Q9EPZ8

PR
Gene name
Rnf103 (Zfp103)
Protein name
E3 ubiquitin-protein ligase RNF103
Names
Protein ADRG34, RING finger protein 103, RING-type E3 ubiquitin transferase RNF103, Zinc finger protein 103, Zfp-103
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9EPZ8

Entry ID Method Resolution Chain Position Source
AF-Q9EPZ8-F1 Predicted AlphaFoldDB

No variants for Q9EPZ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9EPZ8

No associated diseases with Q9EPZ8

1 regional properties for Q9EPZ8

Type Name Position InterPro Accession
domain Zinc finger, RING-type 617 - 660 IPR001841

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

2 GO annotations of biological process

Name Definition
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VE61 CG7694 E3 ubiquitin-protein ligase RNF181 homolog Drosophila melanogaster (Fruit fly) PR
Q86Y13 DZIP3 E3 ubiquitin-protein ligase DZIP3 Homo sapiens (Human) PR
Q9Y3E7 CHMP3 Charged multivesicular body protein 3 Homo sapiens (Human) EV
O00237 RNF103 E3 ubiquitin-protein ligase RNF103 Homo sapiens (Human) PR
Q9R1W3 Rnf103 E3 ubiquitin-protein ligase RNF103 Mus musculus (Mouse) PR
Q9SI09 XERICO Probable E3 ubiquitin-protein ligase XERICO Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZV51 ATL56 RING-H2 finger protein ATL56 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SKK8 ATL22 RING-H2 finger protein ATL22 Arabidopsis thaliana (Mouse-ear cress) PR
P0CH02 ATL21B Putative RING-H2 finger protein ATL21B Arabidopsis thaliana (Mouse-ear cress) PR
P0CH01 ATL21A Putative RING-H2 finger protein ATL21A Arabidopsis thaliana (Mouse-ear cress) PR
O22255 ATL64 RING-H2 finger protein ATL64 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RXX9 ATL6 E3 ubiquitin-protein ligase ATL6 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GYT9 SIS3 E3 ubiquitin-protein ligase SIS3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LZJ6 ATL5 RING-H2 finger protein ATL5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GXF8 SGR9 E3 ubiquitin-protein ligase SGR9, amyloplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q8LGA5 ATL31 E3 ubiquitin-protein ligase ATL31 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUZ9 ATL63 RING-H2 finger protein ATL63 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT ILECRGLGYS
70 80 90 100 110 120
GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN FSGEMHFYEL VEDTKDGIWL
130 140 150 160 170 180
VQVIANDRSP LVGKIHWEKM VKKVSRFGIR TGTFNCSSDP RYCRRRGWVR STLIMSVPQT
190 200 210 220 230 240
STSKGKVMLK EYSGRKIEVE HIFKWITAHA ASRIKTIYNV EHLKEEWNKS DQYWVKIYLF
250 260 270 280 290 300
ANLDQPPAFF SALSIKFTGR VEFIFVNVEN WNNKSYMTDI GIYNMPSYIL RTPEGIYRYG
310 320 330 340 350 360
NHTGEFISLQ AMDSFLRSLQ PEVNDLFVLS LVLVNLMAWM DLFITQGATI KRFVVLISTL
370 380 390 400 410 420
GTYNSLLIIS WLPVLGFLQL PYLDSFYEYS LRLLRYSNTT TLASWVRADW MFYSSHPALF
430 440 450 460 470 480
LSTYLGHGLL IDYFEKKRRR SNNDEVNANN LEWLSSLWDW YTSYLFHPIA SFQNFPVDSD
490 500 510 520 530 540
WDEDPDLFLE RLAFPDLWLH PLIPTDYIKN LPMWRFKCLG AQSEEEMSES SQDTENDSDS
550 560 570 580 590 600
DNTDTFSSSK DVFEDKQNVH SSPGRTSRCD TEACSCANKC VSSPCERKRR SYGSHNTKED
610 620 630 640 650 660
MEPDWLTWPA GTLHCTECVV CLENFENGCL LMGLPCGHVF HQNCIVMWLA GGRHCCPVCR
670 680
WPSYKKKQPY AQQQPLSNDA PS