Q9FJV0
Gene name |
MKK6 (ANQ1, At5g56580, MIK19.2) |
Protein name |
Mitogen-activated protein kinase kinase 6 |
Names |
AtMKK6, MAP kinase kinase 6, Protein Arabidopsis NQK1 homolog |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G56580 |
EC number |
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
210-233 (Activation loop from InterPro)
Target domain |
70-331 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9FJV0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FJV0-F1 | Predicted | AlphaFoldDB |
17 variants for Q9FJV0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07434457 | 20 | S>F | No | 1000Genomes | |
| ENSVATH03440241 | 21 | P>S | No | 1000Genomes | |
| tmp_5_22906402_G_T | 28 | A>E | No | 1000Genomes | |
| ENSVATH07434451 | 40 | N>T | No | 1000Genomes | |
| tmp_5_22906333_T_C | 51 | K>R | No | 1000Genomes | |
| ENSVATH12808713 | 58 | S>N | No | 1000Genomes | |
| tmp_5_22906205_G_T | 61 | L>I | No | 1000Genomes | |
| ENSVATH07434446 | 103 | M>I | No | 1000Genomes | |
| ENSVATH12808705 | 141 | A>T | No | 1000Genomes | |
| ENSVATH12808699 | 187 | R>T | No | 1000Genomes | |
| tmp_5_22905317_C_T | 265 | R>K | No | 1000Genomes | |
| tmp_5_22905207_G_C | 302 | P>A | No | 1000Genomes | |
| ENSVATH03440212 | 310 | A>D | No | 1000Genomes | |
| tmp_5_22905063_G_C | 317 | P>A | No | 1000Genomes | |
| ENSVATH07434434 | 340 | D>Y | No | 1000Genomes | |
| tmp_5_22904873_G_C | 350 | P>R | No | 1000Genomes | |
| ENSVATH12808658 | 356 | R>K | No | 1000Genomes |
No associated diseases with Q9FJV0
4 regional properties for Q9FJV0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FKBP-type peptidyl-prolyl cis-trans isomerase domain | 51 - 142 | IPR001179 |
| repeat | Tetratricopeptide repeat | 170 - 203 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 218 - 251 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 252 - 285 | IPR019734-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.12.2 | Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| phragmoplast | Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
| mitogen-activated protein kinase binding | Binding to a mitogen-activated protein kinase. |
| mitogen-activated protein kinase kinase kinase binding | Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to oomycetes | Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism. |
| lateral root formation | The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper. |
| male meiosis cytokinesis | A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q90891 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Gallus gallus (Chicken) | PR |
| Q9XT09 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Pan troglodytes (Chimpanzee) | PR |
| Q1HG70 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q24324 | Dsor1 | Dual specificity mitogen-activated protein kinase kinase dSOR1 | Drosophila melanogaster (Fruit fly) | PR |
| Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (Human) | EV |
| Q13163 | MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 | Homo sapiens (Human) | PR |
| P36507 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens (Human) | EV |
| Q9WVS7 | Map2k5 | Dual specificity mitogen-activated protein kinase kinase 5 | Mus musculus (Mouse) | PR |
| P31938 | Map2k1 | Dual specificity mitogen-activated protein kinase kinase 1 | Mus musculus (Mouse) | PR |
| Q63932 | Map2k2 | Dual specificity mitogen-activated protein kinase kinase 2 | Mus musculus (Mouse) | PR |
| Q01986 | Map2k1 | Dual specificity mitogen-activated protein kinase kinase 1 | Rattus norvegicus (Rat) | PR |
| Q62862 | Map2k5 | Dual specificity mitogen-activated protein kinase kinase 5 | Rattus norvegicus (Rat) | PR |
| P36506 | Map2k2 | Dual specificity mitogen-activated protein kinase kinase 2 | Rattus norvegicus (Rat) | SS |
| Q5QN75 | MKK1 | Mitogen-activated protein kinase kinase 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q10664 | mek-2 | Dual specificity mitogen-activated protein kinase kinase mek-2 | Caenorhabditis elegans | PR |
| Q9S7U9 | MKK2 | Mitogen-activated protein kinase kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94A06 | MKK1 | Mitogen-activated protein kinase kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKIKSNLKQ | LKLSVPAQES | PISSFLTASG | TFHDGDFLLN | QKGLRLTSDE | KQSRQSDSKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDFEITAEDL | ETVKVIGKGS | GGVVQLVRHK | WVGKFFAMKV | IQMNIQEEIR | KQIVQELKIN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QASSQCPHVV | VCYHSFYHNG | AFSLVLEYMD | RGSLADVIRQ | VKTILEPYLA | VVCKQVLLGL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VYLHNERHVI | HRDIKPSNLL | VNHKGEVKIS | DFGVSASLAS | SMGQRDTFVG | TYNYMSPERI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SGSTYDYSSD | IWSLGMSVLE | CAIGRFPYLE | SEDQQNPPSF | YELLAAIVEN | PPPTAPSDQF |
| 310 | 320 | 330 | 340 | 350 | |
| SPEFCSFVSA | CIQKDPPARA | SSLDLLSHPF | IKKFEDKDID | LGILVGTLEP | PVNYLR |