Q9FHN5
SS
Gene name |
PME59 (ARATH59, At5g51490, K17N15.4) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 59 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G51490 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
221-521 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q9FHN5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FHN5-F1 | Predicted | AlphaFoldDB |
35 variants for Q9FHN5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12701476 | 3 | M>I | No | 1000Genomes | |
| ENSVATH07395496 | 8 | L>F | No | 1000Genomes | |
| tmp_5_20915476_G_C | 44 | P>R | No | 1000Genomes | |
| tmp_5_20915407_C_T | 67 | R>Q | No | 1000Genomes | |
| ENSVATH07395494 | 68 | V>E | No | 1000Genomes | |
| tmp_5_20915393_C_T | 72 | E>K | No | 1000Genomes | |
| ENSVATH12701475 | 98 | Q>R | No | 1000Genomes | |
| ENSVATH12701464 | 102 | A>V | No | 1000Genomes | |
| ENSVATH03409212 | 110 | D>E | No | 1000Genomes | |
| ENSVATH07395491 | 124 | P>R | No | 1000Genomes | |
| ENSVATH03409211 | 129 | A>E | No | 1000Genomes | |
| ENSVATH03409211 | 129 | A>V | No | 1000Genomes | |
| ENSVATH07395490 | 135 | F>L | No | 1000Genomes | |
| ENSVATH03409208 | 155 | S>T | No | 1000Genomes | |
| ENSVATH03409207 | 158 | L>F | No | 1000Genomes | |
| ENSVATH03409206 | 161 | T>S | No | 1000Genomes | |
| ENSVATH07395488 | 175 | H>Y | No | 1000Genomes | |
| ENSVATH03409204 | 189 | T>P | No | 1000Genomes | |
| ENSVATH14625815 | 196 | T>A | No | 1000Genomes | |
| ENSVATH00726800 | 197 | T>S | No | 1000Genomes | |
| tmp_5_20915008_T_G | 200 | Q>P | No | 1000Genomes | |
| tmp_5_20914984_G_C | 208 | S>C | No | 1000Genomes | |
| ENSVATH12701462 | 223 | V>M | No | 1000Genomes | |
| ENSVATH07395486 | 233 | N>K | No | 1000Genomes | |
| ENSVATH12701459 | 240 | D>E | No | 1000Genomes | |
| ENSVATH07395484 | 273 | D>N | No | 1000Genomes | |
| tmp_5_20914741_C_A | 289 | G>V | No | 1000Genomes | |
| tmp_5_20914708_T_C | 300 | N>S | No | 1000Genomes | |
| ENSVATH07395479 | 347 | E>Q | No | 1000Genomes | |
| ENSVATH14625773 | 394 | K>R | No | 1000Genomes | |
| tmp_5_20914003_C_T | 430 | V>M | No | 1000Genomes | |
| ENSVATH14625772 | 452 | Q>H | No | 1000Genomes | |
| tmp_5_20913921_T_A | 457 | N>I | No | 1000Genomes | |
| ENSVATH12701423 | 507 | A>P | No | 1000Genomes | |
| tmp_5_20913711_C_T | 527 | R>H | No | 1000Genomes |
No associated diseases with Q9FHN5
No regional properties for Q9FHN5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9FHN5 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNMMMQKLSI | LFLHLILLVL | LCVHPLTTVA | DRNSTDWCDK | TPYPDPCKCY | FKNHNGFQQP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TQLSEFRVML | VEAAMDRAIS | ARAELTNSGK | NCTDSKKQAV | LADCIDLYGD | TIMQLNRTLH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GVSPKAGAAK | SCTDFDAQTW | LSTALTNTET | CRRGSSDLNV | TDFITPIVSN | TKISHLISNC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAVNGALLTA | GNKGNTTANQ | KGFPTWLSRK | DKRLLRAVRA | NLVVAKDGSG | HFNTVQAAID |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAGRRKVTSG | RFVIYVKRGI | YQENINVRLN | NDDIMLVGDG | MRSTIITGGR | SVQGGYTTYN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SATAGIEGLH | FIAKGITFRN | TAGPAKGQAV | ALRSSSDLSI | FYKCSIEGYQ | DTLMVHSQRQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FYRECYIYGT | VDFIFGNAAA | VFQNCLILPR | RPLKGQANVI | TAQGRADPFQ | NTGISIHNSR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILPAPDLKPV | VGTVKTYMGR | PWMKFSRTVV | LQTYLDNVVS | PVGWSPWIEG | SVFGLDTLFY |
| 490 | 500 | 510 | 520 | 530 | |
| AEYKNTGPAS | STRWRVSWKG | FHVLGRASDA | SAFTVGKFIA | GTAWLPRTGI | PFTSGL |