Q9FJ21
SS
Gene name |
PME58 (ARATH58, At5g49180, K21P3.5) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 58 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G49180 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
259-556 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q9FJ21
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FJ21-F1 | Predicted | AlphaFoldDB |
58 variants for Q9FJ21
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07378832 | 6 | E>Q | No | 1000Genomes | |
| ENSVATH07378831 | 14 | I>F | No | 1000Genomes | |
| ENSVATH12652604 | 17 | V>F | No | 1000Genomes | |
| tmp_5_19942819_C_G | 20 | A>P | No | 1000Genomes | |
| tmp_5_19942807_G_A | 24 | L>F | No | 1000Genomes | |
| ENSVATH07378828 | 36 | N>K | No | 1000Genomes | |
| tmp_5_19942762_G_A | 39 | H>Y | No | 1000Genomes | |
| ENSVATH07378826 | 70 | N>S | No | 1000Genomes | |
| ENSVATH14615771 | 76 | S>F | No | 1000Genomes | |
| ENSVATH07378825 | 78 | D>E | No | 1000Genomes | |
| ENSVATH12652603 | 98 | E>K | No | 1000Genomes | |
| ENSVATH07378823 | 108 | L>V | No | 1000Genomes | |
| tmp_5_19942537_T_A | 114 | N>Y | No | 1000Genomes | |
| ENSVATH07378821 | 115 | D>E | No | 1000Genomes | |
| ENSVATH07378822 | 115 | D>N | No | 1000Genomes | |
| ENSVATH12652602 | 127 | K>N | No | 1000Genomes | |
| tmp_5_19942486_C_T | 131 | D>N | No | 1000Genomes | |
| ENSVATH07378820 | 133 | T>S | No | 1000Genomes | |
| tmp_5_19942432_G_A | 149 | P>S | No | 1000Genomes | |
| tmp_5_19942401_C_T | 159 | R>H | No | 1000Genomes | |
| tmp_5_19942313_C_A | 188 | Q>H | No | 1000Genomes | |
| ENSVATH07378819 | 201 | G>D | No | 1000Genomes | |
| tmp_5_19942265_C_T | 204 | M>I | No | 1000Genomes | |
| tmp_5_19942260_G_T | 206 | T>N | No | 1000Genomes | |
| ENSVATH12652551 | 220 | V>L | No | 1000Genomes | |
| ENSVATH12652549 | 234 | A>T | No | 1000Genomes | |
| tmp_5_19942094_G_C | 236 | D>E | No | 1000Genomes | |
| ENSVATH07378815 | 252 | T>M | No | 1000Genomes | |
| tmp_5_19942015_C_A | 263 | A>S | No | 1000Genomes | |
| ENSVATH07378813 | 264 | H>Q | No | 1000Genomes | |
| tmp_5_19941997_G_C | 269 | Q>E | No | 1000Genomes | |
| ENSVATH07378810 | 276 | A>P | No | 1000Genomes | |
| ENSVATH07378809 | 284 | N>S | No | 1000Genomes | |
| tmp_5_19941944_C_A | 286 | K>N | No | 1000Genomes | |
| tmp_5_19941938_A_T | 288 | F>L | No | 1000Genomes | |
| tmp_5_19941937_C_A | 289 | V>F | No | 1000Genomes | |
| tmp_5_19941905_C_A | 299 | E>D | No | 1000Genomes | |
| tmp_5_19941898_C_A | 302 | D>Y | No | 1000Genomes | |
| tmp_5_19941888_T_C | 305 | K>R | No | 1000Genomes | |
| ENSVATH14615769 | 317 | P>S | No | 1000Genomes | |
| tmp_5_19941838_T_G | 322 | I>L | No | 1000Genomes | |
| ENSVATH03395918 | 354 | G>R | No | 1000Genomes | |
| ENSVATH12652535 | 356 | E>K | No | 1000Genomes | |
| ENSVATH14615765 | 362 | E>A | No | 1000Genomes | |
| ENSVATH03395915 | 403 | T>K | No | 1000Genomes | |
| ENSVATH03395914 | 425 | V>I | No | 1000Genomes | |
| tmp_5_19941215_T_G | 428 | K>N | No | 1000Genomes | |
| ENSVATH12652494 | 457 | H>Y | No | 1000Genomes | |
| ENSVATH14615743 | 466 | P>T | No | 1000Genomes | |
| tmp_5_19941100_C_G | 467 | V>L | No | 1000Genomes | |
| ENSVATH07378789 | 481 | E>A | No | 1000Genomes | |
| tmp_5_19940946_T_C | 518 | Y>C | No | 1000Genomes | |
| ENSVATH00721465 | 526 | N>D | No | 1000Genomes | |
| ENSVATH00721464 | 529 | Q>E | No | 1000Genomes | |
| tmp_5_19940851_C_T | 550 | A>T | No | 1000Genomes | |
| tmp_5_19940835_C_A | 555 | G>V | No | 1000Genomes | |
| ENSVATH07378783 | 567 | M>I | No | 1000Genomes | |
| ENSVATH07378782 | 568 | G>R | No | 1000Genomes |
No associated diseases with Q9FJ21
6 regional properties for Q9FJ21
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 30 - 154 | IPR000008 |
| domain | HECT domain | 647 - 1003 | IPR000569 |
| domain | WW domain | 221 - 254 | IPR001202-1 |
| domain | WW domain | 414 - 447 | IPR001202-2 |
| domain | WW domain | 526 - 559 | IPR001202-3 |
| domain | WW domain | 577 - 610 | IPR001202-4 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| mucilage metabolic process involved in seed coat development | The chemical reactions and pathways involving mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development. |
| mucilage pectin biosynthetic process | The chemical reactions and pathways resulting in the formation of the pectin component of mucilage. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVDGELKKK | KCIIAGVITA | LLVLMVVAVG | ITTSRNTSHS | EKIVPVQIKT | ATTAVEAVCA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PTDYKETCVN | SLMKASPDST | QPLDLIKLGF | NVTIRSIEDS | IKKASVELTA | KAANDKDTKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALELCEKLMN | DATDDLKKCL | DNFDGFSIPQ | IEDFVEDLRV | WLSGSIAYQQ | TCMDTFEETN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SKLSQDMQKI | FKTSRELTSN | GLAMITNISN | LLGEFNVTGV | TGDLGKYARK | LLSAEDGIPS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WVGPNTRRLM | ATKGGVKANV | VVAHDGSGQY | KTINEALNAV | PKANQKPFVI | YIKQGVYNEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VDVTKKMTHV | TFIGDGPTKT | KITGSLNYYI | GKVKTYLTAT | VAINGDNFTA | KNIGFENTAG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEGHQAVALR | VSADLAVFYN | CQIDGYQDTL | YVHSHRQFFR | DCTVSGTVDF | IFGDGIVVLQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NCNIVVRKPM | KSQSCMITAQ | GRSDKRESTG | LVLQNCHITG | EPAYIPVKSI | NKAYLGRPWK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EFSRTIIMGT | TIDDVIDPAG | WLPWNGDFAL | NTLYYAEYEN | NGPGSNQAQR | VKWPGIKKLS |
| 550 | 560 | 570 | |||
| PKQALRFTPA | RFLRGNLWIP | PNRVPYMGNF | Q |