Q9ESV0

PR
Gene name
Ddx24
Protein name
ATP-dependent RNA helicase DDX24
Names
DEAD box protein 24
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:27225
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-211 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ESV0

Entry ID Method Resolution Chain Position Source
AF-Q9ESV0-F1 Predicted AlphaFoldDB

43 variants for Q9ESV0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389216810 6 T>I No EVA
rs3389241976 9 K>R No EVA
rs3389258630 30 K>N No EVA
rs3389267674 49 C>* No EVA
rs1133792776 105 A>G No EVA
rs227379747 107 R>L No EVA
rs52033508 112 A>G No EVA
rs218828574 112 A>T No EVA
rs3389241916 143 K>R No EVA
rs3389264804 163 L>M No EVA
rs3389256887 178 K>N No EVA
rs3389188024 191 D>H No EVA
rs3389255826 258 Q>* No EVA
rs3389257241 259 W>* No EVA
rs3389257291 260 H>L No EVA
rs3389267644 285 H>N No EVA
rs3389229672 304 R>I No EVA
rs51570416 337 D>A No EVA
rs3403669225 352 K>I No EVA
rs3389264739 353 Q>L No EVA
rs3389224049 355 E>D No EVA
rs3389255816 359 E>G No EVA
rs3389249947 360 K>T No EVA
rs3389224048 377 I>T No EVA
rs3389255662 400 A>P No EVA
rs3389271684 453 K>T No EVA
rs3389257250 500 S>N No EVA
rs3389255830 576 D>E No EVA
rs3389258581 588 G>C No EVA
rs3389257209 618 H>Y No EVA
rs3403838055 620 C>G No EVA
rs3389256902 633 F>S No EVA
rs3389241962 647 A>T No EVA
rs3389266237 659 V>A No EVA
rs3403577768 665 P>R No EVA
rs3403577818 666 R>G No EVA
rs1135208975 682 A>T No EVA
rs46579155 707 Q>K No EVA
rs3403783008 734 Q>R No EVA
rs3389255844 756 A>V No EVA
rs3389252928 764 E>V No EVA
rs1133097844 775 Q>E No EVA
rs51112490 820 V>A No EVA

No associated diseases with Q9ESV0

4 regional properties for Q9ESV0

Type Name Position InterPro Accession
domain Protein kinase domain 86 - 369 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 91 - 365 IPR001245
active_site Serine/threonine-protein kinase, active site 214 - 226 IPR008271
binding_site Protein kinase, ATP binding site 92 - 122 IPR017441

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9GZR7 DDX24 ATP-dependent RNA helicase DDX24 Homo sapiens (Human) PR
Q8K363 Ddx18 ATP-dependent RNA helicase DDX18 Mus musculus (Mouse) PR
Q4FZF3 Ddx49 Probable ATP-dependent RNA helicase DDX49 Mus musculus (Mouse) PR
Q8K4L0 Ddx54 ATP-dependent RNA helicase DDX54 Mus musculus (Mouse) PR
Q9CWX9 Ddx47 Probable ATP-dependent RNA helicase DDX47 Mus musculus (Mouse) PR
Q9CWT6 Ddx28 Probable ATP-dependent RNA helicase DDX28 Mus musculus (Mouse) PR
Q91VR5 Ddx1 ATP-dependent RNA helicase DDX1 Mus musculus (Mouse) PR
Q6ZPL9 Ddx55 ATP-dependent RNA helicase DDX55 Mus musculus (Mouse) PR
P60843 Eif4a1 Eukaryotic initiation factor 4A-I Mus musculus (Mouse) PR
P10630 Eif4a2 Eukaryotic initiation factor 4A-II Mus musculus (Mouse) PR
Q569Z5 Ddx46 Probable ATP-dependent RNA helicase DDX46 Mus musculus (Mouse) PR
10 20 30 40 50 60
MKVKETNSKP KLASRGTFQR KGIKIVGKWK QVTIDPNLFA DGQMDDLVCF EELTDYRLVK
70 80 90 100 110 120
NPSRLFSSEE TKKRKAQAVS EEEEEEEGQS SSPKKKIKLK KQRDAARAAE GAAAQNEYEV
130 140 150 160 170 180
KASEPEAQGE VTACSDQKVG GAKSESLAQA APRKKKNKGK KKLDTFQSTS PKLPKKSKKT
190 200 210 220 230 240
WMAEVHDQKA DVSAWRDLFV PKAVLRALSF LGFSAPTPIQ ALTLAPAIRD KLDILGAAET
250 260 270 280 290 300
GSGKTLAFAI PMIHSVLQWH KMKAPPIPRS TGMPPREMRF GATAHLGSPC KDRTESGVLP
310 320 330 340 350 360
EEARIETEAQ PSDSGVQATP ETSASASAQT LLVCDDDAGE GPSSLEEKPV PKQNEDGEEK
370 380 390 400 410 420
FDAEQAGKLK QELCDQIAIY KVHPRRPLLG LVLTPTRELA IQVRQHIDAV AKFTGINTAI
430 440 450 460 470 480
LVGGMSTQKQ QRMLNRHPEI VIATPGRLWE LVKEKHPHLS NLRQLRCLVI DEADRMVEKG
490 500 510 520 530 540
HFAELSQLLE MLNDSQYNPS RQTLVFSATL TLVHQAPARI LHKKHVKKMD KTDKLDLLMQ
550 560 570 580 590 600
KVGMRGKPKV IDLTRNEGTV ETLTETKIHC ETDEKDLYLY YFLMQYPGRS LVFANSISCI
610 620 630 640 650 660
KRLSGLLKVL DVMPLTLHAC MHQKQRLRNL EQFARLQDCV LLATDVAARG LDIPKVQHVI
670 680 690 700 710 720
HYQVPRTSEI YIHRSGRTAR AASEGLSLML IGPEDVINFK KIYKTLQKDE DIPLFPVQSK
730 740 750 760 770 780
YMDVVKERIR LARQIEKAEY RNFQACLHNS WIEQAAAALE IELEEEMYKG GKADQQEERR
790 800 810 820 830 840
RQKQMKMLKQ ELRHLLSQPL FQENLKTRYP TQSGRPPQPV LASRNIESAL SCLSRQKRRR
850
KKPKEPRAPP QPGSSTS