Q9FG33
Gene name |
LECRKS5 (At5g06740, MPH15.10) |
Protein name |
Probable L-type lectin-domain containing receptor kinase S.5 |
Names |
LecRK-S.5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G06740 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
472-479 (Activation loop from InterPro)
Target domain |
330-622 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
490-498 (Activation loop from InterPro)
Target domain |
330-622 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9FG33
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FG33-F1 | Predicted | AlphaFoldDB |
40 variants for Q9FG33
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06932948 | 2 | R>I | No | 1000Genomes | |
| ENSVATH03031440 | 2 | R>S | No | 1000Genomes | |
| tmp_5_2084106_C_T,A | 5 | L>F | No | 1000Genomes | |
| tmp_5_2084106_C_T,A | 5 | L>I | No | 1000Genomes | |
| tmp_5_2084250_C_G | 53 | Q>E | No | 1000Genomes | |
| ENSVATH00609392 | 65 | T>S | No | 1000Genomes | |
| tmp_5_2084333_G_C | 80 | R>S | No | 1000Genomes | |
| tmp_5_2084474_G_A | 127 | W>* | No | 1000Genomes | |
| ENSVATH13944900 | 179 | S>R | No | 1000Genomes | |
| tmp_5_2084680_G_A | 196 | R>Q | No | 1000Genomes | |
| tmp_5_2084693_G_C | 200 | K>N | No | 1000Genomes | |
| ENSVATH06932949 | 201 | N>I | No | 1000Genomes | |
| tmp_5_2084737_A_G | 215 | Q>R | No | 1000Genomes | |
| tmp_5_2084760_G_A | 223 | A>T | No | 1000Genomes | |
| ENSVATH06932950 | 223 | A>V | No | 1000Genomes | |
| ENSVATH06932951 | 227 | S>A | No | 1000Genomes | |
| ENSVATH06932952 | 264 | D>N | No | 1000Genomes | |
| ENSVATH10617404 | 265 | G>E | No | 1000Genomes | |
| ENSVATH06932953 | 279 | I>V | No | 1000Genomes | |
| tmp_5_2084931_G_A | 280 | V>I | No | 1000Genomes | |
| tmp_5_2084985_G_C | 298 | G>R | No | 1000Genomes | |
| ENSVATH10617425 | 304 | I>L | No | 1000Genomes | |
| tmp_5_2085085_G_A | 331 | G>D | No | 1000Genomes | |
| tmp_5_2085141_C_T | 350 | Q>* | No | 1000Genomes | |
| tmp_5_2085178_A_T | 362 | K>I | No | 1000Genomes | |
| ENSVATH10617426 | 418 | D>Y | No | 1000Genomes | |
| ENSVATH13944901 | 426 | W>C | No | 1000Genomes | |
| ENSVATH13944902 | 431 | N>S | No | 1000Genomes | |
| tmp_5_2085394_C_T | 434 | T>I | No | 1000Genomes | |
| tmp_5_2085414_G_C | 441 | E>Q | No | 1000Genomes | |
| ENSVATH06932955 | 473 | D>Y | No | 1000Genomes | |
| tmp_5_2085627_G_A | 512 | V>I | No | 1000Genomes | |
| tmp_5_2085640_T_C | 516 | V>A | No | 1000Genomes | |
| tmp_5_2085662_G_C | 523 | M>I | No | 1000Genomes | |
| tmp_5_2085661_T_A | 523 | M>K | No | 1000Genomes | |
| tmp_5_2085697_T_C | 535 | V>A | No | 1000Genomes | |
| tmp_5_2085738_G_C | 549 | V>L | No | 1000Genomes | |
| ENSVATH00609394 | 573 | F>L | No | 1000Genomes | |
| tmp_5_2085840_C_G | 583 | L>V | No | 1000Genomes | |
| ENSVATH06932958 | 601 | T>S | No | 1000Genomes |
No associated diseases with Q9FG33
5 regional properties for Q9FG33
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 330 - 622 | IPR000719 |
| domain | Legume lectin domain | 25 - 257 | IPR001220 |
| active_site | Serine/threonine-protein kinase, active site | 451 - 463 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 336 - 357 | IPR017441 |
| binding_site | Legume lectin, beta chain, Mn/Ca-binding site | 144 - 150 | IPR019825 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| defense response to oomycetes | Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
