Q9ERI2
PR
Gene name |
Rab27a |
Protein name |
Ras-related protein Rab-27A |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11891 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9ERI2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3BC1 | X-ray | 180 A | A/E | 1-193 | PDB |
| AF-Q9ERI2-F1 | Predicted | AlphaFoldDB |
10 variants for Q9ERI2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3400380788 | 2 | S>L | No | EVA | |
| rs3389052944 | 10 | I>T | No | EVA | |
| rs3389037707 | 15 | L>W | No | EVA | |
| rs3400017670 | 28 | Q>E | No | EVA | |
| rs3412507146 | 58 | P>S | No | EVA | |
| rs3389055114 | 73 | W>C | No | EVA | |
| rs3389065392 | 100 | D>E | No | EVA | |
| rs3389037741 | 104 | E>Q | No | EVA | |
| rs3389052888 | 190 | D>E | No | EVA | |
| rs3389061114 | 221 | C>R | No | EVA |
No associated diseases with Q9ERI2
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| exocytic vesicle | A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| multivesicular body membrane | The lipid bilayer surrounding a multivesicular body. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
| secretory granule | A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. |
| secretory granule membrane | The lipid bilayer surrounding a secretory granule. |
| Weibel-Palade body | A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein activity | A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). |
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| myosin V binding | Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. |
| protein domain specific binding | Binding to a specific domain of a protein. |
22 GO annotations of biological process
| Name | Definition |
|---|---|
| antigen processing and presentation | The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. |
| blood coagulation | The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. |
| complement-dependent cytotoxicity | Cell killing caused by the membrane attack complex formed following complement activation. |
| cytotoxic T cell degranulation | The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| exosomal secretion | The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. |
| melanocyte differentiation | The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. |
| melanosome localization | Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell. |
| melanosome transport | The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| multivesicular body organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
| multivesicular body sorting pathway | A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. |
| natural killer cell degranulation | The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell. |
| pigment granule localization | Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. |
| pigment granule transport | The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| pigmentation | The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. |
| positive regulation of constitutive secretory pathway | Any process that activates or increases the frequency, rate or extent of constitutive secretory pathway. |
| positive regulation of exocytosis | Any process that activates or increases the frequency, rate or extent of exocytosis. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of phagocytosis | Any process that activates or increases the frequency, rate or extent of phagocytosis. |
| positive regulation of reactive oxygen species biosynthetic process | Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. |
| positive regulation of regulated secretory pathway | Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8HZJ5 | RAB27B | Ras-related protein Rab-27B | Bos taurus (Bovine) | PR |
| Q1HE58 | RAB27A | Ras-related protein Rab-27A | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| O00194 | RAB27B | Ras-related protein Rab-27B | Homo sapiens (Human) | PR |
| P51159 | RAB27A | Ras-related protein Rab-27A | Homo sapiens (Human) | PR |
| Q99P58 | Rab27b | Ras-related protein Rab-27B | Mus musculus (Mouse) | PR |
| Q8CB87 | Rab44 | Ras-related protein Rab-44 | Mus musculus (Mouse) | PR |
| Q8CAM5 | Rab36 | Ras-related protein Rab-36 | Mus musculus (Mouse) | PR |
| Q4LE85 | RAB27A | Ras-related protein Rab-27A | Sus scrofa (Pig) | PR |
| Q99P74 | Rab27b | Ras-related protein Rab-27B | Rattus norvegicus (Rat) | PR |
| P23640 | Rab27a | Ras-related protein Rab-27A | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDGDYDYLI | KFLALGDSGV | GKTSVLYQYT | DGKFNSKFIT | TVGIDFREKR | VVYRANGPDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVGRGQRIHL | QLWDTAGQER | FRSLTTAFFR | DAMGFLLLFD | LTNEQSFLNV | RNWISQLQMH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AYCENPDIVL | CGNKSDLEDQ | RAVKEEEARE | LAEKYGIPYF | ETSAANGTNI | SHAIEMLLDL |
| 190 | 200 | 210 | 220 | ||
| IMKRMERCVD | KSWIPEGVVR | SNGHTSADQL | SEEKEKGLCG | C |