Q9EQW7

SS
Gene name
Kif13a
Protein name
Kinesin-like protein KIF13A
Names
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

Kinesin-3 KIF13B autoinhibition involves the coiled-coil 1 (CC1) segment, which interacts with both the neck coil (NC) and the motor domain (MD). This interaction not only inhibits the NC-mediated dimerization, but also prevents the ADP release from the MD, effectively inhibiting the motor activity.

Autoinhibitory domains (AIDs)

389-431 (Coiled-coil 1) SS

Target domain

1-388 (Motor domain and neck coil)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9EQW7

Entry ID Method Resolution Chain Position Source
5DJO X-ray 174 A A/B 390-555 PDB
AF-Q9EQW7-F1 Predicted AlphaFoldDB

No variants for Q9EQW7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9EQW7

No associated diseases with Q9EQW7

6 regional properties for Q9EQW7

Type Name Position InterPro Accession
domain Forkhead-associated (FHA) domain 470 - 534 IPR000253
domain Kinesin motor domain 3 - 360 IPR001752
conserved_site Kinesin motor domain, conserved site 246 - 257 IPR019821
domain Kinesin-like KIF1-type 748 - 792 IPR022140
domain Kinesin-like 1209 - 1268 IPR022164
domain Kinesin-associated 391 - 468 IPR032405

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Midbody
  • Endosome membrane
  • Recruited to the midbody during cytokinesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
endosome membrane The lipid bilayer surrounding an endosome.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
trans-Golgi network membrane The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

