Q9ES52
PR
Gene name |
Inpp5d (7a33, Ship, Ship1) |
Protein name |
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 |
Names |
Inositol polyphosphate-5-phosphatase D, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, Phosphatidylinositol-4,5-bisphosphate 5-phosphatase, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:16331 |
EC number |
3.1.3.36: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9ES52
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6DLG | X-ray | 150 A | A | 402-861 | PDB |
| AF-Q9ES52-F1 | Predicted | AlphaFoldDB |
60 variants for Q9ES52
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388486531 | 24 | R>S | No | EVA | |
| rs3388485520 | 39 | I>T | No | EVA | |
| rs3388485505 | 41 | R>Q | No | EVA | |
| rs3388485537 | 44 | A>S | No | EVA | |
| rs3388484218 | 73 | G>S | No | EVA | |
| rs3388483702 | 102 | Y>C | No | EVA | |
| rs3388486419 | 110 | D>V | No | EVA | |
| rs3388483634 | 112 | I>F | No | EVA | |
| rs3388483967 | 139 | G>V | No | EVA | |
| rs47755963 | 216 | M>T | No | EVA | |
| rs3388483687 | 231 | L>M | No | EVA | |
| rs3390296888 | 235 | E>G | No | EVA | |
| rs3388483695 | 240 | L>* | No | EVA | |
| rs3388484473 | 250 | R>H | No | EVA | |
| rs3388485692 | 251 | P>S | No | EVA | |
| rs3388484167 | 252 | R>L | No | EVA | |
| rs3390274823 | 278 | I>M | No | EVA | |
| rs3390289219 | 298 | L>R | No | EVA | |
| rs3388487133 | 322 | D>G | No | EVA | |
| rs3388485806 | 340 | K>M | No | EVA | |
| rs3388486445 | 364 | V>M | No | EVA | |
| rs3388485693 | 411 | I>V | No | EVA | |
| rs3388484492 | 436 | K>R | No | EVA | |
| rs3388485545 | 437 | T>A | No | EVA | |
| rs3388484476 | 452 | I>F | No | EVA | |
| rs3388487214 | 498 | K>* | No | EVA | |
| rs3388485078 | 501 | H>R | No | EVA | |
| rs3388485682 | 502 | E>D | No | EVA | |
| rs3388485727 | 521 | L>V | No | EVA | |
| rs3388483674 | 540 | F>Y | No | EVA | |
| rs3388483946 | 546 | T>I | No | EVA | |
| rs3388483902 | 551 | K>Q | No | EVA | |
| rs3388487226 | 601 | E>D | No | EVA | |
| rs3388484753 | 615 | S>P | No | EVA | |
| rs3388485536 | 625 | L>Q | No | EVA | |
| rs3390143282 | 633 | F>L | No | EVA | |
| rs3388484472 | 697 | S>R | No | EVA | |
| rs3388487149 | 739 | C>G | No | EVA | |
| rs3388484477 | 758 | S>R | No | EVA | |
| rs3388487189 | 787 | L>F | No | EVA | |
| rs3388487237 | 792 | P>L | No | EVA | |
| rs3388484483 | 798 | E>D | No | EVA | |
| rs3388485605 | 853 | E>D | No | EVA | |
| rs3388487229 | 878 | S>T | No | EVA | |
| rs3388485456 | 884 | L>S | No | EVA | |
| rs3388484931 | 892 | P>H | No | EVA | |
| rs3388485753 | 933 | T>A | No | EVA | |
| rs3388484195 | 935 | S>F | No | EVA | |
| rs3390210137 | 976 | F>L | No | EVA | |
| rs3388484805 | 985 | P>H | No | EVA | |
| rs3390210099 | 986 | C>W | No | EVA | |
| rs3390272814 | 987 | P>A | No | EVA | |
| rs3390210130 | 987 | P>R | No | EVA | |
| rs3388486217 | 996 | D>N | No | EVA | |
| rs3388486737 | 1006 | E>* | No | EVA | |
| rs3388485369 | 1026 | S>F | No | EVA | |
| rs3388486237 | 1054 | I>F | No | EVA | |
| rs3388484229 | 1089 | R>C | No | EVA | |
| rs3413106506 | 1133 | E>* | No | EVA | |
| rs3388486449 | 1179 | R>S | No | EVA |
No associated diseases with Q9ES52
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.36 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin filament | A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. |
| cortical cytoskeleton | The portion of the cytoskeleton that lies just beneath the plasma membrane. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. |
| inositol-4,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. |
| inositol-polyphosphate 5-phosphatase activity | Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate. |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| immunoglobulin mediated immune response | An immune response mediated by immunoglobulins, whether cell-bound or in solution. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| negative regulation of B cell activation | Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. |
| negative regulation of B cell proliferation | Any process that stops, prevents or reduces the rate or extent of B cell proliferation. |
| negative regulation of bone resorption | Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. |
| negative regulation of granulocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation. |
