Q9FN93

PR
Gene name
At5g59680 (MTH12.14)
Protein name
Probable LRR receptor-like serine/threonine-protein kinase At5g59680
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G59680
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

515-585 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FN93

Entry ID Method Resolution Chain Position Source
AF-Q9FN93-F1 Predicted AlphaFoldDB

83 variants for Q9FN93

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH08581591 13 R>G No 1000Genomes
tmp_5_24046835_T_C 15 L>S No 1000Genomes
ENSVATH14641202 47 P>L No 1000Genomes
tmp_5_24047050_G_C 50 G>R No 1000Genomes
ENSVATH08581607 65 I>N No 1000Genomes
ENSVATH08581607 65 I>T No 1000Genomes
ENSVATH09557790 68 I>L No 1000Genomes
tmp_5_24047127_C_A 75 D>E No 1000Genomes
ENSVATH00743302 119 D>N No 1000Genomes
tmp_5_24047306_C_T 135 T>M No 1000Genomes
ENSVATH12863665 151 H>Y No 1000Genomes
ENSVATH03454210 157 K>N No 1000Genomes
ENSVATH08581621 177 V>I No 1000Genomes
ENSVATH07451383 182 S>N No 1000Genomes
tmp_5_24047496_A_C 198 E>D No 1000Genomes
ENSVATH03454215 228 Q>H No 1000Genomes
ENSVATH03454216 230 N>Y No 1000Genomes
ENSVATH12863761 237 N>I No 1000Genomes
ENSVATH12863762 238 S>F No 1000Genomes
tmp_5_24047932_A_G 249 T>A No 1000Genomes
ENSVATH00743309 260 P>Q No 1000Genomes
ENSVATH00743310 273 Q>K No 1000Genomes
ENSVATH03454218 315 S>C No 1000Genomes
ENSVATH03454219 315 S>T No 1000Genomes
ENSVATH03454220 327 G>E No 1000Genomes
tmp_5_24048223_C_T 346 L>F No 1000Genomes
tmp_5_24048241_T_A 352 Y>N No 1000Genomes
ENSVATH03454233 372 N>S No 1000Genomes
ENSVATH03454237 376 T>S No 1000Genomes
ENSVATH12863763 380 S>C No 1000Genomes
ENSVATH03454239 386 S>G No 1000Genomes
tmp_5_24048522_T_G 399 L>V No 1000Genomes
ENSVATH12863815 417 L>F No 1000Genomes
ENSVATH00743314 427 T>A No 1000Genomes
ENSVATH08581687 435 T>S No 1000Genomes
tmp_5_24048726_A_G 438 K>E No 1000Genomes
ENSVATH12863820 479 Q>E No 1000Genomes
ENSVATH03454260 479 Q>H No 1000Genomes
tmp_5_24049055_G_C 484 E>Q No 1000Genomes
ENSVATH03454262 486 L>V No 1000Genomes
ENSVATH07451407 494 I>T No 1000Genomes
ENSVATH07451409 508 P>L No 1000Genomes
ENSVATH12863823 510 T>A No 1000Genomes
ENSVATH12863824 510 T>I No 1000Genomes
ENSVATH12863824 510 T>K No 1000Genomes
ENSVATH07451410 522 I>V No 1000Genomes
ENSVATH12863845 524 V>L No 1000Genomes
ENSVATH03454275 525 L>V No 1000Genomes
ENSVATH08581713 528 V>I No 1000Genomes
ENSVATH08581713 528 V>L No 1000Genomes
ENSVATH07451412 530 F>V No 1000Genomes
ENSVATH09557865 538 A>T No 1000Genomes
ENSVATH00743315 543 L>H No 1000Genomes
ENSVATH03454279 556 A>V No 1000Genomes
ENSVATH03454280 569 K>R No 1000Genomes
ENSVATH03454281 573 S>L No 1000Genomes
ENSVATH03454282 576 T>M No 1000Genomes
ENSVATH03454285 581 N>H No 1000Genomes
ENSVATH03454287 583 G>E No 1000Genomes
ENSVATH03454315 645 E>D No 1000Genomes
ENSVATH08581725 647 D>E No 1000Genomes
ENSVATH07451422 648 H>D No 1000Genomes
ENSVATH12863916 669 G>R No 1000Genomes
ENSVATH00743322 671 K>E No 1000Genomes
ENSVATH00743322 671 K>Q No 1000Genomes
ENSVATH00743323 684 A>V No 1000Genomes
ENSVATH03454344 736 S>T No 1000Genomes
ENSVATH03454350 755 H>Q No 1000Genomes
tmp_5_24050409_C_G 758 R>G No 1000Genomes
ENSVATH03454352 760 S>G No 1000Genomes
ENSVATH03454357 777 T>S No 1000Genomes
tmp_5_24050493_C_G 786 R>G No 1000Genomes
tmp_5_24050527_C_A 797 S>Y No 1000Genomes
tmp_5_24050550_G_A 805 A>T No 1000Genomes
ENSVATH00743328 810 L>P No 1000Genomes
ENSVATH00743332 838 R>K No 1000Genomes
tmp_5_24050703_G_C 856 E>Q No 1000Genomes
tmp_5_24050728_G_A 864 R>Q No 1000Genomes
tmp_5_24050730_G_A 865 G>S No 1000Genomes
tmp_5_24050736_G_T 867 D>Y No 1000Genomes
ENSVATH03454370 868 T>S No 1000Genomes
tmp_5_24050746_G_A 870 S>N No 1000Genomes
ENSVATH14641203 883 I>F No 1000Genomes

