Q9FF77
SS
Gene name |
PME47 (ARATH47, At5g04970, MUG13.17) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 47 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G04970 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
308-605 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q9FF77
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FF77-F1 | Predicted | AlphaFoldDB |
55 variants for Q9FF77
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_1466994_G_T | 3 | T>N | No | 1000Genomes | |
| ENSVATH03024374 | 6 | S>L | No | 1000Genomes | |
| ENSVATH10578099 | 15 | C>S | No | 1000Genomes | |
| ENSVATH06924209 | 26 | R>H | No | 1000Genomes | |
| ENSVATH03024373 | 34 | H>L | No | 1000Genomes | |
| tmp_5_1466902_G_A | 34 | H>Y | No | 1000Genomes | |
| ENSVATH06924208 | 36 | P>T | No | 1000Genomes | |
| tmp_5_1466892_A_T | 37 | I>K | No | 1000Genomes | |
| ENSVATH03024372 | 39 | P>L | No | 1000Genomes | |
| ENSVATH06924207 | 40 | S>P | No | 1000Genomes | |
| ENSVATH06924206 | 41 | S>L | No | 1000Genomes | |
| tmp_5_1466875_G_A | 43 | P>S | No | 1000Genomes | |
| ENSVATH03024371 | 54 | Q>K | No | 1000Genomes | |
| tmp_5_1466832_G_T | 57 | T>K | No | 1000Genomes | |
| ENSVATH03024370 | 62 | H>Q | No | 1000Genomes | |
| ENSVATH10578084 | 63 | P>T | No | 1000Genomes | |
| ENSVATH06924200 | 70 | P>Q | No | 1000Genomes | |
| ENSVATH13926688 | 131 | K>* | No | 1000Genomes | |
| ENSVATH06924198 | 132 | V>I | No | 1000Genomes | |
| tmp_5_1466605_T_G | 133 | I>L | No | 1000Genomes | |
| ENSVATH03024369 | 150 | E>Q | No | 1000Genomes | |
| tmp_5_1466527_C_T | 159 | G>S | No | 1000Genomes | |
| tmp_5_1466517_G_A | 162 | A>V | No | 1000Genomes | |
| tmp_5_1466513_C_A | 163 | E>D | No | 1000Genomes | |
| ENSVATH06924196 | 215 | F>L | No | 1000Genomes | |
| tmp_5_1466352_G_A | 217 | T>M | No | 1000Genomes | |
| ENSVATH06924195 | 226 | L>V | No | 1000Genomes | |
| ENSVATH00607081 | 243 | R>C | No | 1000Genomes | |
| tmp_5_1466259_T_A | 248 | Y>F | No | 1000Genomes | |
| tmp_5_1466251_A_T | 251 | S>T | No | 1000Genomes | |
| ENSVATH10578075 | 269 | T>A | No | 1000Genomes | |
| tmp_5_1465304_C_T | 345 | A>T | No | 1000Genomes | |
| ENSVATH06924185 | 346 | G>S | No | 1000Genomes | |
| ENSVATH10578026 | 350 | E>D | No | 1000Genomes | |
| ENSVATH10578025 | 357 | K>E | No | 1000Genomes | |
| tmp_5_1465192_C_T | 382 | G>D | No | 1000Genomes | |
| tmp_5_1465193_C_T | 382 | G>S | No | 1000Genomes | |
| tmp_5_1465059_G_A | 392 | A>V | No | 1000Genomes | |
| tmp_5_1464912_T_C | 441 | Y>C | No | 1000Genomes | |
| tmp_5_1464909_A_C | 442 | V>G | No | 1000Genomes | |
| tmp_5_1464756_T_G | 461 | I>L | No | 1000Genomes | |
| tmp_5_1464714_A_T | 475 | Y>N | No | 1000Genomes | |
| ENSVATH10577971 | 482 | N>Y | No | 1000Genomes | |
| ENSVATH10577969 | 486 | A>V | No | 1000Genomes | |
| ENSVATH06924181 | 505 | N>S | No | 1000Genomes | |
| tmp_5_1464611_C_T | 509 | G>E | No | 1000Genomes | |
| tmp_5_1464575_G_A | 521 | T>I | No | 1000Genomes | |
| tmp_5_1464531_C_T | 536 | V>I | No | 1000Genomes | |
| tmp_5_1464470_C_T | 556 | G>D | No | 1000Genomes | |
| tmp_5_1464459_G_C | 560 | L>V | No | 1000Genomes | |
| ENSVATH03024360 | 568 | Y>F | No | 1000Genomes | |
| tmp_5_1464431_T_C | 569 | D>G | No | 1000Genomes | |
| ENSVATH03024359 | 592 | V>A | No | 1000Genomes | |
| tmp_5_1464270_T_C | 623 | T>A | No | 1000Genomes | |
| ENSVATH03024357 | 624 | E>G | No | 1000Genomes |
No associated diseases with Q9FF77
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQTHSSSLVF | LALLCLSWAL | LVSPTRPPSQ | PPSHPPIQPS | SQPPTQPPSQ | PPTQPPTQPP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SHPPTQPPTP | PPSQSPSQPS | PLPPNIACKS | TPYPKLCRTI | LSAVKSSPSD | PYHYGKFTMK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QCLKQARRLS | KVINRFAQRV | EADPGTSTVE | EVSAVADCGE | LAELSVEYLE | TVTEELKAAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LMTAALVDRV | TSLLGGVVTN | QQTCLDGLVD | AKSGFATAIG | TPLGNLTRLY | SVSLGLVSHA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNRNLKRYKG | SKGKIFGGGN | KPVREPLETL | IKVLRKTCDK | GKDCRKANRN | LGELGETSGG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SILVREAVTV | GPYETDNFPT | ITEAVAAAPN | HTFPEQGYFV | IYARAGLYEE | YVVISNKKRN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IMLIGDGINK | TIISGNHSFI | DGWTTYNSST | FAVVGDRFVA | VDVTFRNTAG | PEKHQAVAVR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NNADGSTFYR | CSFEGYQDTL | YVHSLRQFYR | ECDIYGTIDF | IFGNAAAIFQ | NCNIYARKPM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ANQKNAVTAH | GRTDPNQKTG | ISIINCTIGA | APDLAADPKS | TMTFLGRPWK | PYSRTVYIQS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YISDVVQPVG | WLEWNGTTGL | DTISYGEYDN | FGPGADTSKR | VQWSGYSLLN | LVQAMNFTVY |
| 610 | 620 | ||||
| NFTLGDTWLP | QTDIPFYGGL | LHTE |