11 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cytoskeleton-dependent intracellular transport The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
endosome to lysosome transport The directed movement of substances from endosomes to lysosomes.
Golgi to plasma membrane protein transport The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
melanosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
plus-end-directed vesicle transport along microtubule The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
vesicle cargo loading The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NQT8 KIF13B Kinesin-like protein KIF13B Homo sapiens (Human) EV
Q9H1H9 KIF13A Kinesin-like protein KIF13A Homo sapiens (Human) SS
Q61768 Kif5b Kinesin-1 heavy chain Mus musculus (Mouse) EV
P28738 Kif5c Kinesin heavy chain isoform 5C Mus musculus (Mouse) SS
Q99PW8 Kif17 Kinesin-like protein KIF17 Mus musculus (Mouse) SS
Q7M6Z4 Kif27 Kinesin-like protein KIF27 Mus musculus (Mouse) SS
Q9QXL1 Kif21b Kinesin-like protein KIF21B Mus musculus (Mouse) SS
Q9QXL2 Kif21a Kinesin-like protein KIF21A Mus musculus (Mouse) EV SS
P33175 Kif5a Kinesin heavy chain isoform 5A Mus musculus (Mouse) SS
B7ZNG0 Kif7 Kinesin-like protein KIF7 Mus musculus (Mouse) SS
Q70AM4 Kif13b Kinesin 13B Rattus norvegicus (Rat) EV
10 20 30 40 50 60
MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK PPKVFAFDYC
70 80 90 100 110 120
FWSMDESNTT KYAGQEVVFK CLGEGILEKA FQGYNACIFA YGQTGSGKSF SMMGHAEQLG
130 140 150 160 170 180
LIPRLCCALF QRIALEQNES QTFKVEVSYM EIYNEKVRDL LDPKGSRQSL KVREHKVLGP
190 200 210 220 230 240
YVDGLSQLAV TSFEDIESLM SEGNKSRTVA ATNMNEESSR SHAVFNIIIT QTLYDLQSGN
250 260 270 280 290 300
SGEKVSKVSL VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKNK
310 320 330 340 350 360
FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK RIVNHAVVNE
370 380 390 400 410 420
DPNAKVIREL REEVEKLREQ LSKAEAMKPP ELKEKLEESE KLIKELTVTW EEKLRKTEAI
430 440 450 460 470 480
AQERQRQLES MGISLETSGI KVGDDKCYLV NLNADPALNE LLVYYLKDHT RVGADTSQDI
490 500 510 520 530 540
QLFGIGIQPE HCEIDIAADG DITLTPKENA RSCVNGTLVC NTTQLWHGDR ILWGNNHFFR
550 560 570 580 590 600
INLPKRKRRD WLKDFERETS SAEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNDPVQN
610 620 630 640 650 660
VVQVLEKQYL EEKRTALEEQ RLMYERELEQ LRQQLSPERQ PPSSASDRLA YSSQTAQQKV
670 680 690 700 710 720
TQWAEERDEL FRQSLAKLRE QLVKANTLVR EANFLAEEMS KLTDYQVTLQ IPAANLSANR
730 740 750 760 770 780
KRGAIVSEPA IQARRKGKGT QVWTIEKLEN KLIDMRDLYQ EWKENVPEAK RLYGKRGDPF
790 800 810 820 830 840
YEAQENHNLI GVANVFLECL FCDVKLQYAV PIISQQGEVA GRLHVEVTRI TGTIPERMAE
850 860 870 880 890 900
DDSSENSSES GSLEVVDSSG EVIHRVKKLT CRVIIKEATG LPISLSNFVF CQYTFWDQCE
910 920 930 940 950 960
STVAAPVVDP DVPSPQSKDA QYTVTFSHCK DYVVTVTEEF LEFISDGALA IEVWGHRCAG
970 980 990 1000 1010 1020
NGSPIWEVDS LHAKTRTLHD RWNEVTRRIE VWISILELNE LGDYAAVELH QAKDVNTGGV
1030 1040 1050 1060 1070 1080
FQLRQGHSRR VQVTVKPVQH SGTLPLMVEA ILSVSIGCVT ARSTKLQRGL DSYQEEDLNC
1090 1100 1110 1120 1130 1140
VRERWSDALI KRREYLDEQI KKVSNKKEKT EDDMEREARL VEQWVGLTEE RNAVLVPAPG
1150 1160 1170 1180 1190 1200
SGIPGAPADW VPPPGMETHI PVLFLDLNAD DLSANEQLVG PHASGVNSIL PKEHGSQFFY
1210 1220 1230 1240 1250 1260
LPIIKHSDDE VSATASWDSS VHDSLHLNRV TPQNERIYLI VKTTVQLSHP AAMELVLRKR
1270 1280 1290 1300 1310 1320
IAANIYNKQS FTQSLKRRIS LINICYSCGV TYEIVSNIPK ATEEIEDRET LALLAARSEN
1330 1340 1350 1360 1370 1380
EGTLDGETYI EKYTRGVLQV ENILSLERLR QAVTVKEALS TKARHIRRSL STPNVHNVSS
1390 1400 1410 1420 1430 1440
SRPDLSGFDE DDKGWPENQL DVSDYSSSYQ DVACYGTLPR DSPRRSKEGC PSENPHALTV
1450 1460 1470 1480 1490 1500
SPFKAFSPQP PKFFKPLMPV KEEHKKRLAL EARPLLSQED SEEEENELEA LSRKLMLTQP
1510 1520 1530 1540 1550 1560
YVPVEFADFS VYNASLENRE WSSSKADLTD SRALEKAVSR SPTTSSLTSG YFSHSASNAT
1570 1580 1590 1600 1610 1620
LSDMAVPSSD SSDQLAVSTK EVECAEPPGP SLAPDVRRAS NQELTEVGRG SGKDETIAVP
1630 1640 1650 1660 1670 1680
LEENSALPKG TPSPQSIPEE SSRMPCRTAS CSELDVGPSK DGHQAREFCP GEVTIEHTTN
1690 1700 1710 1720 1730 1740
ILEDHSFTEF MGVSDGKDFD GLADCSVGEP SRRRALTNET DHKGIPERPP DADRLHPKIE
NDQEATATR