Q9FGW5

PR
Gene name
CDKG1 (At5g63370, K9H21.7)
Protein name
Cyclin-dependent kinase G1
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G63370
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

179-267 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

443-466 (Activation loop from InterPro)

Target domain

297-593 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9FGW5

Entry ID Method Resolution Chain Position Source
AF-Q9FGW5-F1 Predicted AlphaFoldDB

42 variants for Q9FGW5

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_25386764_C_G 10 R>T No 1000Genomes
tmp_5_25386719_C_T 25 G>D No 1000Genomes
ENSVATH12916899 27 R>C No 1000Genomes
ENSVATH12916898 33 Q>P No 1000Genomes
tmp_5_25386685_T_A 36 R>S No 1000Genomes
ENSVATH03469036 38 D>N No 1000Genomes
tmp_5_25386641_A_T 51 L>H No 1000Genomes
ENSVATH07472409 55 D>G No 1000Genomes
ENSVATH14646681 61 R>L No 1000Genomes
ENSVATH12916897 65 E>D No 1000Genomes
ENSVATH12916896 66 K>Q No 1000Genomes
tmp_5_25386511_T_G 94 K>N No 1000Genomes
ENSVATH07472407 105 K>N No 1000Genomes
ENSVATH07472406 122 A>T No 1000Genomes
tmp_5_25386425_C_A 123 G>V No 1000Genomes
ENSVATH07472405 133 A>T No 1000Genomes
ENSVATH07472403 150 A>S No 1000Genomes
tmp_5_25386336_C_T 153 A>T No 1000Genomes
ENSVATH07472402 170 Q>H No 1000Genomes
ENSVATH00749254 174 E>K No 1000Genomes
tmp_5_25386194_C_A 200 G>V No 1000Genomes
tmp_5_25386183_G_A 204 P>S No 1000Genomes
ENSVATH12916884 210 S>T No 1000Genomes
ENSVATH00749253 211 V>D No 1000Genomes
ENSVATH03469034 225 T>I No 1000Genomes
tmp_5_25386116_G_T 226 P>Q No 1000Genomes
tmp_5_25386065_C_T 243 G>E No 1000Genomes
ENSVATH07472400 251 V>G No 1000Genomes
tmp_5_25386027_C_A 256 A>S No 1000Genomes
ENSVATH00749251 261 G>D No 1000Genomes
tmp_5_25386005_T_C 263 E>G No 1000Genomes
tmp_5_25385999_T_C 265 Y>C No 1000Genomes
tmp_5_25385968_T_A 275 E>D No 1000Genomes
tmp_5_25385955_A_C 280 L>V No 1000Genomes
ENSVATH03469033 282 P>L No 1000Genomes
ENSVATH03469032 284 E>G No 1000Genomes
tmp_5_25385615_C_A 393 R>I No 1000Genomes
tmp_5_25385429_A_T 455 I>N No 1000Genomes
tmp_5_25385393_T_A 467 Y>F No 1000Genomes
ENSVATH00749250 481 T>S No 1000Genomes
tmp_5_25385275_A_C 506 S>R No 1000Genomes
ENSVATH00749248 517 V>I No 1000Genomes

No associated diseases with Q9FGW5

3 regional properties for Q9FGW5

Type Name Position InterPro Accession
domain Protein kinase domain 297 - 593 IPR000719
active_site Serine/threonine-protein kinase, active site 422 - 434 IPR008271
domain Cyclin-dependent kinase 11/PITSLRE, catalytic domain 292 - 593 IPR045267

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus speckle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

6 GO annotations of biological process

Name Definition
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
pollen exine formation The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of (1->3)-beta-D-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2TBL8 CDK10 Cyclin-dependent kinase 10 Bos taurus (Bovine) PR
Q15131 CDK10 Cyclin-dependent kinase 10 Homo sapiens (Human) PR
P21127 CDK11B Cyclin-dependent kinase 11B Homo sapiens (Human) PR
Q9UQ88 CDK11A Cyclin-dependent kinase 11A Homo sapiens (Human) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
Q4KM47 Cdk10 Cyclin-dependent kinase 10 Rattus norvegicus (Rat) PR
Q09437 cdk-11.1 Cyclin-dependent kinase 11.1 Caenorhabditis elegans PR
Q9C9U2 CDKD-1 Cyclin-dependent kinase D-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMT0 CDKD-3 Cyclin-dependent kinase D-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVM9 At1g54610 Probable serine/threonine-protein kinase At1g54610 Arabidopsis thaliana (Mouse-ear cress) PR
F4I114 At1g09600 Probable serine/threonine-protein kinase At1g09600 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAAGGVDVSR SSVAVKKDYD FYRNGSRDVY VRQSGRDDER RQIKRPSDHD LRRNDGRHRS
70 80 90 100 110 120
RLAYEKGELR EEAEVQRPSE KRRKFSPIVW NAEKVGRAPS REKTKSPFPV PTTTVISNQA
130 140 150 160 170 180
VAGKTTSNDQ VNALMSPEPS YLAPVQPSEA LLAVKHPVDD LEEGQLEEEQ VMQEDVKEGL
190 200 210 220 230 240
LEEEQVMQEP NIKTSRWGTG LTSPKEELIS VNVSKTNRWN RSSLTPECEE VMVSEEQQCY
250 260 270 280 290 300
SSGSGSGHLS VEKLSADGNS GREYYSSDHD ELEHEDQDSL TPGEMNMMFG SRSVNEFQKL
310 320 330 340 350 360
NKINEGTYGI VYKARDEKTK EIVALKKIKM KEDRFEEEYG FPLTSLREIN ILLSCNHPAI
370 380 390 400 410 420
VNVKEVVVGG KNDNDVYMVM EHLEHDLRGV MDRRKEPFST SEVKCLMMQL LDGLKYLHTN
430 440 450 460 470 480
WIIHRDLKPS NLLMNNCGEL KICDFGMARQ YGSPIKPYTQ MVITQWYRPP ELLLGAKEYS
490 500 510 520 530 540
TAVDMWSVGC IMAELLSQKP LFPGKSELDQ LQKIFAVLGT PNEAIWPGFS SFPNAKAKFP
550 560 570 580 590 600
TQPYNMLRKK FPAISFVGGQ ILSERGFDLL NSLLTLDPEK RLTVEDALNH GWFHEVPLPK
610
SKDFMPTYPP KR