Q9DDU0

PR
Gene name
hoxa11a
Protein name
Homeobox protein Hox-A11a
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:58061
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

138-231 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9DDU0

Entry ID Method Resolution Chain Position Source
AF-Q9DDU0-F1 Predicted AlphaFoldDB

No variants for Q9DDU0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9DDU0

No associated diseases with Q9DDU0

4 regional properties for Q9DDU0

Type Name Position InterPro Accession
domain Homeobox domain 210 - 274 IPR001356
domain Homeobox domain, metazoa 234 - 245 IPR020479-1
domain Homeobox domain, metazoa 249 - 268 IPR020479-2
domain Domain of unknown function DUF3528, homeobox protein, eukaryotic 26 - 152 IPR021918

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

2 GO annotations of biological process

Name Definition
anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P35452 HOXD12 Homeobox protein Hox-D12 Homo sapiens (Human) PR
P23812 Hoxd12 Homeobox protein Hox-D12 Mus musculus (Mouse) PR
Q6JIY5 hoxc13a Homeobox protein Hox-C13a Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMDFDERVSV GSNMYLPSCT YYVPGADFST LPSFLSQSPS TRPVTYSYAS NLPQVQHVRE
70 80 90 100 110 120
VTFRDYAIDP STKWPHRGPL AHCYPSEDSV HKECLPAVTT VGEMFPKNNA SAYYHSTSNT
130 140 150 160 170 180
TSASNFYGNV GRNGVLPQAF DQFFDTAYGG SDSVVDNDYA ARDKMHSSKQ STPAPAPEQQ
190 200 210 220 230 240
PEGKERPETS SPESSSGNNE EKTSGANSGP RFRKKRCPYT KFQIRELERE FFFSVYINKE
250 260 270 280
KRLQLSRMLN LTDRQVKMWF QNRRMKEKKL NRDRLQYYST NPLL