Q9FF78
SS
Gene name |
PME46 (ARATH46, At5g04960, MUG13.18) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 46 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G04960 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
258-550 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q9FF78
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FF78-F1 | Predicted | AlphaFoldDB |
23 variants for Q9FF78
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_1462027_C_A | 15 | L>I | No | 1000Genomes | |
| tmp_5_1462100_T_C | 39 | V>A | No | 1000Genomes | |
| tmp_5_1462099_G_A | 39 | V>I | No | 1000Genomes | |
| ENSVATH10577886 | 56 | P>S | No | 1000Genomes | |
| tmp_5_1462153_A_G | 57 | T>A | No | 1000Genomes | |
| tmp_5_1462213_C_T | 77 | H>Y | No | 1000Genomes | |
| ENSVATH10577889 | 98 | E>G | No | 1000Genomes | |
| ENSVATH10577890 | 104 | V>I | No | 1000Genomes | |
| tmp_5_1462619_G_A | 212 | G>E | No | 1000Genomes | |
| ENSVATH10577892 | 219 | K>Q | No | 1000Genomes | |
| ENSVATH10577893 | 238 | L>F | No | 1000Genomes | |
| tmp_5_1462705_A_C | 241 | M>L | No | 1000Genomes | |
| ENSVATH13926618 | 277 | E>D | No | 1000Genomes | |
| tmp_5_1462835_A_G | 284 | K>R | No | 1000Genomes | |
| tmp_5_1463255_G_A | 381 | D>N | No | 1000Genomes | |
| ENSVATH06924168 | 428 | K>I | No | 1000Genomes | |
| ENSVATH00607074 | 459 | D>N | No | 1000Genomes | |
| ENSVATH10577917 | 479 | V>I | No | 1000Genomes | |
| ENSVATH13926620 | 487 | K>R | No | 1000Genomes | |
| tmp_5_1463646_A_T | 511 | Y>F | No | 1000Genomes | |
| tmp_5_1463655_C_T | 514 | S>F | No | 1000Genomes | |
| ENSVATH06924171 | 527 | Q>K | No | 1000Genomes | |
| tmp_5_1463703_A_C | 530 | K>T | No | 1000Genomes |
No associated diseases with Q9FF78
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
| regulation of cell wall pectin metabolic process | Any process that modulates the frequency, rate or extent of cell wall pectin metabolic process. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSYGRLDEH | EQAKLEASRK | TKKRIAIIAI | SSIVLVCIVV | GAVVGTTARD | NSKKPPTENN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GEPISVSVKA | LCDVTLHKEK | CFETLGSAPN | ASRSSPEELF | KYAVKVTITE | LSKVLDGFSN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GEHMDNATSA | AMGACVELIG | LAVDQLNETM | TSSLKNFDDL | RTWLSSVGTY | QETCMDALVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ANKPSLTTFG | ENHLKNSTEM | TSNALAIITW | LGKIADTVKF | RRRRLLETGN | AKVVVADLPM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MEGRRLLESG | DLKKKATIVV | AKDGSGKYRT | IGEALAEVEE | KNEKPTIIYV | KKGVYLENVR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEKTKWNVVM | VGDGQSKTIV | SAGLNFIDGT | PTFETATFAV | FGKGFMARDM | GFINTAGPAK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HQAVALMVSA | DLSVFYKCTM | DAFQDTMYAH | AQRQFYRDCV | ILGTVDFIFG | NAAVVFQKCE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILPRRPMKGQ | QNTITAQGRK | DPNQNTGISI | HNCTIKPLDN | LTDIQTFLGR | PWKDFSTTVI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MKSFMDKFIN | PKGWLPWTGD | TAPDTIFYAE | YLNSGPGAST | KNRVKWQGLK | TSLTKKEANK |
| 550 | 560 | ||||
| FTVKPFIDGN | NWLPATKVPF | NSDF |