Q9FIJ0
PR
Gene name |
RBOHD |
Protein name |
Respiratory burst oxidase homolog protein D |
Names |
NADPH oxidase RBOHD, AtRBOHD |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G47910 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FIJ0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FIJ0-F1 | Predicted | AlphaFoldDB |
27 variants for Q9FIJ0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07365268 | 14 | L>F | No | 1000Genomes | |
| ENSVATH07365270 | 48 | A>T | No | 1000Genomes | |
| tmp_5_19397753_G_A | 57 | D>N | No | 1000Genomes | |
| ENSVATH00717852 | 64 | N>S | No | 1000Genomes | |
| ENSVATH00717853 | 87 | S>A | No | 1000Genomes | |
| tmp_5_19397879_G_A | 99 | G>S | No | 1000Genomes | |
| tmp_5_19397930_C_A | 116 | L>I | No | 1000Genomes | |
| ENSVATH03384086 | 123 | T>N | No | 1000Genomes | |
| tmp_5_19398045_C_G | 154 | A>G | No | 1000Genomes | |
| ENSVATH14607780 | 159 | D>A | No | 1000Genomes | |
| tmp_5_19398153_A_G | 190 | D>G | No | 1000Genomes | |
| ENSVATH07365277 | 199 | L>V | No | 1000Genomes | |
| tmp_5_19398376_G_A | 234 | G>S | No | 1000Genomes | |
| ENSVATH12614154 | 342 | L>F | No | 1000Genomes | |
| ENSVATH03384107 | 349 | K>N | No | 1000Genomes | |
| ENSVATH03384108 | 356 | S>R | No | 1000Genomes | |
| ENSVATH00717865 | 360 | V>L | No | 1000Genomes | |
| tmp_5_19399934_C_A | 427 | L>I | No | 1000Genomes | |
| tmp_5_19400051_A_G | 466 | I>V | No | 1000Genomes | |
| ENSVATH07365318 | 524 | V>L | No | 1000Genomes | |
| tmp_5_19400235_C_T | 527 | A>V | No | 1000Genomes | |
| tmp_5_19400350_C_G | 565 | I>M | No | 1000Genomes | |
| ENSVATH00717874 | 572 | I>V | No | 1000Genomes | |
| tmp_5_19400977_G_A | 693 | E>K | No | 1000Genomes | |
| ENSVATH14607803 | 735 | K>N | No | 1000Genomes | |
| tmp_5_19401109_G_A | 737 | D>N | No | 1000Genomes | |
| ENSVATH03384117 | 892 | M>I | No | 1000Genomes |
No associated diseases with Q9FIJ0
7 regional properties for Q9FIJ0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 237 - 288 | IPR002048 |
| domain | FAD-binding 8 | 615 - 729 | IPR013112 |
| domain | Ferric reductase, NAD binding domain | 736 - 903 | IPR013121 |
| domain | Ferric reductase transmembrane component-like domain | 416 - 572 | IPR013130 |
| domain | NADPH oxidase Respiratory burst | 157 - 256 | IPR013623 |
| domain | FAD-binding domain, ferredoxin reductase-type | 611 - 732 | IPR017927 |
| binding_site | EF-Hand 1, calcium-binding site | 266 - 278 | IPR018247 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| ferric-chelate reductase activity | Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor. |
| NAD(P)H oxidase H2O2-forming activity | Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. |
| peroxidase activity | Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate homeostasis | A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. |
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| negative regulation of programmed cell death | Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. |
| osmosensory signaling pathway | The series of molecular signals initiated in response to osmotic change. |
| reactive oxygen species metabolic process | The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96PH1 | NOX5 | NADPH oxidase 5 | Homo sapiens (Human) | EV |
| Q948U0 | RBOHA | Respiratory burst oxidase homolog protein A | Solanum tuberosum (Potato) | PR |
| Q948T9 | RBOHB | Respiratory burst oxidase homolog protein B | Solanum tuberosum (Potato) | PR |
| Q2HXK9 | RBOHD | Respiratory burst oxidase homolog protein D | Solanum tuberosum (Potato) | PR |
| Q5ZAJ0 | RBOHB | Respiratory burst oxidase homolog protein B | Oryza sativa subsp japonica (Rice) | PR |
| O48538 | RBOHF | Respiratory burst oxidase homolog protein F | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P92949 | CDC5 | Ferric reduction oxidase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W110 | FRO4 | Ferric reduction oxidase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJD6 | RBOHH | Putative respiratory burst oxidase homolog protein H | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUT8 | RBOHI | Probable respiratory burst oxidase homolog protein I | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4K7 | FRO3 | Ferric reduction oxidase 3, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81211 | RBOHE | Respiratory burst oxidase homolog protein E | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKMRRGNSSN | DHELGILRGA | NSDTNSDTES | IASDRGAFSG | PLGRPKRASK | KNARFADDLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRSNSVAGGR | GDDDEYVEIT | LDIRDDSVAV | HSVQQAAGGG | GHLEDPELAL | LTKKTLESSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NNTTSLSFFR | STSSRIKNAS | RELRRVFSRR | PSPAVRRFDR | TSSAAIHALK | GLKFIATKTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AWPAVDQRFD | KLSADSNGLL | LSAKFWECLG | MNKESKDFAD | QLFRALARRN | NVSGDAITKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QLRIFWEQIS | DESFDAKLQV | FFDMVDKDED | GRVTEEEVAE | IISLSASANK | LSNIQKQAKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YAALIMEELD | PDNAGFIMIE | NLEMLLLQAP | NQSVRMGDSR | ILSQMLSQKL | RPAKESNPLV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RWSEKIKYFI | LDNWQRLWIM | MLWLGICGGL | FTYKFIQYKN | KAAYGVMGYC | VCVAKGGAET |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKFNMALILL | PVCRNTITWL | RNKTKLGTVV | PFDDSLNFHK | VIASGIVVGV | LLHAGAHLTC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DFPRLIAADE | DTYEPMEKYF | GDQPTSYWWF | VKGVEGWTGI | VMVVLMAIAF | TLATPWFRRN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KLNLPNFLKK | LTGFNAFWYT | HHLFIIVYAL | LIVHGIKLYL | TKIWYQKTTW | MYLAVPILLY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ASERLLRAFR | SSIKPVKMIK | VAVYPGNVLS | LHMTKPQGFK | YKSGQFMLVN | CRAVSPFEWH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PFSITSAPGD | DYLSVHIRTL | GDWTRKLRTV | FSEVCKPPTA | GKSGLLRADG | GDGNLPFPKV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LIDGPYGAPA | QDYKKYDVVL | LVGLGIGATP | MISILKDIIN | NMKGPDRDSD | IENNNSNNNS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KGFKTRKAYF | YWVTREQGSF | EWFKGIMDEI | SELDEEGIIE | LHNYCTSVYE | EGDARVALIA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| MLQSLQHAKN | GVDVVSGTRV | KSHFAKPNWR | QVYKKIAVQH | PGKRIGVFYC | GMPGMIKELK |
| 910 | 920 | ||||
| NLALDFSRKT | TTKFDFHKEN | F |