Q9ERD6
PR
Gene name |
Ralgps2 |
Protein name |
Ras-specific guanine nucleotide-releasing factor RalGPS2 |
Names |
Ral GEF with PH domain and SH3-binding motif 2, RalA exchange factor RalGPS2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:78255 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ERD6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ERD6-F1 | Predicted | AlphaFoldDB |
26 variants for Q9ERD6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3412791678 | 14 | A>S | No | EVA | |
| rs3390797952 | 17 | V>A | No | EVA | |
| rs3388511668 | 26 | S>T | No | EVA | |
| rs3388504923 | 32 | S>T | No | EVA | |
| rs3390770018 | 60 | M>E | No | EVA | |
| rs3390855866 | 81 | K>I | No | EVA | |
| rs3388506092 | 82 | E>K | No | EVA | |
| rs3388509094 | 102 | F>L | No | EVA | |
| rs3388504938 | 219 | T>A | No | EVA | |
| rs31270256 | 220 | G>S | No | EVA | |
| rs32326541 | 252 | I>M | No | EVA | |
| rs3390841491 | 262 | S>C | No | EVA | |
| rs3390833392 | 262 | S>T | No | EVA | |
| rs3388509064 | 349 | H>L | No | EVA | |
| rs3388507661 | 355 | F>L | No | EVA | |
| rs3388506396 | 486 | A>S | No | EVA | |
| rs3388506396 | 486 | A>T | No | EVA | |
| rs3388506078 | 510 | A>G | No | EVA | |
| rs3388504662 | 524 | V>M | No | EVA | |
| rs3388504873 | 529 | W>G | No | EVA | |
| rs3388509123 | 535 | D>N | No | EVA | |
| rs3388511709 | 538 | E>D | No | EVA | |
| rs3388510067 | 538 | E>G | No | EVA | |
| rs3388509125 | 555 | K>M | No | EVA | |
| rs3388510223 | 583 | P>R | No | EVA | |
| rs3388504917 | 584 | T>I | No | EVA |
No associated diseases with Q9ERD6
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| Ras protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
| regulation of Ral protein signal transduction | Any process that modulates the frequency, rate or extent of Ral protein signal transduction. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6N9I4 | RASGRP2 | RAS guanyl-releasing protein 2 | Bos taurus (Bovine) | SS |
| Q1LZ97 | RASGRP4 | RAS guanyl-releasing protein 4 | Bos taurus (Bovine) | SS |
| A0A3S5ZPR1 | RASGRP3 | RAS guanyl releasing protein 3 | Gallus gallus (Chicken) | SS |
| P26675 | Sos | Protein son of sevenless | Drosophila melanogaster (Fruit fly) | SS |
| Q07890 | SOS2 | Son of sevenless homolog 2 | Homo sapiens (Human) | SS |
| O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | Homo sapiens (Human) | EV |
| Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | Homo sapiens (Human) | EV SS |
| Q13905 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | Homo sapiens (Human) | PR |
| Q8IV61 | RASGRP3 | Ras guanyl-releasing protein 3 | Homo sapiens (Human) | SS |
| Q07889 | SOS1 | Son of sevenless homolog 1 | Homo sapiens (Human) | EV |
| Q8TDF6 | RASGRP4 | RAS guanyl-releasing protein 4 | Homo sapiens (Human) | SS |
| Q5JS13 | RALGPS1 | Ras-specific guanine nucleotide-releasing factor RalGPS1 | Homo sapiens (Human) | PR |
| Q86X27 | RALGPS2 | Ras-specific guanine nucleotide-releasing factor RalGPS2 | Homo sapiens (Human) | PR |
| Q02384 | Sos2 | Son of sevenless homolog 2 | Mus musculus (Mouse) | SS |
| Q62245 | Sos1 | Son of sevenless homolog 1 | Mus musculus (Mouse) | SS |
| Q8VCC8 | Rapgef3 | Rap guanine nucleotide exchange factor 3 | Mus musculus (Mouse) | SS |
| Q9EQZ6 | Rapgef4 | Rap guanine nucleotide exchange factor 4 | Mus musculus (Mouse) | EV |
| Q9D300 | Rasgef1c | Ras-GEF domain-containing family member 1C | Mus musculus (Mouse) | PR |
| Q03385 | Ralgds | Ral guanine nucleotide dissociation stimulator | Mus musculus (Mouse) | PR |
| Q9Z1S3 | Rasgrp1 | RAS guanyl-releasing protein 1 | Mus musculus (Mouse) | SS |
| Q8BTM9 | Rasgrp4 | RAS guanyl-releasing protein 4 | Mus musculus (Mouse) | SS |
| Q9QUG9 | Rasgrp2 | RAS guanyl-releasing protein 2 | Mus musculus (Mouse) | SS |
| A2AR50 | Ralgps1 | Ras-specific guanine nucleotide-releasing factor RalGPS1 | Mus musculus (Mouse) | PR |
| Q9R1K8 | Rasgrp1 | RAS guanyl-releasing protein 1 | Rattus norvegicus (Rat) | SS |
| P0C643 | Rasgrp2 | RAS guanyl-releasing protein 2 | Rattus norvegicus (Rat) | SS |
| Q8R5I4 | Rasgrp4 | RAS guanyl-releasing protein 4 | Rattus norvegicus (Rat) | SS |
| Q9N5D3 | sos-1 | Son of sevenless homolog | Caenorhabditis elegans | EV |
| A4IJ06 | rasgrp1 | RAS guanyl-releasing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLMNGQASS | VTIAATVSEK | SSSSESLSEK | GSELKKSFDA | VVFDVLKVTP | EEYAGQITLM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DVPVFKAIQP | DELSSCGWNK | KEKYSSAPNA | VAFTRRFNHV | SFWVVREILH | AQTLKIRAEV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSHYIKTAKK | LYELNNLHAL | MAVVSGLQSA | PIFRLTKTWA | LLSRKDKTTF | EKLEYVMSKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DNYKRLRDYI | SSLKMTPCIP | YLGIYLSDLT | YIDSAYPSTG | SILENEQRSN | LMNNILRIIS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLQQSCEYDI | PILPHVQKYL | NSVQYIEELQ | KFVEDDNYKL | SLKIEPGAST | PRSAASREDL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AGPDIGASPQ | GGRKSSAAAA | AAAAAEGALL | PQTPPSPRNL | IPHGHRKCHS | LGYNFIHKMN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TAEFKSATFP | NAGPRHLLDD | SVMEPHAPSR | GQAESSTLSS | GISIGSSDGS | ELSEETSWPA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FERNRLYHSL | GPVTRVPRNG | YRSHTKASSS | AESEDLAVHL | YPGAVTIQGV | LRRKTLLKEG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKPTVASWTK | YWAALCGTQL | FYYAAKSLKA | TERKHFKSTS | NKNVSVVGWM | VMMADDPEHP |
| 550 | 560 | 570 | 580 | ||
| DLFLLTDSEK | GNSYKFQAGS | RMNAMLWFKH | LSAACQSNKQ | QVPTNLMTFE |