Q9FHN4
SS
Gene name |
PME60 (ARATH60, At5g51500, K17N15.5) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 60 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G51500 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
225-526 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q9FHN4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FHN4-F1 | Predicted | AlphaFoldDB |
86 variants for Q9FHN4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12701641 | 2 | N>K | No | 1000Genomes | |
| ENSVATH12701640 | 8 | N>T | No | 1000Genomes | |
| ENSVATH12701639 | 9 | I>V | No | 1000Genomes | |
| tmp_5_20919805_GA_CA,G | 12 | L>V | No | 1000Genomes | |
| ENSVATH07395552 | 25 | R>H | No | 1000Genomes | |
| tmp_5_20919721_C_T | 40 | G>R | No | 1000Genomes | |
| tmp_5_20919713_G_T | 42 | C>* | No | 1000Genomes | |
| ENSVATH12701636 | 51 | C>Y | No | 1000Genomes | |
| ENSVATH07395550 | 57 | K>I | No | 1000Genomes | |
| tmp_5_20919664_T_A | 59 | S>C | No | 1000Genomes | |
| tmp_5_20919660_C_G | 60 | G>A | No | 1000Genomes | |
| tmp_5_20919654_C_T | 62 | R>Q | No | 1000Genomes | |
| tmp_5_20919640_T_A | 67 | I>L | No | 1000Genomes | |
| tmp_5_20919634_C_T | 69 | E>K | No | 1000Genomes | |
| ENSVATH07395549 | 72 | V>A | No | 1000Genomes | |
| tmp_5_20919609_G_A | 77 | A>V | No | 1000Genomes | |
| tmp_5_20919523_C_T | 106 | A>T | No | 1000Genomes | |
| tmp_5_20919507_A_T | 111 | L>H | No | 1000Genomes | |
| ENSVATH12701614 | 115 | T>I | No | 1000Genomes | |
| tmp_5_20919488_C_T | 117 | M>I | No | 1000Genomes | |
| ENSVATH12701613 | 122 | T>M | No | 1000Genomes | |
| ENSVATH00726829 | 123 | L>M | No | 1000Genomes | |
| ENSVATH00726829 | 123 | L>V | No | 1000Genomes | |
| ENSVATH12701612 | 124 | Q>H | No | 1000Genomes | |
| tmp_5_20919450_G_T | 130 | T>N | No | 1000Genomes | |
| tmp_5_20919445_T_C | 132 | R>G | No | 1000Genomes | |
| tmp_5_20919441_C_T | 133 | R>K | No | 1000Genomes | |
| tmp_5_20919440_C_G | 133 | R>S | No | 1000Genomes | |
| ENSVATH07395546 | 137 | F>S | No | 1000Genomes | |
| tmp_5_20919413_C_A | 142 | W>C | No | 1000Genomes | |
| tmp_5_20919387_T_C | 151 | E>G | No | 1000Genomes | |
| ENSVATH07395545 | 154 | R>Q | No | 1000Genomes | |
| tmp_5_20919356_G_T | 161 | N>K | No | 1000Genomes | |
| ENSVATH12701607 | 163 | S>L | No | 1000Genomes | |
| tmp_5_20919342_G_A | 166 | T>I | No | 1000Genomes | |
| ENSVATH07395544 | 171 | S>* | No | 1000Genomes | |
| ENSVATH07395544 | 171 | S>L | No | 1000Genomes | |
| tmp_5_20919322_T_C | 173 | T>A | No | 1000Genomes | |
| tmp_5_20919321_G_T | 173 | T>K | No | 1000Genomes | |
| tmp_5_20919307_G_C | 178 | L>V | No | 1000Genomes | |
| tmp_5_20919286_C_T | 185 | V>I | No | 1000Genomes | |
| tmp_5_20919264_G_A | 192 | A>V | No | 1000Genomes | |
| ENSVATH03409246 | 193 | G>R | No | 1000Genomes | |
| tmp_5_20919213_A_T | 209 | V>D | No | 1000Genomes | |
| tmp_5_20919187_G_A | 218 | Q>* | No | 1000Genomes | |
| ENSVATH12701605 | 222 | V>L | No | 1000Genomes | |
| ENSVATH00726826 | 224 | A>T | No | 1000Genomes | |
| tmp_5_20919145_C_A | 232 | G>* | No | 1000Genomes | |
| ENSVATH03409245 | 251 | V>A | No | 1000Genomes | |
| tmp_5_20919070_C_G | 257 | V>L | No | 1000Genomes | |