25 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05688 | IGF1R | Insulin-like growth factor 1 receptor | Bos taurus (Bovine) | SS |
| F1N9Y5 | SYK | Tyrosine-protein kinase SYK | Gallus gallus (Chicken) | SS |
| P43403 | ZAP70 | Tyrosine-protein kinase ZAP-70 | Homo sapiens (Human) | EV |
| P43405 | SYK | Tyrosine-protein kinase SYK | Homo sapiens (Human) | EV |
| P43404 | Zap70 | Tyrosine-protein kinase ZAP-70 | Mus musculus (Mouse) | SS |
| P48025 | Syk | Tyrosine-protein kinase SYK | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q00655 | SYK | Tyrosine-protein kinase SYK | Sus scrofa (Pig) | SS |
| Q64725 | Syk | Tyrosine-protein kinase SYK | Rattus norvegicus (Rat) | SS |
| P18910 | Npr1 | Atrial natriuretic peptide receptor 1 | Rattus norvegicus (Rat) | PR |
| P51842 | Gucy2f | Retinal guanylyl cyclase 2 | Rattus norvegicus (Rat) | PR |
| P16067 | Npr2 | Atrial natriuretic peptide receptor 2 | Rattus norvegicus (Rat) | PR |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80939 | LECRK41 | L-type lectin-domain containing receptor kinase IV.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1G4 | LECRK15 | Probable L-type lectin-domain containing receptor kinase I.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M345 | LECRK42 | L-type lectin-domain containing receptor kinase IV.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96285 | LECRK55 | L-type lectin-domain containing receptor kinase V.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81292 | LECRK43 | L-type lectin-domain containing receptor kinase IV.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81291 | LECRK44 | L-type lectin-domain containing receptor kinase IV.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E991 | PRK6 | Pollen receptor-like kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGQ4 | MDIS2 | Protein MALE DISCOVERER 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSR8 | LECRK19 | L-type lectin-domain containing receptor kinase I.9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRFSLAWKLL | FLILTCKIET | QVKCLKFDFP | GFNVSNELEL | IRDNSYIVFG | AIQVTPDVTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPGGTIANQA | GRALYKKPFR | LWSKHKSATF | NTTFVINISN | KTDPGGEGLA | FVLTPEETAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QNSSGMWLGM | VNERTNRNNE | SRIVSVEFDT | RKSHSDDLDG | NHVALNVNNI | NSVVQESLSG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RGIKIDSGLD | LTAHVRYDGK | NLSVYVSRNL | DVFEQRNLVF | SRAIDLSAYL | PETVYVGFTA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| STSNFTELNC | VRSWSFEGLK | IDGDGNMLWL | WITIPIVFIV | GIGAFLGALY | LRSRSKAGET |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPDIEAELDN | CAANPQKFKL | RELKRATGNF | GAENKLGQGG | FGMVFKGKWQ | GRDIAVKRVS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EKSHQGKQEF | IAEITTIGNL | NHRNLVKLLG | WCYERKEYLL | VYEYMPNGSL | DKYLFLEDKS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RSNLTWETRK | NIITGLSQAL | EYLHNGCEKR | ILHRDIKASN | VMLDSDFNAK | LGDFGLARMI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QQSEMTHHST | KEIAGTPGYM | APETFLNGRA | TVETDVYAFG | VLMLEVVSGK | KPSYVLVKDN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QNNYNNSIVN | WLWELYRNGT | ITDAADPGMG | NLFDKEEMKS | VLLLGLACCH | PNPNQRPSMK |
| 610 | 620 | 630 | 640 | 650 | |
| TVLKVLTGET | SPPDVPTERP | AFVWPAMPPS | FSDIDYSLTG | SQINSLTELT | GR |