Q9FLZ3
SS
Gene name |
KIN12 (AKIN12, KIN30, SNRK1.3, At5g39440, MUL8.12) |
Protein name |
SNF1-related protein kinase catalytic subunit alpha KIN12 |
Names |
AKIN12 , EC 2.7.11.1 , AKIN alpha-3 , AKINalpha3 , SNF1-related kinase 1.3 , SnRK1.3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G39440 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
AMP-activated protein kinase (AMPK) acts as an energy sensor, being activated by metabolic stresses and regulating cellular metabolism. AMPK is a heterotrimer consisting of a catalytic alpha subunit and two regulatory subunits, beta and gamma. AMPK alpha subunit contains an autoinhibitory domain that inhibits the N-terminal kinase domain. Autoinhibitory region of AMPK alpha are not only responsible for kinase autoinhibition, but may also be responsible for full-length kinase degradation.
Autoinhibitory domains (AIDs)
Target domain |
19-270 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
159-181 (Activation loop from InterPro)
Target domain |
19-270 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Pang T et al. (2007) "Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits", The Journal of biological chemistry, 282, 495-506
- Hardie DG et al. (2012) "AMP-activated protein kinase: a target for drugs both ancient and modern", Chemistry & biology, 19, 1222-36
- Li YY et al. (2013) "Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice", Toxicology and applied pharmacology, 273, 325-34
- Oakhill JS et al. (2009) "Structure and function of AMP-activated protein kinase", Acta physiologica (Oxford, England), 196, 3-14
- Pang T et al. (2008) "Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells", The Journal of biological chemistry, 283, 16051-60
- Scott JW et al. (2014) "ATP sensitive bi-quinoline activator of the AMP-activated protein kinase", Biochemical and biophysical research communications, 443, 435-40
- Handa N et al. (2011) "Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain", Acta crystallographica. Section D, Biological crystallography, 67, 480-7
- Littler DR et al. (2010) "A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation", Acta crystallographica. Section F, Structural biology and crystallization communications, 66, 143-51
Autoinhibited structure
Activated structure
1 structures for Q9FLZ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FLZ3-F1 | Predicted | AlphaFoldDB |
118 variants for Q9FLZ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07267870 | 8 | T>I | No | 1000Genomes | |
| tmp_5_15781938_A_C | 11 | K>T | No | 1000Genomes | |
| tmp_5_15781955_C_T | 17 | P>S | No | 1000Genomes | |
| tmp_5_15781970_G_T | 22 | G>C | No | 1000Genomes | |
| ENSVATH00688332 | 24 | T>A | No | 1000Genomes | |
| tmp_5_15782030_G_C | 42 | G>R | No | 1000Genomes | |
| ENSVATH07267877 | 74 | L>F | No | 1000Genomes | |
| tmp_5_15782579_A_G | 75 | M>V | No | 1000Genomes | |
| ENSVATH07267878 | 78 | H>Q | No | 1000Genomes | |
| ENSVATH00688334 | 80 | I>T | No | 1000Genomes | |
| tmp_5_15782598_GT_AT,G | 81 | R>H | No | 1000Genomes | |
| tmp_5_15782616_A_T,G | 87 | E>G | No | 1000Genomes | |
| tmp_5_15782615_G_A | 87 | E>K | No | 1000Genomes | |
| tmp_5_15782616_A_T,G | 87 | E>V | No | 1000Genomes | |
| tmp_5_15782621_C_T | 89 | P>S | No | 1000Genomes | |
| ENSVATH00688336 | 90 | N>T | No | 1000Genomes | |
| ENSVATH07267879 | 94 | V>F | No | 1000Genomes | |
