Q9ESL4
PR
Gene name |
Map3k20 |
Protein name |
Mitogen-activated protein kinase kinase kinase 20 |
Names |
Human cervical cancer suppressor gene 4 protein, HCCS-4, Leucine zipper- and sterile alpha motif kinase ZAK, Leucine zipper- and sterile alpha motif-containing kinase, MLK-like mitogen-activated protein triple kinase, Mitogen-activated protein kinase kinase kinase MLT, Mixed lineage kinase-related kinase, MLK-related kinase, MRK, Sterile alpha motif- and leucine zipper-containing kinase AZK |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:65964 |
EC number |
2.7.11.25: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
150-171 (Activation loop from InterPro)
Target domain |
16-277 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9ESL4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ESL4-F1 | Predicted | AlphaFoldDB |
32 variants for Q9ESL4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1132600586 | 6 | A>T | No | EVA | |
| rs864268329 | 10 | Q>* | No | EVA | |
| rs3388556345 | 59 | V>I | No | EVA | |
| rs3388559747 | 109 | T>I | No | EVA | |
| rs3388554824 | 187 | C>R | No | EVA | |
| rs3388558184 | 188 | D>H | No | EVA | |
| rs3388560710 | 206 | F>L | No | EVA | |
| rs3388558145 | 262 | S>F | No | EVA | |
| rs3388556337 | 288 | E>K | No | EVA | |
| rs3388560627 | 316 | K>* | No | EVA | |
| rs3388554606 | 335 | E>D | No | EVA | |
| rs3388558412 | 338 | A>V | No | EVA | |
| rs3388559693 | 354 | K>I | No | EVA | |
| rs3388558599 | 373 | I>N | No | EVA | |
| rs3388549835 | 388 | D>E | No | EVA | |
| rs3388558181 | 389 | M>V | No | EVA | |
| rs3391600269 | 449 | G>V | No | EVA | |
| rs3391740131 | 450 | T>P | No | EVA | |
| rs3388556488 | 467 | E>D | No | EVA | |
| rs27970293 | 480 | T>M | No | EVA | |
| rs3388552859 | 499 | K>M | No | EVA | |
| rs27970273 | 518 | N>S | No | EVA | |
| rs3388562550 | 527 | K>N | No | EVA | |
| rs230319491 | 537 | T>R | No | EVA | |
| rs27970271 | 545 | A>V | No | EVA | |
| rs263297129 | 637 | S>A | No | EVA | |
| rs3391737903 | 683 | R>H | No | EVA | |
| rs3388560491 | 687 | S>F | No | EVA | |
| rs222293689 | 759 | G>R | No | EVA | |
| rs3388558159 | 773 | V>L | No | EVA | |
| rs3388554548 | 786 | K>R | No | EVA | |
| rs3388554586 | 789 | K>* | No | EVA |
No associated diseases with Q9ESL4
4 regional properties for Q9ESL4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 16 - 277 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 17 - 260 | IPR001245 |
| domain | Sterile alpha motif domain | 336 - 410 | IPR001660 |
| active_site | Serine/threonine-protein kinase, active site | 129 - 141 | IPR008271 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.25 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| JUN kinase kinase kinase activity | Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cellular response to gamma radiation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| DNA damage checkpoint signaling | A signal transduction process that contributes to a DNA damage checkpoint. |
| embryonic digit morphogenesis | The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| JNK cascade | An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| limb development | The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. |
| p38MAPK cascade | An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of mitotic DNA damage checkpoint | Any process that activates or increases the frequency, rate or extent of mitotic DNA damage checkpoint. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| stress-activated MAPK cascade | The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. |
41 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A2VDU3 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Bos taurus (Bovine) | SS |
| Q4TVR5 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Bos taurus (Bovine) | PR |
| Q3SZJ2 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Bos taurus (Bovine) | PR |
| Q6XUX0 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Gallus gallus (Chicken) | PR |
| P83104 | Takl1 | Putative mitogen-activated protein kinase kinase kinase 7-like | Drosophila melanogaster (Fruit fly) | PR |
| Q95UN8 | slpr | Mitogen-activated protein kinase kinase kinase | Drosophila melanogaster (Fruit fly) | EV |
| O43353 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Homo sapiens (Human) | PR |
| Q02779 | MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 | Homo sapiens (Human) | SS |
| Q8NB16 | MLKL | Mixed lineage kinase domain-like protein | Homo sapiens (Human) | EV |
| Q16584 | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | Homo sapiens (Human) | EV |
