Q9FIL7
Gene name |
CRCK1 (At5g58940, K19M22.13) |
Protein name |
Calmodulin-binding receptor-like cytoplasmic kinase 1 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G58940 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
290-297 (Activation loop from InterPro)
Target domain |
147-423 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
308-316 (Activation loop from InterPro)
Target domain |
147-423 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9FIL7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FIL7-F1 | Predicted | AlphaFoldDB |
49 variants for Q9FIL7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07447241 | 7 | T>A | No | 1000Genomes | |
| ENSVATH07447241 | 7 | T>P | No | 1000Genomes | |
| ENSVATH07447242 | 8 | P>Q | No | 1000Genomes | |
| tmp_5_23798717_G_A | 20 | R>K | No | 1000Genomes | |
| ENSVATH07447243 | 26 | S>G | No | 1000Genomes | |
| tmp_5_23798763_G_T | 35 | K>N | No | 1000Genomes | |
| tmp_5_23798777_C_G | 40 | S>C | No | 1000Genomes | |
| tmp_5_23798791_A_G | 45 | I>V | No | 1000Genomes | |
| ENSVATH03449841 | 54 | V>A | No | 1000Genomes | |
| ENSVATH12848933 | 54 | V>F | No | 1000Genomes | |
| ENSVATH12848933 | 54 | V>I | No | 1000Genomes | |
| ENSVATH12848933 | 54 | V>L | No | 1000Genomes | |
| ENSVATH03449843 | 101 | E>K | No | 1000Genomes | |
| tmp_5_23799199_G_A | 106 | G>S | No | 1000Genomes | |
| ENSVATH12848934 | 109 | R>S | No | 1000Genomes | |
| ENSVATH00741585 | 119 | G>A | No | 1000Genomes | |
| ENSVATH12848975 | 119 | G>W | No | 1000Genomes | |
| ENSVATH12848976 | 122 | S>F | No | 1000Genomes | |
| tmp_5_23799261_A_T | 126 | K>N | No | 1000Genomes | |
| ENSVATH07447248 | 126 | K>Q | No | 1000Genomes | |
| ENSVATH07447249 | 149 | S>L | No | 1000Genomes | |
| ENSVATH07447250 | 150 | V>G | No | 1000Genomes | |
| ENSVATH03449848 | 201 | E>K | No | 1000Genomes | |
| ENSVATH12848977 | 216 | D>E | No | 1000Genomes | |
| ENSVATH12848978 | 221 | V>F | No | 1000Genomes | |
| ENSVATH07447257 | 238 | R>T | No | 1000Genomes | |
| tmp_5_23799851_G_A,C | 239 | G>A | No | 1000Genomes | |
| tmp_5_23799851_G_A,C | 239 | G>D | No | 1000Genomes | |
| tmp_5_23799873_A_C | 246 | E>D | No | 1000Genomes | |
| tmp_5_23799881_A_C | 249 | E>A | No | 1000Genomes | |
| tmp_5_23799899_C_T | 255 | A>V | No | 1000Genomes | |
| tmp_5_23799916_T_A | 261 | L>M | No | 1000Genomes | |
| tmp_5_23800063_A_G | 283 | N>D | No | 1000Genomes | |
| ENSVATH12848980 | 313 | G>E | No | 1000Genomes | |
| tmp_5_23800262_G_A | 349 | R>H | No | 1000Genomes | |
| tmp_5_23800282_C_T | 356 | P>S | No | 1000Genomes | |
| ENSVATH07447261 | 372 | D>G | No | 1000Genomes | |
| tmp_5_23800433_T_C | 377 | L>P | No | 1000Genomes | |
| ENSVATH00741589 | 378 | I>L | No | 1000Genomes | |
| ENSVATH07447262 | 378 | I>M | No | 1000Genomes | |
| ENSVATH03449850 | 389 | A>V | No | 1000Genomes | |
| ENSVATH14639998 | 400 | A>T | No | 1000Genomes | |
| tmp_5_23800520_C_A | 406 | P>Q | No | 1000Genomes | |
| ENSVATH03449851 | 416 | G>C | No | 1000Genomes | |
| tmp_5_23800582_G_C | 427 | E>Q | No | 1000Genomes | |
| ENSVATH14639999 | 429 | K>* | No | 1000Genomes | |
| tmp_5_23800625_C_A | 441 | S>Y | No | 1000Genomes | |
| ENSVATH03449852 | 445 | T>R | No | 1000Genomes | |
| ENSVATH03449853 | 470 | E>G | No | 1000Genomes |
No associated diseases with Q9FIL7
5 regional properties for Q9FIL7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 12 - 264 | IPR000719 |
| domain | NAF domain | 294 - 351 | IPR004041 |
| active_site | Serine/threonine-protein kinase, active site | 130 - 142 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 18 - 41 | IPR017441 |
| domain | NAF/FISL domain | 291 - 315 | IPR018451 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| calmodulin-dependent protein kinase activity | Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| response to abscisic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. |
| response to cold | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| response to salt stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. |
25 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| Q8K4B2 | Irak3 | Interleukin-1 receptor-associated kinase 3 | Mus musculus (Mouse) | PR |
| Q8CFA1 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Mus musculus (Mouse) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTC0 | PBL19 | Probable serine/threonine-protein kinase PBL19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFG1 | At3g53590 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPMRSKTPTP | LRFSNGKHQR | DDSEYSWTDV | GTGEKARNVS | VLGAIRRAAK | KVFVIIFLGQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RKLKPTECRS | DPGESSTHDR | ESTLSGWTGY | SSPSSFGRST | ERKVSGQYRF | SGSRFQSPGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DSSSSKSWHQ | GPVIFSFGEL | QRATANFSSV | HQIGEGGFGT | VFKGKLDDGT | IVAIKRARKN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NYGKSWLLEF | KNEIYTLSKI | EHMNLVKLYG | FLEHGDEKVI | VVEYVANGNL | REHLDGLRGN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLEMAERLEI | AIDVAHALTY | LHTYTDSPII | HRDIKASNIL | ITNKLRAKVA | DFGFARLVSE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DLGATHISTQ | VKGSAGYVDP | DYLRTFQLTD | KSDVYSFGVL | LVEILTGRRP | IELKRPRKDR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LTVKWALRRL | KDDEAVLIMD | PFLKRNRAAI | EVAEKMLRLA | SECVTPTRAT | RPAMKGIAEK |
| 430 | 440 | 450 | 460 | ||
| LWAIRREMKE | TMICSSASNS | SCSSTTHSFI | GRDSDRYALP | RIEDNENSIE |