| ENSVATH07267879 | 94 | V>I | No | 1000Genomes | |
| tmp_5_15782681_G_C | 109 | V>L | No | 1000Genomes | |
| ENSVATH12230986 | 110 | E>Q | No | 1000Genomes | |
| ENSVATH07267882 | 115 | Q>K | No | 1000Genomes | |
| ENSVATH07267885 | 131 | E>G | No | 1000Genomes | |
| ENSVATH12230989 | 135 | R>H | No | 1000Genomes | |
| tmp_5_15782887_A_C | 144 | K>T | No | 1000Genomes | |
| tmp_5_15782898_G_A | 148 | V>M | No | 1000Genomes | |
| tmp_5_15782901_C_A | 149 | L>I | No | 1000Genomes | |
| ENSVATH07267886 | 151 | D>V | No | 1000Genomes | |
| tmp_5_15782918_C_G | 154 | C>W | No | 1000Genomes | |
| ENSVATH14549155 | 155 | N>K | No | 1000Genomes | |
| ENSVATH12230990 | 156 | I>V | No | 1000Genomes | |
| tmp_5_15782934_G_A | 160 | D>N | No | 1000Genomes | |
| ENSVATH07267887 | 161 | F>I | No | 1000Genomes | |
| ENSVATH07267888 | 165 | N>Y | No | 1000Genomes | |
| ENSVATH14549156 | 171 | H>R | No | 1000Genomes | |
| tmp_5_15782975_A_T | 173 | L>F | No | 1000Genomes | |
| ENSVATH07267890 | 174 | K>E | No | 1000Genomes | |
| tmp_5_15783000_TA_CA,T | 182 | Y>H | No | 1000Genomes | |
| tmp_5_15783147_A_G | 199 | I>M | No | 1000Genomes | |
| ENSVATH07267895 | 206 | L>I | No | 1000Genomes | |
| ENSVATH07267896 | 217 | D>Y | No | 1000Genomes | |
| tmp_5_15783202_G_A | 218 | D>N | No | 1000Genomes | |
| ENSVATH03290816 | 223 | N>D | No | 1000Genomes | |
| ENSVATH03290817 | 224 | V>I | No | 1000Genomes | |
| ENSVATH03290817 | 224 | V>L | No | 1000Genomes | |
| ENSVATH07267897 | 225 | F>L | No | 1000Genomes | |
| ENSVATH03290818 | 226 | E>D | No | 1000Genomes | |
| tmp_5_15783232_A_G | 228 | I>V | No | 1000Genomes | |
| tmp_5_15783336_A_C | 237 | N>H | No | 1000Genomes | |
| ENSVATH12231059 | 257 | M>T | No | 1000Genomes | |
| ENSVATH07267899 | 261 | I>F | No | 1000Genomes | |
| ENSVATH14549161 | 261 | I>T | No | 1000Genomes | |
| tmp_5_15783414_G_T | 263 | E>* | No | 1000Genomes | |
| ENSVATH12231060 | 268 | P>S | No | 1000Genomes | |
| ENSVATH07267902 | 272 | N>Y | No | 1000Genomes | |
| ENSVATH03290822 | 277 | Y>F | No | 1000Genomes | |
| ENSVATH07267903 | 280 | I>S | No | 1000Genomes | |
| tmp_5_15783468_C_A,T | 281 | P>S | No | 1000Genomes | |
| tmp_5_15783468_C_A,T | 281 | P>T | No | 1000Genomes | |
| ENSVATH03290825 | 287 | D>E | No | 1000Genomes | |
| ENSVATH00688341 | 299 | N>K | No | 1000Genomes | |
| tmp_5_15783620_A_G | 303 | I>V | No | 1000Genomes | |
| tmp_5_15783623_G_A | 304 | G>R | No | 1000Genomes | |
| tmp_5_15783629_G_A | 306 | D>N | No | 1000Genomes | |
| ENSVATH00688342 | 309 | H>Q | No | 1000Genomes | |
| tmp_5_15783638_C_T | 309 | H>Y | No | 1000Genomes | |
| ENSVATH14549163 | 311 | V>A | No | 1000Genomes | |
| tmp_5_15783651_C_G,T | 313 | S>C | No | 1000Genomes | |
| tmp_5_15783651_C_G,T | 313 | S>F | No | 1000Genomes | |
| ENSVATH03290834 | 315 | A>V | No | 1000Genomes | |
| tmp_5_15783661_T_A | 316 | N>K | No | 1000Genomes | |
| tmp_5_15783667_C_G | 318 | I>M | No | 1000Genomes | |
| tmp_5_15783668_C_G | 319 | Q>E | No | 1000Genomes | |
| tmp_5_15783670_A_T | 319 | Q>H | No | 1000Genomes | |
| tmp_5_15783669_A_T | 319 | Q>L | No | 1000Genomes | |
| ENSVATH03290835 | 320 | N>K | No | 1000Genomes | |
| tmp_5_15783779_ACC_A | 326 | Y>* | No | 1000Genomes | |
| ENSVATH07267908 | 331 | D>H | No | 1000Genomes | |
| tmp_5_15783800_G_A | 333 | R>Q | No | 1000Genomes | |
| ENSVATH00688345 | 336 | N>T | No | 1000Genomes | |