| P00540 | MOS | Proto-oncogene serine/threonine-protein kinase mos | Homo sapiens (Human) | PR |
| Q5TCX8 | MAP3K21 | Mitogen-activated protein kinase kinase kinase 21 | Homo sapiens (Human) | PR |
| Q6XUX3 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Homo sapiens (Human) | PR |
| O43318 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens (Human) | SS |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| P80192 | MAP3K9 | Mitogen-activated protein kinase kinase kinase 9 | Homo sapiens (Human) | SS |
| Q9NYL2 | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20 | Homo sapiens (Human) | PR |
| Q62073 | Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | Mus musculus (Mouse) | EV |
| P00536 | Mos | Proto-oncogene serine/threonine-protein kinase mos | Mus musculus (Mouse) | PR |
| P58801 | Ripk2 | Receptor-interacting serine/threonine-protein kinase 2 | Mus musculus (Mouse) | PR |
| Q66L42 | Map3k10 | Mitogen-activated protein kinase kinase kinase 10 | Mus musculus (Mouse) | SS |
| Q3U1V8 | Map3k9 | Mitogen-activated protein kinase kinase kinase 9 | Mus musculus (Mouse) | SS |
| Q8VDG6 | Map3k21 | Mitogen-activated protein kinase kinase kinase 21 | Mus musculus (Mouse) | PR |
| Q80XI6 | Map3k11 | Mitogen-activated protein kinase kinase kinase 11 | Mus musculus (Mouse) | PR |
| O55222 | Ilk | Integrin-linked protein kinase | Mus musculus (Mouse) | PR |
| Q99N57 | Raf1 | RAF proto-oncogene serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| P04627 | Araf | Serine/threonine-protein kinase A-Raf | Mus musculus (Mouse) | PR |
| P28028 | Braf | Serine/threonine-protein kinase B-raf | Mus musculus (Mouse) | SS |
| Q9D2Y4 | Mlkl | Mixed lineage kinase domain-like protein | Mus musculus (Mouse) | SS |
| P0C8E4 | Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | Rattus norvegicus (Rat) | SS |
| Q66HA1 | Map3k11 | Mitogen-activated protein kinase kinase kinase 11 | Rattus norvegicus (Rat) | PR |
| D3ZG83 | Map3k10 | Mitogen-activated protein kinase kinase kinase 10 | Rattus norvegicus (Rat) | SS |
| P00539 | Mos | Proto-oncogene serine/threonine-protein kinase mos | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9FPR3 | EDR1 | Serine/threonine-protein kinase EDR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q2MHE4 | HT1 | Serine/threonine/tyrosine-protein kinase HT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22558 | STY8 | Serine/threonine-protein kinase STY8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWL6 | STY17 | Serine/threonine-protein kinase STY17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4JTP5 | STY46 | Serine/threonine-protein kinase STY46 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q05609 | CTR1 | Serine/threonine-protein kinase CTR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q67E00 | dstyk | Dual serine/threonine and tyrosine protein kinase | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSLGASFVQ | IKFDDLQFFE | NCGGGSFGSV | YRAKWISQDK | EVAVKKLLKI | EKEAEILSVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SHRNIIQFYG | VILEPPNYGI | VTEYASLGSL | YDYINSNRSE | EMDMEHIMTW | ATDVAKGMHY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHMEAPVKVI | HRDLKSRNVV | IAADGVLKIC | DFGASRFHNH | TTHMSLVGTF | PWMAPEVIQS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPVSETCDTY | SYGVVLWEML | TREVPFKGLE | GLQVAWLVVE | KNERLTIPSS | CPRSFAELLH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QCWEADAKKR | PSFKQIISIL | ESMSNDTNLP | DQCNSFLHNK | AEWRCEIEAT | LERLKKLERD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSFKEQELKE | RERRLKMWEQ | KLTEQSNTPL | LPSFEIGAWT | EDDVYFWVQQ | LVRKGESSVE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MSGYASLFKE | NNITGKRLLL | LEEEDLKDMG | IVSKGHIIHF | KSAIEKLTHD | YLNLFHFPPL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IKDSGGEPEE | NEEKIVNLEL | VFGFHLKPGT | GPQDCKWKMY | MEMDGDEVAI | TYIKDVTFNT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SLPDAEILKM | TKPPFVMEKW | IVGIAEDQTV | ECTVTYENDV | RTPKLTKHVH | SIQWDRTKPQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DEVKAVQLAI | QTLFSSSEGN | PGSRSDSSAD | CQWLDTLRMR | QIASHTSLQR | SQSNPILGSP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FFPYFANQDS | YAAAVRRTQT | PVKYQQITPS | INPSRSSSPT | QYGLSRNFSS | LNLSSRDSGF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SSLNDSSSER | GRYSDRSRNK | YYRGSVSLNS | SPKGRYGGKS | QHSTPSRERY | SGKFYRLPQS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ALNTHQSPDF | KRSPNDHDRR | VPRTIPGMPL | HPETASKAGE | EESRVSEGGW | TKVEYRKKTH |
| 790 | 800 | ||||
| RQLSAKTSKE | RTRGNYRGRR | NF |