| negative regulation of immune response | Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
| negative regulation of interleukin-6 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. |
| negative regulation of monocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. |
| negative regulation of neutrophil differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation. |
| negative regulation of osteoclast differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. |
| negative regulation of signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. |
| phosphatidylinositol dephosphorylation | The process of removing one or more phosphate groups from a phosphatidylinositol. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of B cell differentiation | Any process that activates or increases the frequency, rate or extent of B cell differentiation. |
| positive regulation of erythrocyte differentiation | Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. |
| positive regulation of lymphocyte differentiation | Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. |
| regulation of immune response | Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
| regulation of signal transduction | Any process that modulates the frequency, rate or extent of signal transduction. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32019 | INPP5B | Type II inositol 1,4,5-trisphosphate 5-phosphatase | Homo sapiens (Human) | PR |
| Q9NRR6 | INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV | Homo sapiens (Human) | PR |
| Q92835 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Homo sapiens (Human) | PR |
| Q6NVF0 | Ocrl | Inositol polyphosphate 5-phosphatase OCRL | Mus musculus (Mouse) | PR |
| Q8K337 | Inpp5b | Type II inositol 1,4,5-trisphosphate 5-phosphatase | Mus musculus (Mouse) | PR |
| P97573 | Inpp5d | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPAMVPGWNH | GNITRSKAEE | LLSRAGKDGS | FLVRASESIP | RAYALCVLFR | NCVYTYRILP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NEDDKFTVQA | SEGVPMRFFT | KLDQLIDFYK | KENMGLVTHL | QYPVPLEEED | AIDEAEEDTV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESVMSPPELP | PRNIPMSAGP | SEAKDLPLAT | ENPRAPEVTR | LSLSETLFQR | LQSMDTSGLP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEHLKAIQDY | LSTQLLLDSD | FLKTGSSNLP | HLKKLMSLLC | KELHGEVIRT | LPSLESLQRL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FDQQLSPGLR | PRPQVPGEAS | PITMVAKLSQ | LTSLLSSIED | KVKSLLHEGS | ESTNRRSLIP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PVTFEVKSES | LGIPQKMHLK | VDVESGKLIV | KKSKDGSEDK | FYSHKKILQL | IKSQKFLNKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VILVETEKEK | ILRKEYVFAD | SKKREGFCQL | LQQMKNKHSE | QPEPDMITIF | IGTWNMGNAP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPKKITSWFL | SKGQGKTRDD | SADYIPHDIY | VIGTQEDPLG | EKEWLELLRH | SLQEVTSMTF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KTVAIHTLWN | IRIVVLAKPE | HENRISHICT | DNVKTGIANT | LGNKGAVGVS | FMFNGTSLGF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VNSHLTSGSE | KKLRRNQNYM | NILRFLALGD | KKLSPFNITH | RFTHLFWLGD | LNYRVELPTW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EAEAIIQKIK | QQQYSDLLAH | DQLLLERKDQ | KVFLHFEEEE | ITFAPTYRFE | RLTRDKYAYT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KQKATGMKYN | LPSWCDRVLW | KSYPLVHVVC | QSYGSTSDIM | TSDHSPVFAT | FEAGVTSQFV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SKNGPGTVDS | QGQIEFLACY | ATLKTKSQTK | FYLEFHSSCL | ESFVKSQEGE | NEEGSEGELV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VRFGETLPKL | KPIISDPEYL | LDQHILISIK | SSDSDESYGE | GCIALRLETT | EAQHPIYTPL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| THHGEMTGHF | RGEIKLQTSQ | GKMREKLYDF | VKTERDESSG | MKCLKNLTSH | DPMRQWEPSG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| RVPACGVSSL | NEMINPNYIG | MGPFGQPLHG | KSTLSPDQQL | TAWSYDQLPK | DSSLGPGRGE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GPPTPPSQPP | LSPKKFSSST | ANRGPCPRVQ | EARPGDLGKV | EALLQEDLLL | TKPEMFENPL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| YGSVSSFPKL | VPRKEQESPK | MLRKEPPPCP | DPGISSPSIV | LPKAQEVESV | KGTSKQAPVP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VLGPTPRIRS | FTCSSSAEGR | MTSGDKSQGK | PKASASSQAP | VPVKRPVKPS | RSEMSQQTTP |
| 1150 | 1160 | 1170 | 1180 | 1190 | |
| IPAPRPPLPV | KSPAVLQLQH | SKGRDYRDNT | ELPHHGKHRQ | EEGLLGRTAM | Q |