| tmp_5_15783812_C_T | 337 | S>F | No | 1000Genomes | |
| ENSVATH07267910 | 354 | I>L | No | 1000Genomes | |
| ENSVATH07267910 | 354 | I>V | No | 1000Genomes | |
| ENSVATH07267911 | 355 | F>I | No | 1000Genomes | |
| ENSVATH03290847 | 359 | L>F | No | 1000Genomes | |
| ENSVATH00688348 | 359 | L>S | No | 1000Genomes | |
| ENSVATH03290848 | 361 | V>A | No | 1000Genomes | |
| tmp_5_15784007_C_G | 370 | H>D | No | 1000Genomes | |
| ENSVATH00688349 | 373 | S>A | No | 1000Genomes | |
| ENSVATH07267912 | 374 | A>E | No | 1000Genomes | |
| ENSVATH07267913 | 375 | L>M | No | 1000Genomes | |
| tmp_5_15784038_C_T | 380 | S>F | No | 1000Genomes | |
| ENSVATH07267914 | 386 | K>E | No | 1000Genomes | |
| ENSVATH07267915 | 386 | K>I | No | 1000Genomes | |
| tmp_5_15784059_C_T | 387 | T>I | No | 1000Genomes | |
| tmp_5_15784065_C_A,T | 389 | T>I | No | 1000Genomes | |
| tmp_5_15784065_C_A,T | 389 | T>N | No | 1000Genomes | |
| ENSVATH03290854 | 399 | Y>H | No | 1000Genomes | |
| tmp_5_15784240_A_C | 399 | Y>S | No | 1000Genomes | |
| tmp_5_15784263_A_T | 407 | K>* | No | 1000Genomes | |
| ENSVATH14549175 | 408 | A>T | No | 1000Genomes | |
| ENSVATH12231156 | 424 | I>K | No | 1000Genomes | |
| tmp_5_15784330_T_C | 429 | V>A | No | 1000Genomes | |
| ENSVATH07267917 | 430 | R>P | No | 1000Genomes | |
| tmp_5_15784338_T_G | 432 | F>V | No | 1000Genomes | |
| ENSVATH07267918 | 435 | Y>S | No | 1000Genomes | |
| ENSVATH07267919 | 436 | K>N | No | 1000Genomes | |
| ENSVATH07267920 | 446 | I>F | No | 1000Genomes | |
| ENSVATH00688351 | 449 | P>L | No | 1000Genomes | |
| ENSVATH00688351 | 449 | P>R | No | 1000Genomes | |
| tmp_5_15784389_C_A | 449 | P>T | No | 1000Genomes | |
| ENSVATH03290856 | 450 | T>S | No | 1000Genomes | |
| ENSVATH07267921 | 455 | E>* | No | 1000Genomes | |
| ENSVATH07267926 | 462 | R>H | No | 1000Genomes | |
| ENSVATH12231197 | 464 | G>D | No | 1000Genomes | |
| ENSVATH14549178 | 471 | L>Q | No | 1000Genomes | |
| ENSVATH03290868 | 472 | R>K | No | 1000Genomes | |
| ENSVATH14549179 | 479 | I>V | No | 1000Genomes | |
| tmp_5_15784685_C_A | 491 | L>I | No | 1000Genomes |
No associated diseases with Q9FLZ3
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
73 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02066 | Abscisic acid-inducible protein kinase | Triticum aestivum (Wheat) | PR | |
| P06782 | SNF1 | Carbon catabolite-derepressing protein kinase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| Q5GLH2 | TRIB2 | Tribbles homolog 2 | Bos taurus (Bovine) | SS |
| Q0VCE3 | TRIB3 | Tribbles homolog 3 | Bos taurus (Bovine) | SS |
| Q3SZW1 | TSSK1B | Testis-specific serine/threonine-protein kinase 1 | Bos taurus (Bovine) | PR |
| Q92519 | TRIB2 | Tribbles homolog 2 | Homo sapiens (Human) | SS |
| Q96RU7 | TRIB3 | Tribbles homolog 3 | Homo sapiens (Human) | PR |
| Q96RU8 | TRIB1 | Tribbles homolog 1 | Homo sapiens (Human) | EV |
| Q15831 | STK11 | Serine/threonine-protein kinase STK11 | Homo sapiens (Human) | PR |
| Q96RG2 | PASK | PAS domain-containing serine/threonine-protein kinase | Homo sapiens (Human) | EV |
| Q9BXA7 | TSSK1B | Testis-specific serine/threonine-protein kinase 1 | Homo sapiens (Human) | PR |
| Q14680 | MELK | Maternal embryonic leucine zipper kinase | Homo sapiens (Human) | EV |
| P54646 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Homo sapiens (Human) | EV |
| Q9NRH2 | SNRK | SNF-related serine/threonine-protein kinase | Homo sapiens (Human) | SS |
