557676 320 S>L No 1000Genomes
ENSVATH15959194 320 S>P No 1000Genomes
ENSVATH15959194 320 S>T No 1000Genomes
ENSVATH03453989 323 I>T No 1000Genomes
ENSVATH00743244 324 S>T No 1000Genomes
ENSVATH07451291 328 W>G No 1000Genomes
ENSVATH03453990 329 A>E No 1000Genomes
ENSVATH00743245 329 A>P No 1000Genomes
ENSVATH00743245 329 A>T No 1000Genomes
ENSVATH03453992 331 N>I No 1000Genomes
ENSVATH03453991 331 N>Y No 1000Genomes
ENSVATH03453993 332 F>L No 1000Genomes
ENSVATH03453994 338 K>N No 1000Genomes
ENSVATH00743246 349 L>F No 1000Genomes
ENSVATH00743247 351 V>I No 1000Genomes
ENSVATH03453999 359 R>Q No 1000Genomes
ENSVATH03454000 360 S>F No 1000Genomes
ENSVATH12863366 372 N>D No 1000Genomes
ENSVATH07451297 375 A>V No 1000Genomes
ENSVATH07451298 376 S>T No 1000Genomes
ENSVATH00743250 392 Q>E No 1000Genomes
ENSVATH07451302 395 R>W No 1000Genomes
ENSVATH12863367 400 D>V No 1000Genomes
ENSVATH03454005 402 T>S No 1000Genomes
ENSVATH03454006 404 R>T No 1000Genomes
ENSVATH03454007 408 Q>K No 1000Genomes
ENSVATH03454008 408 Q>P No 1000Genomes
ENSVATH03454012 428 A>T No 1000Genomes
ENSVATH03454014 433 I>L No 1000Genomes
ENSVATH03454028 443 Y>N No 1000Genomes
tmp_5_24043533_A_T 446 L>F No 1000Genomes
ENSVATH03454029 449 E>G No 1000Genomes
ENSVATH14641182 455 G>D No 1000Genomes
ENSVATH03454035 483 L>V No 1000Genomes
ENSVATH03454042 496 P>R No 1000Genomes
ENSVATH03454044 499 K>E No 1000Genomes
ENSVATH03454045 500 E>K No 1000Genomes
ENSVATH03454046 501 F>I No 1000Genomes
ENSVATH09557692 502 P>S No 1000Genomes
ENSVATH03454047 507 T>A No 1000Genomes
ENSVATH08581466 518 L>I No 1000Genomes
ENSVATH08581468 522 F>L No 1000Genomes
ENSVATH03454049 525 K>R No 1000Genomes
ENSVATH03454050 526 M>K No 1000Genomes
ENSVATH00743259 531 K>Q No 1000Genomes
ENSVATH03454055 533 L>I No 1000Genomes
ENSVATH03454056 534 R>P No 1000Genomes
ENSVATH08581486 541 M>T No 1000Genomes
ENSVATH08581487 542 V>E No 1000Genomes
ENSVATH08581488 543 D>N No 1000Genomes
tmp_5_24044120_G_T 544 V>F No 1000Genomes
ENSVATH08581490 547 S>A No 1000Genomes
ENSVATH03454057 548 N>K No 1000Genomes
ENSVATH00743261 562 V>M No 1000Genomes
ENSVATH08581494 569 V>G No 1000Genomes
ENSVATH03454075 615 V>A No 1000Genomes
ENSVATH03454082 628 C>R No 1000Genomes
ENSVATH03454083 628 C>Y No 1000Genomes
ENSVATH03454084 631 D>N No 1000Genomes
ENSVATH03454085 632 Y>H No 1000Genomes
ENSVATH00743266 636 V>I No 1000Genomes
ENSVATH03454091 655 N>K No 1000Genomes
ENSVATH14641185 670 A>P No 1000Genomes
ENSVATH00743270 682 T>K No 1000Genomes
tmp_5_24044880_T_G 705 L>R No 1000Genomes
ENSVATH07451320 717 E>G No 1000Genomes
ENSVATH07451321 723 S>L No 1000Genomes
ENSVATH03454110 730 L>P No 1000Genomes
ENSVATH07451327 737 C>Y No 1000Genomes
ENSVATH07451328 739 H>R No 1000Genomes
ENSVATH07451330 740 S>T No 1000Genomes
tmp_5_24045093_G_A 741 G>D No 1000Genomes
tmp_5_24045092_G_A 741 G>S No 1000Genomes
ENSVATH03454123 744 G>A No 1000Genomes
tmp_5_24045123_G_A 751 S>N No 1000Genomes
ENSVATH14641190 767 N>D No 1000Genomes
ENSVATH03454131 771 G>E No 1000Genomes
ENSVATH03454132 772 D>N No 1000Genomes
ENSVATH03454133 774 H>L No 1000Genomes
ENSVATH03454136 783 M>I No 1000Genomes
ENSVATH00743278 789 L>H No 1000Genomes
ENSVATH00743279 797 R>G No 1000Genomes
ENSVATH03454137 801 N>D No 1000Genomes
ENSVATH03454140 809 L>F No 1000Genomes
ENSVATH00743281 817 Y>N No 1000Genomes
ENSVATH03454143 821 S>L No 1000Genomes
ENSVATH03454145 822 K>N No 1000Genomes
ENSVATH00743284 849 S>G No 1000Genomes
ENSVATH00743285 852 Y>S No 1000Genomes
ENSVATH03454147 858 S>G No 1000Genomes
ENSVATH03454148 858 S>N No 1000Genomes
ENSVATH03454149 861 T>S No 1000Genomes
tmp_5_24045456_C_T 862 T>M No 1000Genomes
ENSVATH03454150 862 T>S No 1000Genomes
ENSVATH03454152 863 A>V No 1000Genomes

