Q9EQU5
Gene name |
Set |
Protein name |
Protein SET |
Names |
Phosphatase 2A inhibitor I2PP2A , I-2PP2A , Template-activating factor I , TAF-I |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56086 |
EC number |
|
Protein Class |
TESTIS-SPECIFIC Y-ENCODED PROTEIN (PTHR11875) |
Descriptions
Template-activating factor I (TAF-I) is a multifunctional protein that plays a role in apoptosis, transcription, nucleosome assembly, and histone chaperoning. In human and murine cells, two TAF-I subtypes exist, namely TAF-Iɑ and TAF-Iβ. In comparison to the histone chaperone activity of TAF-Iβ, TAF-Iɑ exhibits reduced histone chaperone activity due to the N-terminal region of TAF-Iɑ autoinhibiting its activity via intramolecular interaction with its C-terminal region. The replacement of basic amino acids within the N-terminal region with alanines disrupts the intramolecular interactions between the N- and C-terminal regions, enhancing the histone chaperone activity to a similar extent to that of TAF-Iβ.
Autoinhibitory domains (AIDs)
Target domain |
237-290 (C-terminal regions) |
Relief mechanism |
Others |
Assay |
Structural analysis, Deletion assay |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9EQU5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9EQU5-F1 | Predicted | AlphaFoldDB |
5 variants for Q9EQU5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388537096 | 3 | P>S | No | EVA | |
| rs3388538104 | 10 | L>M | No | EVA | |
| rs3388541022 | 160 | S>N | No | EVA | |
| rs3388537007 | 199 | E>D | No | EVA | |
| rs3388544879 | 204 | W>* | No | EVA |
No associated diseases with Q9EQU5
No regional properties for Q9EQU5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9EQU5 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR11875 | TESTIS-SPECIFIC Y-ENCODED PROTEIN |
| PANTHER Subfamily | PTHR11875:SF67 | PROTEIN SET |
| PANTHER Protein Class | chromatin/chromatin-binding, or -regulatory protein | |
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of neuron apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O19110 | TSPY1 | Testis-specific Y-encoded protein 1 | Bos taurus (Bovine) | PR |
| Q8N831 | TSPYL6 | Testis-specific Y-encoded-like protein 6 | Homo sapiens (Human) | PR |
| Q9H2G4 | TSPYL2 | Testis-specific Y-encoded-like protein 2 | Homo sapiens (Human) | PR |
| P0DME0 | SETSIP | Protein SETSIP | Homo sapiens (Human) | SS |
| Q01105 | SET | Protein SET | Homo sapiens (Human) | SS |
| P0CV98 | TSPY3 | Testis-specific Y-encoded protein 3 | Homo sapiens (Human) | PR |
| P0CV99 | TSPY4 | Testis-specific Y-encoded protein 4 | Homo sapiens (Human) | PR |
| Q01534 | TSPY1 | Testis-specific Y-encoded protein 1 | Homo sapiens (Human) | PR |
| A6NKD2 | TSPY2 | Testis-specific Y-encoded protein 2 | Homo sapiens (Human) | PR |
| P0CW01 | TSPY10 | Testis-specific Y-encoded protein 10 | Homo sapiens (Human) | PR |
| Q63945 | Set | Protein SET | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPKRQSAIL | PQPKKPRPAA | APKLEDKSAS | PGLPKGEKEQ | QEAIEHIDEV | QNEIDRLNEQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ASEEILKVEQ | KYNKLRQPFF | QKRSELIAKI | PNFWVTTFVN | HPQVSALLGE | EDEEALHYLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVEVTEFEDI | KSGYRIDFYF | DENPYFENKV | LSKEFHLNES | GDPSSKSTEI | KWKSGKDLTK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RSSQTQNKAS | RKRQHEEPES | FFTWFTDHSD | AGADELGEVI | KDDIWPNPLQ | YYLVPDMDDE |
| 250 | 260 | 270 | 280 | ||
| EGEAEDDDDD | DEEEEGLEDI | DEEGDEDEGE | EDDDEDEGEE | GEEDEGEDD |