| P57059 | SIK1 | Serine/threonine-protein kinase SIK1 | Homo sapiens (Human) | PR |
| O60285 | NUAK1 | NUAK family SNF1-like kinase 1 | Homo sapiens (Human) | PR |
| Q13131 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens (Human) | EV |
| Q8K4K3 | Trib2 | Tribbles homolog 2 | Mus musculus (Mouse) | SS |
| Q61241 | Tssk1b | Testis-specific serine/threonine-protein kinase 1 | Mus musculus (Mouse) | PR |
| Q8K4K2 | Trib3 | Tribbles homolog 3 | Mus musculus (Mouse) | SS |
| O54863 | Tssk2 | Testis-specific serine/threonine-protein kinase 2 | Mus musculus (Mouse) | PR |
| Q8K4K4 | Trib1 | Tribbles homolog 1 | Mus musculus (Mouse) | SS |
| Q5EG47 | Prkaa1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Mus musculus (Mouse) | SS |
| Q61846 | Melk | Maternal embryonic leucine zipper kinase | Mus musculus (Mouse) | PR |
| Q8BRK8 | Prkaa2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Mus musculus (Mouse) | SS |
| Q8C0X8 | Sperm motility kinase X | Mus musculus (Mouse) | PR | |
| A0AUV4 | Gm7168 | Sperm motility kinase Y | Mus musculus (Mouse) | PR |
| Q8C0N0 | Gm4922 | Sperm motility kinase Z | Mus musculus (Mouse) | PR |
| Q641K5 | Nuak1 | NUAK family SNF1-like kinase 1 | Mus musculus (Mouse) | PR |
| A2KF29 | Smoktcr | Sperm motility kinase Tcr mutant form | Mus musculus (Mouse) | PR |
| Q28948 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Sus scrofa (Pig) | SS |
| Q09136 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Sus scrofa (Pig) | SS |
| Q9WTQ6 | Trib3 | Tribbles homolog 3 | Rattus norvegicus (Rat) | SS |
| P54645 | Prkaa1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Rattus norvegicus (Rat) | EV |
| Q09137 | Prkaa2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Rattus norvegicus (Rat) | EV |
| Q5QNM6 | CIPK13 | Putative CBL-interacting protein kinase 13 | Oryza sativa subsp japonica (Rice) | PR |
| Q5JLQ9 | CIPK30 | CBL-interacting protein kinase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q5N942 | SAPK4 | Serine/threonine-protein kinase SAPK4 | Oryza sativa subsp japonica (Rice) | PR |
| Q852Q0 | OSK3 | Serine/threonine protein kinase OSK3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75LR7 | SAPK1 | Serine/threonine-protein kinase SAPK1 | Oryza sativa subsp japonica (Rice) | PR |
| Q75H77 | SAPK10 | Serine/threonine-protein kinase SAPK10 | Oryza sativa subsp japonica (Rice) | PR |
| Q7Y0B9 | SAPK8 | Serine/threonine-protein kinase SAPK8 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XQP4 | SAPK7 | Serine/threonine-protein kinase SAPK7 | Oryza sativa subsp japonica (Rice) | PR |
| Q6ZLP5 | CIPK23 | CBL-interacting protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| Q0D4J7 | SAPK2 | Serine/threonine-protein kinase SAPK2 | Oryza sativa subsp japonica (Rice) | PR |
| Q8LIG4 | CIPK3 | CBL-interacting protein kinase 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q6ERS4 | CIPK16 | CBL-interacting protein kinase 16 | Oryza sativa subsp japonica (Rice) | PR |
| P0C5D6 | SAPK3 | Serine/threonine-protein kinase SAPK3 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAX3 | CIPK33 | CBL-interacting protein kinase 33 | Oryza sativa subsp japonica (Rice) | PR |
| Q75V57 | SAPK9 | Serine/threonine-protein kinase SAPK9 | Oryza sativa subsp japonica (Rice) | PR |
