Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9DER7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9DER7-F1 | Predicted | AlphaFoldDB |
No variants for Q9DER7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9DER7 | |||||
No associated diseases with Q9DER7
14 regional properties for Q9DER7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| ptm | EGF-type aspartate/asparagine hydroxylation site | 740 - 751 | IPR000152 |
| domain | EGF-like domain | 573 - 610 | IPR000742-1 |
| domain | EGF-like domain | 725 - 765 | IPR000742-2 |
| domain | CUB domain | 345 - 457 | IPR000859-1 |
| domain | CUB domain | 458 - 570 | IPR000859-2 |
| domain | CUB domain | 613 - 725 | IPR000859-3 |
| domain | CUB domain | 769 - 881 | IPR000859-4 |
| domain | CUB domain | 882 - 998 | IPR000859-5 |
| domain | Peptidase M12A | 144 - 343 | IPR001506 |
| domain | EGF-like calcium-binding domain | 574 - 610 | IPR001881-1 |
| domain | EGF-like calcium-binding domain | 725 - 765 | IPR001881-2 |
| domain | Peptidase, metallopeptidase | 149 - 291 | IPR006026 |
| conserved_site | EGF-like calcium-binding, conserved site | 725 - 749 | IPR018097 |
| domain | Tolloid/BMP1 peptidase domain | 144 - 343 | IPR034036 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| dorsal/ventral pattern formation | The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. |
| protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P25723 | tld | Dorsal-ventral patterning protein tolloid | Drosophila melanogaster (Fruit fly) | PR |
| P98066 | TNFAIP6 | Tumor necrosis factor-inducible gene 6 protein | Homo sapiens (Human) | PR |
| P13497 | BMP1 | Bone morphogenetic protein 1 | Homo sapiens (Human) | PR |
| Q9Y6L7 | TLL2 | Tolloid-like protein 2 | Homo sapiens (Human) | PR |
| O43897 | TLL1 | Tolloid-like protein 1 | Homo sapiens (Human) | PR |
| P98063 | Bmp1 | Bone morphogenetic protein 1 | Mus musculus (Mouse) | PR |
| Q9WVM6 | Tll2 | Tolloid-like protein 2 | Mus musculus (Mouse) | PR |
| Q6HA09 | Astl | Astacin-like metalloendopeptidase | Mus musculus (Mouse) | PR |
| O08859 | Tnfaip6 | Tumor necrosis factor-inducible gene 6 protein | Mus musculus (Mouse) | PR |
| Q62381 | Tll1 | Tolloid-like protein 1 | Mus musculus (Mouse) | PR |
| Q9U3S9 | nas-6 | Zinc metalloproteinase nas-6 | Caenorhabditis elegans | PR |
| P55112 | nas-4 | Zinc metalloproteinase nas-4 | Caenorhabditis elegans | PR |
| P55113 | nas-7 | Zinc metalloproteinase nas-7 | Caenorhabditis elegans | PR |
| Q18439 | nas-8 | Zinc metalloproteinase nas-8 | Caenorhabditis elegans | PR |
| Q20942 | nas-38 | Zinc metalloproteinase nas-38 | Caenorhabditis elegans | PR |
| Q21252 | nas-3 | Zinc metalloproteinase nas-3 | Caenorhabditis elegans | PR |
| P55115 | nas-15 | Zinc metalloproteinase nas-15 | Caenorhabditis elegans | PR |
| Q20176 | nas-39 | Zinc metalloproteinase nas-39 | Caenorhabditis elegans | PR |
| O57460 | tll1 | Dorsal-ventral patterning tolloid-like protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKMLCWRLAL | WLAAWAVCGK | PSFCSALDYD | YTYDFTEEDK | AEAIDYKDPC | KAAVFWGDIA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDDEDLKIFQ | IDRTIDLTQH | SNERLGHNTG | GFGEHGMSKK | RGALYQLIER | IRRFGSGFEQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NNTSKGRTTV | KFSGKNEKNR | FPRAATSRTE | RIWPGGVIPY | VIGGNFTGTQ | RAMFKQAMRH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WEKYTCVTFI | ERSDEESYIV | FTYRPCGCCS | YVGRRGNGPQ | AISIGKNCDK | FGIVVHELGH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIGFWHEHTR | PDRDDHVTII | RENIQPGQEY | NFLKMEPGEV | NSLGEPYDFD | SIMHYARNTF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SRGMFLDTIL | PSRDDNGIRP | AIGQRTRLSK | GDIAQARKLY | RCPACGETLQ | ESTGNFSSPG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPNGYPSYTH | CIWRISVTPG | EKIVLNFTTM | DLYKSSLCWY | DYIEVRDGYW | RKSPLLGRFC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GDKLPEVLAS | SDSRMWIEFR | SSSNWVGKGF | AAVYEAICGG | EIHKNEGQIQ | SPNYPDDYRP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MKECVWKITV | SENYNVGLTF | QAFEIERHDN | CAYDYLEIRD | GMNENSPLIG | HFCGYDKPED |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IRSTSNTLWM | KFVSDGTVNK | AGFAANFFKE | EMMCQPDNGG | CEQRCVNTLG | SYQCACDPGY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELGPDKKSCE | AACGGLLTKL | NGTIPTPGWP | KEYPPNKNCV | WQVVAPTQYR | ISMKFEFFEL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EGNEVCKYDY | VEIRSGLSSD | SKLHGKFCGT | EVPEVITSQY | NNMRIEFRSD | NTVSKKGFKA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HFFSDKDECS | KDNGGCQHEC | INTVGSYVCQ | CRNGFVLHEN | KHDCKEAECE | QKIHSPNGII |
| 790 | 800 | 810 | 820 | 830 | 840 |
| MSPNWPDKYP | SRKECTWEIS | ATPGQRVKLT | FNEFEIEQHQ | ECAYDHLEVF | DGESEKSPIL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GRLCGSKIPE | PLIATGNKMF | LRFISDASVQ | RKGFQATHST | ECGGRLKAET | KPKDLYSHAQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| FGDNNYPVQA | DCDWLLVAER | GYRVELMFQT | FEVEEEADCG | YDYVELFDGH | DKTAMRLGRF |
| 970 | 980 | 990 | 1000 | ||
| CGSGPPEEIY | SAGETLLLHF | HTDDTINKKG | FHIRYRSIKY | PDSVHTKK |