No associated diseases with Q9FN94

6 regional properties for Q9FN94

Type Name Position InterPro Accession
domain Protein kinase domain 564 - 837 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 566 - 833 IPR001245
repeat Leucine-rich repeat 410 - 470 IPR001611
active_site Serine/threonine-protein kinase, active site 685 - 697 IPR008271
binding_site Protein kinase, ATP binding site 570 - 592 IPR017441
domain Malectin-like domain 31 - 354 IPR024788

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

32 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
P20594 NPR2 Atrial natriuretic peptide receptor 2 Homo sapiens (Human) PR
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWZ5 SD25 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGG3 At1g51820 Probable LRR receptor-like serine/threonine-protein kinase At1g51820 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGW2 PAM74 Probable LRR receptor-like serine/threonine-protein kinase PAM74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN93 At5g59680 Probable LRR receptor-like serine/threonine-protein kinase At5g59680 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIG2 At3g21340 Receptor-like protein kinase At3g21340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SNA3 At3g46340 Putative receptor-like protein kinase At3g46340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR3 At2g14510 Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
O64556 At2g19230 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JQ4 PRK2 Pollen receptor-like kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MESSFGLLLA LLTLTIIHIV QAQDPQGFIS LDCGLPANET SPYTETQTGL LFSSDATFIQ
70 80 90 100 110 120
SGKTGRVQAN QESKFLKPYR TLRYFPEGVR NCYNLSVFKE RKYLIAASFL YGNYDGHNIA
130 140 150 160 170 180
PVFDLYLGPN LWAKIDLQDV NGTGEEILHI PTSNSLQICL VQTGETTPLI SSLELRPMRT
190 200 210 220 230 240
GSYTTVSGSL KTYRRLYFKK SGSRLRYSKD VYDRSWFPRF MDEWTQISTA LGVINTNIYQ
250 260 270 280 290 300
PPEDALKNAA TPTDASAPLT FKWNSEKLDV QYYFYAHYAE IQDLQANDTR EFNILLNGQN
310 320 330 340 350 360
LSVTGPEVPD KLSIKTFQSS SPISCNGWAC NFQLIRTKRS TLPPLLNALE VYTVIQFPRS
370 380 390 400 410 420
ETDESDVVAM KNISASYGLS RINWQGDPCF PQQLRWDALD CTNRNISQPP RITSLNLSSS
430 440 450 460 470 480
RLNGTIAAAI QSITQLETLD LSYNNLTGEV PEFLGKMKSL SVINLSGNNL NGSIPQALRK
490 500 510 520 530 540
KRLKLYLEGN PRLIKPPKKE FPVAIVTLVV FVTVIVVLFL VFRKKMSTIV KGLRLPPRTS
550 560 570 580 590 600
MVDVTFSNKK SKRFTYSEVV QVTKNFQRVL GKGGFGMVYH GTVKGSEQVA VKVLSQSSTQ
610 620 630 640 650 660
GSKEFKAEVD LLLRVHHTNL VSLVGYCCEG DYLALVYEFL PNGDLKQHLS GKGGNSIINW
670 680 690 700 710 720
SIRLRIALEA ALGLEYLHIG CTPPMVHRDV KTANILLDEN FKAKLADFGL SRSFQGEGES
730 740 750 760 770 780
QESTTIAGTL GYLDPECYHS GRLGEKSDVY SFGIVLLEMI TNQPVINQTS GDSHITQWVG
790 800 810 820 830 840
FQMNRGDILE IMDPNLRKDY NINSAWRALE LAMSCAYPSS SKRPSMSQVI HELKECIACE
850 860
NTGISKNRSL EYQEMNVSLD TTAVPMAR