| Q852Q1 | OSK4 | Serine/threonine protein kinase OSK4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q852Q2 | OSK1 | Serine/threonine protein kinase OSK1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q21017 | kin-29 | Serine/threonine-protein kinase kin-29 | Caenorhabditis elegans | SS |
| Q95ZQ4 | aak-2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Caenorhabditis elegans | SS |
| P45894 | aak-1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Caenorhabditis elegans | SS |
| Q2V452 | CIPK3 | CBL-interacting serine/threonine-protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22971 | CIPK13 | CBL-interacting serine/threonine-protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O65554 | CIPK6 | CBL-interacting serine/threonine-protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJ54 | CIPK20 | CBL-interacting serine/threonine-protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64812 | SRK2J | Serine/threonine-protein kinase SRK2J | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43292 | SRK2G | Serine/threonine-protein kinase SRK2G | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39193 | SRK2I | Serine/threonine-protein kinase SRK2I | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93VD3 | CIPK23 | CBL-interacting serine/threonine-protein kinase 23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94CG0 | CIPK21 | CBL-interacting serine/threonine-protein kinase 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C958 | SRK2B | Serine/threonine-protein kinase SRK2B | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FFP9 | SRK2H | Serine/threonine-protein kinase SRK2H | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDI3 | CIPK24 | CBL-interacting serine/threonine-protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M9E9 | SRK2C | Serine/threonine-protein kinase SRK2C | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43291 | SRK2A | Serine/threonine-protein kinase SRK2A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39192 | SRK2D | Serine/threonine-protein kinase SRK2D | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q940H6 | SRK2E | Serine/threonine-protein kinase SRK2E | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P92958 | KIN11 | SNF1-related protein kinase catalytic subunit alpha KIN11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38997 | KIN10 | SNF1-related protein kinase catalytic subunit alpha KIN10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDGSSEKTTN | KLVSILPNYR | IGKTLGHGSF | AKVKLALHVA | TGHKVAIKIL | NRSKIKNMGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIKVQREIKI | LRFLMHPHII | RQYEVIETPN | DIYVVMEYVK | SGELFDYIVE | KGKLQEDEAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HLFQQIISGV | EYCHRNMIVH | RDLKPENVLL | DSQCNIKIVD | FGLSNVMHDG | HFLKTSCGSP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NYAAPEVISG | KPYGPDVDIW | SCGVILYALL | CGTLPFDDEN | IPNVFEKIKR | GMYTLPNHLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HFARDLIPRM | LMVDPTMRIS | ITEIRQHPWF | NNHLPLYLSI | PPLDTIDQAK | KIEEEIIQNV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VNIGFDRNHV | VDSLANRIQN | EATVAYHLIL | DNRNQNSVPN | DPFQSKFKEI | SDGIFNSTLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VQNITSHVGH | SFSALYGLKS | NVKDDKTWTL | GLQSQGSPYD | IMTEIFKALQ | NLKICWKKIG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LYNIKCRWVR | SFAYYKNHTI | EDECAIILPT | VIKFEIQLYK | VREGKYLLDI | LRIDGPQFIF |
| 490 | |||||
| FDLCVAFLRE | LGVL |