Q9ERE3

PR
Gene name
Sgk3 (Cisk, Sgkl)
Protein name
Serine/threonine-protein kinase Sgk3
Names
Cytokine-independent survival kinase, Serum/glucocorticoid-regulated kinase 3, Serum/glucocorticoid-regulated kinase-like
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:170755
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

88-166 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

303-326 (Activation loop from InterPro)

Target domain

165-490 (Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

3 structures for Q9ERE3

Entry ID Method Resolution Chain Position Source
1XTE X-ray 160 A A 7-160 PDB
1XTN X-ray 220 A A/B 7-126 PDB
AF-Q9ERE3-F1 Predicted AlphaFoldDB

30 variants for Q9ERE3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs254303508 6 I>T No EVA
rs3388457350 12 S>N No EVA
rs3389641737 38 V>D No EVA
rs3388456216 42 R>I No EVA
rs3388456368 99 Q>K No EVA
rs3388456754 123 R>K No EVA
rs3388456156 132 E>V No EVA
rs253226003 138 S>A No EVA
rs3389650427 150 G>V No EVA
rs36356127 160 T>S No EVA
rs3388456322 181 R>W No EVA
rs3388457227 182 K>T No EVA
rs3388456733 190 V>I No EVA
rs3388458198 196 K>N No EVA
rs3388457099 208 M>I No EVA
rs3388456987 217 N>I No EVA
rs3388457203 250 F>I No EVA
rs3388458230 250 F>S No EVA
rs3388457401 260 E>K No EVA
rs3388457553 261 P>L No EVA
rs3388457222 263 A>V No EVA
rs214290643 297 M>I No EVA
rs3389608158 324 T>A No EVA
rs3388456516 325 P>S No EVA
rs3389626051 385 S>R No EVA
rs3389650462 388 A>S No EVA
rs3389652705 393 E>F No EVA
rs3389644607 394 E>V* No EVA
rs3389608179 435 P>H* No EVA
rs3388458931 464 V>M No EVA

No associated diseases with Q9ERE3

8 regional properties for Q9ERE3

Type Name Position InterPro Accession
domain Protein kinase domain 162 - 419 IPR000719
domain AGC-kinase, C-terminal 420 - 496 IPR000961
domain Phox homology 12 - 124 IPR001683
active_site Serine/threonine-protein kinase, active site 282 - 294 IPR008271
binding_site Protein kinase, ATP binding site 168 - 191 IPR017441
domain Protein kinase, C-terminal 440 - 487 IPR017892
domain Serine/threonine-protein kinase Sgk3, catalytic domain 165 - 490 IPR037709
domain CISK, PX domain 12 - 120 IPR037900

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasmic vesicle
  • Early endosome
  • Recycling endosome
  • Endosomal localization is a prerequisite for complete kinase activity
  • It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3
  • Colocalizes with SLC9A3/NHE3 in the recycling endosomes (By similarity)
  • Localized in vesicle-like structures and in the early endosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
potassium channel regulator activity Binds to and modulates the activity of a potassium channel.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

