Q9EST5
SS
Gene name |
Anp32b (Pal31) |
Protein name |
Acidic leucine-rich nuclear phosphoprotein 32 family member B |
Names |
Proliferation-related acidic leucine-rich protein PAL31 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67628 |
EC number |
|
Protein Class |
|
Descriptions
ANP32A(I1<sup>PP2A</sup>) regulates PP2A activity by functioning as a non-competitive inhibitor of this enzyme. PP2A is a major regulator of the phosphorylation of Tau. The activity of PP2A is compromised in Alzheimer's disease brain. ANP32A has an autoinhibitory domain that negatively affects the interaction of ANP32A with PP2Ac and its ability to modulate the PP2A activity, which lies within amino acid residues 121-163. The inhibitory role of the autoinhibitory region might be regulated through the phosphorylation of Ser-158 or both Ser-158 and Ser-204 by casein kinase II. The autoinhibition is disrupted by C-terminal region.
Autoinhibitory domains (AIDs)
Target domain |
1-174 (Leucine-rich region) |
Relief mechanism |
PTM, Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9EST5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9EST5-F1 | Predicted | AlphaFoldDB |
7 variants for Q9EST5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388680903 | 40 | E>G | No | EVA | |
| rs3388684640 | 42 | V>A | No | EVA | |
| rs253100635 | 193 | E>D | No | EVA | |
| rs3393923619 | 223 | E>G | No | EVA | |
| rs3388681385 | 254 | E>D | No | EVA | |
| rs3388681313 | 269 | G>E | No | EVA | |
| rs240874163 | 270 | E>D | No | EVA |
No associated diseases with Q9EST5
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| RNA polymerase binding | Binding to an RNA polymerase molecule or complex. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| G1/S transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. |
| inner ear development | The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of G1/S transition of mitotic cell cycle | Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. |
| positive regulation of protein export from nucleus | Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
| roof of mouth development | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. |
| vasculature development | The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. |
| ventricular system development | The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51122 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Bos taurus (Bovine) | SS |
| Q3SZC6 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Bos taurus (Bovine) | SS |
| Q5F4A3 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Gallus gallus (Chicken) | SS |
| Q5ZMN0 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Gallus gallus (Chicken) | SS |
| Q9V895 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Drosophila melanogaster (Fruit fly) | SS |
| P39687 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Homo sapiens (Human) | EV |
| Q9BTT0 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Homo sapiens (Human) | SS |
| Q92688 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Homo sapiens (Human) | SS |
| P97822 | Anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Mus musculus (Mouse) | SS |
| O35381 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Mus musculus (Mouse) | SS |
| Q5XIE0 | Anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Rattus norvegicus (Rat) | SS |
| P49911 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Rattus norvegicus (Rat) | SS |
| Q9EST6 | Anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Rattus norvegicus (Rat) | SS |
| Q7Y180 | Os03g0668900 | Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q9SCQ7 | At3g50690 | Acidic leucine-rich nuclear phosphoprotein 32-related protein | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q6P1U7 | anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6NUW5 | anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7ZUP0 | anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDMKRRIHLE | LRNRTPAAVR | ELVLDNCKAM | DGKIEGLTDE | FVNLEFLSLI | SVGLFSVSDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PKLPKLKKLE | LSENRIFGGL | DRLAEELPSL | THLNLSGNNL | KDISTLEPLK | RLDCLKSLDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FGCEVTNRSD | YRETVFRLLP | QLSYLDGYDR | EDQEAPDSDV | EVDSVEEAPD | SDGEVDGVDK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEEDEEGEDE | EEEEDEDGEE | EEDEDEEDED | EDEDVEGEDD | EDEVSGEEEE | FGHDGEVDED |
| 250 | 260 | 270 | |||
| EEDEDEDEDE | EEEESGKGEK | RKRETDDEGE | DD |