No associated diseases with Q9FN93

5 regional properties for Q9FN93

Type Name Position InterPro Accession
domain Protein kinase domain 580 - 853 IPR000719
repeat Leucine-rich repeat 410 - 470 IPR001611
active_site Serine/threonine-protein kinase, active site 701 - 713 IPR008271
binding_site Protein kinase, ATP binding site 586 - 608 IPR017441
domain Malectin-like domain 32 - 354 IPR024788

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

35 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q91044 NTRK3 NT-3 growth factor receptor Gallus gallus (Chicken) SS
Q91987 NTRK2 BDNF/NT-3 growth factors receptor Gallus gallus (Chicken) SS
Q91009 NTRK1 High affinity nerve growth factor receptor Gallus gallus (Chicken) SS
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
P20594 NPR2 Atrial natriuretic peptide receptor 2 Homo sapiens (Human) PR
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGG3 At1g51820 Probable LRR receptor-like serine/threonine-protein kinase At1g51820 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGW2 PAM74 Probable LRR receptor-like serine/threonine-protein kinase PAM74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN94 At5g59670 Receptor-like protein kinase At5g59670 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIG2 At3g21340 Receptor-like protein kinase At3g21340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SNA3 At3g46340 Putative receptor-like protein kinase At3g46340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR3 At2g14510 Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWZ5 SD25 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 Arabidopsis thaliana (Mouse-ear cress) PR
O64556 At2g19230 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JQ4 PRK2 Pollen receptor-like kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MERSLELLLL LIRTLAIIHI SQAQSQQGFI SLDCGLPANE PSPYTEPRTG LQFSSDAAFI
70 80 90 100 110 120
QSGKIGRIQA NLEADFLKPS TTMRYFPDGK RNCYNLNVEK GRNHLIRARF VYGNYDGRDT
130 140 150 160 170 180
GPKFDLYLGP NPWATIDLAK QVNGTRPEIM HIPTSNKLQV CLVKTGETTP LISVLEVRPM
190 200 210 220 230 240
GSGTYLTKSG SLKLYYREYF SKSDSSLRYP DDIYDRQWTS FFDTEWTQIN TTSDVGNSND
250 260 270 280 290 300
YKPPKVALTT AAIPTNASAP LTNEWSSVNP DEQYYVYAHF SEIQELQANE TREFNMLLNG
310 320 330 340 350 360
KLFFGPVVPP KLAISTILSV SPNTCEGGEC NLQLIRTNRS TLPPLLNAYE VYKVIQFPQL
370 380 390 400 410 420
ETNETDVSAV KNIQATYELS RINWQSDPCV PQQFMWDGLN CSITDITTPP RITTLNLSSS
430 440 450 460 470 480
GLTGTITAAI QNLTTLEKLD LSNNNLTGEV PEFLSNMKSL LVINLSGNDL NGTIPQSLQR
490 500 510 520 530 540
KGLELLYQGN PRLISPGSTE TKSGKSFPVT IVASVGSAAI LIVVLVLVLF LRKKKPSAVE
550 560 570 580 590 600
VVLPRPSRPT MNVPYANSPE PSIEMKKRKF TYSEVTKMTN NFGRVVGEGG FGVVCHGTVN
610 620 630 640 650 660
GSEQVAVKLL SQSSTQGYKE FKAEVDLLLR VHHTNLVSLV GYCDEGDHLA LIYEFVPNGD
670 680 690 700 710 720
LRQHLSGKGG KPIVNWGTRL RIAAEAALGL EYLHIGCTPP MVHRDVKTTN ILLDEHYKAK
730 740 750 760 770 780
LADFGLSRSF PVGGESHVST VIAGTPGYLD PEYYHTSRLS EKSDVYSFGI VLLEMITNQA
790 800 810 820 830 840
VIDRNRRKSH ITQWVGSELN GGDIAKIMDL KLNGDYDSRS AWRALELAMS CADPTSARRP
850 860 870 880
TMSHVVIELK ECLVSENSRR NMSRGMDTLS SPEVSMIFDA EMIPRAR