| tmp_5_20919041_T_G | 266 | Q>H | No | 1000Genomes | |
| tmp_5_20919035_G_T | 268 | N>K | No | 1000Genomes | |
| ENSVATH03409243 | 269 | L>I | No | 1000Genomes | |
| ENSVATH03409242 | 277 | N>D | No | 1000Genomes | |
| ENSVATH12701584 | 281 | V>I | No | 1000Genomes | |
| ENSVATH08570473 | 287 | Y>S | No | 1000Genomes | |
| tmp_5_20918961_C_T | 293 | G>D | No | 1000Genomes | |
| ENSVATH07395542 | 296 | V>I | No | 1000Genomes | |
| ENSVATH03409241 | 297 | K>Q | No | 1000Genomes | |
| tmp_5_20918621_C_G | 311 | E>Q | No | 1000Genomes | |
| tmp_5_20918584_T_C | 323 | Q>R | No | 1000Genomes | |
| ENSVATH00726818 | 335 | A>T | No | 1000Genomes | |
| tmp_5_20918542_C_T | 337 | R>Q | No | 1000Genomes | |
| tmp_5_20918539_G_A | 338 | S>L | No | 1000Genomes | |
| ENSVATH12701580 | 350 | I>M | No | 1000Genomes | |
| ENSVATH03409240 | 351 | E>D | No | 1000Genomes | |
| ENSVATH07395538 | 356 | T>S | No | 1000Genomes | |
| tmp_5_20918471_A_G | 361 | S>P | No | 1000Genomes | |
| tmp_5_20918404_G_A | 383 | A>V | No | 1000Genomes | |
| tmp_5_20918323_G_T | 410 | T>N | No | 1000Genomes | |
| ENSVATH12701578 | 412 | L>I | No | 1000Genomes | |
| ENSVATH00726817 | 413 | F>Y | No | 1000Genomes | |
| tmp_5_20918305_G_A | 416 | T>I | No | 1000Genomes | |
| tmp_5_20918288_T_A | 422 | N>Y | No | 1000Genomes | |
| ENSVATH07395537 | 424 | I>R | No | 1000Genomes | |
| ENSVATH07395536 | 431 | L>S | No | 1000Genomes | |
| tmp_5_20918243_T_G | 437 | S>R | No | 1000Genomes | |
| ENSVATH07395535 | 442 | M>I | No | 1000Genomes | |
| ENSVATH12701575 | 487 | Y>* | No | 1000Genomes | |
| ENSVATH14625820 | 515 | S>P | No | 1000Genomes | |
| ENSVATH03409239 | 517 | F>I | No | 1000Genomes | |
| ENSVATH07395533 | 519 | V>D | No | 1000Genomes | |
| tmp_5_20917986_G_T | 522 | F>L | No | 1000Genomes | |
| ENSVATH03409238 | 523 | I>T | No | 1000Genomes | |
| tmp_5_20917958_A_T | 532 | S>T | No | 1000Genomes | |
| ENSVATH03409237 | 536 | F>S | No | 1000Genomes |
No associated diseases with Q9FHN4
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNIMMVQNIS | FLSLHLLLIL | LLCLRPLTTV | ADGNSTNIDG | WCDKTPYPYP | CKRYFIKHSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FRLPTQISEF | RVLLVEAAMD | RAVSAWDKLT | NSSKNCTDFK | KQAVLADCIN | LYGDTVMQLN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RTLQGVSSKT | GRRCTDFDAQ | TWLSTALTNT | ETCRRGSSDL | NVSDFTTPIV | SNTKISHLIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NCLAVNGALL | TAGKNDSTTG | DSKGFPTWVS | RKERRLLQLQ | SVRANLVVAK | DGSGHFKTVQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AAIDVAGRRK | VTSGRFVIYV | KRGIYQENLN | VRLNNDNIML | VGDGMRYTII | TGGRSVKGGY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTYSSATAGI | EGLHFIAKGI | AFQNTAGPAK | GQAVALRSSS | DLSIFYRCSI | EGYQDTLMVH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SQRQFYRECY | IYGTVDFIFG | NAAVVFQNCI | ILPRLPLKGQ | ANVITAQGRT | DLFQNTGISI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HNSIIIPAPD | LKPVVRSVKT | YMGRPWMMYS | RTVVLKTYID | SVVSPVGWSP | WTKGSTYGLD |
| 490 | 500 | 510 | 520 | 530 | |
| TLFYAEYKNI | GPASSTRWRV | RWKGFHVLSK | ASDASAFSVG | KFIAGTAWLP | GSGIPFTSEL |