Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9FKW6

Entry ID Method Resolution Chain Position Source
AF-Q9FKW6-F1 Predicted AlphaFoldDB

9 variants for Q9FKW6

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH03482618 20 L>P No 1000Genomes
tmp_5_26452916_G_T 33 L>I No 1000Genomes
ENSVATH12949480 62 V>L No 1000Genomes
tmp_5_26452656_A_G 84 Y>H No 1000Genomes
ENSVATH14650950 165 V>I No 1000Genomes
ENSVATH07488147 192 K>R No 1000Genomes
ENSVATH14650948 203 M>I No 1000Genomes
ENSVATH07488144 289 E>D No 1000Genomes
ENSVATH12949461 338 D>E No 1000Genomes

No associated diseases with Q9FKW6

10 regional properties for Q9FKW6

Type Name Position InterPro Accession
domain Oxidoreductase FAD/NAD(P)-binding 213 - 327 IPR001433
domain Flavoprotein pyridine nucleotide cytochrome reductase 116 - 126 IPR001709-1
domain Flavoprotein pyridine nucleotide cytochrome reductase 139 - 146 IPR001709-2
domain Flavoprotein pyridine nucleotide cytochrome reductase 176 - 185 IPR001709-3
domain Flavoprotein pyridine nucleotide cytochrome reductase 212 - 231 IPR001709-4
domain Flavoprotein pyridine nucleotide cytochrome reductase 242 - 251 IPR001709-5
domain Flavoprotein pyridine nucleotide cytochrome reductase 254 - 265 IPR001709-6
domain Flavoprotein pyridine nucleotide cytochrome reductase 290 - 306 IPR001709-7
domain Flavoprotein pyridine nucleotide cytochrome reductase 314 - 322 IPR001709-8
domain FAD-binding domain, ferredoxin reductase-type 81 - 203 IPR017927

Functions

Description
EC Number 1.18.1.2 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Plastid, chloroplast stroma
  • Plastid, chloroplast thylakoid membrane ; Peripheral membrane protein ; Stromal side
  • More abundant in the membrane fraction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
chloroplast thylakoid Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.
chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
chloroplast thylakoid membrane protein complex A protein complex that is part of a chloroplast thylakoid membrane.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
thylakoid lumen The volume enclosed by a thylakoid membrane.

5 GO annotations of molecular function

Name Definition
electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis.
electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis.
ferredoxin-NADP+ reductase activity Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+.
poly(U) RNA binding Binding to a sequence of uracil residues in an RNA molecule.
protein domain specific binding Binding to a specific domain of a protein.

1 GO annotations of biological process

Name Definition
photosynthetic electron transport chain A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P29473 NOS3 Nitric oxide synthase, endothelial Bos taurus (Bovine) EV
Q9UBK8 MTRR Methionine synthase reductase Homo sapiens (Human) PR
P29474 NOS3 Nitric oxide synthase, endothelial Homo sapiens (Human) SS
P29475 NOS1 Nitric oxide synthase, brain Homo sapiens (Human) SS
P70313 Nos3 Nitric oxide synthase 3 Mus musculus (Mouse) SS
Q8C1A3 Mtrr Methionine synthase reductase Mus musculus (Mouse) PR
Q28969 NOS3 Nitric oxide synthase 3 Sus scrofa (Pig) SS
Q62600 Nos3 Nitric oxide synthase 3 Rattus norvegicus (Rat) SS
Q498R1 Mtrr Methionine synthase reductase Rattus norvegicus (Rat) PR
P29476 Nos1 Nitric oxide synthase, brain Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MAAAISAAVS LPSSKSSSLL TKISSVSPQR IFLKKSTVCY RRVVSVKAQV TTDTTEAPPV
70 80 90 100 110 120
KVVKESKKQE EGIVVNKFKP KNPYTGRCLL NTKITGDDAP GETWHIVFTT EGEVPYREGQ
130 140 150 160 170 180
SIGVIPEGID KNGKPHKLRL YSIASSAIGD FGDSKTVSLC VKRLVYTNDG GEIVKGVCSN
190 200 210 220 230 240
FLCDLKPGDE AKITGPVGKE MLMPKDPNAT IIMLGTGTGI APFRSFLWKM FFEEHEDYKF
250 260 270 280 290 300
NGLAWLFLGV PTSSSLLYKE EFEKMKEKNP DNFRLDFAVS REQTNEKGEK MYIQTRMAEY
310 320 330 340 350
AEELWELLKK DNTFVYMCGL KGMEKGIDDI MVSLAAKDGI DWLEYKKQLK RSEQWNVEVY