40 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6TJY3 RPS6KB1 Ribosomal protein S6 kinase beta-1 Bos taurus (Bovine) SS
P23443 RPS6KB1 Ribosomal protein S6 kinase beta-1 Homo sapiens (Human) EV SS
Q9UBS0 RPS6KB2 Ribosomal protein S6 kinase beta-2 Homo sapiens (Human) PR
Q9Y5W7 SNX14 Sorting nexin-14 Homo sapiens (Human) PR
Q96S38 RPS6KC1 Ribosomal protein S6 kinase delta-1 Homo sapiens (Human) PR
Q9Y5W8 SNX13 Sorting nexin-13 Homo sapiens (Human) PR
O00141 SGK1 Serine/threonine-protein kinase Sgk1 Homo sapiens (Human) PR
Q9HBY8 SGK2 Serine/threonine-protein kinase Sgk2 Homo sapiens (Human) SS
Q96BR1 SGK3 Serine/threonine-protein kinase Sgk3 Homo sapiens (Human) SS
Q9Z1M4 Rps6kb2 Ribosomal protein S6 kinase beta-2 Mus musculus (Mouse) SS
Q8BSK8 Rps6kb1 Ribosomal protein S6 kinase beta-1 Mus musculus (Mouse) SS
Q6PHS6 Snx13 Sorting nexin-13 Mus musculus (Mouse) PR
Q8BLK9 Rps6kc1 Ribosomal protein S6 kinase delta-1 Mus musculus (Mouse) PR
Q3ZT31 Snx25 Sorting nexin-25 Mus musculus (Mouse) PR
Q8BHY8 Snx14 Sorting nexin-14 Mus musculus (Mouse) PR
Q8QZV4 Stk32c Serine/threonine-protein kinase 32C Mus musculus (Mouse) PR
Q9Z2A0 Pdpk1 3-phosphoinositide-dependent protein kinase 1 Mus musculus (Mouse) SS
Q02956 Prkcz Protein kinase C zeta type Mus musculus (Mouse) SS
Q62074 Prkci Protein kinase C iota type Mus musculus (Mouse) SS
P70268 Pkn1 Serine/threonine-protein kinase N1 Mus musculus (Mouse) SS
Q8K045 Pkn3 Serine/threonine-protein kinase N3 Mus musculus (Mouse) SS
Q8BWW9 Pkn2 Serine/threonine-protein kinase N2 Mus musculus (Mouse) SS
P23298 Prkch Protein kinase C eta type Mus musculus (Mouse) PR
P16054 Prkce Protein kinase C epsilon type Mus musculus (Mouse) PR
Q02111 Prkcq Protein kinase C theta type Mus musculus (Mouse) PR
P28867 Prkcd Protein kinase C delta type Mus musculus (Mouse) PR
P20444 Prkca Protein kinase C alpha type Mus musculus (Mouse) SS
P63318 Prkcg Protein kinase C gamma type Mus musculus (Mouse) SS
P68404 Prkcb Protein kinase C beta type Mus musculus (Mouse) SS
Q60823 Akt2 RAC-beta serine/threonine-protein kinase Mus musculus (Mouse) PR
P31750 Akt1 RAC-alpha serine/threonine-protein kinase Mus musculus (Mouse) PR
Q9WUA6 Akt3 RAC-gamma serine/threonine-protein kinase Mus musculus (Mouse) PR
Q91VJ4 Stk38 Serine/threonine-protein kinase 38 Mus musculus (Mouse) SS
Q7TSE6 Stk38l Serine/threonine-protein kinase 38-like Mus musculus (Mouse) SS
P67999 Rps6kb1 Ribosomal protein S6 kinase beta-1 Rattus norvegicus (Rat) EV SS
Q9SUA3 D6PKL1 Serine/threonine-protein kinase D6PKL1 Arabidopsis thaliana (Mouse-ear cress) PR
O48963 PHOT1 Phototropin-1 Arabidopsis thaliana (Mouse-ear cress) PR
O64682 PID Protein kinase PINOID Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUL2 WAG2 Serine/threonine-protein kinase WAG2 Arabidopsis thaliana (Mouse-ear cress) PR
Q5BKK4 sgk1 Serine/threonine-protein kinase Sgk1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MQRDCIMDYK ESCPSVSIPS SDEHREKKKR FTVYKVLVSV GRSEWFVFRR YAEFDKLYNS
70 80 90 100 110 120
LKKQFPAMAL KIPAKRIFGD NFDPDFIKQR RAGLNEFIQN LVRYPELYNH PDVRAFLQMD
130 140 150 160 170 180
SPRHQSDPSE DEDERSTSKP HSTSRNINLG PTGNPHAKPT DFDFLKVIGK GSFGKVLLAK
190 200 210 220 230 240
RKLDGKFYAV KVLQKKIVLN RKEQKHIMAE RNVLLKNVKH PFLVGLHYSF QTTEKLYFVL
250 260 270 280 290 300
DFVNGGELFF HLQRERSFPE PRARFYAAEI ASALGYLHSI KIVYRDLKPE NILLDSMGHV
310 320 330 340 350 360
VLTDFGLCKE GIAISDTTTT FCGTPEYLAP EVIRKQPYDN TVDWWCLGAV LYEMLYGLPP
370 380 390 400 410 420
FYCRDVAEMY DNILHKPLNL RPGVSLTAWS ILEELLEKNR QNRLGAKEDF LEIQNHPFFE
430 440 450 460 470 480
SLSWTDLVQK KIPPPFNPNV AGPDDIRNFD AVFTEETVPY SVCVSSDYSI VNASVLEADD
490
AFVGFSYAPP SEDLFL