Q9EST1

SS
Gene name
Gsdma (Gsdm)
Protein name
Gasdermin-A
Names
Gasdermin-1, Gasdermin-A1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:57911
EC number
Protein Class

Descriptions

Gasdermin proteins are a pore-forming protein causing membrane permeabilization and pyroptosis, and functions downstream of the inflammatory caspases. The C-terminal gasdermin domain may adopt an intramolecular complex with the N-terminal domain, which may inhibit the activation of the N-terminal gasdermin domain as observed in GSDMD.

Autoinhibitory domains (AIDs)

255-419 (C-terminal gasdermin domain) SS

Target domain

3-234 (N-terminal gasdermin domain)

Relief mechanism

Cleavage

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9EST1

Entry ID Method Resolution Chain Position Source
AF-Q9EST1-F1 Predicted AlphaFoldDB

4 variants for Q9EST1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs864270457 28 I>M No Ensembl
rs584042146 55 H>R No Ensembl
rs257951147 440 Q>H No Ensembl
rs212392057 445 N>D No Ensembl

No associated diseases with Q9EST1

2 regional properties for Q9EST1

Type Name Position InterPro Accession
domain Gasdermin, pore forming domain 3 - 234 IPR040460
domain Gasdermin, PUB domain 255 - 419 IPR041263

Functions

Description
EC Number
Subcellular Localization
  • [Gasdermin-A]: Cytoplasm, perinuclear region
  • Cytoplasm, cytosol
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
phosphatidylinositol-4,5-bisphosphate binding Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
phosphatidylinositol-4-phosphate binding Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
phosphatidylserine binding Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

3 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
pyroptosis A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P57764 GSDMD Gasdermin-D Homo sapiens (Human) EV
Q9BYG8 GSDMC Gasdermin-C Homo sapiens (Human) SS
Q96QA5 GSDMA Gasdermin-A Homo sapiens (Human) SS
Q8TAX9 GSDMB Gasdermin-B Homo sapiens (Human) EV
Q8CB12 Gsdmc3 Gasdermin-C3 Mus musculus (Mouse) SS
Q2KHK6 Gsdmc2 Gasdermin-C2 Mus musculus (Mouse) SS
Q3TR54 Gsdmc4 Gasdermin-C4 Mus musculus (Mouse) SS
Q5Y4Y6 Gsdma3 Gasdermin-A3 Mus musculus (Mouse) EV
Q99NB5 Gsdmc Gasdermin-C Mus musculus (Mouse) SS
Q9D8T2 Gsdmd Gasdermin-D Mus musculus (Mouse) SS
Q32M21 Gsdma2 Gasdermin-A2 Mus musculus (Mouse) SS
P85967 Gsdmc Gasdermin-C Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MTMFENVTRA LARQLNPRGD LTPLDSLIDF KRFHPFCLVL RKRKSTLFWG ARYVHTDYTL
70 80 90 100 110 120
LDVLEPGSSP SDPTDSGNFS FKNMLDARVE GDVDVPKTVK VKGTAGLSRS STLEVQTLSV
130 140 150 160 170 180
APTALENLHK ERKLSADHPF LKEMRERGEN LYVVMEVVET LQEVTLERAG KAEGCFSLPF
190 200 210 220 230 240
FAPLGLQGSV NHKEAVTIPK GCVLAYRVRQ LMVNGKDEWG IPHICNDSMQ TFPPGEKPGE
250 260 270 280 290 300
GKFILIQASD VGEMHEDFKT LKEEVQRETQ EVEKLSPVGR SSLLTSLSHL LGKKKELQDL
310 320 330 340 350 360
EQTLEGALDK GHEVTLEALP KDVLLSKDAM DAILYFLGAL TVLSEAQQKL LVKSLEKKIL
370 380 390 400 410 420
PVQLKLVEST MEKNFLQDKE GVFPLQPDLL SSLGEEELIL TEALVGLSGL EVQRSGPQYT
430 440
WDPDTLPHLC ALYAGLSLLQ LLSKNS